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The map label for this gene is yfnH [H]

Identifier: 85858243

GI number: 85858243

Start: 398540

End: 399262

Strand: Direct

Name: yfnH [H]

Synonym: SYN_01129

Alternate gene names: 85858243

Gene position: 398540-399262 (Clockwise)

Preceding gene: 85858242

Following gene: 85858244

Centisome position: 12.54

GC content: 57.95

Gene sequence:

>723_bases
ATGAAAGCCGTAGTCCTGGCAGGCGGAAAAGGCGCACGCCTCGCGCCTTACACAAAAATTCTTCCCAAACCGTTAATGCC
CATAGGGGACATGCCCATTCTGGAAGTCCTCCTGCGGCAGATGAAAGTGGCCGGGATCGACCATGTCATCCTCACCGTGG
GACATCTGTCCGAACTCCTGCGCGCCTTCTTCCAGGACGGCAGTCAATTCGGCGTCGACATTTCCTACAGCTACGAAAAA
TGTCCGCTTGGAACCGCCGGGCCGATCTCCCTGATCGACGGCCTGGACGAGACGTTCCTGGTGACCAACGGCGACGTGCT
AACCACCCTGAGCCTGCGCGAGCTGATCGGCTTTCACCGGGAGCAGAAAGCCGCCGCGACCATCGCCGTCCATCAGAGGC
AGACGAAGATCGACCTGGGCGTCATCCAGTGGAACGGCAACTACGAAGTGAAAGGCTACATCGAAAAGCCGGTCTATGAC
TACACCGTCAGCATGGGGGTTTATGTGTTCGAGCCGAAGGTCCTTTCCTATATCCCCCACGGGGAATACCTCGATTTTCC
CGATCTGGTGAAAAAGCTGATCGCCGCCGGCGAAAAAGTGGTCGGCTACCGGTTCCACGGCTACTGGGAAGATCTGGGGC
GGCCGGATGATTACGAGAGGGCGTCGCGCGACTTTGAAAGCATGCGCGAACAGTTCCTTCCTGGCATGGAATGCAGAGGG
TGA

Upstream 100 bases:

>100_bases
AGGACTCAACAGGACCATCGCCTGGATTCGGGAGAATCTGGGGAATTACCGCATCGGCGTTTATGAATTATAGTATGAAT
TATAGAAGGGAGGGCAACCT

Downstream 100 bases:

>100_bases
CATCATGGACTGGCGCATAACGCTTTCCGACATCGACATGGGAAATGAAGAAATCGAGGCGGTGGATCGCGTCCTCCGCA
GCAAATGGCTCACCATGGGA

Product: mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: CDP-glucose pyrophosphorylase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKAVVLAGGKGARLAPYTKILPKPLMPIGDMPILEVLLRQMKVAGIDHVILTVGHLSELLRAFFQDGSQFGVDISYSYEK
CPLGTAGPISLIDGLDETFLVTNGDVLTTLSLRELIGFHREQKAAATIAVHQRQTKIDLGVIQWNGNYEVKGYIEKPVYD
YTVSMGVYVFEPKVLSYIPHGEYLDFPDLVKKLIAAGEKVVGYRFHGYWEDLGRPDDYERASRDFESMREQFLPGMECRG

Sequences:

>Translated_240_residues
MKAVVLAGGKGARLAPYTKILPKPLMPIGDMPILEVLLRQMKVAGIDHVILTVGHLSELLRAFFQDGSQFGVDISYSYEK
CPLGTAGPISLIDGLDETFLVTNGDVLTTLSLRELIGFHREQKAAATIAVHQRQTKIDLGVIQWNGNYEVKGYIEKPVYD
YTVSMGVYVFEPKVLSYIPHGEYLDFPDLVKKLIAAGEKVVGYRFHGYWEDLGRPDDYERASRDFESMREQFLPGMECRG
>Mature_240_residues
MKAVVLAGGKGARLAPYTKILPKPLMPIGDMPILEVLLRQMKVAGIDHVILTVGHLSELLRAFFQDGSQFGVDISYSYEK
CPLGTAGPISLIDGLDETFLVTNGDVLTTLSLRELIGFHREQKAAATIAVHQRQTKIDLGVIQWNGNYEVKGYIEKPVYD
YTVSMGVYVFEPKVLSYIPHGEYLDFPDLVKKLIAAGEKVVGYRFHGYWEDLGRPDDYERASRDFESMREQFLPGMECRG

Specific function: Catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate cytidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=248, Percent_Identity=32.258064516129, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI11761619, Length=248, Percent_Identity=32.258064516129, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI31881779, Length=191, Percent_Identity=30.3664921465969, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI45447090, Length=191, Percent_Identity=30.3664921465969, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788351, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790224, Length=243, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=238, Percent_Identity=30.2521008403361, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17509979, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=231, Percent_Identity=29.004329004329, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355443, Length=228, Percent_Identity=32.0175438596491, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24644084, Length=228, Percent_Identity=32.0175438596491, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653912, Length=188, Percent_Identity=30.8510638297872, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013446
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.33 [H]

Molecular weight: Translated: 26890; Mature: 26890

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00810 ADP_GLC_PYROPHOSPH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVLAGGKGARLAPYTKILPKPLMPIGDMPILEVLLRQMKVAGIDHVILTVGHLSELL
CCEEEEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RAFFQDGSQFGVDISYSYEKCPLGTAGPISLIDGLDETFLVTNGDVLTTLSLRELIGFHR
HHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHCCCCCEEEEECCCEEEHHHHHHHHHHHH
EQKAAATIAVHQRQTKIDLGVIQWNGNYEVKGYIEKPVYDYTVSMGVYVFEPKVLSYIPH
HHHHHHHHEECCCCCEEEEEEEEECCCEEEEEEECCCEEEEEEECCEEEECCHHHHCCCC
GEYLDFPDLVKKLIAAGEKVVGYRFHGYWEDLGRPDDYERASRDFESMREQFLPGMECRG
CCCCCHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKAVVLAGGKGARLAPYTKILPKPLMPIGDMPILEVLLRQMKVAGIDHVILTVGHLSELL
CCEEEEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RAFFQDGSQFGVDISYSYEKCPLGTAGPISLIDGLDETFLVTNGDVLTTLSLRELIGFHR
HHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHCCCCCEEEEECCCEEEHHHHHHHHHHHH
EQKAAATIAVHQRQTKIDLGVIQWNGNYEVKGYIEKPVYDYTVSMGVYVFEPKVLSYIPH
HHHHHHHHEECCCCCEEEEEEEEECCCEEEEEEECCCEEEEEEECCEEEECCHHHHCCCC
GEYLDFPDLVKKLIAAGEKVVGYRFHGYWEDLGRPDDYERASRDFESMREQFLPGMECRG
CCCCCHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]