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The map label for this gene is crp [H]

Identifier: 85860184

GI number: 85860184

Start: 2387048

End: 2387728

Strand: Direct

Name: crp [H]

Synonym: SYN_00574

Alternate gene names: 85860184

Gene position: 2387048-2387728 (Clockwise)

Preceding gene: 85860166

Following gene: 85860187

Centisome position: 75.08

GC content: 51.4

Gene sequence:

>681_bases
ATGAGCATAACGGACCTACTCAAGCAGATCCCTCTTTTCGAATCCCTGAACGATTCTGAGCGTCGGCGGCTGGAGTCGCT
GCTTCAGCGCCGTTCCCTTGAAAAAGGAGAAATTCTTTTTCACAAAGGCGATATCGGCTCGACCTTTTACATCATCATAA
AAGGATTGATTAAAATCGGGGTTTCCAACAAACTCGGAGATGAAGTCACTCTTGCCCTGCTGAGAGACGGGGATTTTTTC
GGAGAAATGGCCCTGCTGGACGAACAACCCCGGTCAGCCGACGCCACAGCCCTTGAAGACAGCATCCTGTATGTTCTGGA
CCGCAATGATTTTTTCCCCTTCCTTATTGAGAATGAAAACGCCGTTCGCTCCATCCTCCGTGCTCTTTCCATGCGCCTCC
GGAGAACGGATGATCTGTTTGCGGAACTGTCCTTTCTTACGGTTTCCGCCCGCCTGGCCAAACGCCTTCTTGAACTGGCG
AAGCCGACTCAAACTCACGGTGAGGAACCCGGGGAATTTCGCGTCCAGATGTCCCAGCGGGAACTGGCCGCCATGCTGGG
CGTTACTCGGGAAAGCATTAACAAGGAATTGAAAATCCTGAAAGATAAAGGGATGGTGACGACCTCCAGAAATGCGATCA
TCATAAAGGATCTCGATCGATTGAAGCGCCGCACCCGTTAA

Upstream 100 bases:

>100_bases
ATTTATTCAAATCGTGAAATTAAATCACTGTTAACAAGATGCAATTGGCTGCAAGTATCAACCTAATTCAGTAAATGAAA
CTAATTCAGGAGTACATGCC

Downstream 100 bases:

>100_bases
CCGTCTTTACAACTGGTGGTAGAGGAACAGATTGGTGGCATATTCGCCGACAAAAAGATAGGCTACAGCGGCAAGAGACA
GAAAAGGGCCGAAAGGCACG

Product: cAMP-dependent transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSITDLLKQIPLFESLNDSERRRLESLLQRRSLEKGEILFHKGDIGSTFYIIIKGLIKIGVSNKLGDEVTLALLRDGDFF
GEMALLDEQPRSADATALEDSILYVLDRNDFFPFLIENENAVRSILRALSMRLRRTDDLFAELSFLTVSARLAKRLLELA
KPTQTHGEEPGEFRVQMSQRELAAMLGVTRESINKELKILKDKGMVTTSRNAIIIKDLDRLKRRTR

Sequences:

>Translated_226_residues
MSITDLLKQIPLFESLNDSERRRLESLLQRRSLEKGEILFHKGDIGSTFYIIIKGLIKIGVSNKLGDEVTLALLRDGDFF
GEMALLDEQPRSADATALEDSILYVLDRNDFFPFLIENENAVRSILRALSMRLRRTDDLFAELSFLTVSARLAKRLLELA
KPTQTHGEEPGEFRVQMSQRELAAMLGVTRESINKELKILKDKGMVTTSRNAIIIKDLDRLKRRTR
>Mature_225_residues
SITDLLKQIPLFESLNDSERRRLESLLQRRSLEKGEILFHKGDIGSTFYIIIKGLIKIGVSNKLGDEVTLALLRDGDFFG
EMALLDEQPRSADATALEDSILYVLDRNDFFPFLIENENAVRSILRALSMRLRRTDDLFAELSFLTVSARLAKRLLELAK
PTQTHGEEPGEFRVQMSQRELAAMLGVTRESINKELKILKDKGMVTTSRNAIIIKDLDRLKRRTR

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI148612818, Length=108, Percent_Identity=36.1111111111111, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI10835242, Length=108, Percent_Identity=36.1111111111111, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789756, Length=180, Percent_Identity=28.8888888888889, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787595, Length=224, Percent_Identity=27.6785714285714, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322156, Length=112, Percent_Identity=34.8214285714286, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25836; Mature: 25705

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00889 CNMP_BINDING_2 ; PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITDLLKQIPLFESLNDSERRRLESLLQRRSLEKGEILFHKGDIGSTFYIIIKGLIKIG
CCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHC
VSNKLGDEVTLALLRDGDFFGEMALLDEQPRSADATALEDSILYVLDRNDFFPFLIENEN
CCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCEEEEEECCCCCCEEECCCH
AVRSILRALSMRLRRTDDLFAELSFLTVSARLAKRLLELAKPTQTHGEEPGEFRVQMSQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHH
ELAAMLGVTRESINKELKILKDKGMVTTSRNAIIIKDLDRLKRRTR
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEHHHHHHHHHCC
>Mature Secondary Structure 
SITDLLKQIPLFESLNDSERRRLESLLQRRSLEKGEILFHKGDIGSTFYIIIKGLIKIG
CHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHC
VSNKLGDEVTLALLRDGDFFGEMALLDEQPRSADATALEDSILYVLDRNDFFPFLIENEN
CCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCEEEEEECCCCCCEEECCCH
AVRSILRALSMRLRRTDDLFAELSFLTVSARLAKRLLELAKPTQTHGEEPGEFRVQMSQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHH
ELAAMLGVTRESINKELKILKDKGMVTTSRNAIIIKDLDRLKRRTR
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]