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The map label for this gene is hbdA [H]

Identifier: 85375663

GI number: 85375663

Start: 2846253

End: 2847122

Strand: Direct

Name: hbdA [H]

Synonym: ELI_14180

Alternate gene names: 85375663

Gene position: 2846253-2847122 (Clockwise)

Preceding gene: 85375662

Following gene: 85375664

Centisome position: 93.25

GC content: 61.03

Gene sequence:

>870_bases
ATGAAGACGATCGGCGTTATCGGCGCGGGCCAGATGGGCTCGGGCATTTCCCAGACGAGTGCCCGGCACTCGATGAATGT
GCTGTTGGCCGACGTATCGCTGGAGGTAGCCGAGAAATCCAAAGCGGGCATCGAGCAGGCGCTGGTCAAACTGGTCGGGC
GCGGCAAGATCGAAGCCGACGAGGCGGAAAAAGCACTCGCGCGCATCACGCCCGTCGCCGACTATGCGCCGATGGCGGAG
GCCGACATGATTATCGAGGCGGCAACCGAGAAGGAAGAGATCAAGAAGGCTATCTTCGAAAAGGCCAGCGAAGTGCTGGG
CGACAATGCGATCATGGCTTCCAACACCAGCTCTATCCCGATCACGCGGATGGCGAACTATTCGAGCGATCCGGAACGCT
TCATCGGCCTGCATTTCTTCAATCCAGTCCCGGTCATGGGGCTGATCGAAGTCATTCCGGGCCTTGCGACGGCCAAGGAT
GTCGAGGAACGCACCGTCGCCTTCGCCGAAAGCTTGGGCAAGCAGGTTGTGTTGTCGCAGGATGAGCCGGGCTTTGTCGT
CAACCGCATCCTGCTGCCGATGATCAACGAGGCGATTTTCGTGCTTGGCCAGTCGACCGCCAGCATCGCCGATATCGACA
AGGGTTGCCGCCTGGGCCTCAACCACCCCATGGGCCCGCTAGAACTGGCCGATTTCGTGGGGCTCGACACCTGCCTCGAC
ATCATCATGGTCCTCTACAACACCACCGGCGACAGCAAGTACCGCCCCGCGCCGCTGCTGGTGAAATATGTCGAGGCCGG
CTGGCTCGGTCGCAAGACCGGCAAGGGCTTTTACGACTATTCCGGCGACGCGCCCGTTCCCACTCGCTGA

Upstream 100 bases:

>100_bases
AATTGGGTGCCCGGCGCCAACCGATAAACATCTGGCCAGCCGAGTACGCCCTCGCTAACAGGCGCGCTTTGCTGCAACTG
CGAAGAGAAAGCGCATTTTC

Downstream 100 bases:

>100_bases
CCTCGGAACCCGCGCAGCCTGCCAGCCGTTTCCTTTGCAAAGGAGATTTGAGATGGCAGACAAGAACGACCCGCAGCCGC
GCGACGCCGATCGCCCGAGC

Product: Hbd, 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKTIGVIGAGQMGSGISQTSARHSMNVLLADVSLEVAEKSKAGIEQALVKLVGRGKIEADEAEKALARITPVADYAPMAE
ADMIIEAATEKEEIKKAIFEKASEVLGDNAIMASNTSSIPITRMANYSSDPERFIGLHFFNPVPVMGLIEVIPGLATAKD
VEERTVAFAESLGKQVVLSQDEPGFVVNRILLPMINEAIFVLGQSTASIADIDKGCRLGLNHPMGPLELADFVGLDTCLD
IIMVLYNTTGDSKYRPAPLLVKYVEAGWLGRKTGKGFYDYSGDAPVPTR

Sequences:

>Translated_289_residues
MKTIGVIGAGQMGSGISQTSARHSMNVLLADVSLEVAEKSKAGIEQALVKLVGRGKIEADEAEKALARITPVADYAPMAE
ADMIIEAATEKEEIKKAIFEKASEVLGDNAIMASNTSSIPITRMANYSSDPERFIGLHFFNPVPVMGLIEVIPGLATAKD
VEERTVAFAESLGKQVVLSQDEPGFVVNRILLPMINEAIFVLGQSTASIADIDKGCRLGLNHPMGPLELADFVGLDTCLD
IIMVLYNTTGDSKYRPAPLLVKYVEAGWLGRKTGKGFYDYSGDAPVPTR
>Mature_289_residues
MKTIGVIGAGQMGSGISQTSARHSMNVLLADVSLEVAEKSKAGIEQALVKLVGRGKIEADEAEKALARITPVADYAPMAE
ADMIIEAATEKEEIKKAIFEKASEVLGDNAIMASNTSSIPITRMANYSSDPERFIGLHFFNPVPVMGLIEVIPGLATAKD
VEERTVAFAESLGKQVVLSQDEPGFVVNRILLPMINEAIFVLGQSTASIADIDKGCRLGLNHPMGPLELADFVGLDTCLD
IIMVLYNTTGDSKYRPAPLLVKYVEAGWLGRKTGKGFYDYSGDAPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=40.7665505226481, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=39.4736842105263, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=33.6879432624113, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI68989263, Length=298, Percent_Identity=28.8590604026846, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI261878539, Length=298, Percent_Identity=28.8590604026846, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI115430219, Length=234, Percent_Identity=26.0683760683761, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=41.5492957746479, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1788682, Length=229, Percent_Identity=40.174672489083, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1790281, Length=268, Percent_Identity=32.8358208955224, Blast_Score=144, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=39.2361111111111, Blast_Score=206, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=38.2758620689655, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=35.5400696864112, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=37.9432624113475, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=37.5886524822695, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=37.9432624113475, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=35.1063829787234, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=29.5774647887324, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=25, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193203623, Length=197, Percent_Identity=25.8883248730964, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=197, Percent_Identity=25.8883248730964, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=36.9718309859155, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=36.9718309859155, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=36.9718309859155, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=26.6949152542373, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI20129993, Length=242, Percent_Identity=26.8595041322314, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30959; Mature: 30959

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIGVIGAGQMGSGISQTSARHSMNVLLADVSLEVAEKSKAGIEQALVKLVGRGKIEAD
CCCEEEEECCCCCCCCHHHHHHHHHEEEEEECHHHHHHHHHCCHHHHHHHHHCCCCCCHH
EAEKALARITPVADYAPMAEADMIIEAATEKEEIKKAIFEKASEVLGDNAIMASNTSSIP
HHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
ITRMANYSSDPERFIGLHFFNPVPVMGLIEVIPGLATAKDVEERTVAFAESLGKQVVLSQ
EEEECCCCCCHHHEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECC
DEPGFVVNRILLPMINEAIFVLGQSTASIADIDKGCRLGLNHPMGPLELADFVGLDTCLD
CCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHHHHH
IIMVLYNTTGDSKYRPAPLLVKYVEAGWLGRKTGKGFYDYSGDAPVPTR
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTIGVIGAGQMGSGISQTSARHSMNVLLADVSLEVAEKSKAGIEQALVKLVGRGKIEAD
CCCEEEEECCCCCCCCHHHHHHHHHEEEEEECHHHHHHHHHCCHHHHHHHHHCCCCCCHH
EAEKALARITPVADYAPMAEADMIIEAATEKEEIKKAIFEKASEVLGDNAIMASNTSSIP
HHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
ITRMANYSSDPERFIGLHFFNPVPVMGLIEVIPGLATAKDVEERTVAFAESLGKQVVLSQ
EEEECCCCCCHHHEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECC
DEPGFVVNRILLPMINEAIFVLGQSTASIADIDKGCRLGLNHPMGPLELADFVGLDTCLD
CCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHHHHH
IIMVLYNTTGDSKYRPAPLLVKYVEAGWLGRKTGKGFYDYSGDAPVPTR
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]