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The map label for this gene is trxA [H]

Identifier: 86747756

GI number: 86747756

Start: 715854

End: 716174

Strand: Direct

Name: trxA [H]

Synonym: RPB_0630

Alternate gene names: 86747756

Gene position: 715854-716174 (Clockwise)

Preceding gene: 86747755

Following gene: 86747768

Centisome position: 13.43

GC content: 63.86

Gene sequence:

>321_bases
ATGGCCGTAGGCAAGGTGTCAGACGCCGATTTCGAAGCTGAAGTTCTCAAGGCGCAGGGCCCTGTGGTGGTGGATTTCTG
GGCCGAGTGGTGCGGCCCCTGCCGCATGATCGCTCCGGCGCTGGACGAAATCTCCGGCGCGATGGGCGACACCGTCAAGA
TCGTGAAGCTCAATGTCGACGAGAGCCCGGTCACGGCGTCGAAATACGGCGTGATGTCGATTCCGACGCTGATGATCTTC
AAGGGCGGCGAGATGGCCTCGCGCCAGGTCGGCGCCGCGCCGAAGGCCAAGCTGCAGCAGTGGATCAGCTCGGCGGTCTG
A

Upstream 100 bases:

>100_bases
GCGTGAGCGCGCTTGACCCCGCCCCGGCGCGTTCATACGTTGAATTCAGCTCCCCGGCGCGATTCCCGCTGCGCCATCAT
CCGCATTCACGAGGGTTCCC

Downstream 100 bases:

>100_bases
GCCGCGCCTGACGAACGTTCTGCAACGGCCGGCTCACGCCGGCCGTTTTGCGTTAGAGGGCCGGGTGCACTCCGCCTAAG
CCGTGCCCGCGTCGCCCTCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MAVGKVSDADFEAEVLKAQGPVVVDFWAEWCGPCRMIAPALDEISGAMGDTVKIVKLNVDESPVTASKYGVMSIPTLMIF
KGGEMASRQVGAAPKAKLQQWISSAV

Sequences:

>Translated_106_residues
MAVGKVSDADFEAEVLKAQGPVVVDFWAEWCGPCRMIAPALDEISGAMGDTVKIVKLNVDESPVTASKYGVMSIPTLMIF
KGGEMASRQVGAAPKAKLQQWISSAV
>Mature_105_residues
AVGKVSDADFEAEVLKAQGPVVVDFWAEWCGPCRMIAPALDEISGAMGDTVKIVKLNVDESPVTASKYGVMSIPTLMIFK
GGEMASRQVGAAPKAKLQQWISSAV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=30.9278350515464, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=49.0196078431373, Blast_Score=120, Evalue=2e-29,
Organism=Escherichia coli, GI1788936, Length=114, Percent_Identity=36.8421052631579, Blast_Score=93, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=40.4255319148936, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=32.2222222222222, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=90, Percent_Identity=40, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=38.3720930232558, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=100, Percent_Identity=42, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=95, Percent_Identity=35.7894736842105, Blast_Score=73, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=83, Percent_Identity=44.578313253012, Blast_Score=71, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=36.0824742268041, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24639826, Length=83, Percent_Identity=42.1686746987952, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17648013, Length=106, Percent_Identity=39.622641509434, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=106, Percent_Identity=39.622641509434, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358065, Length=100, Percent_Identity=35, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11229; Mature: 11098

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVGKVSDADFEAEVLKAQGPVVVDFWAEWCGPCRMIAPALDEISGAMGDTVKIVKLNVD
CCCCCCCCCCCHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEECC
ESPVTASKYGVMSIPTLMIFKGGEMASRQVGAAPKAKLQQWISSAV
CCCCCCCCCCCEECCEEEEEECCCCCCHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AVGKVSDADFEAEVLKAQGPVVVDFWAEWCGPCRMIAPALDEISGAMGDTVKIVKLNVD
CCCCCCCCCCHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEECC
ESPVTASKYGVMSIPTLMIFKGGEMASRQVGAAPKAKLQQWISSAV
CCCCCCCCCCCEECCEEEEEECCCCCCHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3129411 [H]