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The map label for this gene is pyrC' [H]

Identifier: 86608500

GI number: 86608500

Start: 1060249

End: 1061595

Strand: Direct

Name: pyrC' [H]

Synonym: CYB_1021

Alternate gene names: 86608500

Gene position: 1060249-1061595 (Clockwise)

Preceding gene: 86608499

Following gene: 86608504

Centisome position: 34.8

GC content: 64.37

Gene sequence:

>1347_bases
ATGGGCTCATCCCCTCTCCGCGAGCTAACAGGACGACTAACAGGACAAAATGTGCATCTCCAGGGAGTGCGCCTGTTGGA
TCCTTGGCGTCAGCGGGATGAAGTAACCGATGTGTGGTTGCAGGAGGGTCGTCTGCGGGCCACCGAGCCGGCAGGGATCC
CTGCCGACATCCCCACCATCGATGGCTCAGGCTGGGTAGTGGGGCCGGGTTTGCTGGATCTGTATGCCCACAGCGGCGAG
ATGGTTGGCAGCGATCTGGCCCACAGTCGGGAAACCCTGACCTCTTTGGCTGCAGCGGCTTTGGCGGGAGGCTTTACCCA
GGTGGGGCTTCTGCCCACCCCCCTTCCCGGAAGCGGCTTTTTTCCGGTGCTGGATCGCCCGGAGCACTTGAACCGCTACC
CCCGCCAATTGGGGGATCCCCGCTGGCTGCCCTGGGCTGCCCTGAGCGTGGGTGGCCAAGGAGAAACTCCAACCCCCTGG
GGAGAACTGGCGCAAGCGGGAGCAGTTGGCTTTGCAGAGGTTCAGCCACTGCGCTCCTTGGCTTTGGCGCGGCGGGCTCT
GGAGTATTTGCGGCTGGAGAATAAACCCCTGCTGCTCTGGGCCTGGGATCCCACCTTGGCCGGGCAAGGCAGCCTTTACG
AAGGGATCTGGGCGCTGCGCCTGGGGCTGAAAGGGATCCCTGCCAGTGCTGAAACTGCCGCTCTGGCCCGCCTCTTGGAG
GTGATCAGGAGCGTTCCTTCCCCCCCGCCCGTGCACATCATGCGCCTGAGCCAAGCCCGCAGCCTGGAGCTGATCCAACA
GGCCCAAGCCGAAGGACTGCCGGTTACCGCCAGCACCACTTGGATGCACCTGATCTTGTCCGAAGAGGCCGTCCTTGAGC
ATCGCTACGATCCCCACCTTCGTCTCCTGCCCCCTCTTCCCAGCGCCGGCGACCGGGAGGCTCTGATCGCCGGGATCCGT
TCCGGCAACTTGGGGATCGCTACGGATCACCACCCCTACACCTACGAAGAGAAAACCCTGCCCTTTGCCGATGCTCCGCC
GGGGGCGATGGGCCTGGAGCTGGCTCTGCCGCTGCTGTGGCACCATTTGGTAGAAACGGGATCCCTGACGGCGCTGCAAC
TGTGGTCTGCCCTCAGCCTGTACCCGGCCCGCTGCCTAAACCTAGATCCGCCCACCCTCACCCCCCACAGCGACTGGGTG
CTGTTTGATCCCACCCACCCCTGGACGGTTTCTGCGGCCACCCTCCACTCCCGATCGCCAGCGACTCCCTGGCTGGAGAA
AACCCTGTGCGGCAAAGTGCTGCACACCCATGTCGAGGGGATCCCATCCCGCAGCTCTGCCCCTTGA

Upstream 100 bases:

>100_bases
CAGAAGGCAAGGAGGGTGCCCCGGTTTTGAAGGTGTTGAACCTCACCACCCATCTGTCGGGCCAGATCTTGGACTGCACC
ACCGCTGGAGCTTTGTAAAG

Downstream 100 bases:

>100_bases
TCCCGAAGAAGGCCGACAAGACCTGTCCGGAGAAAGAGCCAATTCAAAGAGGGGGATCCCTTCCCGCCAGCGGGACGGGG
TCCCGAATTCAAAACTCCCC

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 42 kDa non-catalytic chain [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MGSSPLRELTGRLTGQNVHLQGVRLLDPWRQRDEVTDVWLQEGRLRATEPAGIPADIPTIDGSGWVVGPGLLDLYAHSGE
MVGSDLAHSRETLTSLAAAALAGGFTQVGLLPTPLPGSGFFPVLDRPEHLNRYPRQLGDPRWLPWAALSVGGQGETPTPW
GELAQAGAVGFAEVQPLRSLALARRALEYLRLENKPLLLWAWDPTLAGQGSLYEGIWALRLGLKGIPASAETAALARLLE
VIRSVPSPPPVHIMRLSQARSLELIQQAQAEGLPVTASTTWMHLILSEEAVLEHRYDPHLRLLPPLPSAGDREALIAGIR
SGNLGIATDHHPYTYEEKTLPFADAPPGAMGLELALPLLWHHLVETGSLTALQLWSALSLYPARCLNLDPPTLTPHSDWV
LFDPTHPWTVSAATLHSRSPATPWLEKTLCGKVLHTHVEGIPSRSSAP

Sequences:

>Translated_448_residues
MGSSPLRELTGRLTGQNVHLQGVRLLDPWRQRDEVTDVWLQEGRLRATEPAGIPADIPTIDGSGWVVGPGLLDLYAHSGE
MVGSDLAHSRETLTSLAAAALAGGFTQVGLLPTPLPGSGFFPVLDRPEHLNRYPRQLGDPRWLPWAALSVGGQGETPTPW
GELAQAGAVGFAEVQPLRSLALARRALEYLRLENKPLLLWAWDPTLAGQGSLYEGIWALRLGLKGIPASAETAALARLLE
VIRSVPSPPPVHIMRLSQARSLELIQQAQAEGLPVTASTTWMHLILSEEAVLEHRYDPHLRLLPPLPSAGDREALIAGIR
SGNLGIATDHHPYTYEEKTLPFADAPPGAMGLELALPLLWHHLVETGSLTALQLWSALSLYPARCLNLDPPTLTPHSDWV
LFDPTHPWTVSAATLHSRSPATPWLEKTLCGKVLHTHVEGIPSRSSAP
>Mature_447_residues
GSSPLRELTGRLTGQNVHLQGVRLLDPWRQRDEVTDVWLQEGRLRATEPAGIPADIPTIDGSGWVVGPGLLDLYAHSGEM
VGSDLAHSRETLTSLAAAALAGGFTQVGLLPTPLPGSGFFPVLDRPEHLNRYPRQLGDPRWLPWAALSVGGQGETPTPWG
ELAQAGAVGFAEVQPLRSLALARRALEYLRLENKPLLLWAWDPTLAGQGSLYEGIWALRLGLKGIPASAETAALARLLEV
IRSVPSPPPVHIMRLSQARSLELIQQAQAEGLPVTASTTWMHLILSEEAVLEHRYDPHLRLLPPLPSAGDREALIAGIRS
GNLGIATDHHPYTYEEKTLPFADAPPGAMGLELALPLLWHHLVETGSLTALQLWSALSLYPARCLNLDPPTLTPHSDWVL
FDPTHPWTVSAATLHSRSPATPWLEKTLCGKVLHTHVEGIPSRSSAP

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=373, Percent_Identity=29.7587131367292, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87082175, Length=403, Percent_Identity=25.0620347394541, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204318, Length=372, Percent_Identity=26.3440860215054, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=221, Percent_Identity=29.8642533936652, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004722 [H]

Pfam domain/function: NA

EC number: 3.5.2.3

Molecular weight: Translated: 48552; Mature: 48421

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSPLRELTGRLTGQNVHLQGVRLLDPWRQRDEVTDVWLQEGRLRATEPAGIPADIPTI
CCCCCHHHHHHHCCCCCEEEECEEECCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCC
DGSGWVVGPGLLDLYAHSGEMVGSDLAHSRETLTSLAAAALAGGFTQVGLLPTPLPGSGF
CCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
FPVLDRPEHLNRYPRQLGDPRWLPWAALSVGGQGETPTPWGELAQAGAVGFAEVQPLRSL
CCCCCCCHHHHHHHHHHCCCCCCCHHEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
ALARRALEYLRLENKPLLLWAWDPTLAGQGSLYEGIWALRLGLKGIPASAETAALARLLE
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VIRSVPSPPPVHIMRLSQARSLELIQQAQAEGLPVTASTTWMHLILSEEAVLEHRYDPHL
HHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEECHHEEEEHHHHHHHHHHCCCCCE
RLLPPLPSAGDREALIAGIRSGNLGIATDHHPYTYEEKTLPFADAPPGAMGLELALPLLW
EEECCCCCCCCCHHHHEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
HHLVETGSLTALQLWSALSLYPARCLNLDPPTLTPHSDWVLFDPTHPWTVSAATLHSRSP
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCEEEEHEECCCCC
ATPWLEKTLCGKVLHTHVEGIPSRSSAP
CCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GSSPLRELTGRLTGQNVHLQGVRLLDPWRQRDEVTDVWLQEGRLRATEPAGIPADIPTI
CCCCHHHHHHHCCCCCEEEECEEECCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCC
DGSGWVVGPGLLDLYAHSGEMVGSDLAHSRETLTSLAAAALAGGFTQVGLLPTPLPGSGF
CCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
FPVLDRPEHLNRYPRQLGDPRWLPWAALSVGGQGETPTPWGELAQAGAVGFAEVQPLRSL
CCCCCCCHHHHHHHHHHCCCCCCCHHEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
ALARRALEYLRLENKPLLLWAWDPTLAGQGSLYEGIWALRLGLKGIPASAETAALARLLE
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VIRSVPSPPPVHIMRLSQARSLELIQQAQAEGLPVTASTTWMHLILSEEAVLEHRYDPHL
HHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEECHHEEEEHHHHHHHHHHCCCCCE
RLLPPLPSAGDREALIAGIRSGNLGIATDHHPYTYEEKTLPFADAPPGAMGLELALPLLW
EEECCCCCCCCCHHHHEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
HHLVETGSLTALQLWSALSLYPARCLNLDPPTLTPHSDWVLFDPTHPWTVSAATLHSRSP
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCEEEEHEECCCCC
ATPWLEKTLCGKVLHTHVEGIPSRSSAP
CCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]