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The map label for this gene is hemF [H]

Identifier: 85374711

GI number: 85374711

Start: 1928086

End: 1928943

Strand: Reverse

Name: hemF [H]

Synonym: ELI_09420

Alternate gene names: 85374711

Gene position: 1928943-1928086 (Counterclockwise)

Preceding gene: 85374714

Following gene: 85374710

Centisome position: 63.19

GC content: 63.17

Gene sequence:

>858_bases
ATGACCGATTGGACATCACAGACCGAACAGGCGCGCGCGTGGTTCGAAAGCCTGCGCGACCAGATCTGCGCCGAATTCGA
GGCTATCGAGCGTGAGGCCGGGTCCGACGCCGCATTCCAGTACACGCCGTGGGACCGCGAGGAAGCGGGCAATGACGACC
CCGGCGGCGGGGTGCAGGGCCTGATGAAAGGCAAAGTGTTCGAGAAGGTCGGGGTCAACGTTTCGACCGTGCGCGGCAGC
TTCGCGCCCGAATTCGCAGCGACGATCAACGGCGCGAGCGTCGAGCATCCGGGCTTTACGGCGACCGGCATTAGCCTCGT
CGCGCACATGGCCAATCCGCATGTGCCAGCAGTGCATATGAACACGCGCTTCCTGACAACGCAGGCGGCTTGGTTCGGCG
GCGGCGCGGACCTCAACCCCCCGATCCCCTACGAGCAGGACACGGCGGAATTTCACGCCCGCTTCCGCGCGGCCTGCGCG
GCACACAACCCGACCTATTACGAGCGCTTCAGGAAATGGGCGGACGATTATTTCTTCATTCCCCACCGCGGCGTCCACCG
CGGGGTCGGCGGGATATTTTACGATCATCTCGAATGCGACGATGCAGCCGCGTTCGAGCGCAATTTCGCCTTCACGCAGG
ACGTCGGCAAGGCCTTCCTCGATATCTTCCCGCAACTCGTCCGCCGGCGCATGGAAAGCGATTTCACGCCGGAAGACAAG
CAGACCCAGCTTGAATGGCGCGGCCGCTATGCCGAATTCAACCTCGTCTATGATCGCGGCACGCTGTTCGGTCTCAAGAC
CGGCGGCAATATTGACGCGATCCTGATGAGCCTGCCGCCCGAGGCAGTGTGGGTGTGA

Upstream 100 bases:

>100_bases
AGCGCGTTGGAGGGTGTCAGGAACATTTCCTGACCGGCGAACGAAACGGGAACCATTCGCCTCACTTGCCGCGACTCATG
CGGTTTGGCAAGGGGGTGGT

Downstream 100 bases:

>100_bases
CTGCGATAGAGATTTCGTTAGGCGATCGGGCGGCTTTTGACGGGCGCGCGAACCAGGTTGACCATGAGAGCGTGCAGGCT
CTGCACTATCTCGGCAATTA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTDWTSQTEQARAWFESLRDQICAEFEAIEREAGSDAAFQYTPWDREEAGNDDPGGGVQGLMKGKVFEKVGVNVSTVRGS
FAPEFAATINGASVEHPGFTATGISLVAHMANPHVPAVHMNTRFLTTQAAWFGGGADLNPPIPYEQDTAEFHARFRAACA
AHNPTYYERFRKWADDYFFIPHRGVHRGVGGIFYDHLECDDAAAFERNFAFTQDVGKAFLDIFPQLVRRRMESDFTPEDK
QTQLEWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPEAVWV

Sequences:

>Translated_285_residues
MTDWTSQTEQARAWFESLRDQICAEFEAIEREAGSDAAFQYTPWDREEAGNDDPGGGVQGLMKGKVFEKVGVNVSTVRGS
FAPEFAATINGASVEHPGFTATGISLVAHMANPHVPAVHMNTRFLTTQAAWFGGGADLNPPIPYEQDTAEFHARFRAACA
AHNPTYYERFRKWADDYFFIPHRGVHRGVGGIFYDHLECDDAAAFERNFAFTQDVGKAFLDIFPQLVRRRMESDFTPEDK
QTQLEWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPEAVWV
>Mature_284_residues
TDWTSQTEQARAWFESLRDQICAEFEAIEREAGSDAAFQYTPWDREEAGNDDPGGGVQGLMKGKVFEKVGVNVSTVRGSF
APEFAATINGASVEHPGFTATGISLVAHMANPHVPAVHMNTRFLTTQAAWFGGGADLNPPIPYEQDTAEFHARFRAACAA
HNPTYYERFRKWADDYFFIPHRGVHRGVGGIFYDHLECDDAAAFERNFAFTQDVGKAFLDIFPQLVRRRMESDFTPEDKQ
TQLEWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPEAVWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=278, Percent_Identity=40.6474820143885, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI1788777, Length=281, Percent_Identity=40.9252669039146, Blast_Score=206, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320249, Length=303, Percent_Identity=37.6237623762376, Blast_Score=191, Evalue=8e-50,
Organism=Drosophila melanogaster, GI17864388, Length=292, Percent_Identity=42.4657534246575, Blast_Score=212, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 31961; Mature: 31830

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDWTSQTEQARAWFESLRDQICAEFEAIEREAGSDAAFQYTPWDREEAGNDDPGGGVQG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCCCHHH
LMKGKVFEKVGVNVSTVRGSFAPEFAATINGASVEHPGFTATGISLVAHMANPHVPAVHM
HHHHHHHHHHCCEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEE
NTRFLTTQAAWFGGGADLNPPIPYEQDTAEFHARFRAACAAHNPTYYERFRKWADDYFFI
CCEEEEEEHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEC
PHRGVHRGVGGIFYDHLECDDAAAFERNFAFTQDVGKAFLDIFPQLVRRRMESDFTPEDK
CCCCHHHCCCCCEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QTQLEWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPEAVWV
CHHHHHCCCEEEEEEEEECCEEEEEECCCCEEEEEEECCCHHCCC
>Mature Secondary Structure 
TDWTSQTEQARAWFESLRDQICAEFEAIEREAGSDAAFQYTPWDREEAGNDDPGGGVQG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCCCHHH
LMKGKVFEKVGVNVSTVRGSFAPEFAATINGASVEHPGFTATGISLVAHMANPHVPAVHM
HHHHHHHHHHCCEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEE
NTRFLTTQAAWFGGGADLNPPIPYEQDTAEFHARFRAACAAHNPTYYERFRKWADDYFFI
CCEEEEEEHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEC
PHRGVHRGVGGIFYDHLECDDAAAFERNFAFTQDVGKAFLDIFPQLVRRRMESDFTPEDK
CCCCHHHCCCCCEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QTQLEWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPEAVWV
CHHHHHCCCEEEEEEEEECCEEEEEECCCCEEEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA