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The map label for this gene is icd [H]

Identifier: 85374367

GI number: 85374367

Start: 1592290

End: 1593510

Strand: Direct

Name: icd [H]

Synonym: ELI_07700

Alternate gene names: 85374367

Gene position: 1592290-1593510 (Clockwise)

Preceding gene: 85374366

Following gene: 85374368

Centisome position: 52.17

GC content: 59.62

Gene sequence:

>1221_bases
ATGCAGAAAATCCAGGTCAAGAACCCGGTCGTCGAGCTCGATGGCGACGAAATGACGAAGATCATCTGGCAGTGGATCCG
CGAGCGGCTGATCCTGCCCTATCTCGATGTGGACCTGAGGTATTACGACCTCTCGATCGAAAGTCGCGACGAAACCGACG
ACCAGATCACCGTGGATGCCGCCAACGCGATCAAGGAACACGGCGTCGGCGTCAAATGCGCTACCATCACGCCGGACGAA
GCCCGCGTCGAAGAATTCGATCTCAAGAAAATGTGGGTCAGCCCCAACGGCACAATCCGCAATATCCTGGGCGGCGTGGT
CTTCCGCGAGCCGATCGTGATCGACAACGTGCCGCGGCTCGTCCCCGGCTGGACCGACCCTATCGTCGTCGGTCGCCATG
CATTCGGTGACCAGTATCGCGCCAAGGACACGCTTATCCCCGGCCCGGGCAAGCTTCGCCTCGTCTTCGAAGGTGCGGAC
GGCGAGAACATCGACATCGACGTTTTCGAGTTCGAAAGCTCCGGCGTCGCCATGGCGATGTACAATCTCGACCAGTCGAT
CCGCGACTTTGCCCGCGCCAGCATGAACTACGGTCTGGATCGCGGATGGCCAGTCTATCTCTCGACCAAGAACACCATCC
TCAAGAAGTACGATGGCCGTTTCAAGGACCTGTTCGAGGAAATCTACGAAGCCGAATTCAAGGACAAGTTCGAGAAGGCC
GGCATCCATTACGAGCACCGCCTGATCGACGACATGGTGGCCGCTGCCATGAAGTGGAACGGCAAGTTCGTATGGGCGTG
CAAGAACTACGACGGCGACGTCCAGTCGGACACCGTTGCGCAGGGCTTCGGGTCGCTCGGCCTGATGACTTCGGTACTGA
TGACGCCTGACGGCAAGACCGTCGAAGCGGAAGCCGCCCACGGCACGGTCACGCGCCACTATCGCCAGCACCAGCAGGGC
AAGGCGACTTCGACGAACCCGATCGCATCGATCTTCGCCTGGACCCGCGGCCTGATGTATCGCGGCAAGTTCGACGACAC
GCCCGATGTCGTGCGTTTCGCCGAAACGCTCGAGCGTGTCTGCATTGAGACAGTCGAAAGCGGCAACATGACGAAGGACC
TGGCGCTGCTGATCGGCCCGAACCAGAACTGGCTCACTACCGAGCAGTTCTTCGAGGCCATCGTGACCAATCTCGAGAAA
GAGATGGCGAACTGGAGTTGA

Upstream 100 bases:

>100_bases
TTGCACGCGGCGGCAGAAAGCCGCGTTCCCTTGCGCGAACGTCCGCCTCTGCTAAAGCGCGCCCAACTTTGAAACTCCCC
AAGAGAGGCAACAGGCAGAC

Downstream 100 bases:

>100_bases
GCTTCGGAACGCCAGGAACTTCCCAGCATGATCCAAGGGCGGCTTGCAACGGCGGGTCGCCCCTTGTGATTCCGGGCGCT
ATCACACCACCATGACCGAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MQKIQVKNPVVELDGDEMTKIIWQWIRERLILPYLDVDLRYYDLSIESRDETDDQITVDAANAIKEHGVGVKCATITPDE
ARVEEFDLKKMWVSPNGTIRNILGGVVFREPIVIDNVPRLVPGWTDPIVVGRHAFGDQYRAKDTLIPGPGKLRLVFEGAD
GENIDIDVFEFESSGVAMAMYNLDQSIRDFARASMNYGLDRGWPVYLSTKNTILKKYDGRFKDLFEEIYEAEFKDKFEKA
GIHYEHRLIDDMVAAAMKWNGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQQG
KATSTNPIASIFAWTRGLMYRGKFDDTPDVVRFAETLERVCIETVESGNMTKDLALLIGPNQNWLTTEQFFEAIVTNLEK
EMANWS

Sequences:

>Translated_406_residues
MQKIQVKNPVVELDGDEMTKIIWQWIRERLILPYLDVDLRYYDLSIESRDETDDQITVDAANAIKEHGVGVKCATITPDE
ARVEEFDLKKMWVSPNGTIRNILGGVVFREPIVIDNVPRLVPGWTDPIVVGRHAFGDQYRAKDTLIPGPGKLRLVFEGAD
GENIDIDVFEFESSGVAMAMYNLDQSIRDFARASMNYGLDRGWPVYLSTKNTILKKYDGRFKDLFEEIYEAEFKDKFEKA
GIHYEHRLIDDMVAAAMKWNGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQQG
KATSTNPIASIFAWTRGLMYRGKFDDTPDVVRFAETLERVCIETVESGNMTKDLALLIGPNQNWLTTEQFFEAIVTNLEK
EMANWS
>Mature_406_residues
MQKIQVKNPVVELDGDEMTKIIWQWIRERLILPYLDVDLRYYDLSIESRDETDDQITVDAANAIKEHGVGVKCATITPDE
ARVEEFDLKKMWVSPNGTIRNILGGVVFREPIVIDNVPRLVPGWTDPIVVGRHAFGDQYRAKDTLIPGPGKLRLVFEGAD
GENIDIDVFEFESSGVAMAMYNLDQSIRDFARASMNYGLDRGWPVYLSTKNTILKKYDGRFKDLFEEIYEAEFKDKFEKA
GIHYEHRLIDDMVAAAMKWNGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQQG
KATSTNPIASIFAWTRGLMYRGKFDDTPDVVRFAETLERVCIETVESGNMTKDLALLIGPNQNWLTTEQFFEAIVTNLEK
EMANWS

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=409, Percent_Identity=62.1026894865526, Blast_Score=550, Evalue=1e-157,
Organism=Homo sapiens, GI28178825, Length=411, Percent_Identity=63.0170316301703, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17550822, Length=408, Percent_Identity=63.7254901960784, Blast_Score=557, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17540874, Length=411, Percent_Identity=63.9902676399027, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6320137, Length=408, Percent_Identity=65.4411764705882, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6323203, Length=407, Percent_Identity=64.3734643734644, Blast_Score=555, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=60.9336609336609, Blast_Score=531, Evalue=1e-152,
Organism=Drosophila melanogaster, GI21356561, Length=408, Percent_Identity=64.9509803921569, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330987, Length=408, Percent_Identity=64.9509803921569, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI221330985, Length=408, Percent_Identity=64.9509803921569, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI28574947, Length=408, Percent_Identity=64.9509803921569, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24660849, Length=408, Percent_Identity=64.9509803921569, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24660856, Length=408, Percent_Identity=64.9509803921569, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI221330983, Length=408, Percent_Identity=64.9509803921569, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24660868, Length=408, Percent_Identity=64.9509803921569, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24660860, Length=408, Percent_Identity=64.9509803921569, Blast_Score=554, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46091; Mature: 46091

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIQVKNPVVELDGDEMTKIIWQWIRERLILPYLDVDLRYYDLSIESRDETDDQITVDA
CCCEECCCCEEEECCHHHHHHHHHHHHHHHCCCEECCEEEEEEEEECCCCCCCCEEEEEH
ANAIKEHGVGVKCATITPDEARVEEFDLKKMWVSPNGTIRNILGGVVFREPIVIDNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCC
VPGWTDPIVVGRHAFGDQYRAKDTLIPGPGKLRLVFEGADGENIDIDVFEFESSGVAMAM
CCCCCCCEEECCHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCEEEEE
YNLDQSIRDFARASMNYGLDRGWPVYLSTKNTILKKYDGRFKDLFEEIYEAEFKDKFEKA
EHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
GIHYEHRLIDDMVAAAMKWNGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKT
CCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCCCCE
VEAEAAHGTVTRHYRQHQQGKATSTNPIASIFAWTRGLMYRGKFDDTPDVVRFAETLERV
EECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHH
CIETVESGNMTKDLALLIGPNQNWLTTEQFFEAIVTNLEKEMANWS
HHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQKIQVKNPVVELDGDEMTKIIWQWIRERLILPYLDVDLRYYDLSIESRDETDDQITVDA
CCCEECCCCEEEECCHHHHHHHHHHHHHHHCCCEECCEEEEEEEEECCCCCCCCEEEEEH
ANAIKEHGVGVKCATITPDEARVEEFDLKKMWVSPNGTIRNILGGVVFREPIVIDNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCC
VPGWTDPIVVGRHAFGDQYRAKDTLIPGPGKLRLVFEGADGENIDIDVFEFESSGVAMAM
CCCCCCCEEECCHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCEEEEE
YNLDQSIRDFARASMNYGLDRGWPVYLSTKNTILKKYDGRFKDLFEEIYEAEFKDKFEKA
EHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
GIHYEHRLIDDMVAAAMKWNGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKT
CCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCCCCE
VEAEAAHGTVTRHYRQHQQGKATSTNPIASIFAWTRGLMYRGKFDDTPDVVRFAETLERV
EECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHH
CIETVESGNMTKDLALLIGPNQNWLTTEQFFEAIVTNLEKEMANWS
HHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]