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The map label for this gene is phoR [H]

Identifier: 85859338

GI number: 85859338

Start: 1533654

End: 1535405

Strand: Direct

Name: phoR [H]

Synonym: SYN_00061

Alternate gene names: 85859338

Gene position: 1533654-1535405 (Clockwise)

Preceding gene: 85859337

Following gene: 85859339

Centisome position: 48.24

GC content: 53.54

Gene sequence:

>1752_bases
TTGAAACCAAAACTATTTCTCCGGATCCTGTTCAGCTATTTCGCGGTAATCCTGCTGGTAGCGGTGATTGTGGGCTTCTT
TTTCACCGAACAGGTTCGCCGGAACGAGACATGGAAAATCGAGGAAAGCCTTCTGAATTATGCGCGTCTGACGGCGTTGC
TGCCACTCCCTGAGATGGCAGATCAGATTGGCCATCTGGAAAAAGTGTCCGAAGCCAGAGTGACCGTGATCGATGCGGGC
GGTCATGTCCTTGCCGACTCACAGGTCGACGCGCCCCGGATGGAAGACCACATGAACCGTCCCGAGGTTCAGGAAGCCAG
GATCAAGGGTTCCGGCAAAGCCATCCGGCAAAGTCATACCCTCCAGGTAGATATGCTTTATGTGGCGCTGGCGCTTCGAG
ACGGAGAGAGCATCCGGGGTTATGTCCGCATGGCCCGTTCCCTGCTGGAAGTGGAACATGCGGTGGATCGTATGTATGGT
TCCCTCTACCGGGCAATCGGTTTTGCCCTTGTTCCCGCGCTTCTGCTTGCCTTTCTCTATACCTGGAAAATTTCCCGGCC
TGTTTTGGAAATGAGGGATTATACCCGGGCCATCCGCCGGGGAGAACTTCCCGGAACCCTCCTCGTGGATTCCGCCGATG
AACTGGGTCAAGTAGCTGAAGACATCAATTATCTGGTCACGGAGTATCGGGAAAAAATCCGGCTGGCCCATGAAGAAAAA
GGCAAACTTGAATCTGCCCTGGCCAGCATGGTGGAAGGAGTCGTGATCCTGGATTCCCGGAATCGAATCGAGTCCTGCAA
TCAGGCTATTGAGGCCATTCTCGAACGACCGGAGACGGAAATCCGGGAGAAAACACTTCTGGAAGCCTTTCTCAACGCGG
ATCTGCAGAATGCGCTGGATCGTTTCCGCATGGAGCGGAAGCCCGTTCTACAGGAAATCAGGCTGGGAAGAAAAGATCCT
CGCGTCGTGGATGTCAGTATTTCCGCCATCAAGGATCTTCCGGACGGAGTGGAAAAAACGATGCTCGTCTTTCACGATGT
GACGCGGCTGAAAAAGCTGGAGCAGATAAGGACCGATTTTGTGGCAAACGTAACTCATGAAATCAAAACCCCTCTGACCG
CGATCATCGGCTTTCTTCAGACTCTGCTGGACGGCGCACTGGATGATCGGGAAACGGCAAGGAAGTTCCTGCAGACCATC
GCAACCAACGCGGAACGGTTAAGCCGGCTTGTGGACGATCTGCTGACGCTTTCCAGTATTGAACTCAACGAAACGAGTCT
CCATCTTGAACCTCTTTCTGTAGACGTCCTGATCCGCTCCATACTGCCCATGGTAAATGCCGACGCGAAGGCAAAAAATA
TTCTCCTTAATGTTGATCTTCCGGAAGCTTTCCTGAATATCCTCGCGGATCGGGACAGGGCCGCGCAGATCCTGATGAAT
GTGCTTCACAATGCCGTAAAATTCACGCCAGCCGGGGGAATCGTCACTGTTTCAGGCAGTGAGGAGGAAAAGGGGAATTT
CGTGATCATTCAGGTTGTGGATACTGGTATAGGCATTCCTCCCCGGGAGATTCCCCGACTCGGTGAACGATTTTATCGGG
TGGACAAGGCGCGATCCCGGGAACTGGGTGGGACCGGTCTGGGTCTGTCCATCGTGAAGCACCTCATGGCGGCGCATGGC
GGAAAAATGCGGATTGAAAGCACTCCCGGCAAGGGAACCATCGTTTCACTTTTCTTTTCCAGGGCGGGATAA

Upstream 100 bases:

>100_bases
TAGCCGACCATGCGGAAGGAATTGCCGATATGGTGATTTACATGGTGACGGGGAAAAGCGTGCGTCACGATTCCTCCACG
GAACCCAAGGGGCGGATGGC

Downstream 100 bases:

>100_bases
TCTCCCGATTCCAACCTCCAATCGAAATAATGATGTTCGGAAAAATCCGAGAACATTCTCCCGAAAAAGTATTTGTCCTG
AATAAATCCTCCGCCTGAAG

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MKPKLFLRILFSYFAVILLVAVIVGFFFTEQVRRNETWKIEESLLNYARLTALLPLPEMADQIGHLEKVSEARVTVIDAG
GHVLADSQVDAPRMEDHMNRPEVQEARIKGSGKAIRQSHTLQVDMLYVALALRDGESIRGYVRMARSLLEVEHAVDRMYG
SLYRAIGFALVPALLLAFLYTWKISRPVLEMRDYTRAIRRGELPGTLLVDSADELGQVAEDINYLVTEYREKIRLAHEEK
GKLESALASMVEGVVILDSRNRIESCNQAIEAILERPETEIREKTLLEAFLNADLQNALDRFRMERKPVLQEIRLGRKDP
RVVDVSISAIKDLPDGVEKTMLVFHDVTRLKKLEQIRTDFVANVTHEIKTPLTAIIGFLQTLLDGALDDRETARKFLQTI
ATNAERLSRLVDDLLTLSSIELNETSLHLEPLSVDVLIRSILPMVNADAKAKNILLNVDLPEAFLNILADRDRAAQILMN
VLHNAVKFTPAGGIVTVSGSEEEKGNFVIIQVVDTGIGIPPREIPRLGERFYRVDKARSRELGGTGLGLSIVKHLMAAHG
GKMRIESTPGKGTIVSLFFSRAG

Sequences:

>Translated_583_residues
MKPKLFLRILFSYFAVILLVAVIVGFFFTEQVRRNETWKIEESLLNYARLTALLPLPEMADQIGHLEKVSEARVTVIDAG
GHVLADSQVDAPRMEDHMNRPEVQEARIKGSGKAIRQSHTLQVDMLYVALALRDGESIRGYVRMARSLLEVEHAVDRMYG
SLYRAIGFALVPALLLAFLYTWKISRPVLEMRDYTRAIRRGELPGTLLVDSADELGQVAEDINYLVTEYREKIRLAHEEK
GKLESALASMVEGVVILDSRNRIESCNQAIEAILERPETEIREKTLLEAFLNADLQNALDRFRMERKPVLQEIRLGRKDP
RVVDVSISAIKDLPDGVEKTMLVFHDVTRLKKLEQIRTDFVANVTHEIKTPLTAIIGFLQTLLDGALDDRETARKFLQTI
ATNAERLSRLVDDLLTLSSIELNETSLHLEPLSVDVLIRSILPMVNADAKAKNILLNVDLPEAFLNILADRDRAAQILMN
VLHNAVKFTPAGGIVTVSGSEEEKGNFVIIQVVDTGIGIPPREIPRLGERFYRVDKARSRELGGTGLGLSIVKHLMAAHG
GKMRIESTPGKGTIVSLFFSRAG
>Mature_583_residues
MKPKLFLRILFSYFAVILLVAVIVGFFFTEQVRRNETWKIEESLLNYARLTALLPLPEMADQIGHLEKVSEARVTVIDAG
GHVLADSQVDAPRMEDHMNRPEVQEARIKGSGKAIRQSHTLQVDMLYVALALRDGESIRGYVRMARSLLEVEHAVDRMYG
SLYRAIGFALVPALLLAFLYTWKISRPVLEMRDYTRAIRRGELPGTLLVDSADELGQVAEDINYLVTEYREKIRLAHEEK
GKLESALASMVEGVVILDSRNRIESCNQAIEAILERPETEIREKTLLEAFLNADLQNALDRFRMERKPVLQEIRLGRKDP
RVVDVSISAIKDLPDGVEKTMLVFHDVTRLKKLEQIRTDFVANVTHEIKTPLTAIIGFLQTLLDGALDDRETARKFLQTI
ATNAERLSRLVDDLLTLSSIELNETSLHLEPLSVDVLIRSILPMVNADAKAKNILLNVDLPEAFLNILADRDRAAQILMN
VLHNAVKFTPAGGIVTVSGSEEEKGNFVIIQVVDTGIGIPPREIPRLGERFYRVDKARSRELGGTGLGLSIVKHLMAAHG
GKMRIESTPGKGTIVSLFFSRAG

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=341, Percent_Identity=33.4310850439883, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=30.6382978723404, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=30.4721030042918, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=32.7272727272727, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=31.8777292576419, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788713, Length=225, Percent_Identity=29.3333333333333, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788549, Length=396, Percent_Identity=24.4949494949495, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790861, Length=223, Percent_Identity=31.390134529148, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=28.7610619469027, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=27.5590551181102, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=29.7297297297297, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789403, Length=208, Percent_Identity=31.25, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790300, Length=346, Percent_Identity=28.3236994219653, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=207, Percent_Identity=28.5024154589372, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=26.7857142857143, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=25.3393665158371, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65291; Mature: 65291

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKLFLRILFSYFAVILLVAVIVGFFFTEQVRRNETWKIEESLLNYARLTALLPLPEMA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHH
DQIGHLEKVSEARVTVIDAGGHVLADSQVDAPRMEDHMNRPEVQEARIKGSGKAIRQSHT
HHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHHHCCCCCHHHHHHCCCCHHHHHCCC
LQVDMLYVALALRDGESIRGYVRMARSLLEVEHAVDRMYGSLYRAIGFALVPALLLAFLY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TWKISRPVLEMRDYTRAIRRGELPGTLLVDSADELGQVAEDINYLVTEYREKIRLAHEEK
HHHCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKLESALASMVEGVVILDSRNRIESCNQAIEAILERPETEIREKTLLEAFLNADLQNALD
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHH
RFRMERKPVLQEIRLGRKDPRVVDVSISAIKDLPDGVEKTMLVFHDVTRLKKLEQIRTDF
HHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VANVTHEIKTPLTAIIGFLQTLLDGALDDRETARKFLQTIATNAERLSRLVDDLLTLSSI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
ELNETSLHLEPLSVDVLIRSILPMVNADAKAKNILLNVDLPEAFLNILADRDRAAQILMN
EECCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHH
VLHNAVKFTPAGGIVTVSGSEEEKGNFVIIQVVDTGIGIPPREIPRLGERFYRVDKARSR
HHHHHHEECCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
ELGGTGLGLSIVKHLMAAHGGKMRIESTPGKGTIVSLFFSRAG
CCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKPKLFLRILFSYFAVILLVAVIVGFFFTEQVRRNETWKIEESLLNYARLTALLPLPEMA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHH
DQIGHLEKVSEARVTVIDAGGHVLADSQVDAPRMEDHMNRPEVQEARIKGSGKAIRQSHT
HHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHHHCCCCCHHHHHHCCCCHHHHHCCC
LQVDMLYVALALRDGESIRGYVRMARSLLEVEHAVDRMYGSLYRAIGFALVPALLLAFLY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TWKISRPVLEMRDYTRAIRRGELPGTLLVDSADELGQVAEDINYLVTEYREKIRLAHEEK
HHHCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKLESALASMVEGVVILDSRNRIESCNQAIEAILERPETEIREKTLLEAFLNADLQNALD
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHH
RFRMERKPVLQEIRLGRKDPRVVDVSISAIKDLPDGVEKTMLVFHDVTRLKKLEQIRTDF
HHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VANVTHEIKTPLTAIIGFLQTLLDGALDDRETARKFLQTIATNAERLSRLVDDLLTLSSI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
ELNETSLHLEPLSVDVLIRSILPMVNADAKAKNILLNVDLPEAFLNILADRDRAAQILMN
EECCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHH
VLHNAVKFTPAGGIVTVSGSEEEKGNFVIIQVVDTGIGIPPREIPRLGERFYRVDKARSR
HHHHHHEECCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
ELGGTGLGLSIVKHLMAAHGGKMRIESTPGKGTIVSLFFSRAG
CCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]