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The map label for this gene is mutY [H]

Identifier: 86608236

GI number: 86608236

Start: 775405

End: 776481

Strand: Direct

Name: mutY [H]

Synonym: CYB_0752

Alternate gene names: 86608236

Gene position: 775405-776481 (Clockwise)

Preceding gene: 86608235

Following gene: 86608237

Centisome position: 25.45

GC content: 58.31

Gene sequence:

>1077_bases
TTGCGGCAGTCTCTTCAGCGTTGGTACCGTGAACACGGGCGGGATCTGCCCTGGCGCCGCACCCGGGATCCTTACGCCAT
TTGGGTTTCGGAAGTGATGTTACAGCAAACCCAGGTGGCAACAGTTATCCCCTACTTTCAGCGCTGGATGCAAACCCTGC
CCGGGATCCCAGCATTGGCGGCAGCCCCCCAGCAGCAGGTGCTGAAACTGTGGGAGGGCCTAGGCTACTACCGGCGGGCC
CTGAACTTGCACAAAGCTGCCCAAATTTTGATGCGGGAACGGAACGGCGAGTTCCCCAGGGATTTGGAGCAGGTGTTGGC
TCTGCCGGGGATCGGGCGCACCACGGCTGGCGGCATTCTCAGCGCTGCCTTCGATCAGCCTTTGCCCATTTTGGATGGCA
ACGTCAAGCGGGTGCTGGCTCGCTTGGTGGCTTTGCAGCAGCCTCCGTCCCAGTGTCTGCCCCTGTTGTGGCAGCTTTCC
CAGCAATTGTTGGATCCTGTGCAGCCGCGGGCTTTTAACCAAGCCCTGATGGATTTGGGGGCTACCGTCTGTCGTCCCAA
AAAGCCTCACTGTGGCCGGTGCCCTTGGCAAGCGGATTGCAGCGCCTACAATCGAGGTCAACACCAACAATTGCCTATGT
CTGCACCCCGTGCCTCCCGTCCTCACAAGCAAATCGCGGTTGCCATTGTTCTGCGGGGGAAAGAAATCCTTATCGATCGA
CGACTGGAAAGCTCAATGCTCAGCGGGCTGTGGGAGTTTCCCGGAGGCAAAATCGAGCCGGGAGAAACGGCTGCCGAGTG
TGTAGTACGGGAGGTAAAAGAAGAAATCGGCATCGATATCGAGGTGGTCGCGCCGCTAGCCACCGTCGAACATGTCTATA
CCCATTTCACCGTTACTCTTATTGCTTTTATCTGCCGCTACCTGGGCGGAGAAGCCCAAGCCCTGCAATGTAGTGAGGTG
CGCTGGGTCAGCCCGGCGGAGCTGTCGGAATTTCCCTTCCCAGGGGCCAATCAAAAGTTGTTTCCCCACTTGCATGCTTG
GCTGGCGGAGCATGGGAACACCTTTGAACACACCTAA

Upstream 100 bases:

>100_bases
GCTTGAGTCTCAGCCCATATCAGAAGCCGAGGTCAGTTTTTCCTACATTGCCAGCCTTCCGAGCAAAGGAGGGGAGTGGG
ACGAGGCTTTCTTGCAACGC

Downstream 100 bases:

>100_bases
TCTGCCAAATGGCTTGGGCCCCTCTGGAGCAGTTGCCCCAAGACATTCGATAGGATAGTAGGTGTCCTGCTGCCGTGAGC
TACGGATATGCTTGTCACTC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MRQSLQRWYREHGRDLPWRRTRDPYAIWVSEVMLQQTQVATVIPYFQRWMQTLPGIPALAAAPQQQVLKLWEGLGYYRRA
LNLHKAAQILMRERNGEFPRDLEQVLALPGIGRTTAGGILSAAFDQPLPILDGNVKRVLARLVALQQPPSQCLPLLWQLS
QQLLDPVQPRAFNQALMDLGATVCRPKKPHCGRCPWQADCSAYNRGQHQQLPMSAPRASRPHKQIAVAIVLRGKEILIDR
RLESSMLSGLWEFPGGKIEPGETAAECVVREVKEEIGIDIEVVAPLATVEHVYTHFTVTLIAFICRYLGGEAQALQCSEV
RWVSPAELSEFPFPGANQKLFPHLHAWLAEHGNTFEHT

Sequences:

>Translated_358_residues
MRQSLQRWYREHGRDLPWRRTRDPYAIWVSEVMLQQTQVATVIPYFQRWMQTLPGIPALAAAPQQQVLKLWEGLGYYRRA
LNLHKAAQILMRERNGEFPRDLEQVLALPGIGRTTAGGILSAAFDQPLPILDGNVKRVLARLVALQQPPSQCLPLLWQLS
QQLLDPVQPRAFNQALMDLGATVCRPKKPHCGRCPWQADCSAYNRGQHQQLPMSAPRASRPHKQIAVAIVLRGKEILIDR
RLESSMLSGLWEFPGGKIEPGETAAECVVREVKEEIGIDIEVVAPLATVEHVYTHFTVTLIAFICRYLGGEAQALQCSEV
RWVSPAELSEFPFPGANQKLFPHLHAWLAEHGNTFEHT
>Mature_358_residues
MRQSLQRWYREHGRDLPWRRTRDPYAIWVSEVMLQQTQVATVIPYFQRWMQTLPGIPALAAAPQQQVLKLWEGLGYYRRA
LNLHKAAQILMRERNGEFPRDLEQVLALPGIGRTTAGGILSAAFDQPLPILDGNVKRVLARLVALQQPPSQCLPLLWQLS
QQLLDPVQPRAFNQALMDLGATVCRPKKPHCGRCPWQADCSAYNRGQHQQLPMSAPRASRPHKQIAVAIVLRGKEILIDR
RLESSMLSGLWEFPGGKIEPGETAAECVVREVKEEIGIDIEVVAPLATVEHVYTHFTVTLIAFICRYLGGEAQALQCSEV
RWVSPAELSEFPFPGANQKLFPHLHAWLAEHGNTFEHT

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=399, Percent_Identity=37.0927318295739, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI115298652, Length=399, Percent_Identity=37.0927318295739, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI115298648, Length=399, Percent_Identity=37.0927318295739, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI115298650, Length=399, Percent_Identity=37.0927318295739, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI6912520, Length=399, Percent_Identity=37.0927318295739, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI190358497, Length=399, Percent_Identity=37.0927318295739, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI1789331, Length=297, Percent_Identity=42.7609427609428, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1788056, Length=126, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786288, Length=122, Percent_Identity=34.4262295081967, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787920, Length=129, Percent_Identity=34.1085271317829, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40457; Mature: 40457

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00893 NUDIX ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSLQRWYREHGRDLPWRRTRDPYAIWVSEVMLQQTQVATVIPYFQRWMQTLPGIPALA
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
AAPQQQVLKLWEGLGYYRRALNLHKAAQILMRERNGEFPRDLEQVLALPGIGRTTAGGIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHH
SAAFDQPLPILDGNVKRVLARLVALQQPPSQCLPLLWQLSQQLLDPVQPRAFNQALMDLG
HHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ATVCRPKKPHCGRCPWQADCSAYNRGQHQQLPMSAPRASRPHKQIAVAIVLRGKEILIDR
HHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHEEEHEEECCHHHHHHH
RLESSMLSGLWEFPGGKIEPGETAAECVVREVKEEIGIDIEVVAPLATVEHVYTHFTVTL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
IAFICRYLGGEAQALQCSEVRWVSPAELSEFPFPGANQKLFPHLHAWLAEHGNTFEHT
HHHHHHHHCCCCCEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRQSLQRWYREHGRDLPWRRTRDPYAIWVSEVMLQQTQVATVIPYFQRWMQTLPGIPALA
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
AAPQQQVLKLWEGLGYYRRALNLHKAAQILMRERNGEFPRDLEQVLALPGIGRTTAGGIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHH
SAAFDQPLPILDGNVKRVLARLVALQQPPSQCLPLLWQLSQQLLDPVQPRAFNQALMDLG
HHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ATVCRPKKPHCGRCPWQADCSAYNRGQHQQLPMSAPRASRPHKQIAVAIVLRGKEILIDR
HHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHEEEHEEECCHHHHHHH
RLESSMLSGLWEFPGGKIEPGETAAECVVREVKEEIGIDIEVVAPLATVEHVYTHFTVTL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
IAFICRYLGGEAQALQCSEVRWVSPAELSEFPFPGANQKLFPHLHAWLAEHGNTFEHT
HHHHHHHHCCCCCEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]