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The map label for this gene is moeA [H]

Identifier: 85859252

GI number: 85859252

Start: 1435541

End: 1436824

Strand: Direct

Name: moeA [H]

Synonym: SYN_00272

Alternate gene names: 85859252

Gene position: 1435541-1436824 (Clockwise)

Preceding gene: 85859251

Following gene: 85859260

Centisome position: 45.15

GC content: 41.67

Gene sequence:

>1284_bases
ATGGCTCAACAATTATTTTTTATAATAACAGTTTGGAAAAGAGGAATGAAAAATATAAATTTACCCATATCCATCGACGA
AGCTCAAAAAATAATCTTAGAATCTGTAAAACCTCTGACCGATGAAGGCATTTCGATAATGGAATCTGCCAATCGTGTTC
TGTATGAGGACATTGTAGCAAGTACAATGATCCCTCCAAGAGATAATTCCGCAATGGATGGCTACGCGGTCATTGCAGCG
GACACGAAGGGAGCAACAGAGACAAGTCCTGTAAAACTTCAAGTTATAGCGGAAATAAGGGCTGGTGGCCTGCTGGATGG
CAAAGAGGTGTTGAAGGGAACGGCAATAAGAATAATGACCGGTGCGCCCCTCCCGAAAAGTGCTGATTCGGTCATTCCGT
TTGAAGATGCGGAAGAAGAAGCCGGATACATAAGAATATTCAATGAGACAGTGAAATACAGTAATTGCAGATTCGCCGGA
GAGGATATCAAAAAAGGCGACAAGGTATTGGAAAAAGGCGACAGGCTCAGATCCGCGGATGTAGGCATCCTTGCTTCCCT
GAATTATCAAACGATTAAAGTCTATAAACAGCCGACTGTCTCGATTATCTCTACAGGCGATGAACTGGCCGAAATCGGTG
AAGAAGTTCAAATGGGTCAGATTCGAAACAGCAATGCCTATTCTTTATACTCTGAAGTGAAAAAATATAGCGGTCTCCCT
GATTATCTGGGCATTGTGAAAGATACCTTGAAAGATACGAGGGAAATGTTTTTGAAGGCCATGAAATCCGACGTCATTAT
ATCCACGGGCGGCGTATCCATGGGGAAATACGATTTTGTTAAGGAGATTTATTCTGATCTGAATATTGAAACAAAATTTG
AATGGATTAAGGTCAAACCCGGGAGACCGTGCACTTTTGGTGTTAAAGAAAACAAACTGTTTTTTGGCCTGCCAGGAAAT
CCTGTTTCGACTCTTACATCATTTCTTCAATTTGTCCGACCGGCGTTACTCAGGTTAATGGGTGCAAAAAGGATCAGAAA
GCCGGTTCTTAATGCAATTCTTGAGGAGGATCTCAAAAAGCAACCGGGCAAAGCTTTTCTGCTGAGAGGGCATTTTTCTA
TTCGAAACAACGAGTTTTATGTTTCAACAACAGGGAATCAGAACTCATCCGTACTTCGTTCAATGAGCAGAGCGAACTGT
CTGATTGTTATCCCGGAAAATACTTCAGAAGTAAAGGCAGGAGAAAAAGTTGCGATCCAATTAATTGACCATGATGAAAT
ATGA

Upstream 100 bases:

>100_bases
CGAGGAAGAAATGTAACAACTGACTGATTCTAAAAGTGAACCTTATCGTTGAGCTCTCCTGCAGGCATTTGTGATTTGGC
CGGAATTCCTTTAACTGATC

Downstream 100 bases:

>100_bases
GAAATGTTTACCGTCCTGAGCAATGATCTTCCTCCGCTTTATCAGGTACGCCGTAAAGTGTTCGGTGACAATGATGATAT
GCGGCTGGAAACCTTCCGTG

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MAQQLFFIITVWKRGMKNINLPISIDEAQKIILESVKPLTDEGISIMESANRVLYEDIVASTMIPPRDNSAMDGYAVIAA
DTKGATETSPVKLQVIAEIRAGGLLDGKEVLKGTAIRIMTGAPLPKSADSVIPFEDAEEEAGYIRIFNETVKYSNCRFAG
EDIKKGDKVLEKGDRLRSADVGILASLNYQTIKVYKQPTVSIISTGDELAEIGEEVQMGQIRNSNAYSLYSEVKKYSGLP
DYLGIVKDTLKDTREMFLKAMKSDVIISTGGVSMGKYDFVKEIYSDLNIETKFEWIKVKPGRPCTFGVKENKLFFGLPGN
PVSTLTSFLQFVRPALLRLMGAKRIRKPVLNAILEEDLKKQPGKAFLLRGHFSIRNNEFYVSTTGNQNSSVLRSMSRANC
LIVIPENTSEVKAGEKVAIQLIDHDEI

Sequences:

>Translated_427_residues
MAQQLFFIITVWKRGMKNINLPISIDEAQKIILESVKPLTDEGISIMESANRVLYEDIVASTMIPPRDNSAMDGYAVIAA
DTKGATETSPVKLQVIAEIRAGGLLDGKEVLKGTAIRIMTGAPLPKSADSVIPFEDAEEEAGYIRIFNETVKYSNCRFAG
EDIKKGDKVLEKGDRLRSADVGILASLNYQTIKVYKQPTVSIISTGDELAEIGEEVQMGQIRNSNAYSLYSEVKKYSGLP
DYLGIVKDTLKDTREMFLKAMKSDVIISTGGVSMGKYDFVKEIYSDLNIETKFEWIKVKPGRPCTFGVKENKLFFGLPGN
PVSTLTSFLQFVRPALLRLMGAKRIRKPVLNAILEEDLKKQPGKAFLLRGHFSIRNNEFYVSTTGNQNSSVLRSMSRANC
LIVIPENTSEVKAGEKVAIQLIDHDEI
>Mature_426_residues
AQQLFFIITVWKRGMKNINLPISIDEAQKIILESVKPLTDEGISIMESANRVLYEDIVASTMIPPRDNSAMDGYAVIAAD
TKGATETSPVKLQVIAEIRAGGLLDGKEVLKGTAIRIMTGAPLPKSADSVIPFEDAEEEAGYIRIFNETVKYSNCRFAGE
DIKKGDKVLEKGDRLRSADVGILASLNYQTIKVYKQPTVSIISTGDELAEIGEEVQMGQIRNSNAYSLYSEVKKYSGLPD
YLGIVKDTLKDTREMFLKAMKSDVIISTGGVSMGKYDFVKEIYSDLNIETKFEWIKVKPGRPCTFGVKENKLFFGLPGNP
VSTLTSFLQFVRPALLRLMGAKRIRKPVLNAILEEDLKKQPGKAFLLRGHFSIRNNEFYVSTTGNQNSSVLRSMSRANCL
IVIPENTSEVKAGEKVAIQLIDHDEI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=419, Percent_Identity=34.6062052505967, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI10880983, Length=419, Percent_Identity=34.6062052505967, Blast_Score=205, Evalue=7e-53,
Organism=Escherichia coli, GI1787049, Length=387, Percent_Identity=37.4677002583979, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147659, Length=352, Percent_Identity=34.0909090909091, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=160, Percent_Identity=26.875, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136978, Length=391, Percent_Identity=31.9693094629156, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24638841, Length=391, Percent_Identity=31.9693094629156, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47323; Mature: 47192

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQLFFIITVWKRGMKNINLPISIDEAQKIILESVKPLTDEGISIMESANRVLYEDIVA
CCCHHEEHHHHHHHCCCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHH
STMIPPRDNSAMDGYAVIAADTKGATETSPVKLQVIAEIRAGGLLDGKEVLKGTAIRIMT
HHCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEHHCCCCCCHHHHHCCCEEEEEE
GAPLPKSADSVIPFEDAEEEAGYIRIFNETVKYSNCRFAGEDIKKGDKVLEKGDRLRSAD
CCCCCCCCCCCCCCCCCCCCCCEEEEEECHHCCCCCEECCHHHHHHHHHHHHCCCCCCCC
VGILASLNYQTIKVYKQPTVSIISTGDELAEIGEEVQMGQIRNSNAYSLYSEVKKYSGLP
CEEEEECCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCH
DYLGIVKDTLKDTREMFLKAMKSDVIISTGGVSMGKYDFVKEIYSDLNIETKFEWIKVKP
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEECC
GRPCTFGVKENKLFFGLPGNPVSTLTSFLQFVRPALLRLMGAKRIRKPVLNAILEEDLKK
CCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QPGKAFLLRGHFSIRNNEFYVSTTGNQNSSVLRSMSRANCLIVIPENTSEVKAGEKVAIQ
CCCCEEEEEEEEEEECCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEE
LIDHDEI
EECCCCC
>Mature Secondary Structure 
AQQLFFIITVWKRGMKNINLPISIDEAQKIILESVKPLTDEGISIMESANRVLYEDIVA
CCHHEEHHHHHHHCCCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHH
STMIPPRDNSAMDGYAVIAADTKGATETSPVKLQVIAEIRAGGLLDGKEVLKGTAIRIMT
HHCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEHHCCCCCCHHHHHCCCEEEEEE
GAPLPKSADSVIPFEDAEEEAGYIRIFNETVKYSNCRFAGEDIKKGDKVLEKGDRLRSAD
CCCCCCCCCCCCCCCCCCCCCCEEEEEECHHCCCCCEECCHHHHHHHHHHHHCCCCCCCC
VGILASLNYQTIKVYKQPTVSIISTGDELAEIGEEVQMGQIRNSNAYSLYSEVKKYSGLP
CEEEEECCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCH
DYLGIVKDTLKDTREMFLKAMKSDVIISTGGVSMGKYDFVKEIYSDLNIETKFEWIKVKP
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEECC
GRPCTFGVKENKLFFGLPGNPVSTLTSFLQFVRPALLRLMGAKRIRKPVLNAILEEDLKK
CCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QPGKAFLLRGHFSIRNNEFYVSTTGNQNSSVLRSMSRANCLIVIPENTSEVKAGEKVAIQ
CCCCEEEEEEEEEEECCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEE
LIDHDEI
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]