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The map label for this gene is hisE

Identifier: 85374737

GI number: 85374737

Start: 1948196

End: 1948510

Strand: Reverse

Name: hisE

Synonym: ELI_09550

Alternate gene names: 85374737

Gene position: 1948510-1948196 (Counterclockwise)

Preceding gene: 85374738

Following gene: 85374735

Centisome position: 63.84

GC content: 63.49

Gene sequence:

>315_bases
ATGAATACGCTGCAACGCCTCGAGGCCACCATCGCCGCGCGCCGCAATGCCGATCCCGACAGCAGTTATGTCGCGCGGCT
CAATGCCAAGGGGCTGCCAAAAATGGCGGAGAAAGTGGGCGAGGAAGCCACCGAAACCGTGATCGCCGCGCTCACCGGCA
GTGACGAGGAACTGGTCGGCGAGGGCGCAGACCTGATCTTCCACTTGCTCGTGCTGCTGCAGGCCCGAGGCGTGTCACTG
GACCAGGTCCTCGCCGAACTCGACCGCCGCGAAGGCTTGTCGGGCCTCGATGAAAAAGCAAAGCGAGGCGATTAG

Upstream 100 bases:

>100_bases
CCTCCATCTTTCATTTCGGCACGCACACCATCGCCGAGGCGCACCAGGCGTTGCGCGATGCAGGCTTGCCCGCGCGCGGC
GCTTAGGCGAGATGGAGAGT

Downstream 100 bases:

>100_bases
CCGTATTTTTCTGCGAATGCCTCGTCACTCATAGTAAGATAGATTATCATCTCGATAAACGCGATAATTGCCGGGATGAA
GGTCCAGCAGAAAAGCAGAT

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 104; Mature: 104

Protein sequence:

>104_residues
MNTLQRLEATIAARRNADPDSSYVARLNAKGLPKMAEKVGEEATETVIAALTGSDEELVGEGADLIFHLLVLLQARGVSL
DQVLAELDRREGLSGLDEKAKRGD

Sequences:

>Translated_104_residues
MNTLQRLEATIAARRNADPDSSYVARLNAKGLPKMAEKVGEEATETVIAALTGSDEELVGEGADLIFHLLVLLQARGVSL
DQVLAELDRREGLSGLDEKAKRGD
>Mature_104_residues
MNTLQRLEATIAARRNADPDSSYVARLNAKGLPKMAEKVGEEATETVIAALTGSDEELVGEGADLIFHLLVLLQARGVSL
DQVLAELDRREGLSGLDEKAKRGD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=46.5909090909091, Blast_Score=83, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_ERYLH (Q2N8I9)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458799.1
- ProteinModelPortal:   Q2N8I9
- SMR:   Q2N8I9
- STRING:   Q2N8I9
- GeneID:   3869493
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_09550
- NMPDR:   fig|314225.3.peg.1129
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   ELIT314225:ELI_09550-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11174; Mature: 11174

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLQRLEATIAARRNADPDSSYVARLNAKGLPKMAEKVGEEATETVIAALTGSDEELVG
CCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHC
EGADLIFHLLVLLQARGVSLDQVLAELDRREGLSGLDEKAKRGD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCC
>Mature Secondary Structure
MNTLQRLEATIAARRNADPDSSYVARLNAKGLPKMAEKVGEEATETVIAALTGSDEELVG
CCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHC
EGADLIFHLLVLLQARGVSLDQVLAELDRREGLSGLDEKAKRGD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA