BacMap

Definition	Rhodopseudomonas palustris HaA2, complete genome.
Accession	NC_007778
Length	5,331,656

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The map label for this gene is livF [H]

Identifier: 86748866

GI number: 86748866

Start: 1991005

End: 1991718

Strand: Reverse

Name: livF [H]

Synonym: RPB_1743

Alternate gene names: 86748866

Gene position: 1991718-1991005 (Counterclockwise)

Preceding gene: 86748867

Following gene: 86748865

Centisome position: 37.36

GC content: 64.71

Gene sequence:

>714_bases
ATGACGGCGATGCTCAACGTTCGCGACCTGCGCGCTTATTACGGCCAGGTCCAGGCGCTGCACGGTCTCGAATTCGACCT
GCAGGAAGGCAGCCTCACCACCCTGCTCGGCGCCAACGGCGCCGGCAAAACCACGACGCTGCGCGCGATCTGCAACATGG
TGCGTTCGACCGGCTCGATCGAATTCCAGGGCACCAAGCTGTCCAGCCGCTCGACCGAATCGATCGTCCGGCTCGGCATC
GCCCACGTGCCGCAGGGCCGCGGCACCTTCACGACGCTCACCGTGCACGAGAACCTCGAGCTCGGTGCGATCAGCCGCAA
GGACCGCAAGGCGATCCCCGGCGACATCGAGCGGATGTATGCGCACTTCCCGGTGCTGAAGCAGCGTCACACCCAGCAGG
CCGGCACGCTGTCCGGCGGCGAACAGCAGATGCTCGCGGTCGCCCGCGCGCTGATGCTTCGGCCGCGGCTGATGCTGCTC
GACGAGCCGTCGTTCGGTCTCGCGCCGCTGGTGGTGCGCGATCTGTTCAAGATCCTCGGCAAGATCAATCGCGAGGACAA
GGTCACCATCCTGGTGGTCGAGCAGAACGCGCAGCTCGCGCTGGAGCTCGCCGACAAGGCTTACGTGATCGAAACAGGAC
GCATCGTGATGTCGGGCAAGGCCGACGACATCGCCAACAATGAAGACGTCCGCAAATCGTATCTCGGATACTGA

Upstream 100 bases:

>100_bases
TCGTCGCGCTGAATTTCGGCCGCAAGCTCGCAGAGGGAACGCCCACGCAGGTGCAGAACGACCCGGATGTGATCAAGGCC
TATCTGGGGAGCAAGGACCA

Downstream 100 bases:

>100_bases
GGAGACTTGCCATGGAACTTCTGCTGAATCAGGTCCTGGCAGGTATCGCCACCGGCGCCATCTACGCATGTATGGCGCTG
GCCGTGGTGATGATCTATCA

Product: ABC transporter related

Products: ADP; phosphate; L-leucine [Cytoplasm]; ADP; L-valine [Cytoplasm]; L-iso-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein F [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTAMLNVRDLRAYYGQVQALHGLEFDLQEGSLTTLLGANGAGKTTTLRAICNMVRSTGSIEFQGTKLSSRSTESIVRLGI
AHVPQGRGTFTTLTVHENLELGAISRKDRKAIPGDIERMYAHFPVLKQRHTQQAGTLSGGEQQMLAVARALMLRPRLMLL
DEPSFGLAPLVVRDLFKILGKINREDKVTILVVEQNAQLALELADKAYVIETGRIVMSGKADDIANNEDVRKSYLGY

Sequences:

>Translated_237_residues
MTAMLNVRDLRAYYGQVQALHGLEFDLQEGSLTTLLGANGAGKTTTLRAICNMVRSTGSIEFQGTKLSSRSTESIVRLGI
AHVPQGRGTFTTLTVHENLELGAISRKDRKAIPGDIERMYAHFPVLKQRHTQQAGTLSGGEQQMLAVARALMLRPRLMLL
DEPSFGLAPLVVRDLFKILGKINREDKVTILVVEQNAQLALELADKAYVIETGRIVMSGKADDIANNEDVRKSYLGY
>Mature_236_residues
TAMLNVRDLRAYYGQVQALHGLEFDLQEGSLTTLLGANGAGKTTTLRAICNMVRSTGSIEFQGTKLSSRSTESIVRLGIA
HVPQGRGTFTTLTVHENLELGAISRKDRKAIPGDIERMYAHFPVLKQRHTQQAGTLSGGEQQMLAVARALMLRPRLMLLD
EPSFGLAPLVVRDLFKILGKINREDKVTILVVEQNAQLALELADKAYVIETGRIVMSGKADDIANNEDVRKSYLGY

Specific function: Component of the leucine-specific transport system [H]

COG id: COG0410

COG function: function code E; ABC-type branched-chain amino acid transport systems, ATPase component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=219, Percent_Identity=32.4200913242009, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI27477115, Length=232, Percent_Identity=31.8965517241379, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI27436953, Length=223, Percent_Identity=31.390134529148, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI27262624, Length=207, Percent_Identity=29.951690821256, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI27262626, Length=207, Percent_Identity=29.951690821256, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21536376, Length=221, Percent_Identity=28.9592760180996, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI27881501, Length=210, Percent_Identity=30.952380952381, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI30795238, Length=210, Percent_Identity=30.952380952381, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI150417984, Length=223, Percent_Identity=30.9417040358744, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI31657092, Length=213, Percent_Identity=29.5774647887324, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI116734710, Length=205, Percent_Identity=28.2926829268293, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI45446740, Length=203, Percent_Identity=29.5566502463054, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI47078218, Length=203, Percent_Identity=29.064039408867, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI105990541, Length=202, Percent_Identity=30.6930693069307, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI148612844, Length=237, Percent_Identity=26.1603375527426, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI255708477, Length=237, Percent_Identity=26.1603375527426, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI11967969, Length=219, Percent_Identity=23.7442922374429, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082268, Length=234, Percent_Identity=46.5811965811966, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI1789593, Length=243, Percent_Identity=29.6296296296296, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789864, Length=249, Percent_Identity=27.710843373494, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788761, Length=238, Percent_Identity=30.2521008403361, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789672, Length=227, Percent_Identity=29.9559471365639, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787029, Length=229, Percent_Identity=27.5109170305677, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790162, Length=232, Percent_Identity=26.7241379310345, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1788450, Length=222, Percent_Identity=30.1801801801802, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790544, Length=248, Percent_Identity=27.8225806451613, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI48994943, Length=239, Percent_Identity=27.1966527196653, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787792, Length=229, Percent_Identity=27.9475982532751, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787089, Length=252, Percent_Identity=30.5555555555556, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788225, Length=240, Percent_Identity=30, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787712, Length=222, Percent_Identity=29.2792792792793, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788210, Length=224, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87081782, Length=232, Percent_Identity=30.1724137931034, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790525, Length=229, Percent_Identity=28.3842794759825, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081709, Length=240, Percent_Identity=27.0833333333333, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87081791, Length=238, Percent_Identity=29.8319327731092, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786398, Length=224, Percent_Identity=27.2321428571429, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789873, Length=203, Percent_Identity=30.5418719211823, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87081834, Length=192, Percent_Identity=30.7291666666667, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790190, Length=211, Percent_Identity=25.5924170616114, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789032, Length=215, Percent_Identity=27.906976744186, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788165, Length=236, Percent_Identity=30.0847457627119, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789991, Length=239, Percent_Identity=25.9414225941423, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787370, Length=228, Percent_Identity=28.0701754385965, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786319, Length=223, Percent_Identity=30.0448430493274, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788472, Length=220, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786253, Length=246, Percent_Identity=26.4227642276423, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786872, Length=248, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48994997, Length=232, Percent_Identity=26.7241379310345, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48994883, Length=245, Percent_Identity=24.8979591836735, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48995001, Length=219, Percent_Identity=26.9406392694064, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789586, Length=235, Percent_Identity=27.6595744680851, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790467, Length=219, Percent_Identity=27.3972602739726, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786563, Length=216, Percent_Identity=30.5555555555556, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787105, Length=238, Percent_Identity=26.890756302521, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788644, Length=248, Percent_Identity=27.0161290322581, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786803, Length=231, Percent_Identity=25.5411255411255, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786703, Length=205, Percent_Identity=29.7560975609756, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1786698, Length=211, Percent_Identity=24.1706161137441, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788897, Length=210, Percent_Identity=30, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787500, Length=239, Percent_Identity=22.5941422594142, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1786345, Length=225, Percent_Identity=26.2222222222222, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788506, Length=210, Percent_Identity=24.2857142857143, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87082267, Length=208, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789963, Length=246, Percent_Identity=23.1707317073171, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787164, Length=203, Percent_Identity=28.0788177339901, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693107, Length=227, Percent_Identity=24.6696035242291, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=223, Percent_Identity=30.9417040358744, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71983510, Length=219, Percent_Identity=31.5068493150685, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71983516, Length=219, Percent_Identity=31.5068493150685, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71983523, Length=219, Percent_Identity=31.5068493150685, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71992285, Length=221, Percent_Identity=28.5067873303167, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17510237, Length=213, Percent_Identity=30.0469483568075, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193208177, Length=217, Percent_Identity=27.1889400921659, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193211017, Length=220, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71996809, Length=220, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193211015, Length=220, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=206, Percent_Identity=27.6699029126214, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539902, Length=209, Percent_Identity=26.7942583732057, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=227, Percent_Identity=27.3127753303965, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322177, Length=186, Percent_Identity=26.8817204301075, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319856, Length=212, Percent_Identity=26.4150943396226, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24666092, Length=214, Percent_Identity=27.1028037383178, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19920532, Length=224, Percent_Identity=25.8928571428571, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24580930, Length=224, Percent_Identity=25.8928571428571, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221512771, Length=216, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24643674, Length=216, Percent_Identity=28.7037037037037, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28574744, Length=217, Percent_Identity=27.6497695852535, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574150, Length=220, Percent_Identity=27.7272727272727, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007328, Length=220, Percent_Identity=27.7272727272727, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648314, Length=216, Percent_Identity=26.8518518518519, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574533, Length=223, Percent_Identity=26.0089686098655, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24662800, Length=212, Percent_Identity=27.3584905660377, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17136592, Length=207, Percent_Identity=26.5700483091787, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650853, Length=197, Percent_Identity=28.9340101522843, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24650855, Length=197, Percent_Identity=28.9340101522843, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357907, Length=217, Percent_Identity=27.6497695852535, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281362751, Length=219, Percent_Identity=28.310502283105, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581191, Length=216, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581189, Length=216, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581193, Length=216, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581195, Length=216, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24582014, Length=201, Percent_Identity=28.3582089552239, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24582012, Length=201, Percent_Identity=28.3582089552239, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI85816269, Length=214, Percent_Identity=25.7009345794392, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24580553, Length=214, Percent_Identity=25.7009345794392, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI85724864, Length=214, Percent_Identity=25.7009345794392, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24580555, Length=214, Percent_Identity=25.7009345794392, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI85725262, Length=205, Percent_Identity=28.2926829268293, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 26067; Mature: 25935

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAMLNVRDLRAYYGQVQALHGLEFDLQEGSLTTLLGANGAGKTTTLRAICNMVRSTGSI
CCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCE
EFQGTKLSSRSTESIVRLGIAHVPQGRGTFTTLTVHENLELGAISRKDRKAIPGDIERMY
EEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
AHFPVLKQRHTQQAGTLSGGEQQMLAVARALMLRPRLMLLDEPSFGLAPLVVRDLFKILG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
KINREDKVTILVVEQNAQLALELADKAYVIETGRIVMSGKADDIANNEDVRKSYLGY
CCCCCCCEEEEEEECCCEEEEEECCCEEEEECCEEEEECCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
TAMLNVRDLRAYYGQVQALHGLEFDLQEGSLTTLLGANGAGKTTTLRAICNMVRSTGSI
CCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCE
EFQGTKLSSRSTESIVRLGIAHVPQGRGTFTTLTVHENLELGAISRKDRKAIPGDIERMY
EEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
AHFPVLKQRHTQQAGTLSGGEQQMLAVARALMLRPRLMLLDEPSFGLAPLVVRDLFKILG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
KINREDKVTILVVEQNAQLALELADKAYVIETGRIVMSGKADDIANNEDVRKSYLGY
CCCCCCCEEEEEEECCCEEEEEECCCEEEEECCEEEEECCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-leucine [Periplasm]; H2O; ATP; L-valine [Periplasm]; L-iso-leucine [Periplasm] [C]

Specific reaction: ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]