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The map label for this gene is cobS [H]

Identifier: 85373361

GI number: 85373361

Start: 571695

End: 572684

Strand: Direct

Name: cobS [H]

Synonym: ELI_02670

Alternate gene names: 85373361

Gene position: 571695-572684 (Clockwise)

Preceding gene: 85373355

Following gene: 85373362

Centisome position: 18.73

GC content: 62.42

Gene sequence:

>990_bases
ATGAACGACATGACCGACAAGAGCTTCGAGCCCAACGCCAAGACGACCCTTTCCGAACCGGACACCACCGTCAACGTGCG
GGAGACCTTCGGGATCGACGTGGACTGGGACGTGCCAGCCTTCAGCAAGGCGGACGAGCGCGTGCCCGATTTCGACGAGA
ATTACGTCTTCGATCCGGACACGACGCTGGCGATCCTCGCCGGCTTCGCCCACAACCGCCGGGTGATGGTGCAGGGCTAT
CACGGCACCGGCAAATCGACCCACATCGAACAGGTCGCGGCGCGTCTCAACTGGCCGTGCATCCGTATCAACCTCGACGC
GCATATCAGCCGTATCGACTTGGTCGGGCGCGACGCCATCGTGCTGCGCGACGGGCTGCAGGTCACCGAATTCCGCGAAG
GACTGCTGCCGTGGGCGCTTCAGCATCCGGTCGCGCTGGTGTTCGACGAATACGATGCGGGCCGCCCGGACGTGATGTTC
GTGATCCAGCGCGTGCTGGAGACCGAGGGCAAGCTTACGCTGCTCGACCAGAACCGCGTGATCCGCCCCGATCCGAACTT
CCGCCTGTTCGCAACCGCCAACACCGTCGGCCTCGGCGATACGTCCGGCCTCTATCACGGCACGCAGCAGATCAACCAGG
GCCAGATGGACCGCTGGAACATCGTCGTCGGTCTCAACTACCTGCCGGCCGACACCGAGCAGGAAATCGTGACCGCGAAG
AACCCGGATACCGATCCGGAGGTCATCTCAAAGATGATAAAAGTCGCCGACCTGACCCGCCAAGGCTTCATCAACGGCGA
TATCTCGACCGTGATGAGCCCGCGCACCGTCATCACCTGGGCCCAGAACGCGGCGATCTTCGAAAATGTCGGCATGGCCT
TCCGCCTGAGCTTCCTCAACAAATGCGACGAAGCCGAACGCATGCTGGTGGCGGAATACTACCAGCGCGTTTTCGGGGAA
GACCTGCCCGAGAGCGTGGTCAAGGCTTGA

Upstream 100 bases:

>100_bases
CGGCATGGTCACGACAATATGTGCATCCGGCGGCAAAAGGAAATGTCGTCTTTCGTCCCGCTTGCGAGTCGCTGGCTCCG
CGTCTAGTCCCGCCGACGAG

Downstream 100 bases:

>100_bases
GACTGGCAATCGCTGTGTTATCCTGCTAATACAGCCGGATGAATTCCCCCTGGTTCCGCAAACTGACCCCTTGGCGGCGC
GATCCCGGTCGGCCGCAGGG

Product: MoxR-like ATPase

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNDMTDKSFEPNAKTTLSEPDTTVNVRETFGIDVDWDVPAFSKADERVPDFDENYVFDPDTTLAILAGFAHNRRVMVQGY
HGTGKSTHIEQVAARLNWPCIRINLDAHISRIDLVGRDAIVLRDGLQVTEFREGLLPWALQHPVALVFDEYDAGRPDVMF
VIQRVLETEGKLTLLDQNRVIRPDPNFRLFATANTVGLGDTSGLYHGTQQINQGQMDRWNIVVGLNYLPADTEQEIVTAK
NPDTDPEVISKMIKVADLTRQGFINGDISTVMSPRTVITWAQNAAIFENVGMAFRLSFLNKCDEAERMLVAEYYQRVFGE
DLPESVVKA

Sequences:

>Translated_329_residues
MNDMTDKSFEPNAKTTLSEPDTTVNVRETFGIDVDWDVPAFSKADERVPDFDENYVFDPDTTLAILAGFAHNRRVMVQGY
HGTGKSTHIEQVAARLNWPCIRINLDAHISRIDLVGRDAIVLRDGLQVTEFREGLLPWALQHPVALVFDEYDAGRPDVMF
VIQRVLETEGKLTLLDQNRVIRPDPNFRLFATANTVGLGDTSGLYHGTQQINQGQMDRWNIVVGLNYLPADTEQEIVTAK
NPDTDPEVISKMIKVADLTRQGFINGDISTVMSPRTVITWAQNAAIFENVGMAFRLSFLNKCDEAERMLVAEYYQRVFGE
DLPESVVKA
>Mature_329_residues
MNDMTDKSFEPNAKTTLSEPDTTVNVRETFGIDVDWDVPAFSKADERVPDFDENYVFDPDTTLAILAGFAHNRRVMVQGY
HGTGKSTHIEQVAARLNWPCIRINLDAHISRIDLVGRDAIVLRDGLQVTEFREGLLPWALQHPVALVFDEYDAGRPDVMF
VIQRVLETEGKLTLLDQNRVIRPDPNFRLFATANTVGLGDTSGLYHGTQQINQGQMDRWNIVVGLNYLPADTEQEIVTAK
NPDTDPEVISKMIKVADLTRQGFINGDISTVMSPRTVITWAQNAAIFENVGMAFRLSFLNKCDEAERMLVAEYYQRVFGE
DLPESVVKA

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=251, Percent_Identity=25.0996015936255, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323135, Length=253, Percent_Identity=24.1106719367589, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076562, Length=207, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI161076560, Length=207, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 37007; Mature: 37007

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDMTDKSFEPNAKTTLSEPDTTVNVRETFGIDVDWDVPAFSKADERVPDFDENYVFDPD
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCEECCCCCCCCCCCCCCCCCCCCEEECCC
TTLAILAGFAHNRRVMVQGYHGTGKSTHIEQVAARLNWPCIRINLDAHISRIDLVGRDAI
CHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCEE
VLRDGLQVTEFREGLLPWALQHPVALVFDEYDAGRPDVMFVIQRVLETEGKLTLLDQNRV
EEECCCCHHHHHHCCCCHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCE
IRPDPNFRLFATANTVGLGDTSGLYHGTQQINQGQMDRWNIVVGLNYLPADTEQEIVTAK
ECCCCCEEEEEECCEECCCCCCCCCCCHHHHCCCCCCEEEEEEEEEECCCCCCCCEEECC
NPDTDPEVISKMIKVADLTRQGFINGDISTVMSPRTVITWAQNAAIFENVGMAFRLSFLN
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCCHHHHHCCHHHHHHHHH
KCDEAERMLVAEYYQRVFGEDLPESVVKA
HCCHHHHHHHHHHHHHHHCCCCHHHHHCC
>Mature Secondary Structure
MNDMTDKSFEPNAKTTLSEPDTTVNVRETFGIDVDWDVPAFSKADERVPDFDENYVFDPD
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCEECCCCCCCCCCCCCCCCCCCCEEECCC
TTLAILAGFAHNRRVMVQGYHGTGKSTHIEQVAARLNWPCIRINLDAHISRIDLVGRDAI
CHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCEE
VLRDGLQVTEFREGLLPWALQHPVALVFDEYDAGRPDVMFVIQRVLETEGKLTLLDQNRV
EEECCCCHHHHHHCCCCHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCE
IRPDPNFRLFATANTVGLGDTSGLYHGTQQINQGQMDRWNIVVGLNYLPADTEQEIVTAK
ECCCCCEEEEEECCEECCCCCCCCCCCHHHHCCCCCCEEEEEEEEEECCCCCCCCEEECC
NPDTDPEVISKMIKVADLTRQGFINGDISTVMSPRTVITWAQNAAIFENVGMAFRLSFLN
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCCHHHHHCCHHHHHHHHH
KCDEAERMLVAEYYQRVFGEDLPESVVKA
HCCHHHHHHHHHHHHHHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]