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The map label for this gene is purE [H]

Identifier: 86608510

GI number: 86608510

Start: 1074130

End: 1074669

Strand: Direct

Name: purE [H]

Synonym: CYB_1031

Alternate gene names: 86608510

Gene position: 1074130-1074669 (Clockwise)

Preceding gene: 86608509

Following gene: 86608511

Centisome position: 35.26

GC content: 59.63

Gene sequence:

>540_bases
ATGGAACTCTCCCCCCTCGTTGCCATCGTAATGGGTAGCGATTCCGATTTGCCCACCCTTGCACCTGCCGCCCAGGTGTG
TGAGGAGTTTGGGATCCCTTACCAATTGCAGATCCTCAGCGCCCATCGCACTCCCGAGGCGATGGTAGAGTTTGCCCGCC
GCGCCCATACCCAAGGGATCCGCGTCATCATTGCCGGGGCAGGGGGAGCAGCCCATTTGCCGGGGATGGTGGCGTCCCTC
ACCCCTCTGCCGGTGATCGGGGTGCCGGTGCTCAGCCCATCCCTGCAGGGGATCGACTCCTTATACTCGATTGTGCAAAT
GCCCAAAGGGATCCCGGTGGCCACGGTGGCCATTGGCAACGGCTACAACGCGGGTCTGTTGGCGGTGCAGATCCTAGCCA
GTGGGGATCCCGATCTGCTCCGGCGGGTGATCGCCTATCGGGAAAGCCTAAAACAGGCGGTGCAGGAGAAAAACGACCAG
TTGCAAACCCAAGGGTGGAAAGCCTACCTCGACTCTATAAAGCATAAGAGCATAATTTAA

Upstream 100 bases:

>100_bases
TGCTGGCAGAGCCCCCACCCATCTCGACGGGGTTGGGCTATGCGATGATGGATCGGCTACGCCGGGCCAGCAGCCTTTCG
CGTTAGCGTCGCTTAGCGAT

Downstream 100 bases:

>100_bases
GGAGCGTTGATCTATCTTGCCGCTTGCAAAGGGCCAGATAGGGCCGAGTTTTGGGAGTTGCCATCGGTGAAGCATCAATC
GGGTCGCCCTTCTTCCGGCC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MELSPLVAIVMGSDSDLPTLAPAAQVCEEFGIPYQLQILSAHRTPEAMVEFARRAHTQGIRVIIAGAGGAAHLPGMVASL
TPLPVIGVPVLSPSLQGIDSLYSIVQMPKGIPVATVAIGNGYNAGLLAVQILASGDPDLLRRVIAYRESLKQAVQEKNDQ
LQTQGWKAYLDSIKHKSII

Sequences:

>Translated_179_residues
MELSPLVAIVMGSDSDLPTLAPAAQVCEEFGIPYQLQILSAHRTPEAMVEFARRAHTQGIRVIIAGAGGAAHLPGMVASL
TPLPVIGVPVLSPSLQGIDSLYSIVQMPKGIPVATVAIGNGYNAGLLAVQILASGDPDLLRRVIAYRESLKQAVQEKNDQ
LQTQGWKAYLDSIKHKSII
>Mature_179_residues
MELSPLVAIVMGSDSDLPTLAPAAQVCEEFGIPYQLQILSAHRTPEAMVEFARRAHTQGIRVIIAGAGGAAHLPGMVASL
TPLPVIGVPVLSPSLQGIDSLYSIVQMPKGIPVATVAIGNGYNAGLLAVQILASGDPDLLRRVIAYRESLKQAVQEKNDQ
LQTQGWKAYLDSIKHKSII

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220559, Length=111, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI119220557, Length=111, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI5453539, Length=111, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=52.258064516129, Blast_Score=135, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324702, Length=170, Percent_Identity=53.5294117647059, Blast_Score=187, Evalue=7e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18984; Mature: 18984

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSPLVAIVMGSDSDLPTLAPAAQVCEEFGIPYQLQILSAHRTPEAMVEFARRAHTQGI
CCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCE
RVIIAGAGGAAHLPGMVASLTPLPVIGVPVLSPSLQGIDSLYSIVQMPKGIPVATVAIGN
EEEEECCCCCHHCCCHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
GYNAGLLAVQILASGDPDLLRRVIAYRESLKQAVQEKNDQLQTQGWKAYLDSIKHKSII
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELSPLVAIVMGSDSDLPTLAPAAQVCEEFGIPYQLQILSAHRTPEAMVEFARRAHTQGI
CCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCE
RVIIAGAGGAAHLPGMVASLTPLPVIGVPVLSPSLQGIDSLYSIVQMPKGIPVATVAIGN
EEEEECCCCCHHCCCHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
GYNAGLLAVQILASGDPDLLRRVIAYRESLKQAVQEKNDQLQTQGWKAYLDSIKHKSII
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]