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The map label for this gene is icd [H]

Identifier: 86609138

GI number: 86609138

Start: 1754173

End: 1755243

Strand: Reverse

Name: icd [H]

Synonym: CYB_1678

Alternate gene names: 86609138

Gene position: 1755243-1754173 (Counterclockwise)

Preceding gene: 86609139

Following gene: 86609136

Centisome position: 57.61

GC content: 59.85

Gene sequence:

>1071_bases
GTGACTTTGATCCCTGGGGATGGCATCGGCCCGGAAGTGGCCAAGGCGATGACCACGGTCTTGGAGGCTACCGGGGTTGG
GTTGGAATGGATCCCGGTAGAGGCAGGGGTGGAGGTGATCGAGAAATACGGCACCCCCTTGCCGCCCCAGGTGTTGGAGT
CCATTCGGGAAACCAAAGTGGCGATCAAAGGGCCGATTGGCACTCCCGTAGGTACTGGCTTTCGTTCGGTCAACGTAGCC
ATTCGCAAGGAGCTGGATCTCTACGCCAATCTGCGCCCGGCCAAATCCATGCTCGGTGTCAAAAGCCCTTTTCAAGACAT
CGACCTAGTGGTGGTGCGGGAAAATACCGAAGATCTCTATGCCGGGATCGAGTTTGAACGGGGCACGCCGGAAGCCATCC
AGGCGCGGGAGGAAATGATGCGCCTTTCCGGCAAACCCATCCGCGAGGGATCCGCCATCGGCATCAAGCCCATTTCGGAC
TTCGGCAGCCGCCGCATTGTCAAATTTGCCTTTGAGTACGCCCGCCAGAATGGCCGCAAGAAGGTGACGGCAGTTCACAA
AGCCAACATCATGAAGTTCACCGATGGCTTGTTTTTGCAGGTGGCGCGGGAGGTGGCCCAGGAGTACCCCGACATCGAGT
TTGAAGATCGCATCGTGGACAACATGTGCATGCAACTGATGCAAAAGCCGCAGCTCTACGATGTGCTGGTGCTCACCAAC
CTCTATGGGGACATCATTTCCGACTTGTGCGCGGGGATGATCGGCGGGCTGGGGGTGGCGCCGGGGGCCAACATCGGCAA
CGGCATTGCGGTTTTTGAGGCCATTCACGGCTCTGCTCCCAAGTACGCTGGCCAAAACAAAGTCAACCCCTGCGCTCTGA
TCCTCTCCGGGGCGATGATGCTGCGCTACCTGGGAGAGCGGGAGGCTGCCGCAAGGGTGGAGGCGGCGGTGCAGGCGGTG
ATCGCCGAGGGCAAGCAGGTCACCTATGACCTGGCCACAGGGGATCCCGTCGGCACTCAGGAAATGGCCAAGGCCATTGC
TGCCCGCGTGCAGGAGATGGCTTTGCAGTAG

Upstream 100 bases:

>100_bases
GTTCTCTAACCTGTCTGGTGGAGGGATCCTCTCACGCCGGCAGGACGGAGTTTTTGCGCTGTCGTTAACACTGCGAGGAG
AAGCATCTGTGGCCTATCGT

Downstream 100 bases:

>100_bases
GGTTTGGCGCCAAATGTTTCTGATCCCAGGCTCCCCAAGGGAGGGGGGCTAGAGGACTCAATACCCCAAAACCGGATCCA
CCACCCCTAGCAAGGGATCC

Product: isopropylmalate/isohomocitrate dehydrogenase family protein

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTLIPGDGIGPEVAKAMTTVLEATGVGLEWIPVEAGVEVIEKYGTPLPPQVLESIRETKVAIKGPIGTPVGTGFRSVNVA
IRKELDLYANLRPAKSMLGVKSPFQDIDLVVVRENTEDLYAGIEFERGTPEAIQAREEMMRLSGKPIREGSAIGIKPISD
FGSRRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDRIVDNMCMQLMQKPQLYDVLVLTN
LYGDIISDLCAGMIGGLGVAPGANIGNGIAVFEAIHGSAPKYAGQNKVNPCALILSGAMMLRYLGEREAAARVEAAVQAV
IAEGKQVTYDLATGDPVGTQEMAKAIAARVQEMALQ

Sequences:

>Translated_356_residues
MTLIPGDGIGPEVAKAMTTVLEATGVGLEWIPVEAGVEVIEKYGTPLPPQVLESIRETKVAIKGPIGTPVGTGFRSVNVA
IRKELDLYANLRPAKSMLGVKSPFQDIDLVVVRENTEDLYAGIEFERGTPEAIQAREEMMRLSGKPIREGSAIGIKPISD
FGSRRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDRIVDNMCMQLMQKPQLYDVLVLTN
LYGDIISDLCAGMIGGLGVAPGANIGNGIAVFEAIHGSAPKYAGQNKVNPCALILSGAMMLRYLGEREAAARVEAAVQAV
IAEGKQVTYDLATGDPVGTQEMAKAIAARVQEMALQ
>Mature_355_residues
TLIPGDGIGPEVAKAMTTVLEATGVGLEWIPVEAGVEVIEKYGTPLPPQVLESIRETKVAIKGPIGTPVGTGFRSVNVAI
RKELDLYANLRPAKSMLGVKSPFQDIDLVVVRENTEDLYAGIEFERGTPEAIQAREEMMRLSGKPIREGSAIGIKPISDF
GSRRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDRIVDNMCMQLMQKPQLYDVLVLTNL
YGDIISDLCAGMIGGLGVAPGANIGNGIAVFEAIHGSAPKYAGQNKVNPCALILSGAMMLRYLGEREAAARVEAAVQAVI
AEGKQVTYDLATGDPVGTQEMAKAIAARVQEMALQ

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=356, Percent_Identity=45.7865168539326, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI28178821, Length=358, Percent_Identity=40.7821229050279, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI28178816, Length=312, Percent_Identity=42.9487179487179, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4758582, Length=334, Percent_Identity=40.1197604790419, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI28178838, Length=322, Percent_Identity=40.9937888198758, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI28178819, Length=200, Percent_Identity=47.5, Blast_Score=164, Evalue=9e-41,
Organism=Escherichia coli, GI1787381, Length=366, Percent_Identity=43.9890710382514, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87081683, Length=379, Percent_Identity=35.8839050131926, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1788101, Length=348, Percent_Identity=31.8965517241379, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71986051, Length=354, Percent_Identity=47.7401129943503, Blast_Score=332, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=38.5269121813031, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI25144293, Length=351, Percent_Identity=36.7521367521368, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17505779, Length=352, Percent_Identity=37.2159090909091, Blast_Score=212, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6324709, Length=356, Percent_Identity=40.4494382022472, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6324291, Length=358, Percent_Identity=41.0614525139665, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6322097, Length=363, Percent_Identity=37.7410468319559, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6319830, Length=381, Percent_Identity=30.9711286089239, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24643270, Length=354, Percent_Identity=44.0677966101695, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24643268, Length=354, Percent_Identity=44.0677966101695, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24661184, Length=337, Percent_Identity=43.3234421364985, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI161078635, Length=335, Percent_Identity=37.0149253731343, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI161078637, Length=335, Percent_Identity=37.0149253731343, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI161078633, Length=335, Percent_Identity=37.0149253731343, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24650122, Length=335, Percent_Identity=37.0149253731343, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI161078639, Length=333, Percent_Identity=36.9369369369369, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI281362242, Length=354, Percent_Identity=39.2655367231638, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24648872, Length=354, Percent_Identity=39.2655367231638, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20130355, Length=348, Percent_Identity=31.8965517241379, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI45550436, Length=247, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 38436; Mature: 38305

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIPGDGIGPEVAKAMTTVLEATGVGLEWIPVEAGVEVIEKYGTPLPPQVLESIRETKV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHE
AIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSMLGVKSPFQDIDLVVVRENTEDLY
EEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEECCCHHHH
AGIEFERGTPEAIQAREEMMRLSGKPIREGSAIGIKPISDFGSRRIVKFAFEYARQNGRK
CCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCH
KVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDRIVDNMCMQLMQKPQLYDVLVLTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
LYGDIISDLCAGMIGGLGVAPGANIGNGIAVFEAIHGSAPKYAGQNKVNPCALILSGAMM
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
LRYLGEREAAARVEAAVQAVIAEGKQVTYDLATGDPVGTQEMAKAIAARVQEMALQ
HHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLIPGDGIGPEVAKAMTTVLEATGVGLEWIPVEAGVEVIEKYGTPLPPQVLESIRETKV
CCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHE
AIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSMLGVKSPFQDIDLVVVRENTEDLY
EEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEECCCHHHH
AGIEFERGTPEAIQAREEMMRLSGKPIREGSAIGIKPISDFGSRRIVKFAFEYARQNGRK
CCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCH
KVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDRIVDNMCMQLMQKPQLYDVLVLTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
LYGDIISDLCAGMIGGLGVAPGANIGNGIAVFEAIHGSAPKYAGQNKVNPCALILSGAMM
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
LRYLGEREAAARVEAAVQAVIAEGKQVTYDLATGDPVGTQEMAKAIAARVQEMALQ
HHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9325430; 9389475 [H]