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The map label for this gene is ctaB

Identifier: 85373374

GI number: 85373374

Start: 584386

End: 585309

Strand: Direct

Name: ctaB

Synonym: ELI_02735

Alternate gene names: 85373374

Gene position: 584386-585309 (Clockwise)

Preceding gene: 85373373

Following gene: 85373375

Centisome position: 19.15

GC content: 64.83

Gene sequence:

>924_bases
ATGACCACCGCCGCTTCCCCTGCAGCCCTCCCGGCCGATTGGCGCGATTTCTTCGCGCTGACGAAGCCGCGGGTGATGAC
GCTGGTGATCTTCACCGGCATCTGCGGGCTGCTGGCGGCGCCGGGCGCTATCAATCCGATCCTCGGCTTCACCGCCATCC
TGTGCATCGCCATGGGCGCTGGCGGCTCGGCCGCACTCAACCAGTGGTGGGAAGCGGATATCGATGCCGGGATGAAGCGC
ACGGCCAAGCGCCCGCTGCCGTCGGGCCGGATGCAGGCCACCGACGCCCGCGATTTCGGGATCCTGATTTCCGTCGCGTC
GGTCGGGATCATGGGGATCGCGATCAACTGGCTGTCGGCAATCATCCTTGCCGCCGCGATCGTCTATTACGCCGTCATCT
ACACCATCTGGCTCAAACCGCGTACACCGCAGAATATCGTCATCGGCGGCGGGGCGGGCGCGTTTCCGCCAATGATCGGC
TGGGTCGCGGTGACGGGCGAGATCACGCTGATGCCGGTGCTGCTGTTCGCCATCATCTTCATGTGGACGCCGCCGCATTT
CTGGGCGCTCGCGCTGTTCGTGAAGACCGATTACGAGAAGGTCGGCATTCCCATGATGCCGGTGGTGAAGGGCGAAGCGA
GCACGCGCCGCCAGATCCTGGTCTATTCCATCCTGTTGATCCCCTTCGCCGTCGCGCCTTGGGCGATCGGCGCGACCGGC
GCGATCTACGGCGTCTCCGCGTTGCTGCTGACCGGTGCCTTCGCGGCGCTGAGTGTCCCTGTGGCCACCCGGCGTCAGAT
CGAAGGCGATACGATGAAGCCGGAGAAGCGGCTGTTCGGATTCAGCATCCTCTACCTTTTCGCCCTGTTTGCCGCGCTTG
TCGCGGACCGCTATCTCACCCCCCTGATCGAGAGCGCAGCATGA

Upstream 100 bases:

>100_bases
AGGGTAGGGCTGGCCCGACAACCAGATCGAGAGGGGGCGCATCGGCAACGGTGCGCCCTTCTTTCAAGAAAGACCGCAAC
GGAACCGATTGAACTCGACG

Downstream 100 bases:

>100_bases
CCCCCGAAGAGCAAGCCGAAATCGAGCGTCGCCGCAAGACCCGCAATCTCGCCCTGGGCGGCGTACTGCTGTTTTTCGTC
GTTCTGTTCTATGCCATTAC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTTAASPAALPADWRDFFALTKPRVMTLVIFTGICGLLAAPGAINPILGFTAILCIAMGAGGSAALNQWWEADIDAGMKR
TAKRPLPSGRMQATDARDFGILISVASVGIMGIAINWLSAIILAAAIVYYAVIYTIWLKPRTPQNIVIGGGAGAFPPMIG
WVAVTGEITLMPVLLFAIIFMWTPPHFWALALFVKTDYEKVGIPMMPVVKGEASTRRQILVYSILLIPFAVAPWAIGATG
AIYGVSALLLTGAFAALSVPVATRRQIEGDTMKPEKRLFGFSILYLFALFAALVADRYLTPLIESAA

Sequences:

>Translated_307_residues
MTTAASPAALPADWRDFFALTKPRVMTLVIFTGICGLLAAPGAINPILGFTAILCIAMGAGGSAALNQWWEADIDAGMKR
TAKRPLPSGRMQATDARDFGILISVASVGIMGIAINWLSAIILAAAIVYYAVIYTIWLKPRTPQNIVIGGGAGAFPPMIG
WVAVTGEITLMPVLLFAIIFMWTPPHFWALALFVKTDYEKVGIPMMPVVKGEASTRRQILVYSILLIPFAVAPWAIGATG
AIYGVSALLLTGAFAALSVPVATRRQIEGDTMKPEKRLFGFSILYLFALFAALVADRYLTPLIESAA
>Mature_306_residues
TTAASPAALPADWRDFFALTKPRVMTLVIFTGICGLLAAPGAINPILGFTAILCIAMGAGGSAALNQWWEADIDAGMKRT
AKRPLPSGRMQATDARDFGILISVASVGIMGIAINWLSAIILAAAIVYYAVIYTIWLKPRTPQNIVIGGGAGAFPPMIGW
VAVTGEITLMPVLLFAIIFMWTPPHFWALALFVKTDYEKVGIPMMPVVKGEASTRRQILVYSILLIPFAVAPWAIGATGA
IYGVSALLLTGAFAALSVPVATRRQIEGDTMKPEKRLFGFSILYLFALFAALVADRYLTPLIESAA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=31.7708333333333, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1786631, Length=284, Percent_Identity=29.2253521126761, Blast_Score=118, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71998235, Length=215, Percent_Identity=30.6976744186047, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=279, Percent_Identity=28.673835125448, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921064, Length=293, Percent_Identity=26.962457337884, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_ERYLH (Q2NCF2)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457436.1
- STRING:   Q2NCF2
- GeneID:   3871775
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_02735
- NMPDR:   fig|314225.3.peg.2536
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q2NCF2
- ProtClustDB:   PRK04375
- BioCyc:   ELIT314225:ELI_02735-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32790; Mature: 32659

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1398fa50)-; HASH(0x13b9054c)-; HASH(0x13b8ea88)-; HASH(0x13b90438)-; HASH(0x13b8f928)-; HASH(0x13607940)-; HASH(0x13b8d06c)-; HASH(0x13b8b5e4)-; HASH(0x13b8f7b4)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAASPAALPADWRDFFALTKPRVMTLVIFTGICGLLAAPGAINPILGFTAILCIAMGA
CCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
GGSAALNQWWEADIDAGMKRTAKRPLPSGRMQATDARDFGILISVASVGIMGIAINWLSA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IILAAAIVYYAVIYTIWLKPRTPQNIVIGGGAGAFPPMIGWVAVTGEITLMPVLLFAIIF
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHEEECCCHHHHHHHHHHHHH
MWTPPHFWALALFVKTDYEKVGIPMMPVVKGEASTRRQILVYSILLIPFAVAPWAIGATG
HCCCCHHHHHHHHHHCCHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
AIYGVSALLLTGAFAALSVPVATRRQIEGDTMKPEKRLFGFSILYLFALFAALVADRYLT
HHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLIESAA
HHHHHCH
>Mature Secondary Structure 
TTAASPAALPADWRDFFALTKPRVMTLVIFTGICGLLAAPGAINPILGFTAILCIAMGA
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
GGSAALNQWWEADIDAGMKRTAKRPLPSGRMQATDARDFGILISVASVGIMGIAINWLSA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IILAAAIVYYAVIYTIWLKPRTPQNIVIGGGAGAFPPMIGWVAVTGEITLMPVLLFAIIF
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHEEECCCHHHHHHHHHHHHH
MWTPPHFWALALFVKTDYEKVGIPMMPVVKGEASTRRQILVYSILLIPFAVAPWAIGATG
HCCCCHHHHHHHHHHCCHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
AIYGVSALLLTGAFAALSVPVATRRQIEGDTMKPEKRLFGFSILYLFALFAALVADRYLT
HHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLIESAA
HHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA