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The map label for this gene is uvrD [H]

Identifier: 85374356

GI number: 85374356

Start: 1580043

End: 1582373

Strand: Direct

Name: uvrD [H]

Synonym: ELI_07645

Alternate gene names: 85374356

Gene position: 1580043-1582373 (Clockwise)

Preceding gene: 85374353

Following gene: 85374357

Centisome position: 51.76

GC content: 64.22

Gene sequence:

>2331_bases
ATGAGCGAGACCGCCCCCACCCCCGACCCGGAAACCTATCCGCTGGCCGAAGCCGCGGGCGACGTCGACCTGCCGGCCTA
TGCGGAGCGGCTCAACATGCCGCAGCGCGAAGCGGTGCTGACCAGCGAGGGCCCGGTCCTGATGCTGGCAGGTGCCGGGA
CGGGCAAGACCGCGGCGCTGACCGCCCGGCTCGCGCATCTCATCGCCACGCGCAAGGCGTGGCCGAGCGAGATCCTGTGC
GTCACCTTCACCAACAAGGCCGCGCGCGAGATGCGCAGCCGCGTCGGCCAACACATTGGCGATGCGGTCGAAGGCATGCC
CTGGCTCGGCACCTTCCATTCGATCTGCGCGCGCATGCTGCGCCGCCATGCCGAGCTGGTGAAGCTGCAGAGCAATTACA
CTATCATCGATACTGACGATCAACTGCGGCTGCTAAAGCAGCTGATCCAGCAGAACGACCTCGACGAAAAGCGCTGGCCC
GCGCGCCAGCTCGCCGGGCTGATCGACCGCTGGAAGAACCGCGGACTCAATCCCGGCGATCTCGATGCAGTGGAAAACGA
AAGCTACGCCAACGGACGCGGCGCGCAGTTTTACGAGCTCTACCAGACGCGGCTGAAAGAGCTGAACGCCTGCGATTTCG
GCGACCTGCTGCTGCACATGCTCAACATCTTCCGCAAGCACCGCGACGTGCTGGAGCAATACCAGAAGCGGTTCAAATAC
GTGCTGGTGGACGAATACCAGGATACCAACGCGGTCCAGTACCTGTGGCTGCGGCTGCTGGCGCAGGAGCGCAAGAACAT
CTGCGTGGTCGGTGACGACGACCAGTCGATCTATTCCTGGCGCGGCGCGGAAGTCGCCAACATCCTGCGTTTCGAAAAAG
ACTTTCCCGGCGCCAAAGTCATTAAGCTGGAACAGAATTATCGCTCGACGCCGCATATTCTCGCCGCCGCCTCGGGCCTG
ATCACCGCCAATAGCGAGCGGCTCGGCAAGACTTTGTGGACCGAGGTCAATGCCGGCGAAAAGGTCCGCGTGATCGGCGT
GTGGGACGGGCCCGAAGAGGCGCGCCGCGTCGGCGAGGAGATCGAGCGGCTCGAACGCGAAGGCGCGCCGCTGGACGAAG
TGGCGATCCTCGTGCGGGCACAATACCAGACGCGCGAATTCGAGGACCGCTTCATCCAGATCGGCCTCAACTACCGCATC
ATTGGCGGCTTCCGCTTCTACGAGCGCGCCGAAATTCGCGACGCCCTCGCCTATTTGCGCGTCATCGCCCAGCCGCAGGA
CGACCTTGCGTTCGAGCGTATCTACAACCAGCCCAAGCGCGGCCTCGGCGCAAAAACGCTGGAGAAGATGCACCAGCACG
CGCGCCGCACAGGCCTTCCGCTCGCCGCCGCCTCGCTGCAACTGGCAGACAGCGACGAACTCCCCGCGCGCGCATCGAAC
ACGATCGGCGGGCTGATGAAGCAGTTCCTGCATTGGCGCGAACAGTCGGAAAAAACCGAGCCTGCCGAATTGCTGCGGCA
GGTCCTCGACGAGAGCGGCTACACCGCCATGCTCGAAAATGAGAAGACTGCCGAGGCCAAAGGACGGCTCGAAAACCTTT
CCGAACTCGCCCGCGCCATGGAGGAATACGAAACGCTCGGCGATTTCCTCGAACATGTCGCGCTGGTCATGGACAATGAC
GCGAACCCCGACGAGGAAAAGGTCACCATCATGACCATGCATGCGGCCAAGGGGCTGGAATTCAATCACGTCTTCCTGCC
GGGCTGGGAAGAAGGTGTTTTCCCCAGCCAGCGCGCGCTCGACGAAGGCGGGCTCGCGAGCCTCGAAGAGGAACGGCGCC
TGGCCTATGTCGCCATTACCCGCGCGCGGCGCCGCTGCACGATCCTCCACGCCGCCAACCGCCGCATTTACGGCCAGTGG
ACGAGCAGCATCCCCAGCCGGTTCATCGAGGAACTGCCGGATGAGCAGGTCGAGAGCGAAACCACGCTGACCGGCGGCGC
ATCGCTTTGGCGCGCCAATTGGAGCGAGAGCGACGATCCGTTCGCCCATGTCGCCCGCGACAAGCCGGATCGATCGGCCC
AGCGCGGCCCCGGCTGGCAGCGCGCGCTCGAAAGCGGCTACGACACCAAACAGCTCGCGGTGAAGGAGAGCCGCCGCAGC
GCCGCCAGCTTCGCCGCCCGGCCTCGCACCGATATCGCGGTCGGCGCGCGCGTGTTCCACGACAAGTTCGGCTACGGCAT
CGTGATGGACCAGGAAGGCAACAAGCTCGAGATCGAATTCGAGAAGAGCGGCACGAAGCGCGTGATCGACAGTTTTGTCA
CAGCGGCCTGA

Upstream 100 bases:

>100_bases
TATGCCTAATCAATGAAAAAAGCCGGTGCAGGTTCCACAAACTTTCCGGAACCTCAGCCTTGCTCATGTGTTGCGCGTTC
CCTAACTGTTCGCTGACAGC

Downstream 100 bases:

>100_bases
GCCCCGTCGTATCGAGGAACTCCGAGCCGCTCAGTCGGTTGAATGTCGACACGGTGCGTCATGCAGTCGCAGGGCCGGGC
TCACCGACATCGCATGAGAC

Product: DNA and RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 775

Protein sequence:

>776_residues
MSETAPTPDPETYPLAEAAGDVDLPAYAERLNMPQREAVLTSEGPVLMLAGAGTGKTAALTARLAHLIATRKAWPSEILC
VTFTNKAAREMRSRVGQHIGDAVEGMPWLGTFHSICARMLRRHAELVKLQSNYTIIDTDDQLRLLKQLIQQNDLDEKRWP
ARQLAGLIDRWKNRGLNPGDLDAVENESYANGRGAQFYELYQTRLKELNACDFGDLLLHMLNIFRKHRDVLEQYQKRFKY
VLVDEYQDTNAVQYLWLRLLAQERKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKVIKLEQNYRSTPHILAAASGL
ITANSERLGKTLWTEVNAGEKVRVIGVWDGPEEARRVGEEIERLEREGAPLDEVAILVRAQYQTREFEDRFIQIGLNYRI
IGGFRFYERAEIRDALAYLRVIAQPQDDLAFERIYNQPKRGLGAKTLEKMHQHARRTGLPLAAASLQLADSDELPARASN
TIGGLMKQFLHWREQSEKTEPAELLRQVLDESGYTAMLENEKTAEAKGRLENLSELARAMEEYETLGDFLEHVALVMDND
ANPDEEKVTIMTMHAAKGLEFNHVFLPGWEEGVFPSQRALDEGGLASLEEERRLAYVAITRARRRCTILHAANRRIYGQW
TSSIPSRFIEELPDEQVESETTLTGGASLWRANWSESDDPFAHVARDKPDRSAQRGPGWQRALESGYDTKQLAVKESRRS
AASFAARPRTDIAVGARVFHDKFGYGIVMDQEGNKLEIEFEKSGTKRVIDSFVTAA

Sequences:

>Translated_776_residues
MSETAPTPDPETYPLAEAAGDVDLPAYAERLNMPQREAVLTSEGPVLMLAGAGTGKTAALTARLAHLIATRKAWPSEILC
VTFTNKAAREMRSRVGQHIGDAVEGMPWLGTFHSICARMLRRHAELVKLQSNYTIIDTDDQLRLLKQLIQQNDLDEKRWP
ARQLAGLIDRWKNRGLNPGDLDAVENESYANGRGAQFYELYQTRLKELNACDFGDLLLHMLNIFRKHRDVLEQYQKRFKY
VLVDEYQDTNAVQYLWLRLLAQERKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKVIKLEQNYRSTPHILAAASGL
ITANSERLGKTLWTEVNAGEKVRVIGVWDGPEEARRVGEEIERLEREGAPLDEVAILVRAQYQTREFEDRFIQIGLNYRI
IGGFRFYERAEIRDALAYLRVIAQPQDDLAFERIYNQPKRGLGAKTLEKMHQHARRTGLPLAAASLQLADSDELPARASN
TIGGLMKQFLHWREQSEKTEPAELLRQVLDESGYTAMLENEKTAEAKGRLENLSELARAMEEYETLGDFLEHVALVMDND
ANPDEEKVTIMTMHAAKGLEFNHVFLPGWEEGVFPSQRALDEGGLASLEEERRLAYVAITRARRRCTILHAANRRIYGQW
TSSIPSRFIEELPDEQVESETTLTGGASLWRANWSESDDPFAHVARDKPDRSAQRGPGWQRALESGYDTKQLAVKESRRS
AASFAARPRTDIAVGARVFHDKFGYGIVMDQEGNKLEIEFEKSGTKRVIDSFVTAA
>Mature_775_residues
SETAPTPDPETYPLAEAAGDVDLPAYAERLNMPQREAVLTSEGPVLMLAGAGTGKTAALTARLAHLIATRKAWPSEILCV
TFTNKAAREMRSRVGQHIGDAVEGMPWLGTFHSICARMLRRHAELVKLQSNYTIIDTDDQLRLLKQLIQQNDLDEKRWPA
RQLAGLIDRWKNRGLNPGDLDAVENESYANGRGAQFYELYQTRLKELNACDFGDLLLHMLNIFRKHRDVLEQYQKRFKYV
LVDEYQDTNAVQYLWLRLLAQERKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKVIKLEQNYRSTPHILAAASGLI
TANSERLGKTLWTEVNAGEKVRVIGVWDGPEEARRVGEEIERLEREGAPLDEVAILVRAQYQTREFEDRFIQIGLNYRII
GGFRFYERAEIRDALAYLRVIAQPQDDLAFERIYNQPKRGLGAKTLEKMHQHARRTGLPLAAASLQLADSDELPARASNT
IGGLMKQFLHWREQSEKTEPAELLRQVLDESGYTAMLENEKTAEAKGRLENLSELARAMEEYETLGDFLEHVALVMDNDA
NPDEEKVTIMTMHAAKGLEFNHVFLPGWEEGVFPSQRALDEGGLASLEEERRLAYVAITRARRRCTILHAANRRIYGQWT
SSIPSRFIEELPDEQVESETTLTGGASLWRANWSESDDPFAHVARDKPDRSAQRGPGWQRALESGYDTKQLAVKESRRSA
ASFAARPRTDIAVGARVFHDKFGYGIVMDQEGNKLEIEFEKSGTKRVIDSFVTAA

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=768, Percent_Identity=40.234375, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI48994965, Length=652, Percent_Identity=37.5766871165644, Blast_Score=388, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322369, Length=736, Percent_Identity=28.3967391304348, Blast_Score=201, Evalue=3e-52,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87876; Mature: 87745

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETAPTPDPETYPLAEAAGDVDLPAYAERLNMPQREAVLTSEGPVLMLAGAGTGKTAAL
CCCCCCCCCCCCCCHHHHCCCCCCHHHHHHCCCCHHHEEEECCCCEEEEECCCCCCHHHH
TARLAHLIATRKAWPSEILCVTFTNKAAREMRSRVGQHIGDAVEGMPWLGTFHSICARML
HHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RRHAELVKLQSNYTIIDTDDQLRLLKQLIQQNDLDEKRWPARQLAGLIDRWKNRGLNPGD
HHHHHHHEECCCEEEEECCHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHCCCCCCC
LDAVENESYANGRGAQFYELYQTRLKELNACDFGDLLLHMLNIFRKHRDVLEQYQKRFKY
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VLVDEYQDTNAVQYLWLRLLAQERKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKV
EEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCCCCEE
IKLEQNYRSTPHILAAASGLITANSERLGKTLWTEVNAGEKVRVIGVWDGPEEARRVGEE
EEEECCCCCCCHHHHHHCCCEECCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
IERLEREGAPLDEVAILVRAQYQTREFEDRFIQIGLNYRIIGGFRFYERAEIRDALAYLR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEECCHHHHHHHHHHHHHHHH
VIAQPQDDLAFERIYNQPKRGLGAKTLEKMHQHARRTGLPLAAASLQLADSDELPARASN
HHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCHHHH
TIGGLMKQFLHWREQSEKTEPAELLRQVLDESGYTAMLENEKTAEAKGRLENLSELARAM
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
EEYETLGDFLEHVALVMDNDANPDEEKVTIMTMHAAKGLEFNHVFLPGWEEGVFPSQRAL
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHC
DEGGLASLEEERRLAYVAITRARRRCTILHAANRRIYGQWTSSIPSRFIEELPDEQVESE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEHHHHHHHHHHHHHCCHHHHCCC
TTLTGGASLWRANWSESDDPFAHVARDKPDRSAQRGPGWQRALESGYDTKQLAVKESRRS
CEECCCHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
AASFAARPRTDIAVGARVFHDKFGYGIVMDQEGNKLEIEFEKSGTKRVIDSFVTAA
HHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SETAPTPDPETYPLAEAAGDVDLPAYAERLNMPQREAVLTSEGPVLMLAGAGTGKTAAL
CCCCCCCCCCCCCHHHHCCCCCCHHHHHHCCCCHHHEEEECCCCEEEEECCCCCCHHHH
TARLAHLIATRKAWPSEILCVTFTNKAAREMRSRVGQHIGDAVEGMPWLGTFHSICARML
HHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RRHAELVKLQSNYTIIDTDDQLRLLKQLIQQNDLDEKRWPARQLAGLIDRWKNRGLNPGD
HHHHHHHEECCCEEEEECCHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHCCCCCCC
LDAVENESYANGRGAQFYELYQTRLKELNACDFGDLLLHMLNIFRKHRDVLEQYQKRFKY
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VLVDEYQDTNAVQYLWLRLLAQERKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKV
EEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCCCCEE
IKLEQNYRSTPHILAAASGLITANSERLGKTLWTEVNAGEKVRVIGVWDGPEEARRVGEE
EEEECCCCCCCHHHHHHCCCEECCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
IERLEREGAPLDEVAILVRAQYQTREFEDRFIQIGLNYRIIGGFRFYERAEIRDALAYLR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEECCHHHHHHHHHHHHHHHH
VIAQPQDDLAFERIYNQPKRGLGAKTLEKMHQHARRTGLPLAAASLQLADSDELPARASN
HHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCHHHH
TIGGLMKQFLHWREQSEKTEPAELLRQVLDESGYTAMLENEKTAEAKGRLENLSELARAM
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
EEYETLGDFLEHVALVMDNDANPDEEKVTIMTMHAAKGLEFNHVFLPGWEEGVFPSQRAL
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHC
DEGGLASLEEERRLAYVAITRARRRCTILHAANRRIYGQWTSSIPSRFIEELPDEQVESE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEHHHHHHHHHHHHHCCHHHHCCC
TTLTGGASLWRANWSESDDPFAHVARDKPDRSAQRGPGWQRALESGYDTKQLAVKESRRS
CEECCCHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
AASFAARPRTDIAVGARVFHDKFGYGIVMDQEGNKLEIEFEKSGTKRVIDSFVTAA
HHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA