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The map label for this gene is nhaA [H]

Identifier: 86748216

GI number: 86748216

Start: 1251941

End: 1252849

Strand: Direct

Name: nhaA [H]

Synonym: RPB_1091

Alternate gene names: 86748216

Gene position: 1251941-1252849 (Clockwise)

Preceding gene: 86748215

Following gene: 86748217

Centisome position: 23.48

GC content: 67.88

Gene sequence:

>909_bases
ATGAATGATCCGGCGACGAGTGGTCGCAGCTCCGCGAGCCTGCTCGACACTTTCGGCAAATGGATTCCGGCCCGGTTCCG
CTCCGATATTCCGGTCGTGCCGGTGGTGCGCCTGTCGGGCGTGATCGGCGCCGTCACGCCGCTGCGGCCGGGCATGTCGC
TGGCGGGCGTCGCCAAGCTGCTGGAGCGTGCGTTCGCGACGCGCAACGCCAAGGCGGTGGCGCTGGCGATCAACTCGCCG
GGCGGCTCGCCGGTGCAGTCGCGGCTGATCTATCTGCGCATCCGCGCGCTGGCGGCCGAAAAGAAACTGCCGGTCTATGC
TTTCGTCGAGGATGTCGCGGCCTCGGGCGGCTACATGATCGCCTGCGGCGCCGACGAGATCTATTGCGACCCCTCCTCGA
TCGTCGGATCGATCGGCGTGGTCGGCGGCAGTTTCGGCTTTCAGGAACTGATCAAGAAGATCGGCGTCGAGCGCCGGCTG
TACACCGCCGGCGAGCACAAGGCGCAGCTCGATCCGTTTCTGCCGGAAGATCCCGGCGACGTCGCCCGCGTCAAGGCGCT
GCAGCAGGAGATCCACGCGCTGTTCATTTCGCTGGTGAAAGACAGCCGCGGTGCGCGGCTGAAGGGCGACGACGCCAAGC
TGTTCTCCGGCGAGTACTGGGCCGGCGCGACCTCGGTGTCGCTGGGTCTGTCCGATGCGATCGGCGACCTCCGCGCGGTG
CTGCGCGACAAATTCGGCGACAAGGTGCGCACGCCGGTGATCGCGGCGCCGACCGGCTTGCTGTCGGGCCTGATGCGCAA
ATCGTCGGGCGCCGGCACAGAGGCCTCGCTCGACGGCTTCGCGGCGCTGCCCGATCAGCTGATCTCGGCGCTGGAGGCGC
GCGCGATCTGGGCGAAATACGGCTTTTAG

Upstream 100 bases:

>100_bases
TCGTTGCAGCCGCGTCCCCATATGAAACTCTGCTCTGCAAAACACGTTCCAGACCACAGCTGATTCGGGTTTGGAAATAG
ATCAACATTTGGGTGAATGC

Downstream 100 bases:

>100_bases
AAGGTCCCAAACGCGCTGTTTCGCCCCGCCGGAGGCGATTGCAGAGGGGGCGCGATTCAGCAAGACTGTCCGCGGGGCGT
GACGTGACCCGAGACGAGGA

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MNDPATSGRSSASLLDTFGKWIPARFRSDIPVVPVVRLSGVIGAVTPLRPGMSLAGVAKLLERAFATRNAKAVALAINSP
GGSPVQSRLIYLRIRALAAEKKLPVYAFVEDVAASGGYMIACGADEIYCDPSSIVGSIGVVGGSFGFQELIKKIGVERRL
YTAGEHKAQLDPFLPEDPGDVARVKALQQEIHALFISLVKDSRGARLKGDDAKLFSGEYWAGATSVSLGLSDAIGDLRAV
LRDKFGDKVRTPVIAAPTGLLSGLMRKSSGAGTEASLDGFAALPDQLISALEARAIWAKYGF

Sequences:

>Translated_302_residues
MNDPATSGRSSASLLDTFGKWIPARFRSDIPVVPVVRLSGVIGAVTPLRPGMSLAGVAKLLERAFATRNAKAVALAINSP
GGSPVQSRLIYLRIRALAAEKKLPVYAFVEDVAASGGYMIACGADEIYCDPSSIVGSIGVVGGSFGFQELIKKIGVERRL
YTAGEHKAQLDPFLPEDPGDVARVKALQQEIHALFISLVKDSRGARLKGDDAKLFSGEYWAGATSVSLGLSDAIGDLRAV
LRDKFGDKVRTPVIAAPTGLLSGLMRKSSGAGTEASLDGFAALPDQLISALEARAIWAKYGF
>Mature_302_residues
MNDPATSGRSSASLLDTFGKWIPARFRSDIPVVPVVRLSGVIGAVTPLRPGMSLAGVAKLLERAFATRNAKAVALAINSP
GGSPVQSRLIYLRIRALAAEKKLPVYAFVEDVAASGGYMIACGADEIYCDPSSIVGSIGVVGGSFGFQELIKKIGVERRL
YTAGEHKAQLDPFLPEDPGDVARVKALQQEIHALFISLVKDSRGARLKGDDAKLFSGEYWAGATSVSLGLSDAIGDLRAV
LRDKFGDKVRTPVIAAPTGLLSGLMRKSSGAGTEASLDGFAALPDQLISALEARAIWAKYGF

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=168, Percent_Identity=35.7142857142857, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788064, Length=178, Percent_Identity=33.1460674157303, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 31803; Mature: 31803

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDPATSGRSSASLLDTFGKWIPARFRSDIPVVPVVRLSGVIGAVTPLRPGMSLAGVAKL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
LERAFATRNAKAVALAINSPGGSPVQSRLIYLRIRALAAEKKLPVYAFVEDVAASGGYMI
HHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEE
ACGADEIYCDPSSIVGSIGVVGGSFGFQELIKKIGVERRLYTAGEHKAQLDPFLPEDPGD
EECCCCEEECHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCH
VARVKALQQEIHALFISLVKDSRGARLKGDDAKLFSGEYWAGATSVSLGLSDAIGDLRAV
HHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEECCCCCCCCCHHHCCHHHHHHHHHHH
LRDKFGDKVRTPVIAAPTGLLSGLMRKSSGAGTEASLDGFAALPDQLISALEARAIWAKY
HHHHHCCHHCCCEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GF
CC
>Mature Secondary Structure
MNDPATSGRSSASLLDTFGKWIPARFRSDIPVVPVVRLSGVIGAVTPLRPGMSLAGVAKL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
LERAFATRNAKAVALAINSPGGSPVQSRLIYLRIRALAAEKKLPVYAFVEDVAASGGYMI
HHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEE
ACGADEIYCDPSSIVGSIGVVGGSFGFQELIKKIGVERRLYTAGEHKAQLDPFLPEDPGD
EECCCCEEECHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCH
VARVKALQQEIHALFISLVKDSRGARLKGDDAKLFSGEYWAGATSVSLGLSDAIGDLRAV
HHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEECCCCCCCCCHHHCCHHHHHHHHHHH
LRDKFGDKVRTPVIAAPTGLLSGLMRKSSGAGTEASLDGFAALPDQLISALEARAIWAKY
HHHHHCCHHCCCEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GF
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA