Click here to switch to the map view.

The map label for this gene is cvrA [H]

Identifier: 86747183

GI number: 86747183

Start: 57528

End: 59321

Strand: Reverse

Name: cvrA [H]

Synonym: RPB_0056

Alternate gene names: 86747183

Gene position: 59321-57528 (Counterclockwise)

Preceding gene: 86747186

Following gene: 86747182

Centisome position: 1.11

GC content: 68.62

Gene sequence:

>1794_bases
ATGGGTTCACTCGACACGGTCAGCATAGCCATCCTGCTCGGCGCGGTCCTGGTGATGGCGGGGATTCTGTCGAGCCTGCT
GGCGCTGCGGTTCGGCGCCCCGTTGCTGCTGGTCTTTCTCGTGCTCGGCATGCTGGCCGGCGAGGCGGGACCCGGCGGCC
TGAAATTCGACGATCTCTCCACCACCTATCTGGTCGGCTCGGTGGCGCTGGCGCTGATTCTGTTCGACGGCGGATTGCGG
ACGCGATTCTCGACCATCAAGGCGGTGCTGGCGCCGTCGATGGGGCTAGCGACGGTCGGCGTGCTGCTGACCGCACTGAT
CACCGCCCCGGTTGCCTATTATGCGCTCGACCTCAACTGGACCGAGGCACTGCTGGCCGGCGCCGTGATCGCCTCCACCG
ACGCCGCGGCGGTGTTCCTGCTGGTGCATTCGCAGGGGTTGCGGCTGCGGCCGCGCGTCGGCGCGACGCTGGAGGTCGAA
TCCGGCACCAACGATCCGTTCGCGGTGTTCCTGACGCTGATGCTGGTCGGGCTGATCACCCGCGGCGAGTCCTCGACCTG
GTATGTCGTGGTCGAATTTCTGTGGGAGGCCCTGCTCGGCACCGCGATCGGCGTGATCGGCGGCCGAATGGTGGTGATGG
CGCTGAATCGGGTGGCGCTGCCGCAGGGGCTGCACGCGCCGTTCGTCGCCACCGCGGCGCTGGTGGTGTTCGGCGCCGCG
CAGATCTCGCACGCCTCGGGGTTCCTCGCCGTCTACCTCGCTGGCATGATCATCGGCAACCAGCCGACCCGCGCGCATAA
TTCGGTGGTGGCGTTCCTCGACGCCGCGACCTGGCTGGCGCAGATCGTGATGTTCGTGCTGCTCGGCCTGTTGGTGTCGC
CGCAGCGGCTGATGTCGAGCATCGGCCCGGCGGTGGTGGTGGCGCTGGCGCTGATGCTGGTGGCGCGGCCGGTCGCCGTA
TTCCTGTGTCTGGCGCCGTTCCGGTTCAACTGGCGGGAGCGGCTGTTCATCGCCTGGGTGGGGTTGCGCGGCGCGGTCGC
GATCTTCCTGGCCTCGATCCCGATGCTGGTCGGGCTGCCGAAGGCCTATCTGTATTTCGACGTCGCCTTCGTGGTGGTGA
TCATCTCGCTGCTGCTGCAGGGCTGGACGCTGGGGCCGGCGGCGCGCAAGCTTCACGTCGCCCTGCAGCGCACCGATCGC
GGCCCGCGCCGGATCGAGCTTGACCTGCCCGGCCAGCTCGAGAAGCAACTGGTCGGCTATCCGGTGCGCGCCAAGAGCCT
GTATCTGAAGCGCGGGCTGATCCCGTCCTGGTCGAAGCCGACGCTGGTGATCCGCGACGAGCGCATCCTGACGCCGGAAG
AGGCCGAACCGGTCGCGCCCGGCGACTATCTGTATCTGCTGGCGCCGCCCGAAAAGGCCGAAGCGCTCGACCGCTTCTTC
GTCGACATGCCGCCCTCGACCGCGCCCGACCCGCATCTGCTCGGCGATTTCATCGTGCCGGGCGAGACCACGCTCGGCGA
TCTCGCAGCGGCCTACGGCGTCAACGTGCCGACCGGCGAGGAGGCGCTGACGCTGGCCGATTATTTCGACATCCATCTCG
ACCGCGCCCCGACCGTCGGCGCCGAGGTGAAGCTCGACACGATCGTCCTCGTCGCGCGCAGCCTCGGCGGCGGCCGGGTC
AATGTCGTCGGCCTGCGGCTGCCGGAAGACGAAGACGACGCCCCGCCGCCGACGCGGGTGCAGAAAGCCCGGCGCAAGCT
GTCGAAGGTCTGGTCGCAACTGTCCGGGGTGTGA

Upstream 100 bases:

>100_bases
AGCGCCTAGTTCGCCGCGCCGGCGAGAATGCAGTTGGCGATGCAGCAATGACGGCGATAAGGATGCGACAGCGGTGATTT
GCTCGGTTACATAGAGGCCA

Downstream 100 bases:

>100_bases
TCAGTCCGGCGTCGTGATGGCCGGGCAAGGCGCGCACCTGACTTGATACTCCGGCGAATTCCGCCGCCCGGCACGTGGGC
AGAGTCGCCCATTATTTCGG

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MGSLDTVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVLGMLAGEAGPGGLKFDDLSTTYLVGSVALALILFDGGLR
TRFSTIKAVLAPSMGLATVGVLLTALITAPVAYYALDLNWTEALLAGAVIASTDAAAVFLLVHSQGLRLRPRVGATLEVE
SGTNDPFAVFLTLMLVGLITRGESSTWYVVVEFLWEALLGTAIGVIGGRMVVMALNRVALPQGLHAPFVATAALVVFGAA
QISHASGFLAVYLAGMIIGNQPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLMSSIGPAVVVALALMLVARPVAV
FLCLAPFRFNWRERLFIAWVGLRGAVAIFLASIPMLVGLPKAYLYFDVAFVVVIISLLLQGWTLGPAARKLHVALQRTDR
GPRRIELDLPGQLEKQLVGYPVRAKSLYLKRGLIPSWSKPTLVIRDERILTPEEAEPVAPGDYLYLLAPPEKAEALDRFF
VDMPPSTAPDPHLLGDFIVPGETTLGDLAAAYGVNVPTGEEALTLADYFDIHLDRAPTVGAEVKLDTIVLVARSLGGGRV
NVVGLRLPEDEDDAPPPTRVQKARRKLSKVWSQLSGV

Sequences:

>Translated_597_residues
MGSLDTVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVLGMLAGEAGPGGLKFDDLSTTYLVGSVALALILFDGGLR
TRFSTIKAVLAPSMGLATVGVLLTALITAPVAYYALDLNWTEALLAGAVIASTDAAAVFLLVHSQGLRLRPRVGATLEVE
SGTNDPFAVFLTLMLVGLITRGESSTWYVVVEFLWEALLGTAIGVIGGRMVVMALNRVALPQGLHAPFVATAALVVFGAA
QISHASGFLAVYLAGMIIGNQPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLMSSIGPAVVVALALMLVARPVAV
FLCLAPFRFNWRERLFIAWVGLRGAVAIFLASIPMLVGLPKAYLYFDVAFVVVIISLLLQGWTLGPAARKLHVALQRTDR
GPRRIELDLPGQLEKQLVGYPVRAKSLYLKRGLIPSWSKPTLVIRDERILTPEEAEPVAPGDYLYLLAPPEKAEALDRFF
VDMPPSTAPDPHLLGDFIVPGETTLGDLAAAYGVNVPTGEEALTLADYFDIHLDRAPTVGAEVKLDTIVLVARSLGGGRV
NVVGLRLPEDEDDAPPPTRVQKARRKLSKVWSQLSGV
>Mature_596_residues
GSLDTVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVLGMLAGEAGPGGLKFDDLSTTYLVGSVALALILFDGGLRT
RFSTIKAVLAPSMGLATVGVLLTALITAPVAYYALDLNWTEALLAGAVIASTDAAAVFLLVHSQGLRLRPRVGATLEVES
GTNDPFAVFLTLMLVGLITRGESSTWYVVVEFLWEALLGTAIGVIGGRMVVMALNRVALPQGLHAPFVATAALVVFGAAQ
ISHASGFLAVYLAGMIIGNQPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLMSSIGPAVVVALALMLVARPVAVF
LCLAPFRFNWRERLFIAWVGLRGAVAIFLASIPMLVGLPKAYLYFDVAFVVVIISLLLQGWTLGPAARKLHVALQRTDRG
PRRIELDLPGQLEKQLVGYPVRAKSLYLKRGLIPSWSKPTLVIRDERILTPEEAEPVAPGDYLYLLAPPEKAEALDRFFV
DMPPSTAPDPHLLGDFIVPGETTLGDLAAAYGVNVPTGEEALTLADYFDIHLDRAPTVGAEVKLDTIVLVARSLGGGRVN
VVGLRLPEDEDDAPPPTRVQKARRKLSKVWSQLSGV

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=578, Percent_Identity=39.4463667820069, Blast_Score=350, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 63604; Mature: 63473

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSLDTVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVLGMLAGEAGPGGLKFDDLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCEECCCC
TTYLVGSVALALILFDGGLRTRFSTIKAVLAPSMGLATVGVLLTALITAPVAYYALDLNW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCH
TEALLAGAVIASTDAAAVFLLVHSQGLRLRPRVGATLEVESGTNDPFAVFLTLMLVGLIT
HHHHHHHHHHCCCCHHEEEEEEECCCCEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHH
RGESSTWYVVVEFLWEALLGTAIGVIGGRMVVMALNRVALPQGLHAPFVATAALVVFGAA
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
QISHASGFLAVYLAGMIIGNQPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLMSS
HHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IGPAVVVALALMLVARPVAVFLCLAPFRFNWRERLFIAWVGLRGAVAIFLASIPMLVGLP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEEEECHHHHHHHHHHHHHHHHCCC
KAYLYFDVAFVVVIISLLLQGWTLGPAARKLHVALQRTDRGPRRIELDLPGQLEKQLVGY
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHCCC
PVRAKSLYLKRGLIPSWSKPTLVIRDERILTPEEAEPVAPGDYLYLLAPPEKAEALDRFF
CCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHH
VDMPPSTAPDPHLLGDFIVPGETTLGDLAAAYGVNVPTGEEALTLADYFDIHLDRAPTVG
HCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCHHEEHHHHHHEEECCCCCCC
AEVKLDTIVLVARSLGGGRVNVVGLRLPEDEDDAPPPTRVQKARRKLSKVWSQLSGV
CCEEHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GSLDTVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVLGMLAGEAGPGGLKFDDLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCEECCCC
TTYLVGSVALALILFDGGLRTRFSTIKAVLAPSMGLATVGVLLTALITAPVAYYALDLNW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCH
TEALLAGAVIASTDAAAVFLLVHSQGLRLRPRVGATLEVESGTNDPFAVFLTLMLVGLIT
HHHHHHHHHHCCCCHHEEEEEEECCCCEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHH
RGESSTWYVVVEFLWEALLGTAIGVIGGRMVVMALNRVALPQGLHAPFVATAALVVFGAA
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
QISHASGFLAVYLAGMIIGNQPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLMSS
HHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IGPAVVVALALMLVARPVAVFLCLAPFRFNWRERLFIAWVGLRGAVAIFLASIPMLVGLP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEEEECHHHHHHHHHHHHHHHHCCC
KAYLYFDVAFVVVIISLLLQGWTLGPAARKLHVALQRTDRGPRRIELDLPGQLEKQLVGY
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHCCC
PVRAKSLYLKRGLIPSWSKPTLVIRDERILTPEEAEPVAPGDYLYLLAPPEKAEALDRFF
CCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHH
VDMPPSTAPDPHLLGDFIVPGETTLGDLAAAYGVNVPTGEEALTLADYFDIHLDRAPTVG
HCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCHHEEHHHHHHEEECCCCCCC
AEVKLDTIVLVARSLGGGRVNVVGLRLPEDEDDAPPPTRVQKARRKLSKVWSQLSGV
CCEEHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA