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The map label for this gene is gmk

Identifier: 85374744

GI number: 85374744

Start: 1952573

End: 1953214

Strand: Direct

Name: gmk

Synonym: ELI_09585

Alternate gene names: 85374744

Gene position: 1952573-1953214 (Clockwise)

Preceding gene: 85374743

Following gene: 85374745

Centisome position: 63.97

GC content: 60.9

Gene sequence:

>642_bases
ATGGCCCACGACCAATCCGATGCGCTGAACCGGCGCGGACTTCTGTTCATCCTCTCTTCCCCTTCCGGCGCGGGGAAGAC
GACGATCTCGCGCATGCTGCTGACGGCGGACGAGCAGATCAAGCTTTCGGTCAGCGCCACGACCCGGCCCAAGCGGCCCG
GCGAAATTGATGGGGTCGATTATCATTTCGTCACCCGCGAAAAGTTCGACGAAATGATCGAGAAGGACGAGTTCTACGAA
TGGGCCGAGGTTTTCGGGCATCGCTACGGCACGCCCAAGGGCTATATCCGGCAGGGGCTGAAGGAAGGGCAGGATTTCCT
GTTCGACATCGACTGGCAGGGCACCCAGCAGCTCAAGCAGAAGGACGACCAGGATGTTGTCACTGTCTTCATCCTGCCGC
CGAGCCTCGACGAGCTGCGTCACCGGCTTGAAACCCGTGCCCAGGACAGCGAGGACGTGATCGACCGCCGGATGGACCGC
GCGCGCGGCGAGATCAGCCACTGGGCCGAATACGATTATGTCGTCGTCAACGACGACGTCGACCATTGCTTCGTCAAGGT
GCGCGAAATCCTCCATGCCGAACGTATGAAGCGCACCCGCCAGACCGGTCTGATCCCGTTTGTGCGTGAACTCATGGCGT
GA

Upstream 100 bases:

>100_bases
AGGGCACCAGGACCGACACCAGACGGCAATTGGCCGCGCACCGGTGCGTTCGCCGCCGGGCGGGGTTGATTTCTTCATCG
TAGCCGGGCCAAGAGCACAC

Downstream 100 bases:

>100_bases
CCCGCTTAAGGCGGCATACACGACCGGAGGCGCATAGCCGCCTTCTCAACCCCAGCTACCGCGAGATTTTGTGAACGCAC
CTTCCTTTGACATGACTGCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MAHDQSDALNRRGLLFILSSPSGAGKTTISRMLLTADEQIKLSVSATTRPKRPGEIDGVDYHFVTREKFDEMIEKDEFYE
WAEVFGHRYGTPKGYIRQGLKEGQDFLFDIDWQGTQQLKQKDDQDVVTVFILPPSLDELRHRLETRAQDSEDVIDRRMDR
ARGEISHWAEYDYVVVNDDVDHCFVKVREILHAERMKRTRQTGLIPFVRELMA

Sequences:

>Translated_213_residues
MAHDQSDALNRRGLLFILSSPSGAGKTTISRMLLTADEQIKLSVSATTRPKRPGEIDGVDYHFVTREKFDEMIEKDEFYE
WAEVFGHRYGTPKGYIRQGLKEGQDFLFDIDWQGTQQLKQKDDQDVVTVFILPPSLDELRHRLETRAQDSEDVIDRRMDR
ARGEISHWAEYDYVVVNDDVDHCFVKVREILHAERMKRTRQTGLIPFVRELMA
>Mature_212_residues
AHDQSDALNRRGLLFILSSPSGAGKTTISRMLLTADEQIKLSVSATTRPKRPGEIDGVDYHFVTREKFDEMIEKDEFYEW
AEVFGHRYGTPKGYIRQGLKEGQDFLFDIDWQGTQQLKQKDDQDVVTVFILPPSLDELRHRLETRAQDSEDVIDRRMDRA
RGEISHWAEYDYVVVNDDVDHCFVKVREILHAERMKRTRQTGLIPFVRELMA

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=36.1256544502618, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=36.1256544502618, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=36.1256544502618, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI38570142, Length=185, Percent_Identity=27.5675675675676, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4505237, Length=183, Percent_Identity=29.5081967213115, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118259, Length=183, Percent_Identity=29.5081967213115, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118255, Length=183, Percent_Identity=29.5081967213115, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118263, Length=183, Percent_Identity=29.5081967213115, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI14780902, Length=181, Percent_Identity=27.0718232044199, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4557529, Length=150, Percent_Identity=31.3333333333333, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI192447426, Length=151, Percent_Identity=31.1258278145695, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI21361598, Length=191, Percent_Identity=25.130890052356, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI111154074, Length=179, Percent_Identity=26.8156424581006, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI148539578, Length=150, Percent_Identity=28.6666666666667, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI148539628, Length=150, Percent_Identity=28.6666666666667, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI119943108, Length=150, Percent_Identity=27.3333333333333, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI261862237, Length=151, Percent_Identity=27.1523178807947, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=49.4791666666667, Blast_Score=186, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=33.1491712707182, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=33.1491712707182, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17557440, Length=188, Percent_Identity=26.5957446808511, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17556244, Length=129, Percent_Identity=28.6821705426357, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=36.2637362637363, Blast_Score=142, Evalue=4e-35,
Organism=Drosophila melanogaster, GI21356141, Length=190, Percent_Identity=32.1052631578947, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI161077626, Length=170, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI116007136, Length=171, Percent_Identity=29.2397660818713, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45554481, Length=170, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45554489, Length=171, Percent_Identity=29.2397660818713, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640542, Length=170, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI85724806, Length=170, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221330162, Length=144, Percent_Identity=32.6388888888889, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330166, Length=144, Percent_Identity=32.6388888888889, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330164, Length=144, Percent_Identity=32.6388888888889, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554813, Length=150, Percent_Identity=30.6666666666667, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24832; Mature: 24701

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDQSDALNRRGLLFILSSPSGAGKTTISRMLLTADEQIKLSVSATTRPKRPGEIDGVD
CCCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCC
YHFVTREKFDEMIEKDEFYEWAEVFGHRYGTPKGYIRQGLKEGQDFLFDIDWQGTQQLKQ
EEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHC
KDDQDVVTVFILPPSLDELRHRLETRAQDSEDVIDRRMDRARGEISHWAEYDYVVVNDDV
CCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
DHCFVKVREILHAERMKRTRQTGLIPFVRELMA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
>Mature Secondary Structure 
AHDQSDALNRRGLLFILSSPSGAGKTTISRMLLTADEQIKLSVSATTRPKRPGEIDGVD
CCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCC
YHFVTREKFDEMIEKDEFYEWAEVFGHRYGTPKGYIRQGLKEGQDFLFDIDWQGTQQLKQ
EEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHC
KDDQDVVTVFILPPSLDELRHRLETRAQDSEDVIDRRMDRARGEISHWAEYDYVVVNDDV
CCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
DHCFVKVREILHAERMKRTRQTGLIPFVRELMA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA