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The map label for this gene is comEC [H]

Identifier: 86608392

GI number: 86608392

Start: 948732

End: 951008

Strand: Direct

Name: comEC [H]

Synonym: CYB_0912

Alternate gene names: 86608392

Gene position: 948732-951008 (Clockwise)

Preceding gene: 86608388

Following gene: 86608394

Centisome position: 31.14

GC content: 64.21

Gene sequence:

>2277_bases
ATGGAAAGAACCTATCTGCTGGGGTTGGGCTGGATCTTAGGCCTGCTGGTGCGGGCTTGGCCCCAAGCTGCCGGGTGGGG
CTGGGGGATCCCTCTGGGATTGGGGCTGGCGGGATCCCTGCTGTGCCGGCGGCAACCGCGTCTGGCCCGCACTTGGCTGG
CGATGGGTCTGGTGGGGTGTCTGGCTTGGAATTACCTGGGTTGGCGGCAGCCTTTTCCCGGGCCGACGGATATCAGCCTG
TTGGCCCCCCAGCAGCAGATGAACTTGGTGGGCACCGTCCTCTCGGAACCTCGTCCCACCCGCAGCGAACGGCGGCAATT
TTGGCTGAGAGCAGAGCAGGTGCTCAACGCCGACTCCACGGCCCGCCAGGTCAGCGGCAAGCTCTACGTCACCACCGGCC
CTGAGGCCCTCCAGGACAAGGATCTCCACCCCAACCAACGGGTGCGCCTGACGGGATCCCTGTACCTGCCCAGTCCGGCC
TTGAACCCGGGCAGCTTTGATTTTCAAGCCTACCTGCAGCGCCAGGGGGCTTTTGCCGGCTTCAGCGCCCGTGAGGTGAT
CCTGCAGCCGGGGGGAAGAGGTTGGGGGGGCTGGGTGTTGCGGCGGCGGGTGCGAGAGGCGTTCGTTGCTGGATTGGGGG
AGCGGCAGGGGAATCTGTTGGCTTCCTTGGTGCTGGGATCCCGGGCCGCCCAATTGGATTTCGACTTGCAGGATGCCTTC
CGGGAAATCGGCATGGCCCATGCGCTGGCCGCCTCTGGGTTCCATGTGTCGCTGTTGGTGGGGGTGGTGTTTGTCCTAAC
ACGGCGGTTGGCGGTGCGCCTGCAGCAGGGGAGCATCCTGGCGGTGCTGGGGCTTTATACCGCCCTCACGGGGTTCAGCC
CTTCGGTGTTGCGAGCGGCACTGATGGGGGCGGCGGCCATGCTGGTGCTGACGGAGCCGCGCCTGGAAGGAAAGGTGAAG
CTCAATCCCCTGGGGACGCTACTGGTGGCGGCAGTTTTGCTCTTAATCTACGAGCCGCTGTGGATTACAGACCTGGGGTT
TCAGCTCAGCTTTGCCGCCACCCTGGGCCTGCTGGTCGGAACAGCCCCAATTGTTTCCCGGCTGGACTTTTTGCCTCCGG
CTGTGGCCACCGCCTTGGCCGTTCCGCTGGCAGCCCAGATCTGGACCTTGCCGCTGCAAGTGGCCATCTTTGGCCGCATC
CCCACCTACTCGCTGCTGGCCAACCCGCTGCTGCTGATTCTGCTAGTGCCGCTGCTGGTGGCGGGGTTCGGGGTGGCGTT
TGGGGCTTTGCTCTGGCCGGGGCTGGGATCCCTGCTGGCCCGGCCCTTGACGTTTTTGATCACGCCTTTAATCAACTGGG
TGAACTGGATGGCCAGCTGGCCTCTGAGTTCCTACTACACCGGCCGGGTCTCCCTGCTCCAGTGCTTGCTCCTCTACGGG
GCGCTGGTGGCCCTAACCTTTTGGCCGCGGTGGCGACAGGCCTTCCGCTGGCAGGGCACAGCCCTGATCATGGCCGCCAT
CCTCCTGGGTCCAAGGATGTGGCCGGGGCCGCCGGTCCAAATTACCGCCTTGGCCAGTGGACGAATTCCCATCCTGGCCA
TTCAAGCGGAAGGGCGCCACCTCTTGCTCAACAGCGGGGATCCCCGTTTGGCAGAACGCACGGTGTTGCCCTTTTTGCGG
CAGCAGGGCTTGCACCGTCTGGACGGGGCGGTGGCCATGACCTCCGCCGGCTCTGCCAATGGCGGCTGGGAGATCCTGCT
GTCGGCTTTCTCCAAAGGAGTACGTCCCGCCAACGCGATTGGGCAATTCTGGGATGGGGGAGGGGCTAATGCGGCTTCCG
AAAGTTACCTGCGTTCCCTTAGTGCCGTGCAAGCTGCCCAGATCCCCTATCAGGTGCTGCAGCCAGGCGATCGGATGCCT
TTCTCGGAGCGGCTGCGGCTGCAAGCTGTCTACACCAATCCCCTGGTGTTGACACTGGAGGCTGAGGGATCCCATTGGCT
GCTGCTGGGCTCTGCCGGCACCCATGTGCAAGTCGAGCTAACCGGATCCCCGCTGATGCCGGCCCAGATCGACTGGCTGT
GGTGGGACGGGGGATCCCTGATTTTGGATCTCCTGGAGCGCTTTCAGGTGCAGGCGGGCATTAGCTCTGGCTCTGTCGGC
GAGACGGTGGTCACCTGGTTCCGGCAGAAACAACGACCCCTCTACGTAGCCGATCGGTCTGGAGCGGTAAGCTGGTCGCG
GCGGGGAGTGCAAACCTTGAGGTCACAATTGGATTGA

Upstream 100 bases:

>100_bases
CTTTAATACAATTCTTTCGGCAGGCGAGCAAGGTTAAGACAACGCAATGGATCCCGCTTGACCACATCGGTACAGTGGGG
GGCAGACGGGTCTGCGGCAC

Downstream 100 bases:

>100_bases
GCAGCGCTGTAGTCTGGGGTACAAACTCGGTAGAATTCGAGCAAAAAAGCTTGCAGCTTCCCAAACAAAGTGGGAGAGAG
GCTAGCAGGGCAAGGCGGCG

Product: DNA internalization competence protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MERTYLLGLGWILGLLVRAWPQAAGWGWGIPLGLGLAGSLLCRRQPRLARTWLAMGLVGCLAWNYLGWRQPFPGPTDISL
LAPQQQMNLVGTVLSEPRPTRSERRQFWLRAEQVLNADSTARQVSGKLYVTTGPEALQDKDLHPNQRVRLTGSLYLPSPA
LNPGSFDFQAYLQRQGAFAGFSAREVILQPGGRGWGGWVLRRRVREAFVAGLGERQGNLLASLVLGSRAAQLDFDLQDAF
REIGMAHALAASGFHVSLLVGVVFVLTRRLAVRLQQGSILAVLGLYTALTGFSPSVLRAALMGAAAMLVLTEPRLEGKVK
LNPLGTLLVAAVLLLIYEPLWITDLGFQLSFAATLGLLVGTAPIVSRLDFLPPAVATALAVPLAAQIWTLPLQVAIFGRI
PTYSLLANPLLLILLVPLLVAGFGVAFGALLWPGLGSLLARPLTFLITPLINWVNWMASWPLSSYYTGRVSLLQCLLLYG
ALVALTFWPRWRQAFRWQGTALIMAAILLGPRMWPGPPVQITALASGRIPILAIQAEGRHLLLNSGDPRLAERTVLPFLR
QQGLHRLDGAVAMTSAGSANGGWEILLSAFSKGVRPANAIGQFWDGGGANAASESYLRSLSAVQAAQIPYQVLQPGDRMP
FSERLRLQAVYTNPLVLTLEAEGSHWLLLGSAGTHVQVELTGSPLMPAQIDWLWWDGGSLILDLLERFQVQAGISSGSVG
ETVVTWFRQKQRPLYVADRSGAVSWSRRGVQTLRSQLD

Sequences:

>Translated_758_residues
MERTYLLGLGWILGLLVRAWPQAAGWGWGIPLGLGLAGSLLCRRQPRLARTWLAMGLVGCLAWNYLGWRQPFPGPTDISL
LAPQQQMNLVGTVLSEPRPTRSERRQFWLRAEQVLNADSTARQVSGKLYVTTGPEALQDKDLHPNQRVRLTGSLYLPSPA
LNPGSFDFQAYLQRQGAFAGFSAREVILQPGGRGWGGWVLRRRVREAFVAGLGERQGNLLASLVLGSRAAQLDFDLQDAF
REIGMAHALAASGFHVSLLVGVVFVLTRRLAVRLQQGSILAVLGLYTALTGFSPSVLRAALMGAAAMLVLTEPRLEGKVK
LNPLGTLLVAAVLLLIYEPLWITDLGFQLSFAATLGLLVGTAPIVSRLDFLPPAVATALAVPLAAQIWTLPLQVAIFGRI
PTYSLLANPLLLILLVPLLVAGFGVAFGALLWPGLGSLLARPLTFLITPLINWVNWMASWPLSSYYTGRVSLLQCLLLYG
ALVALTFWPRWRQAFRWQGTALIMAAILLGPRMWPGPPVQITALASGRIPILAIQAEGRHLLLNSGDPRLAERTVLPFLR
QQGLHRLDGAVAMTSAGSANGGWEILLSAFSKGVRPANAIGQFWDGGGANAASESYLRSLSAVQAAQIPYQVLQPGDRMP
FSERLRLQAVYTNPLVLTLEAEGSHWLLLGSAGTHVQVELTGSPLMPAQIDWLWWDGGSLILDLLERFQVQAGISSGSVG
ETVVTWFRQKQRPLYVADRSGAVSWSRRGVQTLRSQLD
>Mature_758_residues
MERTYLLGLGWILGLLVRAWPQAAGWGWGIPLGLGLAGSLLCRRQPRLARTWLAMGLVGCLAWNYLGWRQPFPGPTDISL
LAPQQQMNLVGTVLSEPRPTRSERRQFWLRAEQVLNADSTARQVSGKLYVTTGPEALQDKDLHPNQRVRLTGSLYLPSPA
LNPGSFDFQAYLQRQGAFAGFSAREVILQPGGRGWGGWVLRRRVREAFVAGLGERQGNLLASLVLGSRAAQLDFDLQDAF
REIGMAHALAASGFHVSLLVGVVFVLTRRLAVRLQQGSILAVLGLYTALTGFSPSVLRAALMGAAAMLVLTEPRLEGKVK
LNPLGTLLVAAVLLLIYEPLWITDLGFQLSFAATLGLLVGTAPIVSRLDFLPPAVATALAVPLAAQIWTLPLQVAIFGRI
PTYSLLANPLLLILLVPLLVAGFGVAFGALLWPGLGSLLARPLTFLITPLINWVNWMASWPLSSYYTGRVSLLQCLLLYG
ALVALTFWPRWRQAFRWQGTALIMAAILLGPRMWPGPPVQITALASGRIPILAIQAEGRHLLLNSGDPRLAERTVLPFLR
QQGLHRLDGAVAMTSAGSANGGWEILLSAFSKGVRPANAIGQFWDGGGANAASESYLRSLSAVQAAQIPYQVLQPGDRMP
FSERLRLQAVYTNPLVLTLEAEGSHWLLLGSAGTHVQVELTGSPLMPAQIDWLWWDGGSLILDLLERFQVQAGISSGSVG
ETVVTWFRQKQRPLYVADRSGAVSWSRRGVQTLRSQLD

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 82422; Mature: 82422

Theoretical pI: Translated: 10.84; Mature: 10.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTYLLGLGWILGLLVRAWPQAAGWGWGIPLGLGLAGSLLCRRQPRLARTWLAMGLVGC
CCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LAWNYLGWRQPFPGPTDISLLAPQQQMNLVGTVLSEPRPTRSERRQFWLRAEQVLNADST
HHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHH
ARQVSGKLYVTTGPEALQDKDLHPNQRVRLTGSLYLPSPALNPGSFDFQAYLQRQGAFAG
HHHHCCEEEEECCCHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHCCCCCC
FSAREVILQPGGRGWGGWVLRRRVREAFVAGLGERQGNLLASLVLGSRAAQLDFDLQDAF
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHCCCCCHHHHH
REIGMAHALAASGFHVSLLVGVVFVLTRRLAVRLQQGSILAVLGLYTALTGFSPSVLRAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHH
LMGAAAMLVLTEPRLEGKVKLNPLGTLLVAAVLLLIYEPLWITDLGFQLSFAATLGLLVG
HHHHHHEEEEECCCCCCEEEECHHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHH
TAPIVSRLDFLPPAVATALAVPLAAQIWTLPLQVAIFGRIPTYSLLANPLLLILLVPLLV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHH
AGFGVAFGALLWPGLGSLLARPLTFLITPLINWVNWMASWPLSSYYTGRVSLLQCLLLYG
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHH
ALVALTFWPRWRQAFRWQGTALIMAAILLGPRMWPGPPVQITALASGRIPILAIQAEGRH
HHHHHHHCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEECCCCE
LLLNSGDPRLAERTVLPFLRQQGLHRLDGAVAMTSAGSANGGWEILLSAFSKGVRPANAI
EEEECCCCCHHHHHHHHHHHHCCHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCHHHH
GQFWDGGGANAASESYLRSLSAVQAAQIPYQVLQPGDRMPFSERLRLQAVYTNPLVLTLE
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHCEEEEEEECCCEEEEEE
AEGSHWLLLGSAGTHVQVELTGSPLMPAQIDWLWWDGGSLILDLLERFQVQAGISSGSVG
CCCCEEEEEECCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCH
ETVVTWFRQKQRPLYVADRSGAVSWSRRGVQTLRSQLD
HHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERTYLLGLGWILGLLVRAWPQAAGWGWGIPLGLGLAGSLLCRRQPRLARTWLAMGLVGC
CCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LAWNYLGWRQPFPGPTDISLLAPQQQMNLVGTVLSEPRPTRSERRQFWLRAEQVLNADST
HHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHH
ARQVSGKLYVTTGPEALQDKDLHPNQRVRLTGSLYLPSPALNPGSFDFQAYLQRQGAFAG
HHHHCCEEEEECCCHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHCCCCCC
FSAREVILQPGGRGWGGWVLRRRVREAFVAGLGERQGNLLASLVLGSRAAQLDFDLQDAF
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHCCCCCHHHHH
REIGMAHALAASGFHVSLLVGVVFVLTRRLAVRLQQGSILAVLGLYTALTGFSPSVLRAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHH
LMGAAAMLVLTEPRLEGKVKLNPLGTLLVAAVLLLIYEPLWITDLGFQLSFAATLGLLVG
HHHHHHEEEEECCCCCCEEEECHHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHH
TAPIVSRLDFLPPAVATALAVPLAAQIWTLPLQVAIFGRIPTYSLLANPLLLILLVPLLV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHH
AGFGVAFGALLWPGLGSLLARPLTFLITPLINWVNWMASWPLSSYYTGRVSLLQCLLLYG
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHH
ALVALTFWPRWRQAFRWQGTALIMAAILLGPRMWPGPPVQITALASGRIPILAIQAEGRH
HHHHHHHCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEECCCCE
LLLNSGDPRLAERTVLPFLRQQGLHRLDGAVAMTSAGSANGGWEILLSAFSKGVRPANAI
EEEECCCCCHHHHHHHHHHHHCCHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCHHHH
GQFWDGGGANAASESYLRSLSAVQAAQIPYQVLQPGDRMPFSERLRLQAVYTNPLVLTLE
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHCEEEEEEECCCEEEEEE
AEGSHWLLLGSAGTHVQVELTGSPLMPAQIDWLWWDGGSLILDLLERFQVQAGISSGSVG
CCCCEEEEEECCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCH
ETVVTWFRQKQRPLYVADRSGAVSWSRRGVQTLRSQLD
HHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]