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The map label for this gene is atpA

Identifier: 85374581

GI number: 85374581

Start: 1787035

End: 1788564

Strand: Direct

Name: atpA

Synonym: ELI_08770

Alternate gene names: 85374581

Gene position: 1787035-1788564 (Clockwise)

Preceding gene: 85374580

Following gene: 85374582

Centisome position: 58.55

GC content: 63.66

Gene sequence:

>1530_bases
ATGGACATCCGCGCCGCAGAAATCTCCAAGGTCATCAAGGACCAGATCGCCAACTTCGGCACCGAAGCGCAGGTCAGCGA
AGTCGGTTCCGTTCTCTCGGTGGGTGACGGTATCGCCCGCATCCACGGCCTCGACAACGTCCAGGCCGGCGAGATGGTCG
AATTCGCCAATGGCGTGCAGGGCATGGCCCTGAACCTCGAAGCCGACAATGTCGGTGTCGTGATCTTCGGCTCGGACGCC
GAGATCAAGGAAGGCGACAACGTCAAGCGGACCGAAACCATCGTGGACGTTCCCGTCGGCAAGGCCCTGCTCGGCCGGGT
CGTCGACGCGCTGGGCAATCCGATCGACGGCAAGGGCCCGATCGAAACGACCGAGCGTCGCCGCGTCGAGCTGAAGGCCC
CGGGAATCATCCCGCGCAAGTCGGTCGACGAGCCGGTGCAGTCGGGCCTCAAGGCGATCGACGCGCTCGTTCCCGTCGGC
CGTGGCCAACGCGAGCTGATCATCGGCGACCGTCAGACCGGCAAGACCGCCGTCGCGATCGACACCTTCATCAACCAGAA
GACCGTCAACGAGAGCGACGACGAGAGCAAGAAGCTCTACTGCGTCTATGTCGCCGTCGGCCAGAAGCGCTCGACCGTCG
CGCAGATCGTGAAGTCGCTCGAAGAGAACGGCGCCATGGAATATTCCATCGTCGTCGCCGCAACCGCTTCGGAGCCTGCT
CCGCTGCAGTATCTCGCACCCTACACCGGCTGCGCCATGGGCGAGTTCTTCCGCGACAACGGCATGCACGCCGTGATCGT
GTATGACGACCTTTCCAAGCAGGCTGTCGCCTATCGCCAGATGTCGTTGCTGCTGCGCCGCCCGCCGGGCCGCGAAGCCT
ATCCGGGCGACGTTTTCTATCTTCACAGCCGCCTGCTCGAGCGTGCGGCCAAGATGAACGACGACAATGGCGGCGGTTCG
CTGACCGCCCTGCCGATCATCGAGACGCAGGCCGGCGACGTTTCGGCCTATATCCCGACCAACGTGATCTCGATCACCGA
CGGCCAGATCTTCCTCGAGACCGACCTGTTCTATCAGGGCGTGCGCCCGGCGATCAACGTCGGCCTCTCGGTCAGCCGTG
TGGGCGGTGCCGCCCAGACGAAGGCGATGAAGAAGGTCTCGGGCTCGATCAAGCTGGAGCTGGCGCAGTATCGCGAGATG
GCCGCCTTCGCCCAGTTCGGTTCGGACCTGGACGCTTCGACGCAGAAGCTGCTCAACCGCGGCGCGCGCCTGACCGAGCT
GCTCAAGCAGCCGCAGTTCAGCCCAATGCCGTTCGAAGAGCAGACCGTGTCGATCTTCGCCGGTACCAATGGCTATATCG
ACGATGTCGCCGTCGACCGCGTGACCGAATACGAATCGCAGATGCTCAGCTTCATGCGCTCCGAGCATGCGGACATACTC
AAAACCATCCGCGACACCGGCAAGTTCGAAGACGACACCAAGGCGGCCACCGTCGCCGCGCTCGACGCCTTCGCCAAGCA
GTTCGCGTAA

Upstream 100 bases:

>100_bases
GCTCGGTGGCCTCGTCGTCACCATCGGCTCCAAGCGCATCGACGGTTCGATCCGCACCCGCTTGAATACCCTCGCCAACG
CGATGAAAGGCTAAGGCACA

Downstream 100 bases:

>100_bases
GTTTCGCCGTCATCCCAGCGGAAGCTGGGATCTCGTGCCGCGAGGTACGACCTAGTGGAAAGAGACCCCAGCCTTCGCTG
GGGTGACGAAAAGGAGAGTT

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDIRAAEISKVIKDQIANFGTEAQVSEVGSVLSVGDGIARIHGLDNVQAGEMVEFANGVQGMALNLEADNVGVVIFGSDA
EIKEGDNVKRTETIVDVPVGKALLGRVVDALGNPIDGKGPIETTERRRVELKAPGIIPRKSVDEPVQSGLKAIDALVPVG
RGQRELIIGDRQTGKTAVAIDTFINQKTVNESDDESKKLYCVYVAVGQKRSTVAQIVKSLEENGAMEYSIVVAATASEPA
PLQYLAPYTGCAMGEFFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDDNGGGS
LTALPIIETQAGDVSAYIPTNVISITDGQIFLETDLFYQGVRPAINVGLSVSRVGGAAQTKAMKKVSGSIKLELAQYREM
AAFAQFGSDLDASTQKLLNRGARLTELLKQPQFSPMPFEEQTVSIFAGTNGYIDDVAVDRVTEYESQMLSFMRSEHADIL
KTIRDTGKFEDDTKAATVAALDAFAKQFA

Sequences:

>Translated_509_residues
MDIRAAEISKVIKDQIANFGTEAQVSEVGSVLSVGDGIARIHGLDNVQAGEMVEFANGVQGMALNLEADNVGVVIFGSDA
EIKEGDNVKRTETIVDVPVGKALLGRVVDALGNPIDGKGPIETTERRRVELKAPGIIPRKSVDEPVQSGLKAIDALVPVG
RGQRELIIGDRQTGKTAVAIDTFINQKTVNESDDESKKLYCVYVAVGQKRSTVAQIVKSLEENGAMEYSIVVAATASEPA
PLQYLAPYTGCAMGEFFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDDNGGGS
LTALPIIETQAGDVSAYIPTNVISITDGQIFLETDLFYQGVRPAINVGLSVSRVGGAAQTKAMKKVSGSIKLELAQYREM
AAFAQFGSDLDASTQKLLNRGARLTELLKQPQFSPMPFEEQTVSIFAGTNGYIDDVAVDRVTEYESQMLSFMRSEHADIL
KTIRDTGKFEDDTKAATVAALDAFAKQFA
>Mature_509_residues
MDIRAAEISKVIKDQIANFGTEAQVSEVGSVLSVGDGIARIHGLDNVQAGEMVEFANGVQGMALNLEADNVGVVIFGSDA
EIKEGDNVKRTETIVDVPVGKALLGRVVDALGNPIDGKGPIETTERRRVELKAPGIIPRKSVDEPVQSGLKAIDALVPVG
RGQRELIIGDRQTGKTAVAIDTFINQKTVNESDDESKKLYCVYVAVGQKRSTVAQIVKSLEENGAMEYSIVVAATASEPA
PLQYLAPYTGCAMGEFFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDDNGGGS
LTALPIIETQAGDVSAYIPTNVISITDGQIFLETDLFYQGVRPAINVGLSVSRVGGAAQTKAMKKVSGSIKLELAQYREM
AAFAQFGSDLDASTQKLLNRGARLTELLKQPQFSPMPFEEQTVSIFAGTNGYIDDVAVDRVTEYESQMLSFMRSEHADIL
KTIRDTGKFEDDTKAATVAALDAFAKQFA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=490, Percent_Identity=72.4489795918367, Blast_Score=744, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=490, Percent_Identity=72.4489795918367, Blast_Score=744, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=302, Percent_Identity=27.8145695364238, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI19913426, Length=380, Percent_Identity=26.3157894736842, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI32189394, Length=297, Percent_Identity=23.9057239057239, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI19913424, Length=387, Percent_Identity=24.031007751938, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790172, Length=515, Percent_Identity=56.504854368932, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1790170, Length=441, Percent_Identity=25.3968253968254, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788251, Length=350, Percent_Identity=26.2857142857143, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=490, Percent_Identity=72.4489795918367, Blast_Score=739, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=490, Percent_Identity=72.4489795918367, Blast_Score=738, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=490, Percent_Identity=67.1428571428571, Blast_Score=674, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17570191, Length=329, Percent_Identity=26.1398176291793, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17510931, Length=381, Percent_Identity=25.9842519685039, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71988068, Length=75, Percent_Identity=54.6666666666667, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=68, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25144756, Length=377, Percent_Identity=22.5464190981432, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=260, Percent_Identity=25.3846153846154, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=68.5258964143426, Blast_Score=729, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=370, Percent_Identity=27.5675675675676, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=356, Percent_Identity=25, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=69.5049504950495, Blast_Score=731, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=301, Percent_Identity=27.2425249169435, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646341, Length=301, Percent_Identity=27.2425249169435, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17136796, Length=301, Percent_Identity=27.2425249169435, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24638766, Length=297, Percent_Identity=24.2424242424242, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574560, Length=436, Percent_Identity=25.6880733944954, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20129479, Length=266, Percent_Identity=26.6917293233083, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583988, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583986, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583984, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583992, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_ERYLH (Q2N8Z5)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458643.1
- HSSP:   P19483
- ProteinModelPortal:   Q2N8Z5
- SMR:   Q2N8Z5
- STRING:   Q2N8Z5
- GeneID:   3868955
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_08770
- NMPDR:   fig|314225.3.peg.1289
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   Q2N8Z5
- ProtClustDB:   PRK09281
- BioCyc:   ELIT314225:ELI_08770-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 54952; Mature: 54952

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRAAEISKVIKDQIANFGTEAQVSEVGSVLSVGDGIARIHGLDNVQAGEMVEFANGVQ
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHCCCC
GMALNLEADNVGVVIFGSDAEIKEGDNVKRTETIVDVPVGKALLGRVVDALGNPIDGKGP
CEEEEEECCCEEEEEECCCCCCCCCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCCCCCC
IETTERRRVELKAPGIIPRKSVDEPVQSGLKAIDALVPVGRGQRELIIGDRQTGKTAVAI
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTFINQKTVNESDDESKKLYCVYVAVGQKRSTVAQIVKSLEENGAMEYSIVVAATASEPA
EHHHCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PLQYLAPYTGCAMGEFFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CCEEECCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKMNDDNGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETDLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEECCCCEEEEECCEEEEEEHHHHHC
VRPAINVGLSVSRVGGAAQTKAMKKVSGSIKLELAQYREMAAFAQFGSDLDASTQKLLNR
CCHHHHCCEEEHHCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHC
GARLTELLKQPQFSPMPFEEQTVSIFAGTNGYIDDVAVDRVTEYESQMLSFMRSEHADIL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KTIRDTGKFEDDTKAATVAALDAFAKQFA
HHHHHCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIRAAEISKVIKDQIANFGTEAQVSEVGSVLSVGDGIARIHGLDNVQAGEMVEFANGVQ
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHCCCC
GMALNLEADNVGVVIFGSDAEIKEGDNVKRTETIVDVPVGKALLGRVVDALGNPIDGKGP
CEEEEEECCCEEEEEECCCCCCCCCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCCCCCC
IETTERRRVELKAPGIIPRKSVDEPVQSGLKAIDALVPVGRGQRELIIGDRQTGKTAVAI
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTFINQKTVNESDDESKKLYCVYVAVGQKRSTVAQIVKSLEENGAMEYSIVVAATASEPA
EHHHCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PLQYLAPYTGCAMGEFFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CCEEECCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKMNDDNGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETDLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEECCCCEEEEECCEEEEEEHHHHHC
VRPAINVGLSVSRVGGAAQTKAMKKVSGSIKLELAQYREMAAFAQFGSDLDASTQKLLNR
CCHHHHCCEEEHHCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHC
GARLTELLKQPQFSPMPFEEQTVSIFAGTNGYIDDVAVDRVTEYESQMLSFMRSEHADIL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KTIRDTGKFEDDTKAATVAALDAFAKQFA
HHHHHCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA