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The map label for this gene is groEL

Identifier: 85859340

GI number: 85859340

Start: 1535976

End: 1537613

Strand: Direct

Name: groEL

Synonym: SYN_03223

Alternate gene names: 85859340

Gene position: 1535976-1537613 (Clockwise)

Preceding gene: 85859339

Following gene: 85859341

Centisome position: 48.31

GC content: 56.59

Gene sequence:

>1638_bases
ATGGGTGCAAAATTACTGCAGTATGATGAAGAAGCGAGAAAATCCATCCTGAACGGTGTCAACGCCCTGGCTGATGCCGT
AAAGGTAACGCTTGGTCCAAAGGGCCGCAACGTGATTATCGATAAAAGCTTCGGCGCGCCGACCGTAACCAAGGACGGCG
TCACCGTCGCCAAGGAAGTCGAACTGGAAGACAAATTTGAAAACATGGGCGCCCAGATGGTCAGGGAAGTGGCCAGCAAG
ACCAGCGATGTCGCCGGTGATGGAACCACGACCGCCACGATCCTCGCCCAGGCGATCTACCGGGAAGGGGCCAAAACCGT
TGCCGCAGGCAGCAATCCCATGGATGTGAAACGCGGTATCGAAAAAGCGGTGGCCGCCGTTGTCACCGAGCTCAAGAATA
TCAGCAAACCCACAAAAGATCAGAAAGAAATCGCCCAGGTCGGGACCATCTCCGCGAACAACGACGAAACCATCGGCAAT
ATCATTGCTGAAGCCATGGGTAAAGTCGGCAAGGAAGGCGTTATCACCGTCGAAGAAGCCAAAGGACTGGAGACGGAACT
GGAGATCGTCGAAGGCATGCAGTTCGACCGGGGTTATCTCTCTCCCTACTTCGTAACCAATCCGGAAAAAATGGAAGTCA
GCCTGGAAGACGCCCTGATCCTGATTTATGAAAAGAAAATCAGTGGAATGAAGGACCTGCTGCCCATTCTTGAGCAGATC
GCGAAGATGGGTCGTCCGCTGCTGATCATCGCCGAGGACATTGAAGGCGAAGCCCTGGCGACCCTCGTGGTCAACAAGAT
TCGCGGCACCCTCCATGTCGCAGCCGTCAAGGCCCCCGGCTTCGGCGACAGGCGCAAGGCCATGCTTGAAGACATCGCCA
TCCTTACGGGCGGAACGGTGATTTCCGAGGATATGGGTTACAAGCTGGAAAATACGCGCCTGGAAGATCTCGGACGCGCC
AAGAGAATCCAGATCGACAAGGACAACACCACCATCATCGACGGCGCCGGCGAACGGGCCGCCCTGGAAGGCCGTGTGAA
ACAGATACGCGCCCAGATCGACGAAACGACTTCCGATTATGACCGGGAGAAACTTCAGGAAAGACTGGCGAAACTCGTAG
GCGGTGTCGCGGTGATCAAGGTCGGCGCGGCGACGGAAACGGAAATGAAGGAAAAGAAAGCCCGCGTCGAAGACGCCCTG
AATGCAACCCGGGCTGCCGTGGAAGAAGGCATCGTACCCGGCGGCGGTGTGGCATATATCCGTACGCTTCCGATACTGGA
GGCTCTGAAGCTTGAGGGTGACGAACAGGTCGGCGTCAACATCGTACGCAAGGCCCTTGAAGAACCTCTGAAGATGATTG
CCGCGAACGCCGGCATGGAAGGCACCATCGTTGTGGAAAAGGTCAAGGAACAGTCCGGCGCCTTCGGCTTCAATGCCCGG
ACCGAAGTCTATGAAGACATGATCGAAGCCGGCGTCATCGATCCCACCAAAGTGACCCGCTTCGCGCTGCAGAATGCGGC
CAGCGTGGCTTCCCTCATGCTGACCACCCAGTGCATGATTGCTGAGAAGCCTGAAGAAAAGGGCGCTGGAATGCCCGGAA
TGCCTCCTGGAGGCGGTTACCCCGGTATGGGCATGTAA

Upstream 100 bases:

>100_bases
ATTTGACGGACAGGAATATCTCATCATGAGAGAGGATGATATTCTGGGGATCGTGGAGAAATAATTACAGAAGATAACAA
CGAAGGAGGAGCATATACGT

Downstream 100 bases:

>100_bases
TGCGCCTGCGCCGTTAAACCTCGGACGGCATCCGCCGTCAGAGTCAAAAAAGCCTCCGAGCTCAAAGCCGGGGGCTTTTT
TACTTTGACTTGAAAACCAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MGAKLLQYDEEARKSILNGVNALADAVKVTLGPKGRNVIIDKSFGAPTVTKDGVTVAKEVELEDKFENMGAQMVREVASK
TSDVAGDGTTTATILAQAIYREGAKTVAAGSNPMDVKRGIEKAVAAVVTELKNISKPTKDQKEIAQVGTISANNDETIGN
IIAEAMGKVGKEGVITVEEAKGLETELEIVEGMQFDRGYLSPYFVTNPEKMEVSLEDALILIYEKKISGMKDLLPILEQI
AKMGRPLLIIAEDIEGEALATLVVNKIRGTLHVAAVKAPGFGDRRKAMLEDIAILTGGTVISEDMGYKLENTRLEDLGRA
KRIQIDKDNTTIIDGAGERAALEGRVKQIRAQIDETTSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDAL
NATRAAVEEGIVPGGGVAYIRTLPILEALKLEGDEQVGVNIVRKALEEPLKMIAANAGMEGTIVVEKVKEQSGAFGFNAR
TEVYEDMIEAGVIDPTKVTRFALQNAASVASLMLTTQCMIAEKPEEKGAGMPGMPPGGGYPGMGM

Sequences:

>Translated_545_residues
MGAKLLQYDEEARKSILNGVNALADAVKVTLGPKGRNVIIDKSFGAPTVTKDGVTVAKEVELEDKFENMGAQMVREVASK
TSDVAGDGTTTATILAQAIYREGAKTVAAGSNPMDVKRGIEKAVAAVVTELKNISKPTKDQKEIAQVGTISANNDETIGN
IIAEAMGKVGKEGVITVEEAKGLETELEIVEGMQFDRGYLSPYFVTNPEKMEVSLEDALILIYEKKISGMKDLLPILEQI
AKMGRPLLIIAEDIEGEALATLVVNKIRGTLHVAAVKAPGFGDRRKAMLEDIAILTGGTVISEDMGYKLENTRLEDLGRA
KRIQIDKDNTTIIDGAGERAALEGRVKQIRAQIDETTSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDAL
NATRAAVEEGIVPGGGVAYIRTLPILEALKLEGDEQVGVNIVRKALEEPLKMIAANAGMEGTIVVEKVKEQSGAFGFNAR
TEVYEDMIEAGVIDPTKVTRFALQNAASVASLMLTTQCMIAEKPEEKGAGMPGMPPGGGYPGMGM
>Mature_544_residues
GAKLLQYDEEARKSILNGVNALADAVKVTLGPKGRNVIIDKSFGAPTVTKDGVTVAKEVELEDKFENMGAQMVREVASKT
SDVAGDGTTTATILAQAIYREGAKTVAAGSNPMDVKRGIEKAVAAVVTELKNISKPTKDQKEIAQVGTISANNDETIGNI
IAEAMGKVGKEGVITVEEAKGLETELEIVEGMQFDRGYLSPYFVTNPEKMEVSLEDALILIYEKKISGMKDLLPILEQIA
KMGRPLLIIAEDIEGEALATLVVNKIRGTLHVAAVKAPGFGDRRKAMLEDIAILTGGTVISEDMGYKLENTRLEDLGRAK
RIQIDKDNTTIIDGAGERAALEGRVKQIRAQIDETTSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALN
ATRAAVEEGIVPGGGVAYIRTLPILEALKLEGDEQVGVNIVRKALEEPLKMIAANAGMEGTIVVEKVKEQSGAFGFNART
EVYEDMIEAGVIDPTKVTRFALQNAASVASLMLTTQCMIAEKPEEKGAGMPGMPPGGGYPGMGM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=51.3307984790874, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=51.3307984790874, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI24307939, Length=536, Percent_Identity=22.5746268656716, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38455427, Length=538, Percent_Identity=23.7918215613383, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=67.4812030075188, Blast_Score=709, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=527, Percent_Identity=52.3719165085389, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=51.1961722488038, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17564182, Length=548, Percent_Identity=22.0802919708029, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.0534351145038, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322524, Length=558, Percent_Identity=21.8637992831541, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322350, Length=583, Percent_Identity=22.2984562607204, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=52.851711026616, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=52.851711026616, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.0948766603416, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.0948766603416, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.0948766603416, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI17864606, Length=525, Percent_Identity=46.6666666666667, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=523, Percent_Identity=36.7112810707457, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI19921262, Length=523, Percent_Identity=36.7112810707457, Blast_Score=325, Evalue=5e-89,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_SYNAS (Q2LTG7)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461542.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q2LTG7
- SMR:   Q2LTG7
- STRING:   Q2LTG7
- GeneID:   3883720
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_03223
- NMPDR:   fig|56780.10.peg.1486
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   DKPAAGM
- PhylomeDB:   Q2LTG7
- ProtClustDB:   PRK00013
- BioCyc:   SACI56780:SYN_03223-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58259; Mature: 58128

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAKLLQYDEEARKSILNGVNALADAVKVTLGPKGRNVIIDKSFGAPTVTKDGVTVAKEV
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHC
ELEDKFENMGAQMVREVASKTSDVAGDGTTTATILAQAIYREGAKTVAAGSNPMDVKRGI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHH
EKAVAAVVTELKNISKPTKDQKEIAQVGTISANNDETIGNIIAEAMGKVGKEGVITVEEA
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
KGLETELEIVEGMQFDRGYLSPYFVTNPEKMEVSLEDALILIYEKKISGMKDLLPILEQI
CCCHHHHHHHHCCCCCCCCCCCEEECCCHHEEEECCCEEEEEEEHHHCCHHHHHHHHHHH
AKMGRPLLIIAEDIEGEALATLVVNKIRGTLHVAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEDMGYKLENTRLEDLGRAKRIQIDKDNTTIIDGAGERAALEGRVKQIRAQIDETTSDY
EECCCCCCCCCCCHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHH
DREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALNATRAAVEEGIVPGGGVAYI
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RTLPILEALKLEGDEQVGVNIVRKALEEPLKMIAANAGMEGTIVVEKVKEQSGAFGFNAR
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCH
TEVYEDMIEAGVIDPTKVTRFALQNAASVASLMLTTQCMIAEKPEEKGAGMPGMPPGGGY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCC
PGMGM
CCCCC
>Mature Secondary Structure 
GAKLLQYDEEARKSILNGVNALADAVKVTLGPKGRNVIIDKSFGAPTVTKDGVTVAKEV
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHC
ELEDKFENMGAQMVREVASKTSDVAGDGTTTATILAQAIYREGAKTVAAGSNPMDVKRGI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHH
EKAVAAVVTELKNISKPTKDQKEIAQVGTISANNDETIGNIIAEAMGKVGKEGVITVEEA
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
KGLETELEIVEGMQFDRGYLSPYFVTNPEKMEVSLEDALILIYEKKISGMKDLLPILEQI
CCCHHHHHHHHCCCCCCCCCCCEEECCCHHEEEECCCEEEEEEEHHHCCHHHHHHHHHHH
AKMGRPLLIIAEDIEGEALATLVVNKIRGTLHVAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEDMGYKLENTRLEDLGRAKRIQIDKDNTTIIDGAGERAALEGRVKQIRAQIDETTSDY
EECCCCCCCCCCCHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHH
DREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALNATRAAVEEGIVPGGGVAYI
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RTLPILEALKLEGDEQVGVNIVRKALEEPLKMIAANAGMEGTIVVEKVKEQSGAFGFNAR
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCH
TEVYEDMIEAGVIDPTKVTRFALQNAASVASLMLTTQCMIAEKPEEKGAGMPGMPPGGGY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCC
PGMGM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA