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The map label for this gene is hpd [H]

Identifier: 85374110

GI number: 85374110

Start: 1333082

End: 1334203

Strand: Direct

Name: hpd [H]

Synonym: ELI_06415

Alternate gene names: 85374110

Gene position: 1333082-1334203 (Clockwise)

Preceding gene: 85374106

Following gene: 85374111

Centisome position: 43.67

GC content: 59.63

Gene sequence:

>1122_bases
ATGGCCGATCTATTCGAAAATCCCGCTGGTCTCGACGGCTTCGAGTTCGTCGAATTCTGCGCGCCCGAGAAAGGCCAGCT
TGAACCTGTGTTCGAAGCAATGGGCTTCACCCATGTCGCAACGCACCGCTCGAAAGACGTGCATTTGTGGCGCCAGGGCG
GCATCAACCTGATCGCGAATTACGAACCGCGCAGCGCCGCGTGGTATTTCGCGCGCGAGCACGGCCCTTCGGCCTGTGGC
ATGGCGTTCCGCGTGAAAGATGCGGCCGCCGCCTGGGATCACCTGATGGATGCAGGGGCCGAACCGGTGCAGGTCGAAAC
CGGCCCGATGGAACTCGCGATCCCTGCGATCCGCGGAATCGGCGGCGCGATCCTGTATCTCGTCGATCGTTATGAGGACG
AGAACGGTGATGGTTTGTCGATCTACGACATCGACTTCGACTATCTGCCGGGTGTCGACAAATACCCCGAGGGCGCAGGT
TTCAAGGTCATCGATCACCTGACCCACAACGTCTACACTGGCCGCATGAAGTACTGGGCGGACTATTACGAGACGCTCTT
CAACTTCAAGGAAATCCGCTTTTTCGACATCAAAGGCGAATATACCGGCCTGACCTCCAAGGCCCTGACCGCGCCCGACG
GCAAGATCCGCATCCCGCTCAACGAAGAAGGCGAAGGCGGCAAGGGCCAGATCGAGGAGTTCCTGCGCGAGTTCAACGGC
GAAGGCATCCAGCACATCGCGTTGATCTGCGATGATCTCATCTCCTGTTGGGACCGGCTGAAGGAATTCGGCGTGCCGTT
CATGACCGCGCCGCCGGAAACCTATTACGAAATGCTCGATGAGCGTTTGCCCGGCCATGGCGAGAATGTCGACGAACTCA
AAATGCGCGGCATCCTGCTCGACGGCACGACTGAGGGCGGTCAGCCCCGCCTGCTGCTGCAGATTTTTGCCGAAGCGCAG
GTCGGCCCGGTGTTCTTCGAATTCATCCAGCGCAAGGGTGACGAAGGCTTCGGCGAAGGGAACTTCAAGGCACTGTTCGA
GTCGATGGAACGCGACCAGATCAAGCGCGGAACCCTGAGTGTCGATGACGCCAAGAGCGTCGAAGCGGAGCCGGCAGAAT
GA

Upstream 100 bases:

>100_bases
ACATTTTACACCCGCCCTACCCCTTGTGTAAATTCGCCTAATGCGATATAGTTTCTCTTGAAACTAGTTTGCCGACCTCA
GAATATTCAGGAGTTCCCCC

Downstream 100 bases:

>100_bases
ACGACCAGTCCAGCCATCCCGTAAAACTGGGCGGCGTCCACCATGCCGCCTATCGCTGCAAGGACGCGAAGGAGACCGTC
GAATGGTACGGCCGCGTCCT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MADLFENPAGLDGFEFVEFCAPEKGQLEPVFEAMGFTHVATHRSKDVHLWRQGGINLIANYEPRSAAWYFAREHGPSACG
MAFRVKDAAAAWDHLMDAGAEPVQVETGPMELAIPAIRGIGGAILYLVDRYEDENGDGLSIYDIDFDYLPGVDKYPEGAG
FKVIDHLTHNVYTGRMKYWADYYETLFNFKEIRFFDIKGEYTGLTSKALTAPDGKIRIPLNEEGEGGKGQIEEFLREFNG
EGIQHIALICDDLISCWDRLKEFGVPFMTAPPETYYEMLDERLPGHGENVDELKMRGILLDGTTEGGQPRLLLQIFAEAQ
VGPVFFEFIQRKGDEGFGEGNFKALFESMERDQIKRGTLSVDDAKSVEAEPAE

Sequences:

>Translated_373_residues
MADLFENPAGLDGFEFVEFCAPEKGQLEPVFEAMGFTHVATHRSKDVHLWRQGGINLIANYEPRSAAWYFAREHGPSACG
MAFRVKDAAAAWDHLMDAGAEPVQVETGPMELAIPAIRGIGGAILYLVDRYEDENGDGLSIYDIDFDYLPGVDKYPEGAG
FKVIDHLTHNVYTGRMKYWADYYETLFNFKEIRFFDIKGEYTGLTSKALTAPDGKIRIPLNEEGEGGKGQIEEFLREFNG
EGIQHIALICDDLISCWDRLKEFGVPFMTAPPETYYEMLDERLPGHGENVDELKMRGILLDGTTEGGQPRLLLQIFAEAQ
VGPVFFEFIQRKGDEGFGEGNFKALFESMERDQIKRGTLSVDDAKSVEAEPAE
>Mature_372_residues
ADLFENPAGLDGFEFVEFCAPEKGQLEPVFEAMGFTHVATHRSKDVHLWRQGGINLIANYEPRSAAWYFAREHGPSACGM
AFRVKDAAAAWDHLMDAGAEPVQVETGPMELAIPAIRGIGGAILYLVDRYEDENGDGLSIYDIDFDYLPGVDKYPEGAGF
KVIDHLTHNVYTGRMKYWADYYETLFNFKEIRFFDIKGEYTGLTSKALTAPDGKIRIPLNEEGEGGKGQIEEFLREFNGE
GIQHIALICDDLISCWDRLKEFGVPFMTAPPETYYEMLDERLPGHGENVDELKMRGILLDGTTEGGQPRLLLQIFAEAQV
GPVFFEFIQRKGDEGFGEGNFKALFESMERDQIKRGTLSVDDAKSVEAEPAE

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=356, Percent_Identity=30.0561797752809, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI4504477, Length=306, Percent_Identity=31.3725490196078, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI14249394, Length=312, Percent_Identity=27.5641025641026, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17550752, Length=342, Percent_Identity=31.2865497076023, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17555220, Length=315, Percent_Identity=33.015873015873, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24667510, Length=358, Percent_Identity=32.122905027933, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21356105, Length=310, Percent_Identity=33.2258064516129, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41784; Mature: 41653

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLFENPAGLDGFEFVEFCAPEKGQLEPVFEAMGFTHVATHRSKDVHLWRQGGINLIAN
CCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHCCHHHHHCCCCCEEEEECCCEEEEEE
YEPRSAAWYFAREHGPSACGMAFRVKDAAAAWDHLMDAGAEPVQVETGPMELAIPAIRGI
CCCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHCC
GGAILYLVDRYEDENGDGLSIYDIDFDYLPGVDKYPEGAGFKVIDHLTHNVYTGRMKYWA
CCEEEEEEECCCCCCCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHEECHHHHHH
DYYETLFNFKEIRFFDIKGEYTGLTSKALTAPDGKIRIPLNEEGEGGKGQIEEFLREFNG
HHHHHHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHCC
EGIQHIALICDDLISCWDRLKEFGVPFMTAPPETYYEMLDERLPGHGENVDELKMRGILL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCEEEE
DGTTEGGQPRLLLQIFAEAQVGPVFFEFIQRKGDEGFGEGNFKALFESMERDQIKRGTLS
ECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
VDDAKSVEAEPAE
CCCCCCCCCCCCC
>Mature Secondary Structure 
ADLFENPAGLDGFEFVEFCAPEKGQLEPVFEAMGFTHVATHRSKDVHLWRQGGINLIAN
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHCCHHHHHCCCCCEEEEECCCEEEEEE
YEPRSAAWYFAREHGPSACGMAFRVKDAAAAWDHLMDAGAEPVQVETGPMELAIPAIRGI
CCCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHCC
GGAILYLVDRYEDENGDGLSIYDIDFDYLPGVDKYPEGAGFKVIDHLTHNVYTGRMKYWA
CCEEEEEEECCCCCCCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHEECHHHHHH
DYYETLFNFKEIRFFDIKGEYTGLTSKALTAPDGKIRIPLNEEGEGGKGQIEEFLREFNG
HHHHHHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHCC
EGIQHIALICDDLISCWDRLKEFGVPFMTAPPETYYEMLDERLPGHGENVDELKMRGILL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCEEEE
DGTTEGGQPRLLLQIFAEAQVGPVFFEFIQRKGDEGFGEGNFKALFESMERDQIKRGTLS
ECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
VDDAKSVEAEPAE
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]