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The map label for this gene is yxbG [H]

Identifier: 85374815

GI number: 85374815

Start: 2018896

End: 2019690

Strand: Direct

Name: yxbG [H]

Synonym: ELI_09940

Alternate gene names: 85374815

Gene position: 2018896-2019690 (Clockwise)

Preceding gene: 85374810

Following gene: 85374822

Centisome position: 66.14

GC content: 64.28

Gene sequence:

>795_bases
ATGAAGTTGGAACAAGGCCACGCGGCTATCGTGACCGGGGGCGCATCGGGGCTCGGCCATGCCAGTGTCGTGGCGTTGGC
CGAGGCGGGCTTCAAGGTTGCGATCTTCGACATCAACACCGATGAAAGCCCGGCCAAGGCCGATGCGATCGGCGGGACTT
TTCATCACGTCGACATCACCGACGAGCAATCGGTGGTCGACGGTTTCGAGGCGGCCCGCGCGGCGCATGGCCAGGAACGG
GTGACCGTCCACTGCGCGATGACCAGCAAGCGCGGCAAGACCATCGGCTGGGACAAGGAAGCCGGCCGCTACAAGAAGCT
GCCGACCGAGGATTACGCCTTCGGCGCGGAGGGCGTACTCGTTTCAAGCTTTCGCATCGCCAGCCATTCGGCGCTCGGGA
TGGCGAACAGCGAGCCCGTGACCGCGGACGGTGAGCGCGGGGCGATTATCCTGACCGCCAGCGTCGCGGCGCAGGATGGG
CAGATCGGGCAGGTGATCTACGGCAGCTGCAAGAGCGGCGTGAACGGCCTTGTCCTGCCGATGGCGCGCGATTTGATGGA
CCTGGGCATTCGCGTCAATTCGATCATGCCCGGCATCTTTGCGACTCCGCTCATGCTCGGCATGAAGGACCGCAACCCGC
AGATGTGGGACCAGCTCAATGCCAGCGTTCCCTTCCCCAAGCGGCTCGGCCATCCGGAGGAGTTCGCCAGCCTCGTCCTC
GAAATCGTTCGCAACGGCTATATCAACGGGCACCAGTTCCGGCTCGACGGGGCAATCCGGATGCCGCCGAAATAG

Upstream 100 bases:

>100_bases
ACGACGTCCGCCCCTCTCGTTCGCCGCAGGGCTTCTTCCCTCCAGCGCCGCCATGCGATAGCAGTCGTGTCTTAAGCCAA
GATCAGTCGGGAGAGCGAGC

Downstream 100 bases:

>100_bases
AGGTCATCGCACCGGCTCAAATGCACCAGTCGAACTGGGGACCTGTATCGTTGCGACCGCGCGCGGCGATCAGGCGGGCG
TGTTGCGCAAGGATCGTCTT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKLEQGHAAIVTGGASGLGHASVVALAEAGFKVAIFDINTDESPAKADAIGGTFHHVDITDEQSVVDGFEAARAAHGQER
VTVHCAMTSKRGKTIGWDKEAGRYKKLPTEDYAFGAEGVLVSSFRIASHSALGMANSEPVTADGERGAIILTASVAAQDG
QIGQVIYGSCKSGVNGLVLPMARDLMDLGIRVNSIMPGIFATPLMLGMKDRNPQMWDQLNASVPFPKRLGHPEEFASLVL
EIVRNGYINGHQFRLDGAIRMPPK

Sequences:

>Translated_264_residues
MKLEQGHAAIVTGGASGLGHASVVALAEAGFKVAIFDINTDESPAKADAIGGTFHHVDITDEQSVVDGFEAARAAHGQER
VTVHCAMTSKRGKTIGWDKEAGRYKKLPTEDYAFGAEGVLVSSFRIASHSALGMANSEPVTADGERGAIILTASVAAQDG
QIGQVIYGSCKSGVNGLVLPMARDLMDLGIRVNSIMPGIFATPLMLGMKDRNPQMWDQLNASVPFPKRLGHPEEFASLVL
EIVRNGYINGHQFRLDGAIRMPPK
>Mature_264_residues
MKLEQGHAAIVTGGASGLGHASVVALAEAGFKVAIFDINTDESPAKADAIGGTFHHVDITDEQSVVDGFEAARAAHGQER
VTVHCAMTSKRGKTIGWDKEAGRYKKLPTEDYAFGAEGVLVSSFRIASHSALGMANSEPVTADGERGAIILTASVAAQDG
QIGQVIYGSCKSGVNGLVLPMARDLMDLGIRVNSIMPGIFATPLMLGMKDRNPQMWDQLNASVPFPKRLGHPEEFASLVL
EIVRNGYINGHQFRLDGAIRMPPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=261, Percent_Identity=39.0804597701149, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI83715985, Length=261, Percent_Identity=36.7816091954023, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI15277342, Length=274, Percent_Identity=27.3722627737226, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI40254992, Length=253, Percent_Identity=24.1106719367589, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=264, Percent_Identity=26.8939393939394, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=26.6409266409266, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=262, Percent_Identity=37.7862595419847, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17555706, Length=258, Percent_Identity=27.906976744186, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=264, Percent_Identity=26.1363636363636, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=39.6887159533074, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=27.7566539923954, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 28036; Mature: 28036

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEQGHAAIVTGGASGLGHASVVALAEAGFKVAIFDINTDESPAKADAIGGTFHHVDIT
CCCCCCCEEEEECCCCCCCHHHHHEEHHCCCEEEEEEECCCCCCCCHHHCCCEEEEEECC
DEQSVVDGFEAARAAHGQERVTVHCAMTSKRGKTIGWDKEAGRYKKLPTEDYAFGAEGVL
CCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VSSFRIASHSALGMANSEPVTADGERGAIILTASVAAQDGQIGQVIYGSCKSGVNGLVLP
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEECHHCCCCEEEHH
MARDLMDLGIRVNSIMPGIFATPLMLGMKDRNPQMWDQLNASVPFPKRLGHPEEFASLVL
HHHHHHHHCEEEEHHCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHCCCHHHHHHHHH
EIVRNGYINGHQFRLDGAIRMPPK
HHHHCCCCCCEEEEECCEEECCCC
>Mature Secondary Structure
MKLEQGHAAIVTGGASGLGHASVVALAEAGFKVAIFDINTDESPAKADAIGGTFHHVDIT
CCCCCCCEEEEECCCCCCCHHHHHEEHHCCCEEEEEEECCCCCCCCHHHCCCEEEEEECC
DEQSVVDGFEAARAAHGQERVTVHCAMTSKRGKTIGWDKEAGRYKKLPTEDYAFGAEGVL
CCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VSSFRIASHSALGMANSEPVTADGERGAIILTASVAAQDGQIGQVIYGSCKSGVNGLVLP
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEECHHCCCCEEEHH
MARDLMDLGIRVNSIMPGIFATPLMLGMKDRNPQMWDQLNASVPFPKRLGHPEEFASLVL
HHHHHHHHCEEEEHHCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHCCCHHHHHHHHH
EIVRNGYINGHQFRLDGAIRMPPK
HHHHCCCCCCEEEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]