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The map label for this gene is pamO [H]

Identifier: 85374793

GI number: 85374793

Start: 1993500

End: 1994882

Strand: Direct

Name: pamO [H]

Synonym: ELI_09830

Alternate gene names: 85374793

Gene position: 1993500-1994882 (Clockwise)

Preceding gene: 85374792

Following gene: 85374795

Centisome position: 65.31

GC content: 63.2

Gene sequence:

>1383_bases
ATGAATGAACTGGGAGACGACGGGTTTTTGCCGCGCGTCTGTATCATCGGGGCGGGCTGCAGTGGCTTCACCACCGCCAA
GCGCCTGCAGGATTACGGCATCCCCTTCGATGTGTTCGAGGCGTCGGACGATATCGGCGGCAATTGGTACTACAAGAACC
CCAACGGCATGTCGGCCTGTTACCAAAGCCTGCATATCGACACGTCCAAATGGCGGCTGGCGTTCGAGGATTATCCGGTG
CGCGAAAACTGGCCCGATTTCCCCAGCCACGCACAGTTGCTCCAGTATTTCCATGATTACGTCGATCATTTCGGCCTGCG
CAAGCACATCCGGTTCAATACGCGCGTGGAGAAAGCGCGGCGGCGGCCCGAGGGCGGCTGGGACATCACGCTGTCGGACG
GCGAGACCCGGCGCTACGACGCACTCGCCGTCGCCAACGGCCACCACTGGGCGGCCCGCATCCCGGACTATCCCGGCGAA
TTTACGGGCGAGCAAATCCACAGCCACGCCTATTCGACCCCGACCGACCCGGTCGACTGCACCGGCAAGCGCGTGCTGGT
GGTCGGCATGGGTAACAGCTCGATGGATATCTCCAGCGAGCTCGCCCAGCGGACCGTGGCCAGCAAGCTGTTCGTCTCGG
CGCGGCGCGGGGTCTGGGTGTTCCCGAAATATATCGGCGGCCAGCCGTCCGACAAGAACCCGGCCCCCGCCTGGATGCCG
CGCTGGATGCGGCAGAAGGTGGGCGAGCGGATCATGCGCAAACTGCTCGGCAAAATGAGCGATTACGGCCTGCCGGAACC
CGACCACGGCATGTTCGCCAACCATCCCAGTGTCTCTGGCGAATTTCTTGTGCGCGCGGGTTCAGGCGATCTCACCATGA
AGCCAGGAATCGAGAGCCTCGATGGCGATGGCGTGGTGTTTGCCGACGGCAGCCGGGAGCAGGTCGATGTCATCGTCTGG
GCGACCGGTTACGACATCCGCTTTCCCTTCTTCGACGACCCGGCCTTCACCGCCGACGCAAACAACCGCCCACCGCCACT
GTTCAAGCGGATCATGAAACCCGACGTACCCGACCTATTTTATATGGGACTGGCCCAGCCGTTGCCGACACTGGTCAATT
TCGCCGAGCAGCAGAGCAAGCTCGTGGGCGCCTATCTGGCCGGCCGGTATGCTCCGCCTTCGCCCGAGGAGATGCACCGC
ATCATTGCCAAGGACGAGCAGTTCAACACCGGGCAGTTCTACACGTCGCGCCGACACACGATCCAGCTCGAGTTTGATCC
CTATGTCCGCGATCTGGCGAAGGAACTGAAGGCCGGGGCCAAGCGCGCGGCGGCGCAAGGCCATGCCCTGCCCGTCGAAC
TGCGAGCGGTGGAGCCGGCCTGA

Upstream 100 bases:

>100_bases
GCGTCGGCATGGTCAGGGAGCAGCGCGGCGCGGGGCAGGTGGTGCAGGACTTCAAGGAAGACTTCGCCGCCAGCTACGAG
CGGATGATGGGATTGCTCGA

Downstream 100 bases:

>100_bases
GCCCTACTTCTGCTCGATGGCAATCACCGCCATCGTCAGGCGGGAAATGCACACCAGCTTGCCCTGTTCGTTGACGATGC
GGATCTGCCAGATCTGCGTG

Product: monooxygenase, flavin-binding family protein

Products: NA

Alternate protein names: PAMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNELGDDGFLPRVCIIGAGCSGFTTAKRLQDYGIPFDVFEASDDIGGNWYYKNPNGMSACYQSLHIDTSKWRLAFEDYPV
RENWPDFPSHAQLLQYFHDYVDHFGLRKHIRFNTRVEKARRRPEGGWDITLSDGETRRYDALAVANGHHWAARIPDYPGE
FTGEQIHSHAYSTPTDPVDCTGKRVLVVGMGNSSMDISSELAQRTVASKLFVSARRGVWVFPKYIGGQPSDKNPAPAWMP
RWMRQKVGERIMRKLLGKMSDYGLPEPDHGMFANHPSVSGEFLVRAGSGDLTMKPGIESLDGDGVVFADGSREQVDVIVW
ATGYDIRFPFFDDPAFTADANNRPPPLFKRIMKPDVPDLFYMGLAQPLPTLVNFAEQQSKLVGAYLAGRYAPPSPEEMHR
IIAKDEQFNTGQFYTSRRHTIQLEFDPYVRDLAKELKAGAKRAAAQGHALPVELRAVEPA

Sequences:

>Translated_460_residues
MNELGDDGFLPRVCIIGAGCSGFTTAKRLQDYGIPFDVFEASDDIGGNWYYKNPNGMSACYQSLHIDTSKWRLAFEDYPV
RENWPDFPSHAQLLQYFHDYVDHFGLRKHIRFNTRVEKARRRPEGGWDITLSDGETRRYDALAVANGHHWAARIPDYPGE
FTGEQIHSHAYSTPTDPVDCTGKRVLVVGMGNSSMDISSELAQRTVASKLFVSARRGVWVFPKYIGGQPSDKNPAPAWMP
RWMRQKVGERIMRKLLGKMSDYGLPEPDHGMFANHPSVSGEFLVRAGSGDLTMKPGIESLDGDGVVFADGSREQVDVIVW
ATGYDIRFPFFDDPAFTADANNRPPPLFKRIMKPDVPDLFYMGLAQPLPTLVNFAEQQSKLVGAYLAGRYAPPSPEEMHR
IIAKDEQFNTGQFYTSRRHTIQLEFDPYVRDLAKELKAGAKRAAAQGHALPVELRAVEPA
>Mature_460_residues
MNELGDDGFLPRVCIIGAGCSGFTTAKRLQDYGIPFDVFEASDDIGGNWYYKNPNGMSACYQSLHIDTSKWRLAFEDYPV
RENWPDFPSHAQLLQYFHDYVDHFGLRKHIRFNTRVEKARRRPEGGWDITLSDGETRRYDALAVANGHHWAARIPDYPGE
FTGEQIHSHAYSTPTDPVDCTGKRVLVVGMGNSSMDISSELAQRTVASKLFVSARRGVWVFPKYIGGQPSDKNPAPAWMP
RWMRQKVGERIMRKLLGKMSDYGLPEPDHGMFANHPSVSGEFLVRAGSGDLTMKPGIESLDGDGVVFADGSREQVDVIVW
ATGYDIRFPFFDDPAFTADANNRPPPLFKRIMKPDVPDLFYMGLAQPLPTLVNFAEQQSKLVGAYLAGRYAPPSPEEMHR
IIAKDEQFNTGQFYTSRRHTIQLEFDPYVRDLAKELKAGAKRAAAQGHALPVELRAVEPA

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI221316672, Length=452, Percent_Identity=31.858407079646, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4503757, Length=455, Percent_Identity=32.967032967033, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI221316674, Length=426, Percent_Identity=31.924882629108, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4503759, Length=450, Percent_Identity=28.6666666666667, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI4503755, Length=453, Percent_Identity=28.476821192053, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI50541965, Length=456, Percent_Identity=29.1666666666667, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541961, Length=456, Percent_Identity=29.1666666666667, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI221316678, Length=280, Percent_Identity=35.3571428571429, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI25145785, Length=434, Percent_Identity=29.4930875576037, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI25150462, Length=454, Percent_Identity=30.6167400881057, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17541300, Length=452, Percent_Identity=32.3008849557522, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17555726, Length=446, Percent_Identity=30.0448430493274, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17561948, Length=448, Percent_Identity=29.2410714285714, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI193202226, Length=390, Percent_Identity=28.7179487179487, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17506045, Length=212, Percent_Identity=32.0754716981132, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321970, Length=194, Percent_Identity=29.8969072164948, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19922866, Length=208, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI19921694, Length=221, Percent_Identity=29.8642533936652, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.92 [H]

Molecular weight: Translated: 51667; Mature: 51667

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELGDDGFLPRVCIIGAGCSGFTTAKRLQDYGIPFDVFEASDDIGGNWYYKNPNGMSAC
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCHHHHH
YQSLHIDTSKWRLAFEDYPVRENWPDFPSHAQLLQYFHDYVDHFGLRKHIRFNTRVEKAR
HHHHCCCCHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEECHHHHHHH
RRPEGGWDITLSDGETRRYDALAVANGHHWAARIPDYPGEFTGEQIHSHAYSTPTDPVDC
CCCCCCCEEEECCCCCCCEEEEEEECCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCC
TGKRVLVVGMGNSSMDISSELAQRTVASKLFVSARRGVWVFPKYIGGQPSDKNPAPAWMP
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCHHHH
RWMRQKVGERIMRKLLGKMSDYGLPEPDHGMFANHPSVSGEFLVRAGSGDLTMKPGIESL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCC
DGDGVVFADGSREQVDVIVWATGYDIRFPFFDDPAFTADANNRPPPLFKRIMKPDVPDLF
CCCEEEEECCCCCEEEEEEEECCCEEECCCCCCCCEECCCCCCCCHHHHHHHCCCCCHHH
YMGLAQPLPTLVNFAEQQSKLVGAYLAGRYAPPSPEEMHRIIAKDEQFNTGQFYTSRRHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCEE
IQLEFDPYVRDLAKELKAGAKRAAAQGHALPVELRAVEPA
EEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure
MNELGDDGFLPRVCIIGAGCSGFTTAKRLQDYGIPFDVFEASDDIGGNWYYKNPNGMSAC
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCHHHHH
YQSLHIDTSKWRLAFEDYPVRENWPDFPSHAQLLQYFHDYVDHFGLRKHIRFNTRVEKAR
HHHHCCCCHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEECHHHHHHH
RRPEGGWDITLSDGETRRYDALAVANGHHWAARIPDYPGEFTGEQIHSHAYSTPTDPVDC
CCCCCCCEEEECCCCCCCEEEEEEECCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCC
TGKRVLVVGMGNSSMDISSELAQRTVASKLFVSARRGVWVFPKYIGGQPSDKNPAPAWMP
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCHHHH
RWMRQKVGERIMRKLLGKMSDYGLPEPDHGMFANHPSVSGEFLVRAGSGDLTMKPGIESL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCC
DGDGVVFADGSREQVDVIVWATGYDIRFPFFDDPAFTADANNRPPPLFKRIMKPDVPDLF
CCCEEEEECCCCCEEEEEEEECCCEEECCCCCCCCEECCCCCCCCHHHHHHHCCCCCHHH
YMGLAQPLPTLVNFAEQQSKLVGAYLAGRYAPPSPEEMHRIIAKDEQFNTGQFYTSRRHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCEE
IQLEFDPYVRDLAKELKAGAKRAAAQGHALPVELRAVEPA
EEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA