| Definition | Synechococcus sp. JA-2-3B'a(2-13), complete genome. |
|---|---|
| Accession | NC_007776 |
| Length | 3,046,682 |
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The map label for this gene is parC [H]
Identifier: 86607511
GI number: 86607511
Start: 7143
End: 9602
Strand: Reverse
Name: parC [H]
Synonym: CYB_0008
Alternate gene names: 86607511
Gene position: 9602-7143 (Counterclockwise)
Preceding gene: 86607512
Following gene: 86607508
Centisome position: 0.32
GC content: 62.85
Gene sequence:
>2460_bases GTGATTGTAACCGATTTGCAGGGGGAGATGCAGCGCTCCTACCTGGAATACGCCATGAGCGTGATCGTGGGGCGGGCCTT GCCGGATGTGCGGGATGGCCTCAAGCCGGTACACCGCCGCATCCTCTACGCCATGCACGAGCTGGGCCTGACGCCGGATC GCCCCTACCGCAAATGCGCACGGGTGGTGGGGGATGTGCTGGGGAAATATCACCCCCACGGGGATCAGGCAGTTTATGAC GCGCTGGTGCGCATGGTGCAAGACTTTTCCAGCCGCTATCCCCTGGTGGCGGGACACGGCAACTTCGGCTCTGTGGATGA TGACCCGCCGGCGGCTATGCGCTACACGGAGTGCCGGCTGGCGGAGCTGAGCCACACAGCGCTTCTGGAGCAGGTGTCGG AAGAGATCGTCGATTTCATGCCCAATTTCGACGGATCCCAGGCGGAGCCCACCGTTCTCCCGGCCCGATTGCCCATTTTG CTGCTCAACGGCTCTTCCGGCATTGCCGTGGGCATGGCCACCAATATCCCACCCCACAACCTGGGGGAAGTGGTGGATGG CCTGTTGGCTTTGATCGACCATCCCGACCTCAGCCCTGAGGAACTGTTGCGGTGGATCCCAGGGCCGGATTTTCCCACCG GCGGCCAAATCTTAGACACCCAAGGGATCCGCGCAGCCTACCTCACCGGGCGCGGTTCCATCACCCTGCGGGGGGTAGCC CGATTTGAGGAGATCCAGCCGGGCAAAGGACGCCACCGGCGGCCTGCTCTAGTCATCAGCGAGTTTCCCTATCAGGTGAA CAAAGCCGCCTGGATCGAAAAAGTGGCCGAGCTGGCCAACCAAGACCGCATCAGCGGCATCGCCGATCTGCGGGATGAGT CGGATCGCAGCGGCATTCGCGTGGTGGTGGAGCTGAAGCGAGAGGCCAACCCACAGGCGGTTTTGCAGCAGTTGTATAAG CTCACCCCTTTGCAAAGCAACTTTGGAGCCATCCTGCTGGCTTTGGTGAACGGGGAACCGCGGCAGCTGAGCCTCAAAGA GATCCTGCAGCACTTTTTGCAATTTCGCGAGGCCACCCTCAACCGGATGTTCCGTGCCGAACTGCAGCAGGTGCAGCGCA AGGCGGAAGAGGTGGCAGGAATGTTGCTGGCGTTGGCGGATCTGGAGGGGGTGATCGAGCTGCTGCGGCAAGCGCCCGAT GGCACCACGGCCAAAGCCCAATTGCAAACTCGCCTGGGCTGTACCCCCCAGCAGGCAGAGACGATTTTGGCCATGCCTCT GCGTCGCCTGACGGGATTGGAGCGGGAACGGCTGCACCAGGAACACGCCCAGTTGCAGACCCGCATCGAAGAACTGCAGG GGCTACTCAGCGACCGCCGCAAGCTCTTGAATTATTTGAAAAAAGAGCTGCGACACCTGAAAAAGACCTTCGGGGATCCC CGGCGCACCCAGATCCTCTCAGCCTCGGAGCTGGAAGCGGAAGTGGCCCAAATCCCCAGCGGCGAAGAGACGGAAGAGAC CCACTTCTTGCTGCAATTCACCCGCAAGGGCTATGTGCGCCGCCTGCCTCTGCCTAGCCGTCGCTCCCGCAGCAACCCGG CGCAACGGGAACTGGGGGAAGATGTGCTGGTCGGCCTGGAATGCGTCACGCTGGAGCAGGAAATCTTGGTGCTCACCGCC GGCGGCAAAGCTTTCACCCTGCCCATCGCAGGGATCCCCCTCAGCACTGGGTCCTCACGGGGGGTGCCTCTGGTTACCCT TCTCCCCAACCCTGAGCCGATCGTCGCCACCTTCACGTTGGATCCGGATCCGGGCAAGGCAAGTTTGGTGGTGCTCAGCC GGCAGGGGCGGATCAAGCGGCTGGCCCTGGCAGAGCTAATGGGCCTCACCCAACGGGGATCCACCGTCCTCAAACTAAAG GAGGGAGATGAGCTGGGCTGGGCAGCCCTTTGGGATCCCGACCACCAAGGCTACAGCGTCGTCCTGGCTACTTCAGGGGG ACGGGTGCTGCGGCTGGATGTCCAACAGATTCCCCTGATGGGTCGGGCGGCTATGGGATCGCCGGCCCTGCGCCTGGGGC GCACCGAGCGAATAGTTGGTATGGCGCTGGTGCCCTCCCAAGGGATCCTGGTTCTGGCCAGCCGGTTGGGCTATCTGAAG CGCTTGTCTCTGGAGGAGATCCCCATCTTGGAGCGGGGTCAAGTGGGCGCGCCGGCCTTTCACTTCTCCGACCGAGGGGA TGTGCTGGTGGGCTTGGTGGGTCTCCCCCCCGAGCTGGAGAGGCCTTCCCATCTGCAACTGGATGTGATCACGGAGTCTG AACAGGTGTACTCCTTCTCTCCTGCCGAGATCCCGCTGCAAAGCCGCTCCGGGGGCGGATCCCTCCTGGTCAAAGGGGAG CGGGTCAGGGAGTTGCGCCTGTTCTGGCCGCAGTGGCTGCCGGAAGGCGATGTGGGATAG
Upstream 100 bases:
>100_bases CAGTAACCTGGAAAGCGTTCCGCTCCTTTGTGCCATGACTCAGCAACTGACTCTCGACGGACTGGGATTTGGCTCGGGTG GGGGATCCCGTCTGGGTCGG
Downstream 100 bases:
>100_bases CTCTTGGGGGAGCAGAAGATCCCTAGGACGAAGAGCCTTCCCCAGGCGAGGCCGAATCGGTCGGCGGGGAGCCGGGATCC GTCTCCGGCACTTCGGGATG
Product: type II DNA topoisomerase, A subunit
Products: NA
Alternate protein names: Topoisomerase IV subunit A [H]
Number of amino acids: Translated: 819; Mature: 819
Protein sequence:
>819_residues MIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYD ALVRMVQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRLAELSHTALLEQVSEEIVDFMPNFDGSQAEPTVLPARLPIL LLNGSSGIAVGMATNIPPHNLGEVVDGLLALIDHPDLSPEELLRWIPGPDFPTGGQILDTQGIRAAYLTGRGSITLRGVA RFEEIQPGKGRHRRPALVISEFPYQVNKAAWIEKVAELANQDRISGIADLRDESDRSGIRVVVELKREANPQAVLQQLYK LTPLQSNFGAILLALVNGEPRQLSLKEILQHFLQFREATLNRMFRAELQQVQRKAEEVAGMLLALADLEGVIELLRQAPD GTTAKAQLQTRLGCTPQQAETILAMPLRRLTGLERERLHQEHAQLQTRIEELQGLLSDRRKLLNYLKKELRHLKKTFGDP RRTQILSASELEAEVAQIPSGEETEETHFLLQFTRKGYVRRLPLPSRRSRSNPAQRELGEDVLVGLECVTLEQEILVLTA GGKAFTLPIAGIPLSTGSSRGVPLVTLLPNPEPIVATFTLDPDPGKASLVVLSRQGRIKRLALAELMGLTQRGSTVLKLK EGDELGWAALWDPDHQGYSVVLATSGGRVLRLDVQQIPLMGRAAMGSPALRLGRTERIVGMALVPSQGILVLASRLGYLK RLSLEEIPILERGQVGAPAFHFSDRGDVLVGLVGLPPELERPSHLQLDVITESEQVYSFSPAEIPLQSRSGGGSLLVKGE RVRELRLFWPQWLPEGDVG
Sequences:
>Translated_819_residues MIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYD ALVRMVQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRLAELSHTALLEQVSEEIVDFMPNFDGSQAEPTVLPARLPIL LLNGSSGIAVGMATNIPPHNLGEVVDGLLALIDHPDLSPEELLRWIPGPDFPTGGQILDTQGIRAAYLTGRGSITLRGVA RFEEIQPGKGRHRRPALVISEFPYQVNKAAWIEKVAELANQDRISGIADLRDESDRSGIRVVVELKREANPQAVLQQLYK LTPLQSNFGAILLALVNGEPRQLSLKEILQHFLQFREATLNRMFRAELQQVQRKAEEVAGMLLALADLEGVIELLRQAPD GTTAKAQLQTRLGCTPQQAETILAMPLRRLTGLERERLHQEHAQLQTRIEELQGLLSDRRKLLNYLKKELRHLKKTFGDP RRTQILSASELEAEVAQIPSGEETEETHFLLQFTRKGYVRRLPLPSRRSRSNPAQRELGEDVLVGLECVTLEQEILVLTA GGKAFTLPIAGIPLSTGSSRGVPLVTLLPNPEPIVATFTLDPDPGKASLVVLSRQGRIKRLALAELMGLTQRGSTVLKLK EGDELGWAALWDPDHQGYSVVLATSGGRVLRLDVQQIPLMGRAAMGSPALRLGRTERIVGMALVPSQGILVLASRLGYLK RLSLEEIPILERGQVGAPAFHFSDRGDVLVGLVGLPPELERPSHLQLDVITESEQVYSFSPAEIPLQSRSGGGSLLVKGE RVRELRLFWPQWLPEGDVG >Mature_819_residues MIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYD ALVRMVQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRLAELSHTALLEQVSEEIVDFMPNFDGSQAEPTVLPARLPIL LLNGSSGIAVGMATNIPPHNLGEVVDGLLALIDHPDLSPEELLRWIPGPDFPTGGQILDTQGIRAAYLTGRGSITLRGVA RFEEIQPGKGRHRRPALVISEFPYQVNKAAWIEKVAELANQDRISGIADLRDESDRSGIRVVVELKREANPQAVLQQLYK LTPLQSNFGAILLALVNGEPRQLSLKEILQHFLQFREATLNRMFRAELQQVQRKAEEVAGMLLALADLEGVIELLRQAPD GTTAKAQLQTRLGCTPQQAETILAMPLRRLTGLERERLHQEHAQLQTRIEELQGLLSDRRKLLNYLKKELRHLKKTFGDP RRTQILSASELEAEVAQIPSGEETEETHFLLQFTRKGYVRRLPLPSRRSRSNPAQRELGEDVLVGLECVTLEQEILVLTA GGKAFTLPIAGIPLSTGSSRGVPLVTLLPNPEPIVATFTLDPDPGKASLVVLSRQGRIKRLALAELMGLTQRGSTVLKLK EGDELGWAALWDPDHQGYSVVLATSGGRVLRLDVQQIPLMGRAAMGSPALRLGRTERIVGMALVPSQGILVLASRLGYLK RLSLEEIPILERGQVGAPAFHFSDRGDVLVGLVGLPPELERPSHLQLDVITESEQVYSFSPAEIPLQSRSGGGSLLVKGE RVRELRLFWPQWLPEGDVG
Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=23.546511627907, Blast_Score=80, Evalue=1e-14, Organism=Homo sapiens, GI19913406, Length=355, Percent_Identity=23.0985915492958, Blast_Score=69, Evalue=2e-11, Organism=Escherichia coli, GI1788562, Length=835, Percent_Identity=38.562874251497, Blast_Score=555, Evalue=1e-159, Organism=Escherichia coli, GI1789396, Length=488, Percent_Identity=42.827868852459, Blast_Score=371, Evalue=1e-103, Organism=Caenorhabditis elegans, GI212645845, Length=519, Percent_Identity=23.5067437379576, Blast_Score=84, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=29.8850574712644, Blast_Score=70, Evalue=5e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=25.0720461095101, Blast_Score=77, Evalue=8e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: 5.99.1.3
Molecular weight: Translated: 90469; Mature: 90469
Theoretical pI: Translated: 6.77; Mature: 6.77
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCA CEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH RVVGDVLGKYHPHGDQAVYDALVRMVQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRL HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHH AELSHTALLEQVSEEIVDFMPNFDGSQAEPTVLPARLPILLLNGSSGIAVGMATNIPPHN HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEECCCCEEEEEECCCCCCC LGEVVDGLLALIDHPDLSPEELLRWIPGPDFPTGGQILDTQGIRAAYLTGRGSITLRGVA HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCEEEEEECCCCEEEEEHH RFEEIQPGKGRHRRPALVISEFPYQVNKAAWIEKVAELANQDRISGIADLRDESDRSGIR HHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHCCHHHHCCCCCCCCCE VVVELKREANPQAVLQQLYKLTPLQSNFGAILLALVNGEPRQLSLKEILQHFLQFREATL EEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEECHHHHHHHHHHHHHHHH NRMFRAELQQVQRKAEEVAGMLLALADLEGVIELLRQAPDGTTAKAQLQTRLGCTPQQAE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHH TILAMPLRRLTGLERERLHQEHAQLQTRIEELQGLLSDRRKLLNYLKKELRHLKKTFGDP HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC RRTQILSASELEAEVAQIPSGEETEETHFLLQFTRKGYVRRLPLPSRRSRSNPAQRELGE HHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHCCH DVLVGLECVTLEQEILVLTAGGKAFTLPIAGIPLSTGSSRGVPLVTLLPNPEPIVATFTL HHHCCEEEEEECCEEEEEEECCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEE DPDPGKASLVVLSRQGRIKRLALAELMGLTQRGSTVLKLKEGDELGWAALWDPDHQGYSV CCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCEEE VLATSGGRVLRLDVQQIPLMGRAAMGSPALRLGRTERIVGMALVPSQGILVLASRLGYLK EEEECCCEEEEEEHHHCCCCCCCCCCCCHHHCCCCHHEEEEEECCCCCHHHHHHHHHHHH RLSLEEIPILERGQVGAPAFHFSDRGDVLVGLVGLPPELERPSHLQLDVITESEQVYSFS HCCHHHCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCEEECC PAEIPLQSRSGGGSLLVKGERVRELRLFWPQWLPEGDVG CCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCC >Mature Secondary Structure MIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCA CEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH RVVGDVLGKYHPHGDQAVYDALVRMVQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRL HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHH AELSHTALLEQVSEEIVDFMPNFDGSQAEPTVLPARLPILLLNGSSGIAVGMATNIPPHN HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEECCCCEEEEEECCCCCCC LGEVVDGLLALIDHPDLSPEELLRWIPGPDFPTGGQILDTQGIRAAYLTGRGSITLRGVA HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCEEEEEECCCCEEEEEHH RFEEIQPGKGRHRRPALVISEFPYQVNKAAWIEKVAELANQDRISGIADLRDESDRSGIR HHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHCCHHHHCCCCCCCCCE VVVELKREANPQAVLQQLYKLTPLQSNFGAILLALVNGEPRQLSLKEILQHFLQFREATL EEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEECHHHHHHHHHHHHHHHH NRMFRAELQQVQRKAEEVAGMLLALADLEGVIELLRQAPDGTTAKAQLQTRLGCTPQQAE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHH TILAMPLRRLTGLERERLHQEHAQLQTRIEELQGLLSDRRKLLNYLKKELRHLKKTFGDP HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC RRTQILSASELEAEVAQIPSGEETEETHFLLQFTRKGYVRRLPLPSRRSRSNPAQRELGE HHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHCCH DVLVGLECVTLEQEILVLTAGGKAFTLPIAGIPLSTGSSRGVPLVTLLPNPEPIVATFTL HHHCCEEEEEECCEEEEEEECCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEE DPDPGKASLVVLSRQGRIKRLALAELMGLTQRGSTVLKLKEGDELGWAALWDPDHQGYSV CCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCEEE VLATSGGRVLRLDVQQIPLMGRAAMGSPALRLGRTERIVGMALVPSQGILVLASRLGYLK EEEECCCEEEEEEHHHCCCCCCCCCCCCHHHCCCCHHEEEEEECCCCCHHHHHHHHHHHH RLSLEEIPILERGQVGAPAFHFSDRGDVLVGLVGLPPELERPSHLQLDVITESEQVYSFS HCCHHHCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCEEECC PAEIPLQSRSGGGSLLVKGERVRELRLFWPQWLPEGDVG CCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Isomerization [C]
Inhibitor: CJ-12, 371; CJ-12, 372; Coumermycin; Doxorubicin; Sitafloxacin [C]
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 8905231 [H]