Click here to switch to the map view.

The map label for this gene is trpS [H]

Identifier: 85374929

GI number: 85374929

Start: 2131980

End: 2133038

Strand: Direct

Name: trpS [H]

Synonym: ELI_10510

Alternate gene names: 85374929

Gene position: 2131980-2133038 (Clockwise)

Preceding gene: 85374928

Following gene: 85374930

Centisome position: 69.85

GC content: 63.08

Gene sequence:

>1059_bases
ATGCGTGTCGTCTCGGGCATCCAGCCCACCGGTAATCTTCATCTCGGCAATTATCTCGGCGCGATCCGTAACTGGGTGAA
GATGCAGGATGAGATGGGTGCCCCCGCTCAAGCAGCCGAAGGCGGTAGCGCAGAAGAAGCCAGCGAGTGCCTTTTCTTCC
TCGCCGATTTGCACGCCATCTCGCAGCCACACGATCCGGCGGAACTGCGCCGGAACACGCTGGAGATGGCGGCCGCCCTG
GTCGCTTGCGGGATCGATCCCGACAGATCGGTGATGTTCAACCAGGCCCAGGTCCCGGCGCATGCGGAGTTGCAGTGGCT
GCTGATGGGCACCGGACGCATGGGTTGGCTCAACCGGATGACGCAGTGGAAGGACAAGGCGGGCAAAAACCGCGAAGGCC
AGTCCGTCGCGCTGTTCGCCTATCCGGTGCTGCAGGCCGCCGATGTGCTGCTCTACCAAGCGACGCACGTACCCGTGGGC
GAAGACCAGAAGCAGCATCTGGAGCTGGCCCGCGACATCGCGCAGAAATTCAACAACGATTTCGCGTCCGAAGATGCACC
GGTTTTCACCCTGCCCGATCCCTACATTCCGCCGCAGGCCGCGCGGATCATGAGCCTGCGCGACGGTTCGGCCAAGATGA
GCAAATCCGATCTCTCCGAAATGAGCCGCATCAACCTGACCGATGATGCCGATACGATCATGAAGAAGGTCAAGAAGGCC
AAAACCGATCCCGAGCCGCTGCCGAGCGAGGCCGAGGGTCTCGCGGATCGCCCCGAGGCGCTCAATCTCGTGACGATCTA
TGCTGCGCTGGCCGAAAGCACTGTCGATAGTGTGCTCGGCGATTTCGGCGGCGAGGGCTTCGGAAAGTTCAAGCCGGCGC
TGGGTGAATTGATGGTCGAAACGCTGGCACCGACTTCCGCGCGCTTTACCGAGCTGCTGGAAGACCGCGAGGCTATCGAA
GCGATCCTGGCGCGCGGCGCGGCCAAGGCTCGAGAACGCGGCCTGCCGACGCTCGATGCGACATACGAGGCGCTCGGGCT
GCTGCGCGGCCCGCGCTAA

Upstream 100 bases:

>100_bases
CTTGTGCGCCGCCGTGGTCTATTTCGGCGTCGCCTACCTGATCGGCGCCGTCGACAAGCAGCGCCTCCTCTCCTTCACCA
AGAAAAAGGCCGACTGATCC

Downstream 100 bases:

>100_bases
GCCACTGTATTCGTGCGCATTCAACCTCGGTTCATAGCCGAATCGACATAGTTCGTGCATTGTTGCCCGGATGCGGGCCG
CGTCCCCTTGCGGCTCGCCC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MRVVSGIQPTGNLHLGNYLGAIRNWVKMQDEMGAPAQAAEGGSAEEASECLFFLADLHAISQPHDPAELRRNTLEMAAAL
VACGIDPDRSVMFNQAQVPAHAELQWLLMGTGRMGWLNRMTQWKDKAGKNREGQSVALFAYPVLQAADVLLYQATHVPVG
EDQKQHLELARDIAQKFNNDFASEDAPVFTLPDPYIPPQAARIMSLRDGSAKMSKSDLSEMSRINLTDDADTIMKKVKKA
KTDPEPLPSEAEGLADRPEALNLVTIYAALAESTVDSVLGDFGGEGFGKFKPALGELMVETLAPTSARFTELLEDREAIE
AILARGAAKARERGLPTLDATYEALGLLRGPR

Sequences:

>Translated_352_residues
MRVVSGIQPTGNLHLGNYLGAIRNWVKMQDEMGAPAQAAEGGSAEEASECLFFLADLHAISQPHDPAELRRNTLEMAAAL
VACGIDPDRSVMFNQAQVPAHAELQWLLMGTGRMGWLNRMTQWKDKAGKNREGQSVALFAYPVLQAADVLLYQATHVPVG
EDQKQHLELARDIAQKFNNDFASEDAPVFTLPDPYIPPQAARIMSLRDGSAKMSKSDLSEMSRINLTDDADTIMKKVKKA
KTDPEPLPSEAEGLADRPEALNLVTIYAALAESTVDSVLGDFGGEGFGKFKPALGELMVETLAPTSARFTELLEDREAIE
AILARGAAKARERGLPTLDATYEALGLLRGPR
>Mature_352_residues
MRVVSGIQPTGNLHLGNYLGAIRNWVKMQDEMGAPAQAAEGGSAEEASECLFFLADLHAISQPHDPAELRRNTLEMAAAL
VACGIDPDRSVMFNQAQVPAHAELQWLLMGTGRMGWLNRMTQWKDKAGKNREGQSVALFAYPVLQAADVLLYQATHVPVG
EDQKQHLELARDIAQKFNNDFASEDAPVFTLPDPYIPPQAARIMSLRDGSAKMSKSDLSEMSRINLTDDADTIMKKVKKA
KTDPEPLPSEAEGLADRPEALNLVTIYAALAESTVDSVLGDFGGEGFGKFKPALGELMVETLAPTSARFTELLEDREAIE
AILARGAAKARERGLPTLDATYEALGLLRGPR

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=348, Percent_Identity=40.5172413793103, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI41352700, Length=187, Percent_Identity=50.2673796791444, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1789786, Length=349, Percent_Identity=39.2550143266476, Blast_Score=264, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI71982800, Length=349, Percent_Identity=36.1031518624642, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71982793, Length=349, Percent_Identity=36.1031518624642, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6320474, Length=369, Percent_Identity=36.3143631436314, Blast_Score=219, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24666151, Length=348, Percent_Identity=39.0804597701149, Blast_Score=237, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 38254; Mature: 38254

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVSGIQPTGNLHLGNYLGAIRNWVKMQDEMGAPAQAAEGGSAEEASECLFFLADLHAI
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SQPHDPAELRRNTLEMAAALVACGIDPDRSVMFNQAQVPAHAELQWLLMGTGRMGWLNRM
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHHH
TQWKDKAGKNREGQSVALFAYPVLQAADVLLYQATHVPVGEDQKQHLELARDIAQKFNND
HHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
FASEDAPVFTLPDPYIPPQAARIMSLRDGSAKMSKSDLSEMSRINLTDDADTIMKKVKKA
CCCCCCCEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
KTDPEPLPSEAEGLADRPEALNLVTIYAALAESTVDSVLGDFGGEGFGKFKPALGELMVE
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TLAPTSARFTELLEDREAIEAILARGAAKARERGLPTLDATYEALGLLRGPR
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVVSGIQPTGNLHLGNYLGAIRNWVKMQDEMGAPAQAAEGGSAEEASECLFFLADLHAI
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SQPHDPAELRRNTLEMAAALVACGIDPDRSVMFNQAQVPAHAELQWLLMGTGRMGWLNRM
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHHH
TQWKDKAGKNREGQSVALFAYPVLQAADVLLYQATHVPVGEDQKQHLELARDIAQKFNND
HHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
FASEDAPVFTLPDPYIPPQAARIMSLRDGSAKMSKSDLSEMSRINLTDDADTIMKKVKKA
CCCCCCCEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
KTDPEPLPSEAEGLADRPEALNLVTIYAALAESTVDSVLGDFGGEGFGKFKPALGELMVE
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TLAPTSARFTELLEDREAIEAILARGAAKARERGLPTLDATYEALGLLRGPR
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]