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The map label for this gene is ispB [H]

Identifier: 86748213

GI number: 86748213

Start: 1249447

End: 1250457

Strand: Reverse

Name: ispB [H]

Synonym: RPB_1088

Alternate gene names: 86748213

Gene position: 1250457-1249447 (Counterclockwise)

Preceding gene: 86748222

Following gene: 86748208

Centisome position: 23.45

GC content: 67.46

Gene sequence:

>1011_bases
GTGGCCGTAGTCGTACCTTTCGAAGGCCCCCCGCCCGCCTCGATCGATCAATTGGTCGGACTTGTCGCGGCGGACATGGA
GCGGGTCAACGCCACCATCCTGTCGCGCACCGGCTCGGACGTCACGATGATCCCCGAGGTCGCGAACCATCTGATCTCCT
CGGGCGGCAAGCGGCTGCGGCCGATGCTGACGCTGGCGATGGCCAACCTCACCGGCTATGCCGGCGACGGCCACATCAAG
CTCGCCGCGGCGGTCGAATTCATGCACACCGCGACGCTGCTGCACGACGACGTCGTCGACGAGAGCGAGATGCGCCGCGG
CAAGAAGTCGGCGCGGATGCTGTGGGGCAACGAGGCCAGCGTGCTGGTCGGCGACTTCCTGCTCGGCCAGGCGTTCCGGA
TGATGGTCGAGGTCGGCTCGCTGCGCGCACTCGACATTCTGTCGGCGGCCTCGGCGACGATCGCCGAAGGCGAGGTAATG
CAGCTCGCCGCCGCCAAGAACACCGCCACCACCGAGGACGAATATCTCGCGGTGATCCGCGGCAAGACCGCCGAACTGTT
CGCCGCCGCCTGCGAAGTCGGGCCCGCCATCGCCGACCGGCCGAAGGCCGAGCAGTCGGCCTGCCGCTCGTTCGGCATGA
ACATCGGCATCGCCTTCCAGCTCGTCGACGACGTGCTCGATTACGGCGGCAAGGCCGCCAAACTCGGCAAGAATGTCGGC
GACGATTTCCGCGAGGGCAAGATCACGCTGCCGGTGGTGCTGGCGTTCCGCCGCGGCAACGATTCCGAGCGGGCGTTCTG
GATCAAGGCGCTGGAGCGCGGCGAGATCACCGAGGCCGATCTCGACCAGGCGATCAAGCTGATGACCAAGCACCGCGCCC
TCGAGGACACCATCCAGCGCGCGCACCACTACGGCGCGATGGCCGTCGACGCATTGGCGCTGTTCCCGTCGTCGCCGATG
AAAACCGCGCTGGAGCAGGTGGTGGCGTTCTGCTTGGCGCGGTCGCACTGA

Upstream 100 bases:

>100_bases
GGCACCGCGTCGGCGTCCCCACTTCGCCCCGAGCAACGAAATCAGGGAGTTTTCGCGCGGACTCGATGTGCCGGAAACCT
CCCGAATCTGGAGACTGAGC

Downstream 100 bases:

>100_bases
GCTGCAGCCGGCGCTGGGACTGCCAGCCGATCACCTGCGACCACGATCCGGCGAGACGCGCGCCCCTTAGGGCGCGCTCC
TCATCCTGGCGCTGCGCGCT

Product: farnesyltranstransferase

Products: NA

Alternate protein names: All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAVVVPFEGPPPASIDQLVGLVAADMERVNATILSRTGSDVTMIPEVANHLISSGGKRLRPMLTLAMANLTGYAGDGHIK
LAAAVEFMHTATLLHDDVVDESEMRRGKKSARMLWGNEASVLVGDFLLGQAFRMMVEVGSLRALDILSAASATIAEGEVM
QLAAAKNTATTEDEYLAVIRGKTAELFAAACEVGPAIADRPKAEQSACRSFGMNIGIAFQLVDDVLDYGGKAAKLGKNVG
DDFREGKITLPVVLAFRRGNDSERAFWIKALERGEITEADLDQAIKLMTKHRALEDTIQRAHHYGAMAVDALALFPSSPM
KTALEQVVAFCLARSH

Sequences:

>Translated_336_residues
MAVVVPFEGPPPASIDQLVGLVAADMERVNATILSRTGSDVTMIPEVANHLISSGGKRLRPMLTLAMANLTGYAGDGHIK
LAAAVEFMHTATLLHDDVVDESEMRRGKKSARMLWGNEASVLVGDFLLGQAFRMMVEVGSLRALDILSAASATIAEGEVM
QLAAAKNTATTEDEYLAVIRGKTAELFAAACEVGPAIADRPKAEQSACRSFGMNIGIAFQLVDDVLDYGGKAAKLGKNVG
DDFREGKITLPVVLAFRRGNDSERAFWIKALERGEITEADLDQAIKLMTKHRALEDTIQRAHHYGAMAVDALALFPSSPM
KTALEQVVAFCLARSH
>Mature_335_residues
AVVVPFEGPPPASIDQLVGLVAADMERVNATILSRTGSDVTMIPEVANHLISSGGKRLRPMLTLAMANLTGYAGDGHIKL
AAAVEFMHTATLLHDDVVDESEMRRGKKSARMLWGNEASVLVGDFLLGQAFRMMVEVGSLRALDILSAASATIAEGEVMQ
LAAAKNTATTEDEYLAVIRGKTAELFAAACEVGPAIADRPKAEQSACRSFGMNIGIAFQLVDDVLDYGGKAAKLGKNVGD
DFREGKITLPVVLAFRRGNDSERAFWIKALERGEITEADLDQAIKLMTKHRALEDTIQRAHHYGAMAVDALALFPSSPMK
TALEQVVAFCLARSH

Specific function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=298, Percent_Identity=27.8523489932886, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI169808399, Length=263, Percent_Identity=24.3346007604563, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4758430, Length=211, Percent_Identity=23.696682464455, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI83700220, Length=211, Percent_Identity=23.696682464455, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789578, Length=311, Percent_Identity=44.0514469453376, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1786623, Length=223, Percent_Identity=32.2869955156951, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17505681, Length=319, Percent_Identity=28.5266457680251, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6319475, Length=303, Percent_Identity=29.7029702970297, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6325188, Length=232, Percent_Identity=22.8448275862069, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24651612, Length=309, Percent_Identity=29.7734627831715, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281365769, Length=214, Percent_Identity=23.8317757009346, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24660002, Length=214, Percent_Identity=23.8317757009346, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.90 [H]

Molecular weight: Translated: 36037; Mature: 35906

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVVPFEGPPPASIDQLVGLVAADMERVNATILSRTGSDVTMIPEVANHLISSGGKRLR
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCHHHH
PMLTLAMANLTGYAGDGHIKLAAAVEFMHTATLLHDDVVDESEMRRGKKSARMLWGNEAS
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHEECCCCCH
VLVGDFLLGQAFRMMVEVGSLRALDILSAASATIAEGEVMQLAAAKNTATTEDEYLAVIR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHEEEEEE
GKTAELFAAACEVGPAIADRPKAEQSACRSFGMNIGIAFQLVDDVLDYGGKAAKLGKNVG
CCHHHHHHHHHHHCCHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCC
DDFREGKITLPVVLAFRRGNDSERAFWIKALERGEITEADLDQAIKLMTKHRALEDTIQR
CHHHCCCEEEEEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AHHYGAMAVDALALFPSSPMKTALEQVVAFCLARSH
HHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVVVPFEGPPPASIDQLVGLVAADMERVNATILSRTGSDVTMIPEVANHLISSGGKRLR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCHHHH
PMLTLAMANLTGYAGDGHIKLAAAVEFMHTATLLHDDVVDESEMRRGKKSARMLWGNEAS
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHEECCCCCH
VLVGDFLLGQAFRMMVEVGSLRALDILSAASATIAEGEVMQLAAAKNTATTEDEYLAVIR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHEEEEEE
GKTAELFAAACEVGPAIADRPKAEQSACRSFGMNIGIAFQLVDDVLDYGGKAAKLGKNVG
CCHHHHHHHHHHHCCHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCC
DDFREGKITLPVVLAFRRGNDSERAFWIKALERGEITEADLDQAIKLMTKHRALEDTIQR
CHHHCCCEEEEEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AHHYGAMAVDALALFPSSPMKTALEQVVAFCLARSH
HHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]