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The map label for this gene is panF [H]

Identifier: 86608167

GI number: 86608167

Start: 695292

End: 696746

Strand: Direct

Name: panF [H]

Synonym: CYB_0681

Alternate gene names: 86608167

Gene position: 695292-696746 (Clockwise)

Preceding gene: 86608166

Following gene: 86608170

Centisome position: 22.82

GC content: 60.27

Gene sequence:

>1455_bases
ATGAGTAACACGGTTTTGAGTCTGGGTGTGGTGGGGGTGTACTTGCTGCTGCTGGCAGCCATCGGCTTCTGGAGCTATCG
CCACAGCGGTCGGGATCCGGTTAGCTACTTTTTGGCGGGGCGGGGTCTGGGATCCCTGGCTCTAACCTTGACGACGCTGG
CGACGCTGCTCAGTGCCTTTACCTTCATTGGGGTGCCGGCAGATGCCTATACCCACGGCCTAGGGATCTTCCTGGGGGTG
GGGGTGACCACCGCCCTCATTTCGGGGCTGTTTTTGTGGGTGGGCTACCGGGTATGGCTAGCAGCCCAACACTTTGGCTT
CATCACCCCTTCCGAGTTTTTCGGCCACCGCTTCAACAGCCCTCTTTTGGCTCTACTCTACTGCCTTAGCGCCCTGATGT
TTACCGCCCCCTACATCAGCATCCAGATCATTGGCGGAGCCCGCACCCTGGCGGCGGTGTTGGGGGAGGGGATCCCCTAC
TGGCCCTTGGCGGTGGTGGTGGCGCTGGTGATCTTGGGGTATGTGCTCTTTGGCGGATCCCAGGCGGTGGTCTGGACGGA
CGTGGTGCAGGGGATCATCTTGATTCTGGGGATGGGGGTGGCCTTTGTTGCAGTGGCTTTCTCCCTAGGGAGAGAAGCGG
GTAGCGAACTGGATCCCTGGCTGAGCTTGCCCGGCCCCCAAGGACGCTGGAGCTGGCAAGGGTTACTCGGCAATCAACTG
CTGTTTTTCATGGCCACTCCCCTTTTCCCACAATTTTTCCAGCGCTTTTACATGGCCAGGAGTGCTCATCCCTTCAAGAC
CCTGATGGTAGTCTGGCCGCTGCTGATTCTGCTGGTCTTTTTCCCGGCAGCTCTTCTTGGGGTTTGGGGCCGCCTGGCTT
TTCCCGGCCTGGAGAAAGCGGACCAGATCATGCCCCTGATGTTGCAAACTCTGCCCGGCGGTGTGGCAGCGGTGGTGATT
ACAGCAGCTCTGGCCGCCCTCATGTCCACGGCAGACTCACAGCTCCTTACGGCCAGCTCGTTGGTAACGCGGGATCTGGT
AGTGACCCTCTTTAGACGCCAGCTTTCCCCCCACCAAGAAGAACAATTGGGACGCTGGGTGGTGCTGGGGATCGGTTTGG
CCTCTTTTGCCATTGCCCTTAACCCGCCGGGGCTGATTGTGGAGATCGCCACCTGGAGCTTTCAGGGAAATGCCATGCTG
TTCCCAATCCTGATAGCCGGTCTGTACTGGAAGCGGGCTACCCGCGCTGGGGCTGTAGCCGGGGCCCTCGTCTCCAGTGG
CCTGACTTTAGGTTGGCTGTCGGGTCTGTTGCCGCGGGCTTGGACAGGGGGCTGGTTACCCGTAATCCCGGCAGTGGTGA
TCGGCAGTGGGGTGTTAATTGGCGTAAGCTTGCTTACCCAGCCGCCCAAGGAGCAGGTGACCGCCTACTACGAGGAAGGG
CCTTGGGGAGAGTAG

Upstream 100 bases:

>100_bases
TTGGGGATCCCGGCCTGGTATTGGCTGGCGGGATTGGCTGTCCTGCTGTTGGTACCTCTTAACTTCTACATTGTGCGCGT
TTGCTGGCCGAGAGGCGGAG

Downstream 100 bases:

>100_bases
GTTATTCTTTATCGATCAGCTCAATCAACGCTTTTCCAGGTCTGCCGGTAGCCAGCCAGCTTGAGCCAGGCCGTTGAGAA
ATGCGAAAGTCCCTCCTAGA

Product: solute/sodium symporter (SSS) family protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSNTVLSLGVVGVYLLLLAAIGFWSYRHSGRDPVSYFLAGRGLGSLALTLTTLATLLSAFTFIGVPADAYTHGLGIFLGV
GVTTALISGLFLWVGYRVWLAAQHFGFITPSEFFGHRFNSPLLALLYCLSALMFTAPYISIQIIGGARTLAAVLGEGIPY
WPLAVVVALVILGYVLFGGSQAVVWTDVVQGIILILGMGVAFVAVAFSLGREAGSELDPWLSLPGPQGRWSWQGLLGNQL
LFFMATPLFPQFFQRFYMARSAHPFKTLMVVWPLLILLVFFPAALLGVWGRLAFPGLEKADQIMPLMLQTLPGGVAAVVI
TAALAALMSTADSQLLTASSLVTRDLVVTLFRRQLSPHQEEQLGRWVVLGIGLASFAIALNPPGLIVEIATWSFQGNAML
FPILIAGLYWKRATRAGAVAGALVSSGLTLGWLSGLLPRAWTGGWLPVIPAVVIGSGVLIGVSLLTQPPKEQVTAYYEEG
PWGE

Sequences:

>Translated_484_residues
MSNTVLSLGVVGVYLLLLAAIGFWSYRHSGRDPVSYFLAGRGLGSLALTLTTLATLLSAFTFIGVPADAYTHGLGIFLGV
GVTTALISGLFLWVGYRVWLAAQHFGFITPSEFFGHRFNSPLLALLYCLSALMFTAPYISIQIIGGARTLAAVLGEGIPY
WPLAVVVALVILGYVLFGGSQAVVWTDVVQGIILILGMGVAFVAVAFSLGREAGSELDPWLSLPGPQGRWSWQGLLGNQL
LFFMATPLFPQFFQRFYMARSAHPFKTLMVVWPLLILLVFFPAALLGVWGRLAFPGLEKADQIMPLMLQTLPGGVAAVVI
TAALAALMSTADSQLLTASSLVTRDLVVTLFRRQLSPHQEEQLGRWVVLGIGLASFAIALNPPGLIVEIATWSFQGNAML
FPILIAGLYWKRATRAGAVAGALVSSGLTLGWLSGLLPRAWTGGWLPVIPAVVIGSGVLIGVSLLTQPPKEQVTAYYEEG
PWGE
>Mature_483_residues
SNTVLSLGVVGVYLLLLAAIGFWSYRHSGRDPVSYFLAGRGLGSLALTLTTLATLLSAFTFIGVPADAYTHGLGIFLGVG
VTTALISGLFLWVGYRVWLAAQHFGFITPSEFFGHRFNSPLLALLYCLSALMFTAPYISIQIIGGARTLAAVLGEGIPYW
PLAVVVALVILGYVLFGGSQAVVWTDVVQGIILILGMGVAFVAVAFSLGREAGSELDPWLSLPGPQGRWSWQGLLGNQLL
FFMATPLFPQFFQRFYMARSAHPFKTLMVVWPLLILLVFFPAALLGVWGRLAFPGLEKADQIMPLMLQTLPGGVAAVVIT
AALAALMSTADSQLLTASSLVTRDLVVTLFRRQLSPHQEEQLGRWVVLGIGLASFAIALNPPGLIVEIATWSFQGNAMLF
PILIAGLYWKRATRAGAVAGALVSSGLTLGWLSGLLPRAWTGGWLPVIPAVVIGSGVLIGVSLLTQPPKEQVTAYYEEGP
WGE

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=495, Percent_Identity=25.0505050505051, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4507035, Length=402, Percent_Identity=25.8706467661692, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI11141885, Length=305, Percent_Identity=28.5245901639344, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI167466278, Length=393, Percent_Identity=25.1908396946565, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI256985183, Length=440, Percent_Identity=26.3636363636364, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI157671931, Length=427, Percent_Identity=24.1217798594848, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082237, Length=430, Percent_Identity=29.0697674418605, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1787251, Length=503, Percent_Identity=27.037773359841, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790503, Length=476, Percent_Identity=22.2689075630252, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539284, Length=473, Percent_Identity=26.215644820296, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI115533094, Length=375, Percent_Identity=24.2666666666667, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648033, Length=448, Percent_Identity=25.2232142857143, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356865, Length=448, Percent_Identity=25.2232142857143, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221459584, Length=379, Percent_Identity=24.5382585751979, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51804; Mature: 51673

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTVLSLGVVGVYLLLLAAIGFWSYRHSGRDPVSYFLAGRGLGSLALTLTTLATLLSAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TFIGVPADAYTHGLGIFLGVGVTTALISGLFLWVGYRVWLAAQHFGFITPSEFFGHRFNS
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
PLLALLYCLSALMFTAPYISIQIIGGARTLAAVLGEGIPYWPLAVVVALVILGYVLFGGS
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
QAVVWTDVVQGIILILGMGVAFVAVAFSLGREAGSELDPWLSLPGPQGRWSWQGLLGNQL
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LFFMATPLFPQFFQRFYMARSAHPFKTLMVVWPLLILLVFFPAALLGVWGRLAFPGLEKA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DQIMPLMLQTLPGGVAAVVITAALAALMSTADSQLLTASSLVTRDLVVTLFRRQLSPHQE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EQLGRWVVLGIGLASFAIALNPPGLIVEIATWSFQGNAMLFPILIAGLYWKRATRAGAVA
HHCCCEEEEEHHHHHHEEEECCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GALVSSGLTLGWLSGLLPRAWTGGWLPVIPAVVIGSGVLIGVSLLTQPPKEQVTAYYEEG
HHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCC
PWGE
CCCC
>Mature Secondary Structure 
SNTVLSLGVVGVYLLLLAAIGFWSYRHSGRDPVSYFLAGRGLGSLALTLTTLATLLSAF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TFIGVPADAYTHGLGIFLGVGVTTALISGLFLWVGYRVWLAAQHFGFITPSEFFGHRFNS
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
PLLALLYCLSALMFTAPYISIQIIGGARTLAAVLGEGIPYWPLAVVVALVILGYVLFGGS
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
QAVVWTDVVQGIILILGMGVAFVAVAFSLGREAGSELDPWLSLPGPQGRWSWQGLLGNQL
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LFFMATPLFPQFFQRFYMARSAHPFKTLMVVWPLLILLVFFPAALLGVWGRLAFPGLEKA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DQIMPLMLQTLPGGVAAVVITAALAALMSTADSQLLTASSLVTRDLVVTLFRRQLSPHQE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EQLGRWVVLGIGLASFAIALNPPGLIVEIATWSFQGNAMLFPILIAGLYWKRATRAGAVA
HHCCCEEEEEHHHHHHEEEECCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GALVSSGLTLGWLSGLLPRAWTGGWLPVIPAVVIGSGVLIGVSLLTQPPKEQVTAYYEEG
HHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCC
PWGE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]