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The map label for this gene is uvrB [H]

Identifier: 85374647

GI number: 85374647

Start: 1852400

End: 1854583

Strand: Direct

Name: uvrB [H]

Synonym: ELI_09100

Alternate gene names: 85374647

Gene position: 1852400-1854583 (Clockwise)

Preceding gene: 85374637

Following gene: 85374650

Centisome position: 60.69

GC content: 62.5

Gene sequence:

>2184_bases
ATGGCAGAATTGGTGATCAGGCGCGGGTTGGATGAGCCCGAGACCGGGGAAGAATTCACCCCGCACCGCCCCGCAAGGCC
CGAAAAGTCGATGCCGGGCAAGAGGTTCGAACTGGTGTCGGAATACGAACCTGCGGGTGACCAGCCGACTGCCATCGCCG
AACTGGTCGAAAGCGCGCGCGAAGGCGAAAAGACTCAGACACTGCTCGGTGTGACCGGGAGCGGCAAGACCTTCACCATG
GCCAAGGTGATCGAGACGCTCCAGCGCCCGGCGCTGGTGCTGGCCCCCAACAAGATCCTCGCCGCGCAACTTTACGGGGA
GTTCAAGAGCTTCTTCCCCCACAACGCGGTCGAGTATTTCGTCAGCTACTACGACTATTACCAGCCGGAAGCCTACGTCC
CGCGCTCGGACACCTATATCGAGAAAGAGTCGAGCGTGAACGAGGCGATCGACCGGATGCGCCACTCGGCCACTCGCGCG
CTACTCGAGCGCGACGACGTGATTATCGTCGCTTCGGTATCCTGCCTCTACGGTATCGGATCGGTCGAGACCTATTCGGC
GATGATCTTCGATATCAAGAAGGACGAGACGGTCGACCAGCGCGAGCTCATCCGCAAGCTCGTCGCTCTGCAATACAAGC
GCAACGATGCAGCGTTCCAGCGCGGCACGTTCCGCGTGCGCGGGGACAATCTGGAGATTTTCCCGAGCCACTACGAAGAC
CGGGCCTGGAGGGTCAGCTTCTTCGGCGACGATATCGAAGAGATCAACGAATTCGATCCGTTGACCGGCGAAAAAGGCGC
GAGCCTCGACAGCGTGCGGGTCTATGCCAATTCGCACTACGTTACGCCCGGTCCGACGATGAAACAGGCGAGCGAAGCGA
TCAAGTTCGAGCTGCAGGAGCGGCTCAAGGAACTGCACGCGGAAGGCCGCTTGCTGGAAGCCCAGCGGCTGGAGCAGCGC
ACCAATTTCGACCTCGAGATGATTGCGGCCACGGGAAGCTGTGCAGGGATCGAGAACTATTCGCGCTTCCTCACTGGCCG
CCTGCCCGGCGAACCACCGCCCACGCTCTTCGAATATCTGCCCGAGAACGCGCTGCTGTTCGTCGACGAAAGCCATCAGA
CGGTGCCGCAGATCGGCGCAATGGCGCGCGGGGACCACCGGCGCAAGCTGACGCTGGCCGAATACGGCTTCCGCCTGCCC
AGCTGTATCGACAACCGCCCGCTCCGCTTCAACGAATGGGACGCGATGCGCCCCCAGACCTTCTGTGTTTCGGCGACGCC
CGGAAACTGGGAGATGGAGCAGACCGGCGGCGTGTTCGCCGAACAGGTCATTCGCCCCACCGGCCTGATCGATCCGCCCG
TGGAAATCCGCCCGGTCGAGGACCAGGTGCAGGACTGCATCAACGAGTGCAACGAAACCGCGAAGAAAGGATATCGCACG
CTCGTCACCACGCTGACCAAGCGGATGGCCGAAGACCTGACCGAGTTTATGCACGAGGCGGGGGTGAAGGTCCGCTACAT
GCATTCGGATGTCGAGACACTGGAGCGTATCGAGCTGATCCGCGACCTGCGGCTGGGCGTCTATGACGTCCTGATCGGCA
TCAACCTGCTGCGCGAAGGGCTCGACATCCCCGAATGCGGGCTGGTGTGCATCCTCGACGCCGACAAGGAAGGTTTCCTG
CGCTCCGAAACTTCGCTGGTGCAGACCATCGGCCGGGCCGCGCGGAATGTCGATGGCAAGGTTATCCTCTATGCCGACCG
CATCACCGGCAGCATGGAACGCGCCATGGCGGAGACCGAACGCCGCCGCGAGAAGCAGCGCGCCTATAACGAGGAACACG
GCATCACGCCGCAAACGATCAAGCGCCAGATCGCCGATATCGTCGCGCACACGGCCTCGCAGGACGGCGTGACTGTCGAC
ACCGGCGATGACGAGCGCAACAACCTCGTCGGCCACAACCTGCGCGCTTACATCGAAGACCTCGAGAAGCGCATGCGCGA
AGCCGCCGCCGATCTCGAGTTCGAGGAAGCCGGCCGCCTGCGCGATGAAATCCGGCGGCTCGAAAACGATGAGCTCGGCT
TGTCCGACAGCGAGAAGAAAGCGCCGCTGGTCGGGCGCAGCAACGAAGGCAAACCCGGCACGCGCAAGATGCGATACGGG
AAGACGCAGCGGAAGATGCGGTGA

Upstream 100 bases:

>100_bases
TCAGGGGATTGAGACGCGTTCCCATGAATGTTGCCTAGCGCGTCACTTTCCAGCCACCAAGAGCTTGCACCGGTGGCGAC
ATGCGCCATATCGACACATC

Downstream 100 bases:

>100_bases
TGCTGGGGATAAAAAAATTTTAAGAGCCCGCTAAGAGGGTTATAAGAAGGCTCTTGACGTGACCCCCAGCTTTCCCCCAG
CTGGGATTAGAGCCGGGCGG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MAELVIRRGLDEPETGEEFTPHRPARPEKSMPGKRFELVSEYEPAGDQPTAIAELVESAREGEKTQTLLGVTGSGKTFTM
AKVIETLQRPALVLAPNKILAAQLYGEFKSFFPHNAVEYFVSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRA
LLERDDVIIVASVSCLYGIGSVETYSAMIFDIKKDETVDQRELIRKLVALQYKRNDAAFQRGTFRVRGDNLEIFPSHYED
RAWRVSFFGDDIEEINEFDPLTGEKGASLDSVRVYANSHYVTPGPTMKQASEAIKFELQERLKELHAEGRLLEAQRLEQR
TNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPENALLFVDESHQTVPQIGAMARGDHRRKLTLAEYGFRLP
SCIDNRPLRFNEWDAMRPQTFCVSATPGNWEMEQTGGVFAEQVIRPTGLIDPPVEIRPVEDQVQDCINECNETAKKGYRT
LVTTLTKRMAEDLTEFMHEAGVKVRYMHSDVETLERIELIRDLRLGVYDVLIGINLLREGLDIPECGLVCILDADKEGFL
RSETSLVQTIGRAARNVDGKVILYADRITGSMERAMAETERRREKQRAYNEEHGITPQTIKRQIADIVAHTASQDGVTVD
TGDDERNNLVGHNLRAYIEDLEKRMREAAADLEFEEAGRLRDEIRRLENDELGLSDSEKKAPLVGRSNEGKPGTRKMRYG
KTQRKMR

Sequences:

>Translated_727_residues
MAELVIRRGLDEPETGEEFTPHRPARPEKSMPGKRFELVSEYEPAGDQPTAIAELVESAREGEKTQTLLGVTGSGKTFTM
AKVIETLQRPALVLAPNKILAAQLYGEFKSFFPHNAVEYFVSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRA
LLERDDVIIVASVSCLYGIGSVETYSAMIFDIKKDETVDQRELIRKLVALQYKRNDAAFQRGTFRVRGDNLEIFPSHYED
RAWRVSFFGDDIEEINEFDPLTGEKGASLDSVRVYANSHYVTPGPTMKQASEAIKFELQERLKELHAEGRLLEAQRLEQR
TNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPENALLFVDESHQTVPQIGAMARGDHRRKLTLAEYGFRLP
SCIDNRPLRFNEWDAMRPQTFCVSATPGNWEMEQTGGVFAEQVIRPTGLIDPPVEIRPVEDQVQDCINECNETAKKGYRT
LVTTLTKRMAEDLTEFMHEAGVKVRYMHSDVETLERIELIRDLRLGVYDVLIGINLLREGLDIPECGLVCILDADKEGFL
RSETSLVQTIGRAARNVDGKVILYADRITGSMERAMAETERRREKQRAYNEEHGITPQTIKRQIADIVAHTASQDGVTVD
TGDDERNNLVGHNLRAYIEDLEKRMREAAADLEFEEAGRLRDEIRRLENDELGLSDSEKKAPLVGRSNEGKPGTRKMRYG
KTQRKMR
>Mature_726_residues
AELVIRRGLDEPETGEEFTPHRPARPEKSMPGKRFELVSEYEPAGDQPTAIAELVESAREGEKTQTLLGVTGSGKTFTMA
KVIETLQRPALVLAPNKILAAQLYGEFKSFFPHNAVEYFVSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRAL
LERDDVIIVASVSCLYGIGSVETYSAMIFDIKKDETVDQRELIRKLVALQYKRNDAAFQRGTFRVRGDNLEIFPSHYEDR
AWRVSFFGDDIEEINEFDPLTGEKGASLDSVRVYANSHYVTPGPTMKQASEAIKFELQERLKELHAEGRLLEAQRLEQRT
NFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPENALLFVDESHQTVPQIGAMARGDHRRKLTLAEYGFRLPS
CIDNRPLRFNEWDAMRPQTFCVSATPGNWEMEQTGGVFAEQVIRPTGLIDPPVEIRPVEDQVQDCINECNETAKKGYRTL
VTTLTKRMAEDLTEFMHEAGVKVRYMHSDVETLERIELIRDLRLGVYDVLIGINLLREGLDIPECGLVCILDADKEGFLR
SETSLVQTIGRAARNVDGKVILYADRITGSMERAMAETERRREKQRAYNEEHGITPQTIKRQIADIVAHTASQDGVTVDT
GDDERNNLVGHNLRAYIEDLEKRMREAAADLEFEEAGRLRDEIRRLENDELGLSDSEKKAPLVGRSNEGKPGTRKMRYGK
TQRKMR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=59.2760180995475, Blast_Score=781, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 82560; Mature: 82429

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELVIRRGLDEPETGEEFTPHRPARPEKSMPGKRFELVSEYEPAGDQPTAIAELVESAR
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
EGEKTQTLLGVTGSGKTFTMAKVIETLQRPALVLAPNKILAAQLYGEFKSFFPHNAVEYF
CCCCCEEEEEECCCCCEEHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHH
VSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRALLERDDVIIVASVSCLYGIG
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCC
SVETYSAMIFDIKKDETVDQRELIRKLVALQYKRNDAAFQRGTFRVRGDNLEIFPSHYED
CHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCEEECCCCCCC
RAWRVSFFGDDIEEINEFDPLTGEKGASLDSVRVYANSHYVTPGPTMKQASEAIKFELQE
CEEEEEECCCCHHHHHCCCCCCCCCCCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHH
RLKELHAEGRLLEAQRLEQRTNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYL
HHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHC
PENALLFVDESHQTVPQIGAMARGDHRRKLTLAEYGFRLPSCIDNRPLRFNEWDAMRPQT
CCCEEEEEECCCCHHHHHHHHCCCCCCCEEEHHHHCCCCCHHHCCCCCCCCCCCCCCCCE
FCVSATPGNWEMEQTGGVFAEQVIRPTGLIDPPVEIRPVEDQVQDCINECNETAKKGYRT
EEEECCCCCCCHHHHCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
LVTTLTKRMAEDLTEFMHEAGVKVRYMHSDVETLERIELIRDLRLGVYDVLIGINLLREG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDIPECGLVCILDADKEGFLRSETSLVQTIGRAARNVDGKVILYADRITGSMERAMAETE
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
RRREKQRAYNEEHGITPQTIKRQIADIVAHTASQDGVTVDTGDDERNNLVGHNLRAYIED
HHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHH
LEKRMREAAADLEFEEAGRLRDEIRRLENDELGLSDSEKKAPLVGRSNEGKPGTRKMRYG
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
KTQRKMR
CHHHCCC
>Mature Secondary Structure 
AELVIRRGLDEPETGEEFTPHRPARPEKSMPGKRFELVSEYEPAGDQPTAIAELVESAR
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
EGEKTQTLLGVTGSGKTFTMAKVIETLQRPALVLAPNKILAAQLYGEFKSFFPHNAVEYF
CCCCCEEEEEECCCCCEEHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHH
VSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRALLERDDVIIVASVSCLYGIG
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCC
SVETYSAMIFDIKKDETVDQRELIRKLVALQYKRNDAAFQRGTFRVRGDNLEIFPSHYED
CHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCEEECCCCCCC
RAWRVSFFGDDIEEINEFDPLTGEKGASLDSVRVYANSHYVTPGPTMKQASEAIKFELQE
CEEEEEECCCCHHHHHCCCCCCCCCCCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHH
RLKELHAEGRLLEAQRLEQRTNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYL
HHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHC
PENALLFVDESHQTVPQIGAMARGDHRRKLTLAEYGFRLPSCIDNRPLRFNEWDAMRPQT
CCCEEEEEECCCCHHHHHHHHCCCCCCCEEEHHHHCCCCCHHHCCCCCCCCCCCCCCCCE
FCVSATPGNWEMEQTGGVFAEQVIRPTGLIDPPVEIRPVEDQVQDCINECNETAKKGYRT
EEEECCCCCCCHHHHCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
LVTTLTKRMAEDLTEFMHEAGVKVRYMHSDVETLERIELIRDLRLGVYDVLIGINLLREG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDIPECGLVCILDADKEGFLRSETSLVQTIGRAARNVDGKVILYADRITGSMERAMAETE
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
RRREKQRAYNEEHGITPQTIKRQIADIVAHTASQDGVTVDTGDDERNNLVGHNLRAYIED
HHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHH
LEKRMREAAADLEFEEAGRLRDEIRRLENDELGLSDSEKKAPLVGRSNEGKPGTRKMRYG
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
KTQRKMR
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA