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The map label for this gene is ytfL [C]

Identifier: 85375534

GI number: 85375534

Start: 2726930

End: 2728234

Strand: Direct

Name: ytfL [C]

Synonym: ELI_13535

Alternate gene names: 85375534

Gene position: 2726930-2728234 (Clockwise)

Preceding gene: 85375532

Following gene: 85375546

Centisome position: 89.34

GC content: 64.29

Gene sequence:

>1305_bases
GTGACACCATTTCCCTGGCCTGACCTCTTCATTATCGCTGCCCTGATCCTGCTCAACGGGATTTTTGCCATGTCCGAGCT
GGCGATCGTTTCCGCCAAGCCTACGCGGCTGAAATCGAAGGCGGAAAAAGGCAGCTCGGGGGCGCAACTTGCGCTCGACC
TGGCGGCAAACCCGGGGAAATTCCTTTCTACCGTGCAGATCGGCATCACGCTGGTCGCCATCATCACCGGCGCGCTCTCG
GGGGCCAGCCTCGAGGCGCCGGTGGGCGAACGCCTGGTCGCGCTGGGCATTCCGGCAGATGTGTCGGGCGAAGTCGCATT
CATCGGCGTGATCGCGCTCACCACTTATTTCAGCGTGGTCGTCGGCGAGCTGGTACCCAAGCAGCTCGCTCTGCGCGCTG
CTGTGCCGATCTCCGTCGTGATGTCGCGCCCGATGGCGATGCTGGCGAAGATCGCCGCGCCGATCGTCTGGATCCTCGAC
ACCTCGTCGGGCGCGATCGTTCGCCTGTTCGGTATTCGCCCAGGCGGGCAGTCCTCGGTTACGGCCGAAGAATTGCACAT
GATGTTTACCGAAGCGACCAAGACCGGGGTGCTGGAGGAAGAGCAGAGCGCGATCCTGACCGGCGTCGTGCGGCTGGCAG
AGCGCCCTGTGCGCGAGGTGATGACGCCGCGCACCGAGCTCGACTGGATCGACGCGGCGGCGGGCGAAGCGGAGATTTCC
CGCGTGATTGCGGAAAGCCCGCATTCGCTGCTGCCGGTGGCCGAAGGCTCCAGCGACAAGGTGCTGGGCGTGATCAAAGT
GCGCGAAGTGCTGGCACAGCAGGTTGCCGGCCTGCCGGTCGAACTCGCCGTCCTGATGAAGAAGCCCGAGGTCATTCCCG
ACCAGCTCGACGCGATGGACGCACTCCGCGTGCTGCAGCAGTCCGAAGTCGCGATGGCGATGGTCCATGACGAGTACGGC
CACCTGGACGGGATCGTCACCCCGGTCGACATCCTGACCGCGATGGTCGGCGATTTCGTGAGCGACCAGGACCAAGGCGA
AATGCCGGAAGTGATCGAACGCGAGGATGGCTCGCTGCTCGTTTCGGGCGCGCTTTCTGCGGATATTCTCGCCGACCGGC
TGGGTCTCGACTACGGCGACGACCGCGAGTTCGCGACGGTGGCCGGCTATGCTTTGGCCGTCCTGAAGAAGCTGCCGGGC
GAAGGGGAAATTTTCACCGACCAGGGCTGGCGTTTCGAGGTGCTCGATATGGACGGGCGCAAGATCGACAAGCTGCTGGT
GAGCGAGGTGGGGGAAGAGGGGTAG

Upstream 100 bases:

>100_bases
TGCTCTACCAACTCGCAAACCCTTCCGGCGTTCCAATTCTGTGGCCACCCCGAAGCGAAAGGCTGGCACGGCCCGGCAAT
TGTGCTAGCGCCTGCATGCC

Downstream 100 bases:

>100_bases
TTGAACGCGCCGCGTAGGTGGCGGGGATGGCTACCGGGCGGTGCGCTTGTGGTTAGGTTTTGAGTTTTTGTGTTTCGCAC
CCCATCCGGGGTGCGGTGTC

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTPFPWPDLFIIAALILLNGIFAMSELAIVSAKPTRLKSKAEKGSSGAQLALDLAANPGKFLSTVQIGITLVAIITGALS
GASLEAPVGERLVALGIPADVSGEVAFIGVIALTTYFSVVVGELVPKQLALRAAVPISVVMSRPMAMLAKIAAPIVWILD
TSSGAIVRLFGIRPGGQSSVTAEELHMMFTEATKTGVLEEEQSAILTGVVRLAERPVREVMTPRTELDWIDAAAGEAEIS
RVIAESPHSLLPVAEGSSDKVLGVIKVREVLAQQVAGLPVELAVLMKKPEVIPDQLDAMDALRVLQQSEVAMAMVHDEYG
HLDGIVTPVDILTAMVGDFVSDQDQGEMPEVIEREDGSLLVSGALSADILADRLGLDYGDDREFATVAGYALAVLKKLPG
EGEIFTDQGWRFEVLDMDGRKIDKLLVSEVGEEG

Sequences:

>Translated_434_residues
MTPFPWPDLFIIAALILLNGIFAMSELAIVSAKPTRLKSKAEKGSSGAQLALDLAANPGKFLSTVQIGITLVAIITGALS
GASLEAPVGERLVALGIPADVSGEVAFIGVIALTTYFSVVVGELVPKQLALRAAVPISVVMSRPMAMLAKIAAPIVWILD
TSSGAIVRLFGIRPGGQSSVTAEELHMMFTEATKTGVLEEEQSAILTGVVRLAERPVREVMTPRTELDWIDAAAGEAEIS
RVIAESPHSLLPVAEGSSDKVLGVIKVREVLAQQVAGLPVELAVLMKKPEVIPDQLDAMDALRVLQQSEVAMAMVHDEYG
HLDGIVTPVDILTAMVGDFVSDQDQGEMPEVIEREDGSLLVSGALSADILADRLGLDYGDDREFATVAGYALAVLKKLPG
EGEIFTDQGWRFEVLDMDGRKIDKLLVSEVGEEG
>Mature_433_residues
TPFPWPDLFIIAALILLNGIFAMSELAIVSAKPTRLKSKAEKGSSGAQLALDLAANPGKFLSTVQIGITLVAIITGALSG
ASLEAPVGERLVALGIPADVSGEVAFIGVIALTTYFSVVVGELVPKQLALRAAVPISVVMSRPMAMLAKIAAPIVWILDT
SSGAIVRLFGIRPGGQSSVTAEELHMMFTEATKTGVLEEEQSAILTGVVRLAERPVREVMTPRTELDWIDAAAGEAEISR
VIAESPHSLLPVAEGSSDKVLGVIKVREVLAQQVAGLPVELAVLMKKPEVIPDQLDAMDALRVLQQSEVAMAMVHDEYGH
LDGIVTPVDILTAMVGDFVSDQDQGEMPEVIEREDGSLLVSGALSADILADRLGLDYGDDREFATVAGYALAVLKKLPGE
GEIFTDQGWRFEVLDMDGRKIDKLLVSEVGEEG

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=407, Percent_Identity=25.7985257985258, Blast_Score=185, Evalue=6e-47,
Organism=Escherichia coli, GI1790664, Length=429, Percent_Identity=26.8065268065268, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1788119, Length=273, Percent_Identity=30.7692307692308, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI145693175, Length=411, Percent_Identity=24.5742092457421, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87082033, Length=249, Percent_Identity=26.1044176706827, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786879, Length=243, Percent_Identity=24.2798353909465, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 46023; Mature: 45892

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPFPWPDLFIIAALILLNGIFAMSELAIVSAKPTRLKSKAEKGSSGAQLALDLAANPGK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHCCCCCCEEEEEECCCCCH
FLSTVQIGITLVAIITGALSGASLEAPVGERLVALGIPADVSGEVAFIGVIALTTYFSVV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
VGELVPKQLALRAAVPISVVMSRPMAMLAKIAAPIVWILDTSSGAIVRLFGIRPGGQSSV
HHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCC
TAEELHMMFTEATKTGVLEEEQSAILTGVVRLAERPVREVMTPRTELDWIDAAAGEAEIS
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHH
RVIAESPHSLLPVAEGSSDKVLGVIKVREVLAQQVAGLPVELAVLMKKPEVIPDQLDAMD
HHHHCCCCCEEEECCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHH
ALRVLQQSEVAMAMVHDEYGHLDGIVTPVDILTAMVGDFVSDQDQGEMPEVIEREDGSLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEE
VSGALSADILADRLGLDYGDDREFATVAGYALAVLKKLPGEGEIFTDQGWRFEVLDMDGR
EECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCH
KIDKLLVSEVGEEG
HHHHHHHHHCCCCC
>Mature Secondary Structure 
TPFPWPDLFIIAALILLNGIFAMSELAIVSAKPTRLKSKAEKGSSGAQLALDLAANPGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHCCCCCCEEEEEECCCCCH
FLSTVQIGITLVAIITGALSGASLEAPVGERLVALGIPADVSGEVAFIGVIALTTYFSVV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
VGELVPKQLALRAAVPISVVMSRPMAMLAKIAAPIVWILDTSSGAIVRLFGIRPGGQSSV
HHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCC
TAEELHMMFTEATKTGVLEEEQSAILTGVVRLAERPVREVMTPRTELDWIDAAAGEAEIS
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHH
RVIAESPHSLLPVAEGSSDKVLGVIKVREVLAQQVAGLPVELAVLMKKPEVIPDQLDAMD
HHHHCCCCCEEEECCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHH
ALRVLQQSEVAMAMVHDEYGHLDGIVTPVDILTAMVGDFVSDQDQGEMPEVIEREDGSLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEE
VSGALSADILADRLGLDYGDDREFATVAGYALAVLKKLPGEGEIFTDQGWRFEVLDMDGR
EECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCH
KIDKLLVSEVGEEG
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]