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The map label for this gene is cat1 [H]

Identifier: 86747629

GI number: 86747629

Start: 562278

End: 563924

Strand: Direct

Name: cat1 [H]

Synonym: RPB_0503

Alternate gene names: 86747629

Gene position: 562278-563924 (Clockwise)

Preceding gene: 86747628

Following gene: 86747631

Centisome position: 10.55

GC content: 64.48

Gene sequence:

>1647_bases
ATGGCTCTTTTCGGCGAACCGATTAGACGAATCGGATCAATCACTTCCGCGGGCCCGGCTGGCCCCCGATCAGAAAGAGC
CGTGATGGTCGTTTCCGCCTCTCGCGTCCAAGCGCCCCACCTTCGTTCGAAGATCATGACGGCGGCCGACGCCGCAGCCC
AAATTCCCTCGGGCGCCAATGTCGGCATGAGCGGCTTCACCGGGGCGGGCTATCCGAAGCTGCTGCCGCTGGCGCTGGCC
GAGCGCATCAACGCGCATCACGCCCGCGGGCAGAAGTTCAAGGTCTCGGTGTGGACCGGCGCCTCGACCGCGCCCGAGCT
CGACGGCGCGCTCGCCAAGGTCGACGGCATCGAGATGCGGCTGCCCTATCAGTCCGATCCGACCTGCCGCAAGCGCATCA
ATGCCGGGCGGATGGAGTACATCGACATCCACCTGTCGCACGTCGCCCAGCACGTCTGGTTCGGCTTTCTCGGCAAGCTC
GATGTCGCCATCGTCGAGGTCGCCGGCATCCGCGAGGACGGCAGCCTGATCCCGTCGTCGTCGATCGGCAACAACAAGAG
CTGGCTCGACCTCGCCGACAAGGTGATTCTCGAAGTCAACGCCTGGCAGGACCTCCGGCTCGAAGGCATGCATGACGTGT
ATTACGGCACGCAATTGCCGCCGCACCGCAAGCCGATCCCGATCCTGGCCACGGGAGACCGCATCGGCGAGCCGTATCTG
CGCTGCGATCCGTCGAAGATCGTCGCCATCGTCGAAACCAATCTGCCCGACCGCAATTCGGGGTTCTCCGCGCCCGACGA
GAGTTCGCAGGCGATCGCCGAACACATTCTCGACTTCCTCGGCCACGAAGTGAAGAAAGGCCGGCTGCCGCCGAACCTGC
TGCCGCTGCAATCCGGCGTCGGCAACGTCGCCAATGCGGTGATGGCCGGGCTCGAGAGCGGCCCGTTCGAGAACATGACG
GCCTACACCGAGGTGCTGCAGGACGGCATGCTGAGCCTGCTGCGCAAGGGCAAGCTGACGCTGGCCTCGGCCACCGCGCT
GTCGCTGTCGCCGGACGGCTACGACGAATTCCTGCGCAACCTCGATTTCTATCGCGAGCGCATCGTGCTGCGGCCGCAGG
AAATCTCCAATCATCCGGAAGTGATCCGCAGGCTGGGCGTGATCGCGATGAACGGGCTGATCGAGGCCGACATCTACGGC
AACGTCAATTCGACCCACATCATGGGCACCAGCATCATGAACGGCATCGGCGGCTCGGGCGATTTCGCCCGCAACAGCTA
CCTGTCGTTCTTCATGACGCCGTCGGCGGCGAAGGGCGGCAAGATCTCCTGCATCGTGCCGATGGCCTCGCATGTCGATC
ACACCGAACACGACGTCCAGATCATCGTCACCGAGCAGGGGCTGGCCGATCTGCGCGGACTGTCGCCGAAGGCCAGGGCG
AAAGTCATCATCGAGAATTGCGCGCATCCGACCTTCAAGCCGGCGTTGAAGGAATACTACAAGCGCGCGCTGGAATATTC
GCCCGGCCTGCATACCCCGCACATCCTCGACGAGGCGCTGACCTTCCTGCCGAACTGGATGGCCAACAAGGCGGCGCGCG
AAGCCTGGCGCGAGGACGCGGTGGTGCAGGCGGATGTGTGGCGGTGA

Upstream 100 bases:

>100_bases
ATGCGCTAGCACCCAGGCGAATCCAGCGCCGGATCGGTGCGCCGGACCGCACCCGGAAATATCGCAGCGCAGCATTCAAC
GGCACTCCGCCGTTGGTTGC

Downstream 100 bases:

>100_bases
GGCACGCCTCGATTTCGCTGGAGCGGCCGTAGCCGCGCGCGCCCCGTCATCCTGAGGTGCGAGCGCAGCGAGCCTCGAAG
GATGTGCGACGAGGGTCGTG

Product: Acetyl-CoA hydrolase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MALFGEPIRRIGSITSAGPAGPRSERAVMVVSASRVQAPHLRSKIMTAADAAAQIPSGANVGMSGFTGAGYPKLLPLALA
ERINAHHARGQKFKVSVWTGASTAPELDGALAKVDGIEMRLPYQSDPTCRKRINAGRMEYIDIHLSHVAQHVWFGFLGKL
DVAIVEVAGIREDGSLIPSSSIGNNKSWLDLADKVILEVNAWQDLRLEGMHDVYYGTQLPPHRKPIPILATGDRIGEPYL
RCDPSKIVAIVETNLPDRNSGFSAPDESSQAIAEHILDFLGHEVKKGRLPPNLLPLQSGVGNVANAVMAGLESGPFENMT
AYTEVLQDGMLSLLRKGKLTLASATALSLSPDGYDEFLRNLDFYRERIVLRPQEISNHPEVIRRLGVIAMNGLIEADIYG
NVNSTHIMGTSIMNGIGGSGDFARNSYLSFFMTPSAAKGGKISCIVPMASHVDHTEHDVQIIVTEQGLADLRGLSPKARA
KVIIENCAHPTFKPALKEYYKRALEYSPGLHTPHILDEALTFLPNWMANKAAREAWREDAVVQADVWR

Sequences:

>Translated_548_residues
MALFGEPIRRIGSITSAGPAGPRSERAVMVVSASRVQAPHLRSKIMTAADAAAQIPSGANVGMSGFTGAGYPKLLPLALA
ERINAHHARGQKFKVSVWTGASTAPELDGALAKVDGIEMRLPYQSDPTCRKRINAGRMEYIDIHLSHVAQHVWFGFLGKL
DVAIVEVAGIREDGSLIPSSSIGNNKSWLDLADKVILEVNAWQDLRLEGMHDVYYGTQLPPHRKPIPILATGDRIGEPYL
RCDPSKIVAIVETNLPDRNSGFSAPDESSQAIAEHILDFLGHEVKKGRLPPNLLPLQSGVGNVANAVMAGLESGPFENMT
AYTEVLQDGMLSLLRKGKLTLASATALSLSPDGYDEFLRNLDFYRERIVLRPQEISNHPEVIRRLGVIAMNGLIEADIYG
NVNSTHIMGTSIMNGIGGSGDFARNSYLSFFMTPSAAKGGKISCIVPMASHVDHTEHDVQIIVTEQGLADLRGLSPKARA
KVIIENCAHPTFKPALKEYYKRALEYSPGLHTPHILDEALTFLPNWMANKAAREAWREDAVVQADVWR
>Mature_547_residues
ALFGEPIRRIGSITSAGPAGPRSERAVMVVSASRVQAPHLRSKIMTAADAAAQIPSGANVGMSGFTGAGYPKLLPLALAE
RINAHHARGQKFKVSVWTGASTAPELDGALAKVDGIEMRLPYQSDPTCRKRINAGRMEYIDIHLSHVAQHVWFGFLGKLD
VAIVEVAGIREDGSLIPSSSIGNNKSWLDLADKVILEVNAWQDLRLEGMHDVYYGTQLPPHRKPIPILATGDRIGEPYLR
CDPSKIVAIVETNLPDRNSGFSAPDESSQAIAEHILDFLGHEVKKGRLPPNLLPLQSGVGNVANAVMAGLESGPFENMTA
YTEVLQDGMLSLLRKGKLTLASATALSLSPDGYDEFLRNLDFYRERIVLRPQEISNHPEVIRRLGVIAMNGLIEADIYGN
VNSTHIMGTSIMNGIGGSGDFARNSYLSFFMTPSAAKGGKISCIVPMASHVDHTEHDVQIIVTEQGLADLRGLSPKARAK
VIIENCAHPTFKPALKEYYKRALEYSPGLHTPHILDEALTFLPNWMANKAAREAWREDAVVQADVWR

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=484, Percent_Identity=48.5537190082645, Blast_Score=463, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17538151, Length=477, Percent_Identity=24.9475890985325, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319456, Length=502, Percent_Identity=44.8207171314741, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 59648; Mature: 59517

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFGEPIRRIGSITSAGPAGPRSERAVMVVSASRVQAPHLRSKIMTAADAAAQIPSGAN
CCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
VGMSGFTGAGYPKLLPLALAERINAHHARGQKFKVSVWTGASTAPELDGALAKVDGIEMR
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEEE
LPYQSDPTCRKRINAGRMEYIDIHLSHVAQHVWFGFLGKLDVAIVEVAGIREDGSLIPSS
CCCCCCCHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCC
SIGNNKSWLDLADKVILEVNAWQDLRLEGMHDVYYGTQLPPHRKPIPILATGDRIGEPYL
CCCCCCHHHHHHHHHEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCCCCCCCCE
RCDPSKIVAIVETNLPDRNSGFSAPDESSQAIAEHILDFLGHEVKKGRLPPNLLPLQSGV
EECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHCCC
GNVANAVMAGLESGPFENMTAYTEVLQDGMLSLLRKGKLTLASATALSLSPDGYDEFLRN
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHH
LDFYRERIVLRPQEISNHPEVIRRLGVIAMNGLIEADIYGNVNSTHIMGTSIMNGIGGSG
HHHHHHHHEECCHHHCCCHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHHHHHCCCCCC
DFARNSYLSFFMTPSAAKGGKISCIVPMASHVDHTEHDVQIIVTEQGLADLRGLSPKARA
CCCCCCEEEEEECCCCCCCCEEEEEEECHHCCCCCCCCEEEEEECCCHHHHHCCCCHHHH
KVIIENCAHPTFKPALKEYYKRALEYSPGLHTPHILDEALTFLPNWMANKAAREAWREDA
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCC
VVQADVWR
EEEECCCC
>Mature Secondary Structure 
ALFGEPIRRIGSITSAGPAGPRSERAVMVVSASRVQAPHLRSKIMTAADAAAQIPSGAN
CCCCHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
VGMSGFTGAGYPKLLPLALAERINAHHARGQKFKVSVWTGASTAPELDGALAKVDGIEMR
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEEE
LPYQSDPTCRKRINAGRMEYIDIHLSHVAQHVWFGFLGKLDVAIVEVAGIREDGSLIPSS
CCCCCCCHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCC
SIGNNKSWLDLADKVILEVNAWQDLRLEGMHDVYYGTQLPPHRKPIPILATGDRIGEPYL
CCCCCCHHHHHHHHHEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCCCCCCCCE
RCDPSKIVAIVETNLPDRNSGFSAPDESSQAIAEHILDFLGHEVKKGRLPPNLLPLQSGV
EECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHCCC
GNVANAVMAGLESGPFENMTAYTEVLQDGMLSLLRKGKLTLASATALSLSPDGYDEFLRN
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHH
LDFYRERIVLRPQEISNHPEVIRRLGVIAMNGLIEADIYGNVNSTHIMGTSIMNGIGGSG
HHHHHHHHEECCHHHCCCHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHHHHHCCCCCC
DFARNSYLSFFMTPSAAKGGKISCIVPMASHVDHTEHDVQIIVTEQGLADLRGLSPKARA
CCCCCCEEEEEECCCCCCCCEEEEEEECHHCCCCCCCCEEEEEECCCHHHHHCCCCHHHH
KVIIENCAHPTFKPALKEYYKRALEYSPGLHTPHILDEALTFLPNWMANKAAREAWREDA
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCC
VVQADVWR
EEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]