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The map label for this gene is cyoB [H]

Identifier: 86747367

GI number: 86747367

Start: 273416

End: 275425

Strand: Reverse

Name: cyoB [H]

Synonym: RPB_0241

Alternate gene names: 86747367

Gene position: 275425-273416 (Counterclockwise)

Preceding gene: 86747368

Following gene: 86747366

Centisome position: 5.17

GC content: 61.99

Gene sequence:

>2010_bases
ATGCTTACCAATCCTGATATCGTCAAGGCGATCTTCGGCCGGCTGTCTCTGGAATCGCTGCCGTTGCACGAGCCGATCGT
CGTCCTCACCTTCGTGGCGGTCGCGCTCGGCGGCGCCGCTCTGGTCGCGGGCCTGACCTATTTCAAGCTGTGGGGCTATC
TGTGGCGCGAGTGGTTCACCACCGTCGACCACAAGCGCATCGGCATCATGTACATGATCCTCGGCATCGTCATGCTGCTG
CGCGGCTTCGCCGACGCGGTGATGATGCGGGCCCAGCAGGCGATGGCCTTCAACGGCTCCGAGGGCTATCTCAACGCGCA
TCACTACGATCAGGTGTTCACCGCCCACGGCGTGATCATGATCTTCTTCGTGGCGATGCCGATGGTCACCGGCCTGATGA
ACTACGTCGTGCCGCTGCAGATCGGCGCCCGCGACGTGTCGTTCCCGTTCCTGAACAATTTCAGCTTCTGGATGACGACT
GCCGGCGCCGTGCTGGTGATGATCTCGCTGTTCGTCGGCGAGTTCGCCCGCACCGGCTGGCTGGCCTATCCGCCGCTGTC
GAACATCGGTTACAGTCCGGACGTCGGCGTTGACTACTACATCTGGGCGCTGCAGGTCGCGGGCGTCGGAACCACATTGT
CCGGCGTCAACCTGATCTGCACCATCGTCAAGGTGCGGGCGCCCGGCATGACCATGATGCGGATGCCGATCTTCACCTGG
ACCTCGCTCTGCACCAACATCCTGATCGTCGCCTCGTTTCCGGTTCTGACCGTAGTGCTGGCGCTGCTGTCGCTCGATCG
TTACGTCGGCACCAATTTCTTCACGAACGACTTCGGCGGCAACCCGATGATGTACGTGAACCTGATCTGGATCTGGGGCC
ATCCGGAGGTCTACATCCTGATCCTGCCGGCCTTCGGGATCTTCTCCGAAGTCACCTCGACGTTCTCCGGCAAGCGGCTG
TTCGGCTACACCTCGATGGTCTACGCCACGGTGGTCATCACCATCCTGTCGTACCTGGTGTGGTTGCACCATTTCTTCAC
GATGGGCTCGGGCGCCAGCGTCAACTCGTTCTTCGGCATTACCACGATGATCATCTCGATCCCGACGGGCGCGAAGATGT
TCAACTGGCTGTTCACGATGTACCGCGGCCGGATCCGTTACGACCTGCCGATGATGTGGACGATCGCATTCATGCTGACC
TTCGTGATCGGCGGCATGACCGGGGTGCTGCTCGCGGTGCCGCCGGCCGACTTCGTGCTGCACAACAGCCTGTTCCTGGT
CGCGCATTTCCACAATGTCATCATCGGCGGCGTGGTGTTCGGCCTGTTCGCCGGCATCGCCTACTGGTTCCCGAAGGCGT
TCGGCTTCAAGCTCGACGTGTTCTGGGGCAAGATCTCGTTCTGGTGCTGGGTGGTCGGCTTCTACTTCGCCTTCATGCCG
CTCTACGTGCTGGGCCTGATGGGCGTCACCCGTCGTCTGCGGGTGTTCGACGACCCCAGCCTGCAGATCTGGTTCATCAT
CGCCGGCTTCGGCGCGTTCCTGATCCTGATCGGCATCGTCGCGTTCCTGATCCAGATCGCCGTCAGCGTGATGCGACGCG
AGCAGCTTCGCGACGTCACCGGCGACCCTTGGAACGGCCGCACGCTGGAATGGGCGACGTCGTCGCCGCCGCCGGACTAC
AACTTCGCCTTCACGCCGATGGTGCGCGATTCCGATGCGTGGTGGGACATGAAAAAGGCTGGCTACAAGCGTCCGCTCGA
AGGCTTCAAGCCGATCCACATGCCGAGCAATACCGGCACCGGAATCATCCTGTCCGGGCTGAGCATGGTGATGGCGTTCG
GCTTGATCTGGTACATCTGGTGGCTGGCGGCGCTGTCCTTCATCGCGCTGCTCGCCGTCGCGATCGGCCACACCTTCAAT
TATCACCGCGACTTCCACATCCCCGCCGAAGAGGTGGTTCGCGTCGAGGACGAGCGGACGCGACTGCTCGCCGAGGGAGC
CAAGCCATGA

Upstream 100 bases:

>100_bases
TCGGCGCCGGGTTGAAGCGTCCGCCGCTGTTCACGCCGCTCGGGTCGTCCACCTCGCTGCTGTTCGCCCCGGCGTCGAAA
TCCGAGTCCTGAGGGATCGC

Downstream 100 bases:

>100_bases
GCGTCGTCGCCGCCGCCCCGCAGGCCGCAGAGCCGGTGTTCCACGTCGTCGACGAGCATGCCCATCCGGAAGGCGCGAGC
ACGATGCTCGGCTTCTGGAT

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MLTNPDIVKAIFGRLSLESLPLHEPIVVLTFVAVALGGAALVAGLTYFKLWGYLWREWFTTVDHKRIGIMYMILGIVMLL
RGFADAVMMRAQQAMAFNGSEGYLNAHHYDQVFTAHGVIMIFFVAMPMVTGLMNYVVPLQIGARDVSFPFLNNFSFWMTT
AGAVLVMISLFVGEFARTGWLAYPPLSNIGYSPDVGVDYYIWALQVAGVGTTLSGVNLICTIVKVRAPGMTMMRMPIFTW
TSLCTNILIVASFPVLTVVLALLSLDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYILILPAFGIFSEVTSTFSGKRL
FGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKMFNWLFTMYRGRIRYDLPMMWTIAFMLT
FVIGGMTGVLLAVPPADFVLHNSLFLVAHFHNVIIGGVVFGLFAGIAYWFPKAFGFKLDVFWGKISFWCWVVGFYFAFMP
LYVLGLMGVTRRLRVFDDPSLQIWFIIAGFGAFLILIGIVAFLIQIAVSVMRREQLRDVTGDPWNGRTLEWATSSPPPDY
NFAFTPMVRDSDAWWDMKKAGYKRPLEGFKPIHMPSNTGTGIILSGLSMVMAFGLIWYIWWLAALSFIALLAVAIGHTFN
YHRDFHIPAEEVVRVEDERTRLLAEGAKP

Sequences:

>Translated_669_residues
MLTNPDIVKAIFGRLSLESLPLHEPIVVLTFVAVALGGAALVAGLTYFKLWGYLWREWFTTVDHKRIGIMYMILGIVMLL
RGFADAVMMRAQQAMAFNGSEGYLNAHHYDQVFTAHGVIMIFFVAMPMVTGLMNYVVPLQIGARDVSFPFLNNFSFWMTT
AGAVLVMISLFVGEFARTGWLAYPPLSNIGYSPDVGVDYYIWALQVAGVGTTLSGVNLICTIVKVRAPGMTMMRMPIFTW
TSLCTNILIVASFPVLTVVLALLSLDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYILILPAFGIFSEVTSTFSGKRL
FGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKMFNWLFTMYRGRIRYDLPMMWTIAFMLT
FVIGGMTGVLLAVPPADFVLHNSLFLVAHFHNVIIGGVVFGLFAGIAYWFPKAFGFKLDVFWGKISFWCWVVGFYFAFMP
LYVLGLMGVTRRLRVFDDPSLQIWFIIAGFGAFLILIGIVAFLIQIAVSVMRREQLRDVTGDPWNGRTLEWATSSPPPDY
NFAFTPMVRDSDAWWDMKKAGYKRPLEGFKPIHMPSNTGTGIILSGLSMVMAFGLIWYIWWLAALSFIALLAVAIGHTFN
YHRDFHIPAEEVVRVEDERTRLLAEGAKP
>Mature_669_residues
MLTNPDIVKAIFGRLSLESLPLHEPIVVLTFVAVALGGAALVAGLTYFKLWGYLWREWFTTVDHKRIGIMYMILGIVMLL
RGFADAVMMRAQQAMAFNGSEGYLNAHHYDQVFTAHGVIMIFFVAMPMVTGLMNYVVPLQIGARDVSFPFLNNFSFWMTT
AGAVLVMISLFVGEFARTGWLAYPPLSNIGYSPDVGVDYYIWALQVAGVGTTLSGVNLICTIVKVRAPGMTMMRMPIFTW
TSLCTNILIVASFPVLTVVLALLSLDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYILILPAFGIFSEVTSTFSGKRL
FGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKMFNWLFTMYRGRIRYDLPMMWTIAFMLT
FVIGGMTGVLLAVPPADFVLHNSLFLVAHFHNVIIGGVVFGLFAGIAYWFPKAFGFKLDVFWGKISFWCWVVGFYFAFMP
LYVLGLMGVTRRLRVFDDPSLQIWFIIAGFGAFLILIGIVAFLIQIAVSVMRREQLRDVTGDPWNGRTLEWATSSPPPDY
NFAFTPMVRDSDAWWDMKKAGYKRPLEGFKPIHMPSNTGTGIILSGLSMVMAFGLIWYIWWLAALSFIALLAVAIGHTFN
YHRDFHIPAEEVVRVEDERTRLLAEGAKP

