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The map label for this gene is dsbD [H]

Identifier: 85374654

GI number: 85374654

Start: 1856976

End: 1859039

Strand: Reverse

Name: dsbD [H]

Synonym: ELI_09135

Alternate gene names: 85374654

Gene position: 1859039-1856976 (Counterclockwise)

Preceding gene: 85374656

Following gene: 85374652

Centisome position: 60.9

GC content: 66.09

Gene sequence:

>2064_bases
ATGTTCGCGCTTCTGGCGCTGCTGCTCGCTGCGCTGGCGGCAGTCCCTGCTGCGGCGCAGGGGCAGAACATTCGCGTGGC
GCTGGTGGCCGAGGGGCCGGTTGCGCCGGGCGGCGAGACGACACTCGCTTTCAAATTTGCGCCGGTGTCCGAGGAATGGC
ACGGCTATTGGGCCAATCCGGGCGATGCGGGCCTGCCGATGCAGCTGGAGTGGGACCTGCCCGAAGGTGTGTCCGTCGGC
GAGCCGCTCTATCCCACACCCAAGCGGCTGGTGATCGACGGGCTGATGAACCACATTTTCGAGGGCGATTATGCGGTGCT
GCTGCCGTTGCGCCTGACCGAGGATTATGCGGGGCCGGATGTCTTGCAAGTGTCGGTCGAAGCCTTCTACCTTGCCTGCA
CTGACCAGATCTGCGTGCCCGAGGACGCGCAATTGCAGGTGTCGATCCCGGTTGGCGAGAGCACCGCTTCAGGCACCGAA
TTCGCGGCATTCCGTAGCGCGCTCGCCCCGCTGATCGACAGCACGGCGCGGTTCGAGCAGACCGCCAGCCTGCTGCGTCT
CGCCATCCCGCTCCCGGCAGCCGTCGATCCGGGAGAACCGCATGTCTTTATCGCCAATCGCGACCTGGTGAATTACGTGC
AGGCGCAGGGCTTTCGCCGCAATGGCGACTGGCTGATCGCCGAAATCCCACTGGCGCGGACGGGGGAGCAGCCGGAAACC
GTCGAAGGCATCGTCAGGCTGGGGAGCGGACAGGGTCTGCGCTTCGTCGCCGAGGCGGGCGAGGTGCCAAGCGGCGACCG
TGTCCTGATGGCGCGCGATGCCGAACTGCCCTCGCTCTGGCTGCTCTTGGGCGGAGCGTTGCTCGGAGGGCTGATCCTCA
ACATCATGCCCTGTGTCTTCCCGATTCTGAGCCTGAAGGCGCTTAGCCTCGCGAAGGCTGGCGCCGGAGCCCAAGAGGCG
CGGATGGAAGGCCTCGCTTACACCGCAGGCGTGATCCTCGCCTGTGTTGCGCTGGGCGGCGCAATGCTGGCCTTGCGCGC
GGCGGGCGAGCAGGTTGGCTGGGCTTTCCAGTTGCAGGAGCCGGGTGTCGTCGTCGCGCTGCTGGTGTTGGCGAGCCTAA
TCACCGCCAACCTGCTCGGCTTTTTCGAATTGCCGGGCCTGTCGATTTCGGAAGGCAGCACCCCGCGCGGAGCCTTTTCG
ACCGGGCTGCTGGCGGCGTTCGTTGCGACGCCTTGCACAGGCCCCTTCATGGCAGCGGCGCTCGGAGCGGCGCTGCTTCT
GCCCGCAGAAACCGCACTGCTACTTTTCGCCGTCCTGGGGCTGGGCCTTGCGCTCCCGTTTCTCCTGCTCGGCTTTATAC
CTGCATTTCGACGATTACTGCCGAAACCGGGCGCTTGGATGGAGACATTTCGCAAGGTGCTCGCCGTTCCGATGGGGCTG
ACCGCGCTGGCGCTGGTTTGGCTGGTCTGGCGTATCGGGGGCGTCGGTTTCGCGCTCTCGGCGATGTCGATCGCCTTCAT
CGCAACTTTGGCAGCCGTGCTGTTCCGTGGCCGTAACCAGCGATTGCGTGGAGCCGTGACGGCACTTGGCGCGGTGCTGA
TGGCTGTCGGGGTGTTGGCGAGTTTCGAATCGCCGACGCGAGCGCAGGCCGAGACGGTCCTTGCAAGCAAGCCATTCACC
CTAGCAGCGCTCGATGAAGCGCGCGCCTCCGGTGCACCGGTGTTCGTCTATTTCACCGCCGACTGGTGCGTCAGCTGCAA
GGTCAACGAGCGGGTCGCGATCGAGCGCGAGGCGACCCGCGAGGCGTTCGAGCAGGCAGGTGTTACTACGCTGCGCGGCG
ACTGGACCCTGCGCCAGCCCGAGATCACCGAATTCCTCAACGCCCAAGGCGTCGCCGGGGTGCCGCTTTACCTGTGGTAC
GATCCCGGTGTGGCCGAGCCGCGCCAATTGCAGCAATTGCTGGGCCCTGACAGCCTCGTCACTTTGGCGCGCGAGGCTGG
TCCTCGGGCGGCTCGTCGTCCGGAAGGTCGCGTTCGGCCTCTTCCGCGTCAGGCGCAACGCTAG

Upstream 100 bases:

>100_bases
GTTTCGGCCATGGAATTCCTTTGCATTCAAACTTACATGGCGCAGTAGGACCGAAGTGATGCCCTCCGCAAGATCGACCT
TCAGCCGCATTGCCGCTCCC

Downstream 100 bases:

>100_bases
GGCGGCATGCATTGACCAGCTCGCGGATGCGCGGGCTCGCCTTCAGCATGACCGATCCTGCCCCCGGGATGGTCGCCTCG
ACATCGCGCTGGCCGGTCAG

Product: thiol:disulfide interchange protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 687; Mature: 687

Protein sequence:

>687_residues
MFALLALLLAALAAVPAAAQGQNIRVALVAEGPVAPGGETTLAFKFAPVSEEWHGYWANPGDAGLPMQLEWDLPEGVSVG
EPLYPTPKRLVIDGLMNHIFEGDYAVLLPLRLTEDYAGPDVLQVSVEAFYLACTDQICVPEDAQLQVSIPVGESTASGTE
FAAFRSALAPLIDSTARFEQTASLLRLAIPLPAAVDPGEPHVFIANRDLVNYVQAQGFRRNGDWLIAEIPLARTGEQPET
VEGIVRLGSGQGLRFVAEAGEVPSGDRVLMARDAELPSLWLLLGGALLGGLILNIMPCVFPILSLKALSLAKAGAGAQEA
RMEGLAYTAGVILACVALGGAMLALRAAGEQVGWAFQLQEPGVVVALLVLASLITANLLGFFELPGLSISEGSTPRGAFS
TGLLAAFVATPCTGPFMAAALGAALLLPAETALLLFAVLGLGLALPFLLLGFIPAFRRLLPKPGAWMETFRKVLAVPMGL
TALALVWLVWRIGGVGFALSAMSIAFIATLAAVLFRGRNQRLRGAVTALGAVLMAVGVLASFESPTRAQAETVLASKPFT
LAALDEARASGAPVFVYFTADWCVSCKVNERVAIEREATREAFEQAGVTTLRGDWTLRQPEITEFLNAQGVAGVPLYLWY
DPGVAEPRQLQQLLGPDSLVTLAREAGPRAARRPEGRVRPLPRQAQR

Sequences:

>Translated_687_residues
MFALLALLLAALAAVPAAAQGQNIRVALVAEGPVAPGGETTLAFKFAPVSEEWHGYWANPGDAGLPMQLEWDLPEGVSVG
EPLYPTPKRLVIDGLMNHIFEGDYAVLLPLRLTEDYAGPDVLQVSVEAFYLACTDQICVPEDAQLQVSIPVGESTASGTE
FAAFRSALAPLIDSTARFEQTASLLRLAIPLPAAVDPGEPHVFIANRDLVNYVQAQGFRRNGDWLIAEIPLARTGEQPET
VEGIVRLGSGQGLRFVAEAGEVPSGDRVLMARDAELPSLWLLLGGALLGGLILNIMPCVFPILSLKALSLAKAGAGAQEA
RMEGLAYTAGVILACVALGGAMLALRAAGEQVGWAFQLQEPGVVVALLVLASLITANLLGFFELPGLSISEGSTPRGAFS
TGLLAAFVATPCTGPFMAAALGAALLLPAETALLLFAVLGLGLALPFLLLGFIPAFRRLLPKPGAWMETFRKVLAVPMGL
TALALVWLVWRIGGVGFALSAMSIAFIATLAAVLFRGRNQRLRGAVTALGAVLMAVGVLASFESPTRAQAETVLASKPFT
LAALDEARASGAPVFVYFTADWCVSCKVNERVAIEREATREAFEQAGVTTLRGDWTLRQPEITEFLNAQGVAGVPLYLWY
DPGVAEPRQLQQLLGPDSLVTLAREAGPRAARRPEGRVRPLPRQAQR
>Mature_687_residues
MFALLALLLAALAAVPAAAQGQNIRVALVAEGPVAPGGETTLAFKFAPVSEEWHGYWANPGDAGLPMQLEWDLPEGVSVG
EPLYPTPKRLVIDGLMNHIFEGDYAVLLPLRLTEDYAGPDVLQVSVEAFYLACTDQICVPEDAQLQVSIPVGESTASGTE
FAAFRSALAPLIDSTARFEQTASLLRLAIPLPAAVDPGEPHVFIANRDLVNYVQAQGFRRNGDWLIAEIPLARTGEQPET
VEGIVRLGSGQGLRFVAEAGEVPSGDRVLMARDAELPSLWLLLGGALLGGLILNIMPCVFPILSLKALSLAKAGAGAQEA
RMEGLAYTAGVILACVALGGAMLALRAAGEQVGWAFQLQEPGVVVALLVLASLITANLLGFFELPGLSISEGSTPRGAFS
TGLLAAFVATPCTGPFMAAALGAALLLPAETALLLFAVLGLGLALPFLLLGFIPAFRRLLPKPGAWMETFRKVLAVPMGL
TALALVWLVWRIGGVGFALSAMSIAFIATLAAVLFRGRNQRLRGAVTALGAVLMAVGVLASFESPTRAQAETVLASKPFT
LAALDEARASGAPVFVYFTADWCVSCKVNERVAIEREATREAFEQAGVTTLRGDWTLRQPEITEFLNAQGVAGVPLYLWY
DPGVAEPRQLQQLLGPDSLVTLAREAGPRAARRPEGRVRPLPRQAQR

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=406, Percent_Identity=30.0492610837438, Blast_Score=99, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 72612; Mature: 72612

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALLALLLAALAAVPAAAQGQNIRVALVAEGPVAPGGETTLAFKFAPVSEEWHGYWANP
CHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCEECCC
GDAGLPMQLEWDLPEGVSVGEPLYPTPKRLVIDGLMNHIFEGDYAVLLPLRLTEDYAGPD
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
VLQVSVEAFYLACTDQICVPEDAQLQVSIPVGESTASGTEFAAFRSALAPLIDSTARFEQ
EEEEEEEEEEEEECCCEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TASLLRLAIPLPAAVDPGEPHVFIANRDLVNYVQAQGFRRNGDWLIAEIPLARTGEQPET
HHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCEEEEECCHHCCCCCCHH
VEGIVRLGSGQGLRFVAEAGEVPSGDRVLMARDAELPSLWLLLGGALLGGLILNIMPCVF
HHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
PILSLKALSLAKAGAGAQEARMEGLAYTAGVILACVALGGAMLALRAAGEQVGWAFQLQE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
PGVVVALLVLASLITANLLGFFELPGLSISEGSTPRGAFSTGLLAAFVATPCTGPFMAAA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LGAALLLPAETALLLFAVLGLGLALPFLLLGFIPAFRRLLPKPGAWMETFRKVLAVPMGL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
TALALVWLVWRIGGVGFALSAMSIAFIATLAAVLFRGRNQRLRGAVTALGAVLMAVGVLA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SFESPTRAQAETVLASKPFTLAALDEARASGAPVFVYFTADWCVSCKVNERVAIEREATR
CCCCCCHHHHHHHHCCCCCEEEEHHHHHCCCCCEEEEEECCEEEEEECCCCEEEHHHHHH
EAFEQAGVTTLRGDWTLRQPEITEFLNAQGVAGVPLYLWYDPGVAEPRQLQQLLGPDSLV
HHHHHCCCEEEECCEEECCCHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHH
TLAREAGPRAARRPEGRVRPLPRQAQR
HHHHHCCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MFALLALLLAALAAVPAAAQGQNIRVALVAEGPVAPGGETTLAFKFAPVSEEWHGYWANP
CHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCEECCC
GDAGLPMQLEWDLPEGVSVGEPLYPTPKRLVIDGLMNHIFEGDYAVLLPLRLTEDYAGPD
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
VLQVSVEAFYLACTDQICVPEDAQLQVSIPVGESTASGTEFAAFRSALAPLIDSTARFEQ
EEEEEEEEEEEEECCCEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TASLLRLAIPLPAAVDPGEPHVFIANRDLVNYVQAQGFRRNGDWLIAEIPLARTGEQPET
HHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCEEEEECCHHCCCCCCHH
VEGIVRLGSGQGLRFVAEAGEVPSGDRVLMARDAELPSLWLLLGGALLGGLILNIMPCVF
HHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
PILSLKALSLAKAGAGAQEARMEGLAYTAGVILACVALGGAMLALRAAGEQVGWAFQLQE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
PGVVVALLVLASLITANLLGFFELPGLSISEGSTPRGAFSTGLLAAFVATPCTGPFMAAA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LGAALLLPAETALLLFAVLGLGLALPFLLLGFIPAFRRLLPKPGAWMETFRKVLAVPMGL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
TALALVWLVWRIGGVGFALSAMSIAFIATLAAVLFRGRNQRLRGAVTALGAVLMAVGVLA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SFESPTRAQAETVLASKPFTLAALDEARASGAPVFVYFTADWCVSCKVNERVAIEREATR
CCCCCCHHHHHHHHCCCCCEEEEHHHHHCCCCCEEEEEECCEEEEEECCCCEEEHHHHHH
EAFEQAGVTTLRGDWTLRQPEITEFLNAQGVAGVPLYLWYDPGVAEPRQLQQLLGPDSLV
HHHHHCCCEEEECCEEECCCHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHH
TLAREAGPRAARRPEGRVRPLPRQAQR
HHHHHCCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]