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The map label for this gene is thrC [H]

Identifier: 85373379

GI number: 85373379

Start: 587821

End: 589224

Strand: Direct

Name: thrC [H]

Synonym: ELI_02760

Alternate gene names: 85373379

Gene position: 587821-589224 (Clockwise)

Preceding gene: 85373378

Following gene: 85373380

Centisome position: 19.26

GC content: 64.03

Gene sequence:

>1404_bases
ATGCGCTATATCTCCACCCGTGGCTCTGCGCCCACGCTCTCTTTCGAAGAGGTCACGCTGACCGGCCTCGCCAGCGATGG
CGGGCTGTATCTGCCGCAGGGATGGCCGAGCTTTAGTGCCGACGACATCCGCGCAATGCGGGGCCAGCCCTATGCCGAGA
TCGCCGCGCGGGTGATGGCTCCCTTTGTCGGCGACAGCCTGAGTTTCGAGGAACTGCGGGGGCTGACCGAGGAGGCCTAT
GGGCGCTTCTCCCATGCCGCGGTGGTGCCGCTGGTCCAGCTCGATCACCAGCATTGGCTGATGGAGCTGTTCCACGGGCC
GACGCTCGCGTTCAAGGACGTGGCACTGCAGATGCTCGGCCTGCTGTTCGAGACCTTCCTCGCCCGGCGCGGCGAGCAGC
TCACGCTCGTCGGCGCGACCAGCGGCGATACAGGCAGCGCAGCTATCGATGCGGTGGCTGGGCGCGACGGGGTCGAGATC
TTCATGCTCCATCCGCAAGGCCGGATCAGCGACGTCCAGCGCCGCCAGATGACTACGGTGCGCGCGCCGAATATCCACAA
TATCGCCATCTCCGGCAGTTTCGACGACGGCCAAGCGGCTGTGAAGCGGATGTTCACCGATACTGAAATTGCGGGGAAGA
TCCGCCTCGGCGCGGTCAATTCGATCAACTGGGCGCGGCTGATGGCGCAAGTGGTCTATTACTTCACCACCGCCGTGCAG
CTGGGCGCGCCCGAGCGCAGCGTGGCCTTCAGCGTCCCGACGGGAAATTTCGGCGATGTCTTTGCAGGCTATGTCGCGAG
CAAGATGGGCCTACCCGTCGAGCAATTGATCGTTGCTACCAATGTGAACGACATCCTTCATCGCGCCTTATCCGACGGCG
ATTATTCGGCGGGCACTGTCACACCCACCGCCGCGCCGAGCATGGATATCCAGGTCAGCTCTAATTTCGAGCGCTTGCTG
TTCGATGTCGGCGGGCGCGATGGCGCCGTCATGGCAGAGCAGATGCGCGGCTTCGAAACGTCGAAAGCGATGCAGCTCAC
CAATTCGCAGCGCGAAGGCGCGGCCACGCGTTTCACCAGCGTGCGCGTGGACCAGGATGCGATGGCGCATTCGATGCGGC
GCGCCTTCGAGAATTCGGGCGAAGTGATCGACCCGCATACAGCGATCGGGCTTTATGCCGCTTATCAGGCTGACATCGCG
CCCGACGTACCGATCGTCACGCTCGCTACCGCGCATCCGGCCAAGTTCCGCGATGCGGTCGAGCGCGCGACGGGCACGCG
ACCGCCGCTTCCCACGCGGGTCGGCGACCTGTTCGCGCGCGAAGAAGCCTGCACCGAACTGTCTGGCGATTATGACGAGC
TAACGGACTTCATCCTCACCAATGCCGCGCAGGCTCATGGCTGA

Upstream 100 bases:

>100_bases
ACCACCCCCAAATCCCCTCCTCTGAAGAAGAGGGGGCTTATCCATTCCAACCCCCTCTATCTTGCCCGCATGACTCCTCG
CCGCTAACCCGCTCGCCACG

Downstream 100 bases:

>100_bases
ACTCGTCCGCGCGCCGCAGCTTATGGTCGGCGAGGGGTGGGAGGACTACGCCTTGCTCGATAGCGGCGAGGGGCGCAAGC
TCGAGCGCTTCGGTCCCTAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MRYISTRGSAPTLSFEEVTLTGLASDGGLYLPQGWPSFSADDIRAMRGQPYAEIAARVMAPFVGDSLSFEELRGLTEEAY
GRFSHAAVVPLVQLDHQHWLMELFHGPTLAFKDVALQMLGLLFETFLARRGEQLTLVGATSGDTGSAAIDAVAGRDGVEI
FMLHPQGRISDVQRRQMTTVRAPNIHNIAISGSFDDGQAAVKRMFTDTEIAGKIRLGAVNSINWARLMAQVVYYFTTAVQ
LGAPERSVAFSVPTGNFGDVFAGYVASKMGLPVEQLIVATNVNDILHRALSDGDYSAGTVTPTAAPSMDIQVSSNFERLL
FDVGGRDGAVMAEQMRGFETSKAMQLTNSQREGAATRFTSVRVDQDAMAHSMRRAFENSGEVIDPHTAIGLYAAYQADIA
PDVPIVTLATAHPAKFRDAVERATGTRPPLPTRVGDLFAREEACTELSGDYDELTDFILTNAAQAHG

Sequences:

>Translated_467_residues
MRYISTRGSAPTLSFEEVTLTGLASDGGLYLPQGWPSFSADDIRAMRGQPYAEIAARVMAPFVGDSLSFEELRGLTEEAY
GRFSHAAVVPLVQLDHQHWLMELFHGPTLAFKDVALQMLGLLFETFLARRGEQLTLVGATSGDTGSAAIDAVAGRDGVEI
FMLHPQGRISDVQRRQMTTVRAPNIHNIAISGSFDDGQAAVKRMFTDTEIAGKIRLGAVNSINWARLMAQVVYYFTTAVQ
LGAPERSVAFSVPTGNFGDVFAGYVASKMGLPVEQLIVATNVNDILHRALSDGDYSAGTVTPTAAPSMDIQVSSNFERLL
FDVGGRDGAVMAEQMRGFETSKAMQLTNSQREGAATRFTSVRVDQDAMAHSMRRAFENSGEVIDPHTAIGLYAAYQADIA
PDVPIVTLATAHPAKFRDAVERATGTRPPLPTRVGDLFAREEACTELSGDYDELTDFILTNAAQAHG
>Mature_467_residues
MRYISTRGSAPTLSFEEVTLTGLASDGGLYLPQGWPSFSADDIRAMRGQPYAEIAARVMAPFVGDSLSFEELRGLTEEAY
GRFSHAAVVPLVQLDHQHWLMELFHGPTLAFKDVALQMLGLLFETFLARRGEQLTLVGATSGDTGSAAIDAVAGRDGVEI
FMLHPQGRISDVQRRQMTTVRAPNIHNIAISGSFDDGQAAVKRMFTDTEIAGKIRLGAVNSINWARLMAQVVYYFTTAVQ
LGAPERSVAFSVPTGNFGDVFAGYVASKMGLPVEQLIVATNVNDILHRALSDGDYSAGTVTPTAAPSMDIQVSSNFERLL
FDVGGRDGAVMAEQMRGFETSKAMQLTNSQREGAATRFTSVRVDQDAMAHSMRRAFENSGEVIDPHTAIGLYAAYQADIA
PDVPIVTLATAHPAKFRDAVERATGTRPPLPTRVGDLFAREEACTELSGDYDELTDFILTNAAQAHG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=454, Percent_Identity=36.1233480176211, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI153792148, Length=486, Percent_Identity=30.2469135802469, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1786185, Length=437, Percent_Identity=33.4096109839817, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=42.8884026258206, Blast_Score=339, Evalue=4e-94,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50462; Mature: 50462

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYISTRGSAPTLSFEEVTLTGLASDGGLYLPQGWPSFSADDIRAMRGQPYAEIAARVMA
CCEECCCCCCCCCEECEEEEEEEECCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
PFVGDSLSFEELRGLTEEAYGRFSHAAVVPLVQLDHQHWLMELFHGPTLAFKDVALQMLG
HHCCCCCCHHHHHCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
LLFETFLARRGEQLTLVGATSGDTGSAAIDAVAGRDGVEIFMLHPQGRISDVQRRQMTTV
HHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHEE
RAPNIHNIAISGSFDDGQAAVKRMFTDTEIAGKIRLGAVNSINWARLMAQVVYYFTTAVQ
CCCCCEEEEEECCCCCHHHHHHHHHCCHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
LGAPERSVAFSVPTGNFGDVFAGYVASKMGLPVEQLIVATNVNDILHRALSDGDYSAGTV
CCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCCCCEE
TPTAAPSMDIQVSSNFERLLFDVGGRDGAVMAEQMRGFETSKAMQLTNSQREGAATRFTS
CCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHEEEE
VRVDQDAMAHSMRRAFENSGEVIDPHTAIGLYAAYQADIAPDVPIVTLATAHPAKFRDAV
EEECHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHH
ERATGTRPPLPTRVGDLFAREEACTELSGDYDELTDFILTNAAQAHG
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHCCC
>Mature Secondary Structure
MRYISTRGSAPTLSFEEVTLTGLASDGGLYLPQGWPSFSADDIRAMRGQPYAEIAARVMA
CCEECCCCCCCCCEECEEEEEEEECCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
PFVGDSLSFEELRGLTEEAYGRFSHAAVVPLVQLDHQHWLMELFHGPTLAFKDVALQMLG
HHCCCCCCHHHHHCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
LLFETFLARRGEQLTLVGATSGDTGSAAIDAVAGRDGVEIFMLHPQGRISDVQRRQMTTV
HHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHEE
RAPNIHNIAISGSFDDGQAAVKRMFTDTEIAGKIRLGAVNSINWARLMAQVVYYFTTAVQ
CCCCCEEEEEECCCCCHHHHHHHHHCCHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
LGAPERSVAFSVPTGNFGDVFAGYVASKMGLPVEQLIVATNVNDILHRALSDGDYSAGTV
CCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCCCCEE
TPTAAPSMDIQVSSNFERLLFDVGGRDGAVMAEQMRGFETSKAMQLTNSQREGAATRFTS
CCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHEEEE
VRVDQDAMAHSMRRAFENSGEVIDPHTAIGLYAAYQADIAPDVPIVTLATAHPAKFRDAV
EEECHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHH
ERATGTRPPLPTRVGDLFAREEACTELSGDYDELTDFILTNAAQAHG
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]