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The map label for this gene is pan [H]

Identifier: 85374701

GI number: 85374701

Start: 1912294

End: 1914270

Strand: Direct

Name: pan [H]

Synonym: ELI_09370

Alternate gene names: 85374701

Gene position: 1912294-1914270 (Clockwise)

Preceding gene: 85374700

Following gene: 85374702

Centisome position: 62.65

GC content: 66.31

Gene sequence:

>1977_bases
ATGACCGCGCCGCGCCCCCTCCACGACCTGGCCGTCTGCGCCGAAGAGCAGTTCCGGCTGCATCTGCTCGGCCTCGTCGT
CGACATGCTGCACCGCGAACGCCGCGAGGGCCGTCTGTTCGAATATCTCGACCAGTTTCCGTTCCTGCAAAGCTATGTCG
ACAGGATCGAGACGCTGTTCGGCAGCGATCTGCCCGCGCCGAAGGATTGGCGCGCCGCCGTTCGTCACTGGCAGGGCGAA
ACCGAACTTCCGCTGGACCGATTGCACAAGGCGTGCCCCGGGCCGATTGCGGCTGCATCGCTGCTCCTGATCGCCGCCGT
CGAGGAGGATCCGCGCCTGTCGCTGCTGGACGAGCCAGAAGGCGGTGCCCCGACCCTGGGCGGTATGACCGCGTTCTTGT
GCGACATGTTTCCCGATCACGGCACGGGAGATATCCGTGCGGTTCTGATGCGGATGGCCGAAGTCGGCGTGTTGCAGGTC
GGCAGCCGCGATGCGCCGCGTATCCAGTGGAGCTTGCGGGTCTCGCCGGCGGCGTTCGAACTTGTCTCGGGCGCGCCCTG
CCTTCGTGACCATTTCCGCCTTACCGCGACAGGCGATTTGCCTTCACCCGAAGTGTGGGTTGCCCCCGGCCCTGACAGCG
CGCGGCCCGAAGACCTCTCCAGGTTCCTGCAGTCGACCCGGGACAGCACGATCCTGCTCCGCAGCGACAGCCACAACGGG
CGCAAGACCTTCGTTCGCATGGCTGCGCAGGCTGTCGGCAAAGCGGTCCTGCATTGCCAGAGCGGTACGATGGCGGACCG
CGATCTCTGGGCCGAAGCGAACCTCGTGGCCGCGCTGGCCGATGCACTGCTGCTGATCGAATGTGCGCCTGTCCCCGGCG
AGCGGATCGTCGTCCCTGCCGCTCCCCTGAACGCTCCGCACTGCGCGCTGGTCACGACGCACGCGGCCAGCATCGACCAT
GGCCGGCGACCGGGCGCGCTCTACCCCATCGTCCTCGCGCGACCGGATCAGGACGCCCGCAAGCGGCACTGGCGCAATGC
CGGCTGGTCGCGACATGCGGCGAAGCTGGCCGACCGGCTGCTGACGTCGGGCCATATCTACCGGGTCGCTCGCGGTGCCG
TGCGCGAACGGAAAGACCAGGCGCGCGAAGCCATCGATACCGCGCTGGCTTCGATCCGCGATCCGCGCCTCGAAACGACC
GCGCACCGCATCGCGCTCGGAGACGAGCTCGACGATCTGGTCCTCGATCCAGCCGAGCGGGAAGAGGTCGATGCGCTCGC
TCTGCGATGCCGCTTGCGCGAGCAGCTCCACAGTAGCAGCGAGGCAGGCGTCAAGGCGCTGCTGAGCGGAGCGAGCGGCA
CCGGCAAGACGCTCGCTGCCAAGCATCTCGCCCGCACCCTCTCCCGCCCGCTCTACCGGATCGATCTCGCCGCGACCGTC
AACAAATATATCGGCGAGACCGAAAAGAACCTCGAGATGGCGCTGGCTGCTGCCGAGGAGCTCGATGTCGTATTGCTGCT
CGACGAAGGCGACGCCTTGCTCGCCAAGCGTACCGATGTCGGCTCGGCGACCGATCGCTACGCCAATATGGAAACCAACT
TCCTGCTCCAGCGGCTGGAGGATTTTCGCGGCATCATCCTGGTGACTACCAATGATGGCGAACGCATCGACAAGGCGTTC
CGTCGCCGCATGGATGCGATTATCCCCTTCCGCCTGCCCGACCAGTTGCGCCGCCAGGAAATCCTGATGCGGCAGTTGGG
CGAGCATGACCTCAGCCAGGCGATGATCGACGAAGTCGCCTGCCGCTGCAATTTCACCGGCGGACAGATTCACAACGTGG
TGCTTCATGCCCGGCTGCTGGCGCTCGCTGCGAAGAGCGCCATCACCGACGCGCATATGGTCAAGGCGGTCGAACGCGAA
TACCGCAAGACCGGCGAACATTGCCCGCTGCGCCCCGCTCTGGCCGAGGTCGGCTAG

Upstream 100 bases:

>100_bases
TCGATCTGTCCGATCTCCCCTTCGCCATTCGCTTCGCCGGGCTGGACCGAGATCCGGGCTGGATCCCGCAGGAGGGGCGC
TCGCTCGCCTTCATCTATCG

Downstream 100 bases:

>100_bases
GCCGTGGCGCAGGCAGCCCGCAAACCGGCGGAACCGGCCGCCGCGCCGAAACGGGCCAAGCCACCACCCGTCCGCGCCAA
GCCGAGCGTCCAGCGCAAGC

Product: ATPase, AAA family protein

Products: NA

Alternate protein names: PAN; Proteasomal ATPase; Proteasome regulatory ATPase; Proteasome regulatory particle [H]

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MTAPRPLHDLAVCAEEQFRLHLLGLVVDMLHRERREGRLFEYLDQFPFLQSYVDRIETLFGSDLPAPKDWRAAVRHWQGE
TELPLDRLHKACPGPIAAASLLLIAAVEEDPRLSLLDEPEGGAPTLGGMTAFLCDMFPDHGTGDIRAVLMRMAEVGVLQV
GSRDAPRIQWSLRVSPAAFELVSGAPCLRDHFRLTATGDLPSPEVWVAPGPDSARPEDLSRFLQSTRDSTILLRSDSHNG
RKTFVRMAAQAVGKAVLHCQSGTMADRDLWAEANLVAALADALLLIECAPVPGERIVVPAAPLNAPHCALVTTHAASIDH
GRRPGALYPIVLARPDQDARKRHWRNAGWSRHAAKLADRLLTSGHIYRVARGAVRERKDQAREAIDTALASIRDPRLETT
AHRIALGDELDDLVLDPAEREEVDALALRCRLREQLHSSSEAGVKALLSGASGTGKTLAAKHLARTLSRPLYRIDLAATV
NKYIGETEKNLEMALAAAEELDVVLLLDEGDALLAKRTDVGSATDRYANMETNFLLQRLEDFRGIILVTTNDGERIDKAF
RRRMDAIIPFRLPDQLRRQEILMRQLGEHDLSQAMIDEVACRCNFTGGQIHNVVLHARLLALAAKSAITDAHMVKAVERE
YRKTGEHCPLRPALAEVG

Sequences:

>Translated_658_residues
MTAPRPLHDLAVCAEEQFRLHLLGLVVDMLHRERREGRLFEYLDQFPFLQSYVDRIETLFGSDLPAPKDWRAAVRHWQGE
TELPLDRLHKACPGPIAAASLLLIAAVEEDPRLSLLDEPEGGAPTLGGMTAFLCDMFPDHGTGDIRAVLMRMAEVGVLQV
GSRDAPRIQWSLRVSPAAFELVSGAPCLRDHFRLTATGDLPSPEVWVAPGPDSARPEDLSRFLQSTRDSTILLRSDSHNG
RKTFVRMAAQAVGKAVLHCQSGTMADRDLWAEANLVAALADALLLIECAPVPGERIVVPAAPLNAPHCALVTTHAASIDH
GRRPGALYPIVLARPDQDARKRHWRNAGWSRHAAKLADRLLTSGHIYRVARGAVRERKDQAREAIDTALASIRDPRLETT
AHRIALGDELDDLVLDPAEREEVDALALRCRLREQLHSSSEAGVKALLSGASGTGKTLAAKHLARTLSRPLYRIDLAATV
NKYIGETEKNLEMALAAAEELDVVLLLDEGDALLAKRTDVGSATDRYANMETNFLLQRLEDFRGIILVTTNDGERIDKAF
RRRMDAIIPFRLPDQLRRQEILMRQLGEHDLSQAMIDEVACRCNFTGGQIHNVVLHARLLALAAKSAITDAHMVKAVERE
YRKTGEHCPLRPALAEVG
>Mature_657_residues
TAPRPLHDLAVCAEEQFRLHLLGLVVDMLHRERREGRLFEYLDQFPFLQSYVDRIETLFGSDLPAPKDWRAAVRHWQGET
ELPLDRLHKACPGPIAAASLLLIAAVEEDPRLSLLDEPEGGAPTLGGMTAFLCDMFPDHGTGDIRAVLMRMAEVGVLQVG
SRDAPRIQWSLRVSPAAFELVSGAPCLRDHFRLTATGDLPSPEVWVAPGPDSARPEDLSRFLQSTRDSTILLRSDSHNGR
KTFVRMAAQAVGKAVLHCQSGTMADRDLWAEANLVAALADALLLIECAPVPGERIVVPAAPLNAPHCALVTTHAASIDHG
RRPGALYPIVLARPDQDARKRHWRNAGWSRHAAKLADRLLTSGHIYRVARGAVRERKDQAREAIDTALASIRDPRLETTA
HRIALGDELDDLVLDPAEREEVDALALRCRLREQLHSSSEAGVKALLSGASGTGKTLAAKHLARTLSRPLYRIDLAATVN
KYIGETEKNLEMALAAAEELDVVLLLDEGDALLAKRTDVGSATDRYANMETNFLLQRLEDFRGIILVTTNDGERIDKAFR
RRMDAIIPFRLPDQLRRQEILMRQLGEHDLSQAMIDEVACRCNFTGGQIHNVVLHARLLALAAKSAITDAHMVKAVEREY
RKTGEHCPLRPALAEVG

Specific function: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereb

COG id: COG0464

COG function: function code O; ATPases of the AAA+ class

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI24430151, Length=223, Percent_Identity=29.5964125560538, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI31742536, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI112789543, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI157671927, Length=188, Percent_Identity=34.0425531914894, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71987372, Length=214, Percent_Identity=30.3738317757009, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71987364, Length=214, Percent_Identity=30.3738317757009, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17563250, Length=186, Percent_Identity=32.258064516129, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25146157, Length=156, Percent_Identity=28.8461538461538, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324833, Length=208, Percent_Identity=29.8076923076923, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320197, Length=195, Percent_Identity=32.3076923076923, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324000, Length=253, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322704, Length=203, Percent_Identity=29.5566502463054, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322994, Length=231, Percent_Identity=29.4372294372294, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24640100, Length=207, Percent_Identity=30.4347826086957, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24663015, Length=207, Percent_Identity=28.0193236714976, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649446, Length=223, Percent_Identity=28.6995515695067, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581396, Length=204, Percent_Identity=25.9803921568627, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45552965, Length=200, Percent_Identity=29.5, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24660075, Length=200, Percent_Identity=29.5, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281365776, Length=200, Percent_Identity=29.5, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17137738, Length=204, Percent_Identity=30.3921568627451, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005937
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 72611; Mature: 72480

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPRPLHDLAVCAEEQFRLHLLGLVVDMLHRERREGRLFEYLDQFPFLQSYVDRIETLF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHH
GSDLPAPKDWRAAVRHWQGETELPLDRLHKACPGPIAAASLLLIAAVEEDPRLSLLDEPE
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHEECCCCCCEECCCCC
GGAPTLGGMTAFLCDMFPDHGTGDIRAVLMRMAEVGVLQVGSRDAPRIQWSLRVSPAAFE
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEECCCCCCCEEEEEEECHHHHH
LVSGAPCLRDHFRLTATGDLPSPEVWVAPGPDSARPEDLSRFLQSTRDSTILLRSDSHNG
HHCCCCHHHHCEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCH
RKTFVRMAAQAVGKAVLHCQSGTMADRDLWAEANLVAALADALLLIECAPVPGERIVVPA
HHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEC
APLNAPHCALVTTHAASIDHGRRPGALYPIVLARPDQDARKRHWRNAGWSRHAAKLADRL
CCCCCCCEEEEEEEHHHCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHH
LTSGHIYRVARGAVRERKDQAREAIDTALASIRDPRLETTAHRIALGDELDDLVLDPAER
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHCCCCCH
EEVDALALRCRLREQLHSSSEAGVKALLSGASGTGKTLAAKHLARTLSRPLYRIDLAATV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHH
NKYIGETEKNLEMALAAAEELDVVLLLDEGDALLAKRTDVGSATDRYANMETNFLLQRLE
HHHHCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHH
DFRGIILVTTNDGERIDKAFRRRMDAIIPFRLPDQLRRQEILMRQLGEHDLSQAMIDEVA
HHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
CRCNFTGGQIHNVVLHARLLALAAKSAITDAHMVKAVEREYRKTGEHCPLRPALAEVG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCC
>Mature Secondary Structure 
TAPRPLHDLAVCAEEQFRLHLLGLVVDMLHRERREGRLFEYLDQFPFLQSYVDRIETLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHH
GSDLPAPKDWRAAVRHWQGETELPLDRLHKACPGPIAAASLLLIAAVEEDPRLSLLDEPE
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHEECCCCCCEECCCCC
GGAPTLGGMTAFLCDMFPDHGTGDIRAVLMRMAEVGVLQVGSRDAPRIQWSLRVSPAAFE
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEECCCCCCCEEEEEEECHHHHH
LVSGAPCLRDHFRLTATGDLPSPEVWVAPGPDSARPEDLSRFLQSTRDSTILLRSDSHNG
HHCCCCHHHHCEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCH
RKTFVRMAAQAVGKAVLHCQSGTMADRDLWAEANLVAALADALLLIECAPVPGERIVVPA
HHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEC
APLNAPHCALVTTHAASIDHGRRPGALYPIVLARPDQDARKRHWRNAGWSRHAAKLADRL
CCCCCCCEEEEEEEHHHCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHH
LTSGHIYRVARGAVRERKDQAREAIDTALASIRDPRLETTAHRIALGDELDDLVLDPAER
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHCCCCCH
EEVDALALRCRLREQLHSSSEAGVKALLSGASGTGKTLAAKHLARTLSRPLYRIDLAATV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHH
NKYIGETEKNLEMALAAAEELDVVLLLDEGDALLAKRTDVGSATDRYANMETNFLLQRLE
HHHHCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHH
DFRGIILVTTNDGERIDKAFRRRMDAIIPFRLPDQLRRQEILMRQLGEHDLSQAMIDEVA
HHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
CRCNFTGGQIHNVVLHARLLALAAKSAITDAHMVKAVEREYRKTGEHCPLRPALAEVG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]