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The map label for this gene is rnr [H]

Identifier: 85374050

GI number: 85374050

Start: 1266676

End: 1268922

Strand: Direct

Name: rnr [H]

Synonym: ELI_06115

Alternate gene names: 85374050

Gene position: 1266676-1268922 (Clockwise)

Preceding gene: 85374049

Following gene: 85374051

Centisome position: 41.5

GC content: 63.64

Gene sequence:

>2247_bases
ATGCCCTCGCGCGAGCAAGTCCTCGAATTCATCCAGTCCTCCGACACTCCCGCCGGCAAGCGCGAAATCGCCAAAGCGTT
CGGGCTGAAAGGGCAGGAAAAGATCGGGCTCAAGCGCCTGCTCAAGGATATGGCCGAAGAAGGCCTCATCGACGGCAAGA
AAACCGCCTATCATCGCATGGGCGGCGTGCCGAAAGTCACTGTCCTGCGCATTGTCGAAATCGACGATGGCGAATCCGTC
GCCGAGCCGGAAAACTGGAACCCCGATAGCGGCGAAAAGCCGCCGCGCCTGACTATAGTCGAAAGCAAGGGGGGTCGCGG
CGGGAAGCGCATGCCCGCGCTGAAACGCGGAGACCGGGTCCTCGCCCGAACCGAAGAAAGCGGGAAGGGCTGGCGCGCCT
ATCCGATGAAAAAACTGCCGGCCCGAACCGAAGGGCTGATGGGCGTCGTCGAGATCGACAAGGCGGGCAAGGCATGGCTC
GCCCCGATCGACAAGAAAGTGCGCAACTCGTCGCCCATAAGCGACCTCAATGGTTCCGAGGATGGCGAGCTGGTGCTGGC
CGAACCGGCTGGCAAGGGCCCGCGCTCGGGCGTCAACGTAACCGAAGTCGTCGGCGATCCCCTCGCGCCCAAGAGCTTCA
GCCTGATCGCTATTGCCAAGCACGGCATCCCCCATGTCTTCCCCGAAGCTGCGCTGGAAGAAGCCCAACGCGCCGCGACG
CTTCCGCTGAGCGAAGACAGGCGCGAGGACCTGCGCGATGTCCCGATTCTCGCGATCGATCCGGCCGATGCGCGCGATCA
TGACGATGCCATCTGGGCAGAGCCCGACGGCGAGGGCGGCTTCGACACCATCGTCGCGATTGCAGATGTGAGCTATTACG
TCCGCCCGGGCGGCGCACTCGACCGCGAAGCGCGCAAGCGCGGCAACTCGGTCTATTTCCCCGACCGCGTCGTCCCAATG
CTGCCCGAGGTGCTGAGCGCCGATGCCTGCTCGCTCAAGCACGGGCAGGATCGCGCCGCGATGGCCTGTCACCTGAGGGT
ATCGGCTGAAGGGAAAGTCACCTCGTGGCGCTTCACCCGGGCGATCGTACGGCTCACGCACAATATCGCTTATGAGGACG
CACAAGCGGCCATCGACAGCGGCGATGCTAGCACGGAATTGCAGAACCTCTGGGCCTGCTGGCGCGCGCTCGAGAAGGCG
CGTCATGCGCGCGACCCGCTCGAGCTGGAATTGCCCGAGCGCCGCGTGGTGCTCGACGACGAGGGCCAGATCGCGGACAT
CGCAGTGCGCGAACGGCTCGATGCGCATCGTGTGGTCGAGGATTTCATGATCGCGGCCAATGTCGCGGCGGCTAAGGCGC
TCGAGGCCAAGACCGCGCCGGTGGTCTATCGCATTCATGAACCGCCCAGTCGGGAGAAGCTGATCGCACTGCGAGACTAC
CTCGCGACGCAGGACCGCAAGCTCGCCCTGGGTCAAGTGGTGACGCCGACCCTTTTCAACCGGTTTCTCAAAGACGTGTC
GGACGAGACAGAGCGGGCGCTGCTCATGGAAGCTGTGCTGCGCAGCCAGACACAGGCCTATTACGGGCCGAACAATGCCG
GCCATTTCGGCCTCGCGCTCGGCTCCTATGCGCATTTCACCTCGCCGATCCGGCGCTATTCCGATTTGCTGGTGCATCGC
GCGCTGGTCGACGCTTACGGGCTGGAGCAACCCAAGCCCGCGAAGGGCCTGCCGGATGCCTCTGGCCTGTCGGACCGGGA
CCGGCAGGATCTCCAGCAGATTACCGATGCCATAAGCACCACCGAGCGGCGCGCGATGGAAGCCGAGCGCGACACGATCG
ACCGCTATGTCGCAGCGTATCTCGCGCAGCACGTCGGCAAGACATTTCAGACCCGCATCACCGGGGTGCAAAACTTTGGT
TTTTTTGCGACGATTCTGAATCTCGGTGGTGACGGACTGGTGCCCGTTTCGACGCTCGGGCGCGAGTATTATCGCTACGA
CGAGGCGGCACAGGCGCTGGTCGGCGAAGACAGCGGCAAACGCTACGACGTCGCGCAAAAACTGGAGCTGAAACTGGCGG
AAGCCAATCCGCTCACGGGTGCCCTCAAGTTCGAACCGCTGGATGACGAGAGCGGGAATGCGGAAAGACGCGGCCAACAA
GCTGCGCCGCGCGAGAAGGGCAAGTCTAAGCAGGGAAACCGTGGCCGCCCCAAAAATATTCGTCATCAGGGCAGGCGCCG
CAAATAG

Upstream 100 bases:

>100_bases
TCGTGCCGATCGCTGAGGAAGGGGATGACACCGCCTAGGTCCGACCCCATATGGTCGGCATATGAACCAGAAGAAAAATA
GAAAACCGCGCGCGCATGGA

Downstream 100 bases:

>100_bases
GTCGGAACAGCACAGGCGCGGGGGCCGTTATCCGAGCAAAGGAGAAATATACCGATGCTCAAGCCAGGCCAGAAAGTCCC
CGATCTCGAATTGCCCCTCA

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R [H]

Number of amino acids: Translated: 748; Mature: 747

Protein sequence:

>748_residues
MPSREQVLEFIQSSDTPAGKREIAKAFGLKGQEKIGLKRLLKDMAEEGLIDGKKTAYHRMGGVPKVTVLRIVEIDDGESV
AEPENWNPDSGEKPPRLTIVESKGGRGGKRMPALKRGDRVLARTEESGKGWRAYPMKKLPARTEGLMGVVEIDKAGKAWL
APIDKKVRNSSPISDLNGSEDGELVLAEPAGKGPRSGVNVTEVVGDPLAPKSFSLIAIAKHGIPHVFPEAALEEAQRAAT
LPLSEDRREDLRDVPILAIDPADARDHDDAIWAEPDGEGGFDTIVAIADVSYYVRPGGALDREARKRGNSVYFPDRVVPM
LPEVLSADACSLKHGQDRAAMACHLRVSAEGKVTSWRFTRAIVRLTHNIAYEDAQAAIDSGDASTELQNLWACWRALEKA
RHARDPLELELPERRVVLDDEGQIADIAVRERLDAHRVVEDFMIAANVAAAKALEAKTAPVVYRIHEPPSREKLIALRDY
LATQDRKLALGQVVTPTLFNRFLKDVSDETERALLMEAVLRSQTQAYYGPNNAGHFGLALGSYAHFTSPIRRYSDLLVHR
ALVDAYGLEQPKPAKGLPDASGLSDRDRQDLQQITDAISTTERRAMEAERDTIDRYVAAYLAQHVGKTFQTRITGVQNFG
FFATILNLGGDGLVPVSTLGREYYRYDEAAQALVGEDSGKRYDVAQKLELKLAEANPLTGALKFEPLDDESGNAERRGQQ
AAPREKGKSKQGNRGRPKNIRHQGRRRK

Sequences:

>Translated_748_residues
MPSREQVLEFIQSSDTPAGKREIAKAFGLKGQEKIGLKRLLKDMAEEGLIDGKKTAYHRMGGVPKVTVLRIVEIDDGESV
AEPENWNPDSGEKPPRLTIVESKGGRGGKRMPALKRGDRVLARTEESGKGWRAYPMKKLPARTEGLMGVVEIDKAGKAWL
APIDKKVRNSSPISDLNGSEDGELVLAEPAGKGPRSGVNVTEVVGDPLAPKSFSLIAIAKHGIPHVFPEAALEEAQRAAT
LPLSEDRREDLRDVPILAIDPADARDHDDAIWAEPDGEGGFDTIVAIADVSYYVRPGGALDREARKRGNSVYFPDRVVPM
LPEVLSADACSLKHGQDRAAMACHLRVSAEGKVTSWRFTRAIVRLTHNIAYEDAQAAIDSGDASTELQNLWACWRALEKA
RHARDPLELELPERRVVLDDEGQIADIAVRERLDAHRVVEDFMIAANVAAAKALEAKTAPVVYRIHEPPSREKLIALRDY
LATQDRKLALGQVVTPTLFNRFLKDVSDETERALLMEAVLRSQTQAYYGPNNAGHFGLALGSYAHFTSPIRRYSDLLVHR
ALVDAYGLEQPKPAKGLPDASGLSDRDRQDLQQITDAISTTERRAMEAERDTIDRYVAAYLAQHVGKTFQTRITGVQNFG
FFATILNLGGDGLVPVSTLGREYYRYDEAAQALVGEDSGKRYDVAQKLELKLAEANPLTGALKFEPLDDESGNAERRGQQ
AAPREKGKSKQGNRGRPKNIRHQGRRRK
>Mature_747_residues
PSREQVLEFIQSSDTPAGKREIAKAFGLKGQEKIGLKRLLKDMAEEGLIDGKKTAYHRMGGVPKVTVLRIVEIDDGESVA
EPENWNPDSGEKPPRLTIVESKGGRGGKRMPALKRGDRVLARTEESGKGWRAYPMKKLPARTEGLMGVVEIDKAGKAWLA
PIDKKVRNSSPISDLNGSEDGELVLAEPAGKGPRSGVNVTEVVGDPLAPKSFSLIAIAKHGIPHVFPEAALEEAQRAATL
PLSEDRREDLRDVPILAIDPADARDHDDAIWAEPDGEGGFDTIVAIADVSYYVRPGGALDREARKRGNSVYFPDRVVPML
PEVLSADACSLKHGQDRAAMACHLRVSAEGKVTSWRFTRAIVRLTHNIAYEDAQAAIDSGDASTELQNLWACWRALEKAR
HARDPLELELPERRVVLDDEGQIADIAVRERLDAHRVVEDFMIAANVAAAKALEAKTAPVVYRIHEPPSREKLIALRDYL
ATQDRKLALGQVVTPTLFNRFLKDVSDETERALLMEAVLRSQTQAYYGPNNAGHFGLALGSYAHFTSPIRRYSDLLVHRA
LVDAYGLEQPKPAKGLPDASGLSDRDRQDLQQITDAISTTERRAMEAERDTIDRYVAAYLAQHVGKTFQTRITGVQNFGF
FATILNLGGDGLVPVSTLGREYYRYDEAAQALVGEDSGKRYDVAQKLELKLAEANPLTGALKFEPLDDESGNAERRGQQA
APREKGKSKQGNRGRPKNIRHQGRRRK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=558, Percent_Identity=27.2401433691756, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI190014625, Length=558, Percent_Identity=26.8817204301075, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI19115966, Length=418, Percent_Identity=30.3827751196172, Blast_Score=164, Evalue=4e-40,
Organism=Homo sapiens, GI219521928, Length=418, Percent_Identity=30.3827751196172, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI134288890, Length=359, Percent_Identity=32.033426183844, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI156105695, Length=375, Percent_Identity=27.7333333333333, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI156105693, Length=375, Percent_Identity=27.7333333333333, Blast_Score=85, Evalue=3e-16,
Organism=Escherichia coli, GI87082383, Length=762, Percent_Identity=33.4645669291339, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1787542, Length=424, Percent_Identity=29.0094339622642, Blast_Score=145, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI212645896, Length=467, Percent_Identity=32.1199143468951, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17553506, Length=486, Percent_Identity=28.3950617283951, Blast_Score=172, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324552, Length=487, Percent_Identity=30.8008213552361, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320499, Length=303, Percent_Identity=24.4224422442244, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24649634, Length=376, Percent_Identity=32.4468085106383, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19922976, Length=459, Percent_Identity=28.5403050108932, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24654597, Length=459, Percent_Identity=28.5403050108932, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24654592, Length=459, Percent_Identity=28.5403050108932, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.13.1

Molecular weight: Translated: 82367; Mature: 82236

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSREQVLEFIQSSDTPAGKREIAKAFGLKGQEKIGLKRLLKDMAEEGLIDGKKTAYHRM
CCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GGVPKVTVLRIVEIDDGESVAEPENWNPDSGEKPPRLTIVESKGGRGGKRMPALKRGDRV
CCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCEE
LARTEESGKGWRAYPMKKLPARTEGLMGVVEIDKAGKAWLAPIDKKVRNSSPISDLNGSE
EEECCCCCCCCEECCCHHCCCHHHCCEEEEEECCCCCHHHCHHHHHHCCCCCCCCCCCCC
DGELVLAEPAGKGPRSGVNVTEVVGDPLAPKSFSLIAIAKHGIPHVFPEAALEEAQRAAT
CCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHC
LPLSEDRREDLRDVPILAIDPADARDHDDAIWAEPDGEGGFDTIVAIADVSYYVRPGGAL
CCCCHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCCHHHHHHEECCEEEECCCCCC
DREARKRGNSVYFPDRVVPMLPEVLSADACSLKHGQDRAAMACHLRVSAEGKVTSWRFTR
CHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEEECCCCCCHHHHHH
AIVRLTHNIAYEDAQAAIDSGDASTELQNLWACWRALEKARHARDPLELELPERRVVLDD
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECC
EGQIADIAVRERLDAHRVVEDFMIAANVAAAKALEAKTAPVVYRIHEPPSREKLIALRDY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
LATQDRKLALGQVVTPTLFNRFLKDVSDETERALLMEAVLRSQTQAYYGPNNAGHFGLAL
HHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH
GSYAHFTSPIRRYSDLLVHRALVDAYGLEQPKPAKGLPDASGLSDRDRQDLQQITDAIST
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TERRAMEAERDTIDRYVAAYLAQHVGKTFQTRITGVQNFGFFATILNLGGDGLVPVSTLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
REYYRYDEAAQALVGEDSGKRYDVAQKLELKLAEANPLTGALKFEPLDDESGNAERRGQQ
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEECCCCCCCEEEECCCCCCCCCHHHCCCC
AAPREKGKSKQGNRGRPKNIRHQGRRRK
CCCHHHCCCCCCCCCCCCCHHHCCCCCC
>Mature Secondary Structure 
PSREQVLEFIQSSDTPAGKREIAKAFGLKGQEKIGLKRLLKDMAEEGLIDGKKTAYHRM
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GGVPKVTVLRIVEIDDGESVAEPENWNPDSGEKPPRLTIVESKGGRGGKRMPALKRGDRV
CCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCEE
LARTEESGKGWRAYPMKKLPARTEGLMGVVEIDKAGKAWLAPIDKKVRNSSPISDLNGSE
EEECCCCCCCCEECCCHHCCCHHHCCEEEEEECCCCCHHHCHHHHHHCCCCCCCCCCCCC
DGELVLAEPAGKGPRSGVNVTEVVGDPLAPKSFSLIAIAKHGIPHVFPEAALEEAQRAAT
CCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHC
LPLSEDRREDLRDVPILAIDPADARDHDDAIWAEPDGEGGFDTIVAIADVSYYVRPGGAL
CCCCHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCCHHHHHHEECCEEEECCCCCC
DREARKRGNSVYFPDRVVPMLPEVLSADACSLKHGQDRAAMACHLRVSAEGKVTSWRFTR
CHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEEECCCCCCHHHHHH
AIVRLTHNIAYEDAQAAIDSGDASTELQNLWACWRALEKARHARDPLELELPERRVVLDD
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECC
EGQIADIAVRERLDAHRVVEDFMIAANVAAAKALEAKTAPVVYRIHEPPSREKLIALRDY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
LATQDRKLALGQVVTPTLFNRFLKDVSDETERALLMEAVLRSQTQAYYGPNNAGHFGLAL
HHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH
GSYAHFTSPIRRYSDLLVHRALVDAYGLEQPKPAKGLPDASGLSDRDRQDLQQITDAIST
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TERRAMEAERDTIDRYVAAYLAQHVGKTFQTRITGVQNFGFFATILNLGGDGLVPVSTLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
REYYRYDEAAQALVGEDSGKRYDVAQKLELKLAEANPLTGALKFEPLDDESGNAERRGQQ
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEECCCCCCCEEEECCCCCCCCCHHHCCCC
AAPREKGKSKQGNRGRPKNIRHQGRRRK
CCCHHHCCCCCCCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]