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=510, Percent_Identity=38.2352941176471, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1786634, Length=651, Percent_Identity=65.284178187404, Blast_Score=900, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=508, Percent_Identity=37.7952755905512, Blast_Score=333, Evalue=6e-92,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=41.8461538461538, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=35.0806451612903, Blast_Score=131, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 75159; Mature: 75159

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNPDIVKAIFGRLSLESLPLHEPIVVLTFVAVALGGAALVAGLTYFKLWGYLWREWFT
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
TVDHKRIGIMYMILGIVMLLRGFADAVMMRAQQAMAFNGSEGYLNAHHYDQVFTAHGVIM
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
IFFVAMPMVTGLMNYVVPLQIGARDVSFPFLNNFSFWMTTAGAVLVMISLFVGEFARTGW
HHHHHHHHHHHHHHHHHHHEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LAYPPLSNIGYSPDVGVDYYIWALQVAGVGTTLSGVNLICTIVKVRAPGMTMMRMPIFTW
EECCCCCCCCCCCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHH
TSLCTNILIVASFPVLTVVLALLSLDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEE
ILPAFGIFSEVTSTFSGKRLFGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGI
EEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
TTMIISIPTGAKMFNWLFTMYRGRIRYDLPMMWTIAFMLTFVIGGMTGVLLAVPPADFVL
HHHEEECCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCHHCEEEECCCHHHHH
HNSLFLVAHFHNVIIGGVVFGLFAGIAYWFPKAFGFKLDVFWGKISFWCWVVGFYFAFMP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
LYVLGLMGVTRRLRVFDDPSLQIWFIIAGFGAFLILIGIVAFLIQIAVSVMRREQLRDVT
HHHHHHHHHHHHHHEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDPWNGRTLEWATSSPPPDYNFAFTPMVRDSDAWWDMKKAGYKRPLEGFKPIHMPSNTGT
CCCCCCCEEEECCCCCCCCCCEEECCEECCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
GIILSGLSMVMAFGLIWYIWWLAALSFIALLAVAIGHTFNYHRDFHIPAEEVVRVEDERT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
RLLAEGAKP
HHHHCCCCC
>Mature Secondary Structure
MLTNPDIVKAIFGRLSLESLPLHEPIVVLTFVAVALGGAALVAGLTYFKLWGYLWREWFT
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
TVDHKRIGIMYMILGIVMLLRGFADAVMMRAQQAMAFNGSEGYLNAHHYDQVFTAHGVIM
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
IFFVAMPMVTGLMNYVVPLQIGARDVSFPFLNNFSFWMTTAGAVLVMISLFVGEFARTGW
HHHHHHHHHHHHHHHHHHHEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LAYPPLSNIGYSPDVGVDYYIWALQVAGVGTTLSGVNLICTIVKVRAPGMTMMRMPIFTW
EECCCCCCCCCCCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHH
TSLCTNILIVASFPVLTVVLALLSLDRYVGTNFFTNDFGGNPMMYVNLIWIWGHPEVYIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEE
ILPAFGIFSEVTSTFSGKRLFGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGI
EEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
TTMIISIPTGAKMFNWLFTMYRGRIRYDLPMMWTIAFMLTFVIGGMTGVLLAVPPADFVL
HHHEEECCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCHHCEEEECCCHHHHH
HNSLFLVAHFHNVIIGGVVFGLFAGIAYWFPKAFGFKLDVFWGKISFWCWVVGFYFAFMP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
LYVLGLMGVTRRLRVFDDPSLQIWFIIAGFGAFLILIGIVAFLIQIAVSVMRREQLRDVT
HHHHHHHHHHHHHHEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDPWNGRTLEWATSSPPPDYNFAFTPMVRDSDAWWDMKKAGYKRPLEGFKPIHMPSNTGT
CCCCCCCEEEECCCCCCCCCCEEECCEECCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
GIILSGLSMVMAFGLIWYIWWLAALSFIALLAVAIGHTFNYHRDFHIPAEEVVRVEDERT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
RLLAEGAKP
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]