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The map label for this gene is lrp [H]

Identifier: 85373444

GI number: 85373444

Start: 649698

End: 650162

Strand: Direct

Name: lrp [H]

Synonym: ELI_03085

Alternate gene names: 85373444

Gene position: 649698-650162 (Clockwise)

Preceding gene: 85373441

Following gene: 85373445

Centisome position: 21.28

GC content: 61.72

Gene sequence:

>465_bases
ATGGCCAATCTCGACGAAATCGACCGCCGATTGCTCGCAGAACTGCAGTCCGAAGGTCGCATCACCAACGTCGAGCTTGC
CCAACGTGTCGGTCTCACCGCGCCGCCGTGTCTGCGCCGTGTCCGCGCGCTGGAGGAATCGGGGGTCATCCGTGGCTATC
ATGCCGAGCTGGAGCCTTCGAAGCTCGGTTTCGCGATCACCGTTTTCGCCATGGTCAGCCTCAAGAGCCAAGCCGAGGAC
GCGCTGCGCGAATTCGAAGAGCACATGCGCGACCTGCCCGAAGTGCGCGAAGTGCACATGCTCAATGGCGAGATCGATTT
CATCCTCAAGATCGTCAGCGAAGACCTGCAGAGCTTCCAGGAATTCCTGACCAGCAAGCTGACGCCCGCACCCAATGTGG
CGAGCGTGAAGACCAGCCTGACGATCCGCACCGCCAAGCATGAACCGGGCGTGCCGCTGGGGTGA

Upstream 100 bases:

>100_bases
ATTGCTGTCATGGACAATAATATTAGCCAGAACAGGTGCAGCCCTCTGTAATCGTTTCGCAATCGTGCGAGAGAGGGTGC
AGACAAGGGGAACCGCGCAG

Downstream 100 bases:

>100_bases
GTGACGGTTTCATATGACAAAAAGTAATATTGTCCATAATGAGCAGACTAAGCTGGTCGCAAGCATCGTACAAACGCTTG
CCACAGCCTTGTTCATCGGT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MANLDEIDRRLLAELQSEGRITNVELAQRVGLTAPPCLRRVRALEESGVIRGYHAELEPSKLGFAITVFAMVSLKSQAED
ALREFEEHMRDLPEVREVHMLNGEIDFILKIVSEDLQSFQEFLTSKLTPAPNVASVKTSLTIRTAKHEPGVPLG

Sequences:

>Translated_154_residues
MANLDEIDRRLLAELQSEGRITNVELAQRVGLTAPPCLRRVRALEESGVIRGYHAELEPSKLGFAITVFAMVSLKSQAED
ALREFEEHMRDLPEVREVHMLNGEIDFILKIVSEDLQSFQEFLTSKLTPAPNVASVKTSLTIRTAKHEPGVPLG
>Mature_153_residues
ANLDEIDRRLLAELQSEGRITNVELAQRVGLTAPPCLRRVRALEESGVIRGYHAELEPSKLGFAITVFAMVSLKSQAEDA
LREFEEHMRDLPEVREVHMLNGEIDFILKIVSEDLQSFQEFLTSKLTPAPNVASVKTSLTIRTAKHEPGVPLG

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=145, Percent_Identity=39.3103448275862, Blast_Score=118, Evalue=1e-28,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=29.3333333333333, Blast_Score=96, Evalue=8e-22,
Organism=Escherichia coli, GI1790182, Length=142, Percent_Identity=25.3521126760563, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17191; Mature: 17060

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLDEIDRRLLAELQSEGRITNVELAQRVGLTAPPCLRRVRALEESGVIRGYHAELEPS
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCEECCCCCCCHH
KLGFAITVFAMVSLKSQAEDALREFEEHMRDLPEVREVHMLNGEIDFILKIVSEDLQSFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EFLTSKLTPAPNVASVKTSLTIRTAKHEPGVPLG
HHHHHCCCCCCCCHHHHHHEEEEECCCCCCCCCC
>Mature Secondary Structure 
ANLDEIDRRLLAELQSEGRITNVELAQRVGLTAPPCLRRVRALEESGVIRGYHAELEPS
CCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCEECCCCCCCHH
KLGFAITVFAMVSLKSQAEDALREFEEHMRDLPEVREVHMLNGEIDFILKIVSEDLQSFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EFLTSKLTPAPNVASVKTSLTIRTAKHEPGVPLG
HHHHHCCCCCCCCHHHHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]