Click here to switch to the map view.

The map label for this gene is trpC [H]

Identifier: 85858283

GI number: 85858283

Start: 447364

End: 448101

Strand: Direct

Name: trpC [H]

Synonym: SYN_02591

Alternate gene names: 85858283

Gene position: 447364-448101 (Clockwise)

Preceding gene: 85858282

Following gene: 85858284

Centisome position: 14.07

GC content: 55.69

Gene sequence:

>738_bases
ATGTTGAAAAAAGATGCTTCTGCGGGACAGGGACTAAGACTGTCTCTGTCCGCATCCATCCGGAAAAGACAAAGTGAGAA
GTACTTTCCCGTGATCTCCGAGGTCAAGGTGAGATCGGACAAGGAAGGTGATCTGCTGCGTGGCCGTGACCCCGTGGCGC
TCGCGCAGGAAATGGCGCGGTGTCCTGTTGCGGGAATCAGTGTTGTCACTGAATCGGAGCACTTCGGAGGGCACATGGGC
CTGTTGAGTGCAGTCGCCGCCGCCGTGGACATTCCCGTCCTCCACAAGGATTTCATCAGGAACGAGCGGCAGATCGAAGA
ATCGGCCGACTGCGGCGCTTCGGCGATCTTAATCATTACCGCCCTGCTGGAAACGAAGCAGATGGAACGGCTGATTGAAA
AGGCAATGTGCTGCGGCCTGGAGACCCTGGTTGAGGCGCATAGTCTTGCAGAGATAAAAAAAGTGGAAGACCTTTCGTTT
GATCTGATGGGAATCAATAACCGGGACATTACCGTCTTCGAGTTGGATGACAACGATGTGAGCAGGACGGAGGAGCTTGC
CGGCTTCTGTAAAGGCTCGCGTATCCTGATCAGTGAAAGCTCGATCAGCTCTGCGGTGGAAGCCCGGCGTGCCGGGAAAG
GCGGCGCCGATGCCGTGCTGGTTGGTACGGCTGTTTTGAAAGCGGCCAGCGTGAGAAATTTTCTGGATGAACTGACGTCT
GTCGGATGGCCGCCATGA

Upstream 100 bases:

>100_bases
GGGAATCGACCTGTCCCGTTCTCTTATCGATTCGGGGGCCGCCTCGCGCAAACTCCAGGAATTCGTGGAAAAATCCCATA
AGGTTTAATAGGGTGCGGTC

Downstream 100 bases:

>100_bases
CACGGATCAAGATCTGCGGCATTATAACCGGAGAGGACATCCGCATCTGTGTCGCAGCAGGCGTCGATGCACTGGGATTT
GTCGTGGAGTATCCCATCGA

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLKKDASAGQGLRLSLSASIRKRQSEKYFPVISEVKVRSDKEGDLLRGRDPVALAQEMARCPVAGISVVTESEHFGGHMG
LLSAVAAAVDIPVLHKDFIRNERQIEESADCGASAILIITALLETKQMERLIEKAMCCGLETLVEAHSLAEIKKVEDLSF
DLMGINNRDITVFELDDNDVSRTEELAGFCKGSRILISESSISSAVEARRAGKGGADAVLVGTAVLKAASVRNFLDELTS
VGWPP

Sequences:

>Translated_245_residues
MLKKDASAGQGLRLSLSASIRKRQSEKYFPVISEVKVRSDKEGDLLRGRDPVALAQEMARCPVAGISVVTESEHFGGHMG
LLSAVAAAVDIPVLHKDFIRNERQIEESADCGASAILIITALLETKQMERLIEKAMCCGLETLVEAHSLAEIKKVEDLSF
DLMGINNRDITVFELDDNDVSRTEELAGFCKGSRILISESSISSAVEARRAGKGGADAVLVGTAVLKAASVRNFLDELTS
VGWPP
>Mature_245_residues
MLKKDASAGQGLRLSLSASIRKRQSEKYFPVISEVKVRSDKEGDLLRGRDPVALAQEMARCPVAGISVVTESEHFGGHMG
LLSAVAAAVDIPVLHKDFIRNERQIEESADCGASAILIITALLETKQMERLIEKAMCCGLETLVEAHSLAEIKKVEDLSF
DLMGINNRDITVFELDDNDVSRTEELAGFCKGSRILISESSISSAVEARRAGKGGADAVLVGTAVLKAASVRNFLDELTS
VGWPP

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=195, Percent_Identity=29.7435897435897, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322638, Length=216, Percent_Identity=29.6296296296296, Blast_Score=85, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 26397; Mature: 26397

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKDASAGQGLRLSLSASIRKRQSEKYFPVISEVKVRSDKEGDLLRGRDPVALAQEMAR
CCCCCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
CPVAGISVVTESEHFGGHMGLLSAVAAAVDIPVLHKDFIRNERQIEESADCGASAILIIT
CCCCCCEEEECCHHCCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHH
ALLETKQMERLIEKAMCCGLETLVEAHSLAEIKKVEDLSFDLMGINNRDITVFELDDNDV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEECCCCH
SRTEELAGFCKGSRILISESSISSAVEARRAGKGGADAVLVGTAVLKAASVRNFLDELTS
HHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VGWPP
CCCCC
>Mature Secondary Structure
MLKKDASAGQGLRLSLSASIRKRQSEKYFPVISEVKVRSDKEGDLLRGRDPVALAQEMAR
CCCCCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
CPVAGISVVTESEHFGGHMGLLSAVAAAVDIPVLHKDFIRNERQIEESADCGASAILIIT
CCCCCCEEEECCHHCCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHH
ALLETKQMERLIEKAMCCGLETLVEAHSLAEIKKVEDLSFDLMGINNRDITVFELDDNDV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEECCCCH
SRTEELAGFCKGSRILISESSISSAVEARRAGKGGADAVLVGTAVLKAASVRNFLDELTS
HHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VGWPP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA