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The map label for this gene is ubiB [H]

Identifier: 85374995

GI number: 85374995

Start: 2196604

End: 2198124

Strand: Direct

Name: ubiB [H]

Synonym: ELI_10840

Alternate gene names: 85374995

Gene position: 2196604-2198124 (Clockwise)

Preceding gene: 85374994

Following gene: 85374996

Centisome position: 71.96

GC content: 62.52

Gene sequence:

>1521_bases
ATGTTGAAGACCCTTCGTATCGCACGCCGGGACCGGAAGCGCTTGGAGGAACTATTCAGCGTCACTTCCCGCTATGGACT
CGGCCTTCTGCTGGCGCGGATAGGGCTGGACCGGACGGGCAGCGACGATGCCGGCGACGGGTCGTCACATAGCCTGCCTC
GGCGGACCCGCCTTGCCATGGAAGAGCTTGGGCCAACCTTCGTGAAGCTCGGCCAGATCCTGGCGACACGCGCCGATCTC
CTATCTCCGGAATGGATCGCCGAACTCGAGCAATTGCATAGCAAGGCGCCGACGCTTCCCTTCGAGGAGTTGCGACCGAT
TGTCGAGGAGGCGCTTGGTGAGGCGCCCGAATGCACCTTTGCGGAATTCGATACAGAACCGCTGGCGGCGGCCTCCATGG
CGCAGGTCCATCGTGCGACGCTGCACGACGGGCGCGCGGTGGTGATCAAAATCCGCCGGCCCGGCATTCGTCCGAGGGTG
GAGGCTGATATCCGGCTCCTTGCGCATATTGCGACCCTTGCGGAACGCGGCAGCACCGAAGCCAAGCGCTTCGGACCGAG
CCGGATGATGCGGCAGCTTGCGGACGCGATGGTCGAGGAACTCGACTTCACGAATGAAGCGCGCAATGCTGATCGTCTGC
GGACGGATTTCGCGAACGAGCCCAGTGTCGTTGTGCCCGAAATCCACTGGGAATGGACGTCCGAGACGTTGCTCGTCATG
GATTACATAAACGGTGTGCCGCCGAGCAATGCGCAGGCTCTGGTCGCTGCAGGGCTCGATCCGACCAGAATAGCAGCGCT
GGGCGCCGACATGGTGCTCGACATGATATTGGTGAACGGCCGGTTCCACGGCGATCCGCACCCGGGGAACCTTCTCTGCC
TGCCGGGCAACCATATAGCTCTGCTGGACCTGGGCATGGTTGGTTATGTATCTCCGCGCAGGAGAGAGGAATTCGTCAGC
TTCGTGCAAGCGCTCAGCACTGGCAGCCCCGCGCAGCTCGCCGACGTGCTGACGCGGTGGTCAGTGGGCGACGACGTTCC
GGCCGACCGCGTGCTCTCCGCATCCGAACGGCTGATCGCGCGCCATGGCAGCGGTCGATTGGTTCTGGGCGCCATGGTAA
CCGATTTCCTAGGGCTGATGCGCGACGAGCGCATGACGTTACCACCCGATCTTCTCCTGATCTTCAAGGCGCTGATCACG
ATGGACGGCGTGTTATCGAAAATTGAACCGGATTTCGACCTGACGCATGCCATGCGACGCTCTTCGTTTCGAATCGCGCA
AGCGCGGTTGTCGCCCGAGCACTGGGCTCCCGTTCTGCAGGGCGTCGCCTGGGAATTGCTCAAGATCGGAGATGATGCGC
CGCGCCTGATCCGGGCAGCGATCCGCCGGTTGGAGCAAGACAGAACGCCGCCGGCTTCATCGCCTTCGGATCGCAGCCGC
GCGAGTGCCGACATTCGCTGGGTTGCAGCTGCAATCGTCTCAGGCGCCGTGATCATGGCGATAGCGCCCTGGTTTTATTA
A

Upstream 100 bases:

>100_bases
GATAAGCTACGCCAGATTTCCTCCGCTTGGACAATTGGGCGCGATCGCCCAAGCAAGTTAGCTGTGGAACAGAAGCTGCA
GCGTGCCCATATGCTAAGCC

Downstream 100 bases:

>100_bases
GCCGTGGTCGGCGAGCCCGTCGAATTTCGGTTGAGTCATTAGCTGAATGGCAGCCTTGTGCGCTCACGCCGCTAACATCG
GACAGTCGGCTTGCGGCCCA

Product: ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MLKTLRIARRDRKRLEELFSVTSRYGLGLLLARIGLDRTGSDDAGDGSSHSLPRRTRLAMEELGPTFVKLGQILATRADL
LSPEWIAELEQLHSKAPTLPFEELRPIVEEALGEAPECTFAEFDTEPLAAASMAQVHRATLHDGRAVVIKIRRPGIRPRV
EADIRLLAHIATLAERGSTEAKRFGPSRMMRQLADAMVEELDFTNEARNADRLRTDFANEPSVVVPEIHWEWTSETLLVM
DYINGVPPSNAQALVAAGLDPTRIAALGADMVLDMILVNGRFHGDPHPGNLLCLPGNHIALLDLGMVGYVSPRRREEFVS
FVQALSTGSPAQLADVLTRWSVGDDVPADRVLSASERLIARHGSGRLVLGAMVTDFLGLMRDERMTLPPDLLLIFKALIT
MDGVLSKIEPDFDLTHAMRRSSFRIAQARLSPEHWAPVLQGVAWELLKIGDDAPRLIRAAIRRLEQDRTPPASSPSDRSR
ASADIRWVAAAIVSGAVIMAIAPWFY

Sequences:

>Translated_506_residues
MLKTLRIARRDRKRLEELFSVTSRYGLGLLLARIGLDRTGSDDAGDGSSHSLPRRTRLAMEELGPTFVKLGQILATRADL
LSPEWIAELEQLHSKAPTLPFEELRPIVEEALGEAPECTFAEFDTEPLAAASMAQVHRATLHDGRAVVIKIRRPGIRPRV
EADIRLLAHIATLAERGSTEAKRFGPSRMMRQLADAMVEELDFTNEARNADRLRTDFANEPSVVVPEIHWEWTSETLLVM
DYINGVPPSNAQALVAAGLDPTRIAALGADMVLDMILVNGRFHGDPHPGNLLCLPGNHIALLDLGMVGYVSPRRREEFVS
FVQALSTGSPAQLADVLTRWSVGDDVPADRVLSASERLIARHGSGRLVLGAMVTDFLGLMRDERMTLPPDLLLIFKALIT
MDGVLSKIEPDFDLTHAMRRSSFRIAQARLSPEHWAPVLQGVAWELLKIGDDAPRLIRAAIRRLEQDRTPPASSPSDRSR
ASADIRWVAAAIVSGAVIMAIAPWFY
>Mature_506_residues
MLKTLRIARRDRKRLEELFSVTSRYGLGLLLARIGLDRTGSDDAGDGSSHSLPRRTRLAMEELGPTFVKLGQILATRADL
LSPEWIAELEQLHSKAPTLPFEELRPIVEEALGEAPECTFAEFDTEPLAAASMAQVHRATLHDGRAVVIKIRRPGIRPRV
EADIRLLAHIATLAERGSTEAKRFGPSRMMRQLADAMVEELDFTNEARNADRLRTDFANEPSVVVPEIHWEWTSETLLVM
DYINGVPPSNAQALVAAGLDPTRIAALGADMVLDMILVNGRFHGDPHPGNLLCLPGNHIALLDLGMVGYVSPRRREEFVS
FVQALSTGSPAQLADVLTRWSVGDDVPADRVLSASERLIARHGSGRLVLGAMVTDFLGLMRDERMTLPPDLLLIFKALIT
MDGVLSKIEPDFDLTHAMRRSSFRIAQARLSPEHWAPVLQGVAWELLKIGDDAPRLIRAAIRRLEQDRTPPASSPSDRSR
ASADIRWVAAAIVSGAVIMAIAPWFY

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=291, Percent_Identity=34.020618556701, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI41393593, Length=266, Percent_Identity=35.3383458646617, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI217035081, Length=289, Percent_Identity=30.4498269896194, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI27363457, Length=263, Percent_Identity=26.9961977186312, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI217416386, Length=259, Percent_Identity=26.6409266409266, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI34147522, Length=247, Percent_Identity=25.9109311740891, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI32261307, Length=332, Percent_Identity=23.4939759036145, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI2367309, Length=380, Percent_Identity=31.0526315789474, Blast_Score=176, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17559152, Length=286, Percent_Identity=27.972027972028, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI32565180, Length=380, Percent_Identity=23.1578947368421, Blast_Score=88, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323282, Length=289, Percent_Identity=27.3356401384083, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325148, Length=432, Percent_Identity=21.0648148148148, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=249, Percent_Identity=26.5060240963855, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI22024280, Length=257, Percent_Identity=30.3501945525292, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24662575, Length=286, Percent_Identity=25.5244755244755, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18859849, Length=254, Percent_Identity=27.1653543307087, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 55835; Mature: 55835

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTLRIARRDRKRLEELFSVTSRYGLGLLLARIGLDRTGSDDAGDGSSHSLPRRTRLAM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
EELGPTFVKLGQILATRADLLSPEWIAELEQLHSKAPTLPFEELRPIVEEALGEAPECTF
HHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCH
AEFDTEPLAAASMAQVHRATLHDGRAVVIKIRRPGIRPRVEADIRLLAHIATLAERGSTE
HCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCH
AKRFGPSRMMRQLADAMVEELDFTNEARNADRLRTDFANEPSVVVPEIHWEWTSETLLVM
HHHCCHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHCCCCCCEEECCEEECCCCCCEEEE
DYINGVPPSNAQALVAAGLDPTRIAALGADMVLDMILVNGRFHGDPHPGNLLCLPGNHIA
HHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCEEEECCCCEE
LLDLGMVGYVSPRRREEFVSFVQALSTGSPAQLADVLTRWSVGDDVPADRVLSASERLIA
EEECCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RHGSGRLVLGAMVTDFLGLMRDERMTLPPDLLLIFKALITMDGVLSKIEPDFDLTHAMRR
HCCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SSFRIAQARLSPEHWAPVLQGVAWELLKIGDDAPRLIRAAIRRLEQDRTPPASSPSDRSR
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
ASADIRWVAAAIVSGAVIMAIAPWFY
HHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKTLRIARRDRKRLEELFSVTSRYGLGLLLARIGLDRTGSDDAGDGSSHSLPRRTRLAM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
EELGPTFVKLGQILATRADLLSPEWIAELEQLHSKAPTLPFEELRPIVEEALGEAPECTF
HHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCH
AEFDTEPLAAASMAQVHRATLHDGRAVVIKIRRPGIRPRVEADIRLLAHIATLAERGSTE
HCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCH
AKRFGPSRMMRQLADAMVEELDFTNEARNADRLRTDFANEPSVVVPEIHWEWTSETLLVM
HHHCCHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHCCCCCCEEECCEEECCCCCCEEEE
DYINGVPPSNAQALVAAGLDPTRIAALGADMVLDMILVNGRFHGDPHPGNLLCLPGNHIA
HHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCEEEECCCCEE
LLDLGMVGYVSPRRREEFVSFVQALSTGSPAQLADVLTRWSVGDDVPADRVLSASERLIA
EEECCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RHGSGRLVLGAMVTDFLGLMRDERMTLPPDLLLIFKALITMDGVLSKIEPDFDLTHAMRR
HCCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SSFRIAQARLSPEHWAPVLQGVAWELLKIGDDAPRLIRAAIRRLEQDRTPPASSPSDRSR
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
ASADIRWVAAAIVSGAVIMAIAPWFY
HHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA