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The map label for this gene is fabG [H]

Identifier: 85374261

GI number: 85374261

Start: 1483954

End: 1484679

Strand: Direct

Name: fabG [H]

Synonym: ELI_07170

Alternate gene names: 85374261

Gene position: 1483954-1484679 (Clockwise)

Preceding gene: 85374255

Following gene: 85374262

Centisome position: 48.62

GC content: 67.36

Gene sequence:

>726_bases
ATGTCCACCATCCTCCTCACCGGCTCCAGCCGCGGCATCGGTGCCGCCACCCGCGAAATGCTCGAAGCGCGCGGGGCCAG
GGTGATCGGGCATTCGACGCAAGGCGACGGCGAAAGCGAACTCGCCGCCGATTTTACCGAGCCGACCGCGCCGCAGATGT
TGTGGGAACATGCGCTGGAAATGGCCGGAGGGCGGATCGATGTGCTGATCAACAATGCCGGGTTGTTCCAGCAGAATCCG
CTCAATGCCGCCGATATCCGCTGGCTCGATGCGTGGGAGGACACGCTGCGGATCAACCTGACGGCCGCCGCGCAGCTCAG
CCGCTTCGCCGTCCAGCACTGGCTGGAGCGGGAGCGGGCCGATAGCGAGGAAGCGGGCCGCATCGTCCATATCGCCAGCC
GGGCGGGACATCGCGGGGACAGCCCGGCGCACTGGCACTACGCCGCGGCGAAGGGCGGAATGCTGGCGATGCACAAGACC
ATCGCGCGCGCGTATGGGAACGACGGCATCTACAGCTATGCCGTTACGCCGGGCTTCACCGACACATCGATGGCGGGCGA
CTATCTCGAAAGCCGCGGCGGACCGGGCCTGCTGGCCGACATCCCGCTCGGCCGCGTCGCTAAGCCCGAGGAAATCGCCA
ATGTCGCGACCTATCTCGCGCTCGATGCCCCACCCAGCCTGACCGGCGCGACGCTGGACGCAAACGGGGCGAGCTATGTC
CGCTAG

Upstream 100 bases:

>100_bases
ACGAGCGCTCTGTGCAAGGATAGGCTAAGGGCCGTGCACCAAAGTCCGGTCGTCGATCCATGCTCGACAGCCGCTTCCCC
TTGCGCGTATCGCTCGCGCC

Downstream 100 bases:

>100_bases
CGATATGAAAACGCGCACCACCTCGTCATCCCCGCGCAGGCGGGGATCCAGCTTCTTTTTGGCGCACCTGTGAAGAAGGG
AGGTCACGTCTATATCATGG

Product: 3-oxoacyl-[acyl-carrier-protein] reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSTILLTGSSRGIGAATREMLEARGARVIGHSTQGDGESELAADFTEPTAPQMLWEHALEMAGGRIDVLINNAGLFQQNP
LNAADIRWLDAWEDTLRINLTAAAQLSRFAVQHWLERERADSEEAGRIVHIASRAGHRGDSPAHWHYAAAKGGMLAMHKT
IARAYGNDGIYSYAVTPGFTDTSMAGDYLESRGGPGLLADIPLGRVAKPEEIANVATYLALDAPPSLTGATLDANGASYV
R

Sequences:

>Translated_241_residues
MSTILLTGSSRGIGAATREMLEARGARVIGHSTQGDGESELAADFTEPTAPQMLWEHALEMAGGRIDVLINNAGLFQQNP
LNAADIRWLDAWEDTLRINLTAAAQLSRFAVQHWLERERADSEEAGRIVHIASRAGHRGDSPAHWHYAAAKGGMLAMHKT
IARAYGNDGIYSYAVTPGFTDTSMAGDYLESRGGPGLLADIPLGRVAKPEEIANVATYLALDAPPSLTGATLDANGASYV
R
>Mature_240_residues
STILLTGSSRGIGAATREMLEARGARVIGHSTQGDGESELAADFTEPTAPQMLWEHALEMAGGRIDVLINNAGLFQQNPL
NAADIRWLDAWEDTLRINLTAAAQLSRFAVQHWLERERADSEEAGRIVHIASRAGHRGDSPAHWHYAAAKGGMLAMHKTI
ARAYGNDGIYSYAVTPGFTDTSMAGDYLESRGGPGLLADIPLGRVAKPEEIANVATYLALDAPPSLTGATLDANGASYVR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=239, Percent_Identity=29.7071129707113, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=27.9166666666667, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=25.4752851711027, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI109715829, Length=233, Percent_Identity=26.1802575107296, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=34.6774193548387, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=26.3358778625954, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=25.8823529411765, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=27.6, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=27.4131274131274, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367175, Length=256, Percent_Identity=27.34375, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=24.3027888446215, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=27.710843373494, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=244, Percent_Identity=28.2786885245902, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=266, Percent_Identity=25.5639097744361, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=248, Percent_Identity=27.0161290322581, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=25.5639097744361, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=24.2537313432836, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=23.7918215613383, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=26.2172284644195, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=25, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=26.0377358490566, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=26.2295081967213, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25737; Mature: 25606

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTILLTGSSRGIGAATREMLEARGARVIGHSTQGDGESELAADFTEPTAPQMLWEHALE
CCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHH
MAGGRIDVLINNAGLFQQNPLNAADIRWLDAWEDTLRINLTAAAQLSRFAVQHWLERERA
HCCCEEEEEECCCCCCCCCCCCHHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHC
DSEEAGRIVHIASRAGHRGDSPAHWHYAAAKGGMLAMHKTIARAYGNDGIYSYAVTPGFT
CHHHCCCEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
DTSMAGDYLESRGGPGLLADIPLGRVAKPEEIANVATYLALDAPPSLTGATLDANGASYV
CHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHEEECCCCCCCCCEECCCCCCCC
R
C
>Mature Secondary Structure 
STILLTGSSRGIGAATREMLEARGARVIGHSTQGDGESELAADFTEPTAPQMLWEHALE
CEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHH
MAGGRIDVLINNAGLFQQNPLNAADIRWLDAWEDTLRINLTAAAQLSRFAVQHWLERERA
HCCCEEEEEECCCCCCCCCCCCHHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHC
DSEEAGRIVHIASRAGHRGDSPAHWHYAAAKGGMLAMHKTIARAYGNDGIYSYAVTPGFT
CHHHCCCEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
DTSMAGDYLESRGGPGLLADIPLGRVAKPEEIANVATYLALDAPPSLTGATLDANGASYV
CHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHEEECCCCCCCCCEECCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1556094; 8905232; 9278503; 1314802 [H]