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The map label for this gene is pepA [H]

Identifier: 85374603

GI number: 85374603

Start: 1806086

End: 1807546

Strand: Reverse

Name: pepA [H]

Synonym: ELI_08880

Alternate gene names: 85374603

Gene position: 1807546-1806086 (Counterclockwise)

Preceding gene: 85374608

Following gene: 85374602

Centisome position: 59.22

GC content: 65.02

Gene sequence:

>1461_bases
ATGAAAATCACTTTCGCCGATAGCCGTCCTGCCGATGCCACGCTGGTGGCGCATGTCTGCAACCGCGGGTCCTTGCCCGA
CGGATTGGAACGCGCGCTGACGGAAGGCGCGAGCGCGGCGCGCTTCAAAGGCGGTTCCGGGCAGGTCTTCGAAGGGTTCG
TCGAACGCGACGGCACCGTGGTCCGCGTGGCGCTGGCCGGTGCCGGTTCGAAAGATGCCGAGAACCGCAACATCAATTGC
GAGAAGGCCGGAGCGGCACTGGCGGGCAAGTACCTGTCGTCGGGCGCAAGCACGATCGTGCTCGACTTCGAAGACAGCGG
CCTGACCGGCGAGGAGATCGCATCGGTCTTGCTCGGCCTGCGGCTGCGGACGTGGCGCCAGGATGCCTATCGCACCAAAA
TGAAGGACGAGCAGAAGAAGACGTTGACCGACGCGATCGTGGTTGGCGCGCCGGGCACCGCGCAAACCGCGTGGGATGTG
GAGGAGGCGCTGTGCGAAGGCATCGAATTCACCCGTCACCTGGTCGCAGAGCCCGCCAACAAGCTCTATCCCGAAAGCTT
CGTCGCGCAATGCCGCGATGCGCTGCAGGGCACTGGCATCGAGATCACGGTGCTGACCGACGACGACATGGAAAAGCTCG
GCATGGGCGCGCTGCTTGGCGTGGGGCTCGGGTCGGAGCGACCATCGCGCCTGCTGGCGATGAAATGGAACGGCGGCGAG
CCGGGCCAGCGCCCGATGGCCTTCGTCGGCAAGGGCGTGACCTTTGATACCGGCGGGATCTCGCTGAAGCCCGGGCCCGG
CATGGAAGACATGAAATGGGACATGGGCGGCGCCGGTGCAGTCGCCGGCGCGATGGTCGCGCTGGCCAAGCGAAAGGCCA
GGGCCAATGTCGTTGGTGTGGTGGGGCTGGTCGAGAACATGCCCGATGGCCGCGCAATGCGTCCGGGCGATATCGTCACG
TCGATGTCGGGCCAGACGATCGAAGTGCTCAATACCGATGCGGAGGGGCGGTTGGTCCTGTGCGATGCGCTGCACTGGAC
GCAGAAGGAATTCGATCCGGTTGCAGTGGTCGATTTCGCAACGCTGACCGGCGCGATGATCATCGCGCTCGGCAGCGAGC
ACGGCGGGATTTTCTCCAACGACGACGATCTGGCGGACAAGCTGATGGCTGCCGGCAAGTCCACCGGAGACAAGCTGTGG
CGCTTCCCGCTGATGCCGGAATACGACAAGCTGCTCAACTCGCCGATCGCGGACATGAAGAATATCGGCCCGCGCGGGGC
GGGGTCGATCACCGCCGCGCAGTTCCTGCAGCGCTTCATCGACAAGGATCGCCCGTGGGCGCATTGCGACATCGCCGGCA
TGGTGTGGGCCGACAAGGCAGGCCAGACGTGGGACAAGGGCGCGACCGGCTATGGCGTGCGGATCATCGATCAATACGTC
CGCGACGTGCTGGAAGGGTAA

Upstream 100 bases:

>100_bases
CCTAATCGCAATCGCCCTGTGACGCCGCATGCGGCAGAGCGTGGAAACGCCTGCGATACGGCGCGTTAGACGAAGAAAAC
ATGCCTCTTCCGGAGACCTC

Downstream 100 bases:

>100_bases
CCTCTAGCCTCAAGTAGCGAAGCGGTAGGCCGAATATAATGCCCAGAATGCGCAGGAAGTCCGACTTGCCGAGCAAGGAC
TGCGCGTTTTGCGGTTTGCC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MKITFADSRPADATLVAHVCNRGSLPDGLERALTEGASAARFKGGSGQVFEGFVERDGTVVRVALAGAGSKDAENRNINC
EKAGAALAGKYLSSGASTIVLDFEDSGLTGEEIASVLLGLRLRTWRQDAYRTKMKDEQKKTLTDAIVVGAPGTAQTAWDV
EEALCEGIEFTRHLVAEPANKLYPESFVAQCRDALQGTGIEITVLTDDDMEKLGMGALLGVGLGSERPSRLLAMKWNGGE
PGQRPMAFVGKGVTFDTGGISLKPGPGMEDMKWDMGGAGAVAGAMVALAKRKARANVVGVVGLVENMPDGRAMRPGDIVT
SMSGQTIEVLNTDAEGRLVLCDALHWTQKEFDPVAVVDFATLTGAMIIALGSEHGGIFSNDDDLADKLMAAGKSTGDKLW
RFPLMPEYDKLLNSPIADMKNIGPRGAGSITAAQFLQRFIDKDRPWAHCDIAGMVWADKAGQTWDKGATGYGVRIIDQYV
RDVLEG

Sequences:

>Translated_486_residues
MKITFADSRPADATLVAHVCNRGSLPDGLERALTEGASAARFKGGSGQVFEGFVERDGTVVRVALAGAGSKDAENRNINC
EKAGAALAGKYLSSGASTIVLDFEDSGLTGEEIASVLLGLRLRTWRQDAYRTKMKDEQKKTLTDAIVVGAPGTAQTAWDV
EEALCEGIEFTRHLVAEPANKLYPESFVAQCRDALQGTGIEITVLTDDDMEKLGMGALLGVGLGSERPSRLLAMKWNGGE
PGQRPMAFVGKGVTFDTGGISLKPGPGMEDMKWDMGGAGAVAGAMVALAKRKARANVVGVVGLVENMPDGRAMRPGDIVT
SMSGQTIEVLNTDAEGRLVLCDALHWTQKEFDPVAVVDFATLTGAMIIALGSEHGGIFSNDDDLADKLMAAGKSTGDKLW
RFPLMPEYDKLLNSPIADMKNIGPRGAGSITAAQFLQRFIDKDRPWAHCDIAGMVWADKAGQTWDKGATGYGVRIIDQYV
RDVLEG
>Mature_486_residues
MKITFADSRPADATLVAHVCNRGSLPDGLERALTEGASAARFKGGSGQVFEGFVERDGTVVRVALAGAGSKDAENRNINC
EKAGAALAGKYLSSGASTIVLDFEDSGLTGEEIASVLLGLRLRTWRQDAYRTKMKDEQKKTLTDAIVVGAPGTAQTAWDV
EEALCEGIEFTRHLVAEPANKLYPESFVAQCRDALQGTGIEITVLTDDDMEKLGMGALLGVGLGSERPSRLLAMKWNGGE
PGQRPMAFVGKGVTFDTGGISLKPGPGMEDMKWDMGGAGAVAGAMVALAKRKARANVVGVVGLVENMPDGRAMRPGDIVT
SMSGQTIEVLNTDAEGRLVLCDALHWTQKEFDPVAVVDFATLTGAMIIALGSEHGGIFSNDDDLADKLMAAGKSTGDKLW
RFPLMPEYDKLLNSPIADMKNIGPRGAGSITAAQFLQRFIDKDRPWAHCDIAGMVWADKAGQTWDKGATGYGVRIIDQYV
RDVLEG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=460, Percent_Identity=35.2173913043478, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI47155554, Length=363, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1790710, Length=303, Percent_Identity=48.5148514851485, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=36.5930599369085, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=316, Percent_Identity=35.126582278481, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=340, Percent_Identity=27.0588235294118, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129969, Length=319, Percent_Identity=34.1692789968652, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21355725, Length=314, Percent_Identity=34.0764331210191, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24661038, Length=314, Percent_Identity=34.3949044585987, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24662227, Length=465, Percent_Identity=29.8924731182796, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161077148, Length=418, Percent_Identity=30.3827751196172, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI20130057, Length=418, Percent_Identity=30.3827751196172, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI221379063, Length=317, Percent_Identity=36.2776025236593, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI221379062, Length=317, Percent_Identity=36.2776025236593, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21357381, Length=317, Percent_Identity=36.2776025236593, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI21355645, Length=435, Percent_Identity=29.6551724137931, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24662223, Length=435, Percent_Identity=29.6551724137931, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129963, Length=414, Percent_Identity=31.8840579710145, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI19922386, Length=337, Percent_Identity=31.4540059347181, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24646701, Length=189, Percent_Identity=32.8042328042328, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=189, Percent_Identity=32.8042328042328, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=189, Percent_Identity=32.8042328042328, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51672; Mature: 51672

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITFADSRPADATLVAHVCNRGSLPDGLERALTEGASAARFKGGSGQVFEGFVERDGTV
CEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHEECCCCCHHHHHHHHCCCCE
VRVALAGAGSKDAENRNINCEKAGAALAGKYLSSGASTIVLDFEDSGLTGEEIASVLLGL
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHH
RLRTWRQDAYRTKMKDEQKKTLTDAIVVGAPGTAQTAWDVEEALCEGIEFTRHLVAEPAN
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
KLYPESFVAQCRDALQGTGIEITVLTDDDMEKLGMGALLGVGLGSERPSRLLAMKWNGGE
HCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCHHHEECCCCCCCCCEEEEEEECCCC
PGQRPMAFVGKGVTFDTGGISLKPGPGMEDMKWDMGGAGAVAGAMVALAKRKARANVVGV
CCCCCHHHHCCCCEECCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEE
VGLVENMPDGRAMRPGDIVTSMSGQTIEVLNTDAEGRLVLCDALHWTQKEFDPVAVVDFA
EHHHHCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEECHHHHHHCCCCEEEEHHH
TLTGAMIIALGSEHGGIFSNDDDLADKLMAAGKSTGDKLWRFPLMPEYDKLLNSPIADMK
HHHCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHCCCHHHHH
NIGPRGAGSITAAQFLQRFIDKDRPWAHCDIAGMVWADKAGQTWDKGATGYGVRIIDQYV
HCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECEEEEECCCCCCCCCCCCCCHHHHHHHHH
RDVLEG
HHHHCC
>Mature Secondary Structure
MKITFADSRPADATLVAHVCNRGSLPDGLERALTEGASAARFKGGSGQVFEGFVERDGTV
CEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHEECCCCCHHHHHHHHCCCCE
VRVALAGAGSKDAENRNINCEKAGAALAGKYLSSGASTIVLDFEDSGLTGEEIASVLLGL
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHH
RLRTWRQDAYRTKMKDEQKKTLTDAIVVGAPGTAQTAWDVEEALCEGIEFTRHLVAEPAN
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
KLYPESFVAQCRDALQGTGIEITVLTDDDMEKLGMGALLGVGLGSERPSRLLAMKWNGGE
HCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCHHHEECCCCCCCCCEEEEEEECCCC
PGQRPMAFVGKGVTFDTGGISLKPGPGMEDMKWDMGGAGAVAGAMVALAKRKARANVVGV
CCCCCHHHHCCCCEECCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEE
VGLVENMPDGRAMRPGDIVTSMSGQTIEVLNTDAEGRLVLCDALHWTQKEFDPVAVVDFA
EHHHHCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEECHHHHHHCCCCEEEEHHH
TLTGAMIIALGSEHGGIFSNDDDLADKLMAAGKSTGDKLWRFPLMPEYDKLLNSPIADMK
HHHCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHCCCHHHHH
NIGPRGAGSITAAQFLQRFIDKDRPWAHCDIAGMVWADKAGQTWDKGATGYGVRIIDQYV
HCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECEEEEECCCCCCCCCCCCCCHHHHHHHHH
RDVLEG
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA