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The map label for this gene is uvrC

Identifier: 85373328

GI number: 85373328

Start: 541542

End: 543632

Strand: Direct

Name: uvrC

Synonym: ELI_02505

Alternate gene names: 85373328

Gene position: 541542-543632 (Clockwise)

Preceding gene: 85373325

Following gene: 85373335

Centisome position: 17.74

GC content: 66.43

Gene sequence:

>2091_bases
ATGTCCGGAACCAAAGCAGGCAGCCCCAACGATCCGCGCGGGGCCGAGCGTTTCAACGAGGAACGCGCGGCCTATACCGT
CGCGTCGGCCAAGCCGGATCTGGAGGGCGGGGTCAAGGCGATCCGCGAAGTGGTGCGGACGCTCAAGCCCAAGCCGGGCG
TCTACCGTATGCTCGATGCGCGCGGGGACGTGCTCTATGTCGGCAAGGCGCGCAGCCTGAAGGCGCGGGTGGCGAACTAT
ACCCAGGTTAGCAACCTCTCAGGCCGGCTCCAGCGGATGGTCAGCCAGACGCGCGGGATGGAGATCGTCACCACCAATTC
GGAAGCCGAGGCGCTGCTGCTCGAAGCGCAGCTGATCAAGAGGTATCGCCCGCCTTTCAATGTCTTGCTGCGCGATGATA
AGAGTTTCCCCTTCATCCTCCTGCGCGCCGATCATGACTTTCCGCGGATCATGAAGCACCGCGGCGCGCGGCGGGCCAAG
GGGAATTATTACGGCCCCTTCGCCAGCGCGGGCAGCGTCAACACGACAATTAACGCGCTGCAGAAACTGTTCCTGCTAAG
ATCCTGTACCGACAGCTTTTTCAGCAATCGCGACCGGCCGTGCCTGCTTTACCAGATCAAGCGCTGCAGCGCGCCCTGCG
TCGGGCGGATCGACGAGGAAGGCTATGCCGAGCTGGTGCGCGAGGCGAAGGACTTTCTCGGCGGCAAGAGCGATGCGGTG
CAGCGCAAGATCGAGCGGCAGATGGCCAGAGCGGCCGAGGATCTCGACTTCGAGACCGCCGCGATCCTGCGCGACCGGCT
GCGCGCGGCGACCTTCATCCAGGGCAGCCAGGCGATCAACGCCAGCGGGGTCGGCGATGCGGACGTCTTCGCGCTGGCGC
ACAAGAACGGGCAGATCGCGGTGCAGGCCTTCTTCATCCGTGGCGGTCAGAACTGGGGCCACCGCGCGTTCTTCCCGACC
CACACCAAGGACGTGGAAGAGCCGCAGGTGCTCTCCAACGTCATCCTGCAATTCTACGAGGAAGTCCCGCCGCCGCCGAC
CGTGCTGGTCGATCGCGAACTGCCCGAAAGCGAGCTGATCGAGGCTGCTCTGAGCGAGCTGGCGGGCAAGAAGGTCCAGC
TCTCGATCCCGCAGCGCGGCGACCGGCGCAAGCTGATGCAGCAGGCCAGCCGCAACGCCACCGAAGCGCTCGACCGGCGG
CTGGCGGAGCGCGGCACGCAGGCGAAGCTCAACCGCGAGCTGGCCGAATTCCTCGAGCTCGACGCCCCGCCGGAGCGGAT
CGAGGTCTACGACAACAGCCATATCCAGGGCGCGAAAGCGGTCGGCGCGATGGTGGTCGCGGGGCCGGAAGGCTTCATCA
AGAACCAGTACCGCAAGTTCAACATCCGCGAGGCGCAGTCGAACGACGATTTCGGCATGATGCGCGAAGTGATGCGGCGG
CGGTTCCGCAAGCTGGCGGAGGGCGAGGGACCCTATGAGGAGGACCTCTCGACACGCGCTCGGACTGCGTCCTCGGCTGC
TGCTCGAGACGAACGAGATGGGGCGGCTGACACCGTTCGTCCCGAGCAGCGATCGAGCGAAGCGAAGCGCAGTCGAGAGC
GCGGGTCGAGGGGCAAGAAGGACACGCACGAAACGATCTGGCCCGATCTCGTCCTGATCGACGGCGGCAAGGGGCAGATG
TCGAGCGTGCGCGATACGCTGGCGGAGATGGGGATCGAGGACGTCCCGCTGGTCGCCATCGCCAAGGGGCCGGACCACGG
GCGCGAGGGGCGCGAAGTGTTCCACTTCCCCGACGGGCGCGAGAAGACGCTGCCGGTCAATTCGCCGCTGCTGTTCCACC
TGCAGCGCCTGCGCGACGAGGTCCACCGCTACGCCATCGGCGCCCACCGCGCCAAACGCAGCCGCGCCATCACCGCCTCA
CCGCTCGACGAAATCCCCGGCATCGGTCCGGCCCGCAAGCGCGCCCTGCTGCTGCATTTCGGCACCGCCAGCAAGGTGCG
TGCGGCGGCGCTGGAAGACCTCCAACGCGCGCCCGGCGTCAGCAATGCGGTGGCGCGCAAGGTGTATGATTTTTATCATG
CCGGGGGGTGA

Upstream 100 bases:

>100_bases
TAACAGGCGCGGGGGGAAGGTCAAGCTGACGGCCCCGTCAACAGGTTCCGCAACGACAGGGTTTCCCACAGCGAGACGGC
TCCCTAAATCGGGGCCTGCC

Downstream 100 bases:

>100_bases
GGGCTGTTTTGGTCATAGTCCCACACCCCCGGACCGCATTGCGGCGGCTCAGTCTATCGTGACCGTCACGGCCCGCCGAT
TCTGTGACCACGCCGCCTGA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MSGTKAGSPNDPRGAERFNEERAAYTVASAKPDLEGGVKAIREVVRTLKPKPGVYRMLDARGDVLYVGKARSLKARVANY
TQVSNLSGRLQRMVSQTRGMEIVTTNSEAEALLLEAQLIKRYRPPFNVLLRDDKSFPFILLRADHDFPRIMKHRGARRAK
GNYYGPFASAGSVNTTINALQKLFLLRSCTDSFFSNRDRPCLLYQIKRCSAPCVGRIDEEGYAELVREAKDFLGGKSDAV
QRKIERQMARAAEDLDFETAAILRDRLRAATFIQGSQAINASGVGDADVFALAHKNGQIAVQAFFIRGGQNWGHRAFFPT
HTKDVEEPQVLSNVILQFYEEVPPPPTVLVDRELPESELIEAALSELAGKKVQLSIPQRGDRRKLMQQASRNATEALDRR
LAERGTQAKLNRELAEFLELDAPPERIEVYDNSHIQGAKAVGAMVVAGPEGFIKNQYRKFNIREAQSNDDFGMMREVMRR
RFRKLAEGEGPYEEDLSTRARTASSAAARDERDGAADTVRPEQRSSEAKRSRERGSRGKKDTHETIWPDLVLIDGGKGQM
SSVRDTLAEMGIEDVPLVAIAKGPDHGREGREVFHFPDGREKTLPVNSPLLFHLQRLRDEVHRYAIGAHRAKRSRAITAS
PLDEIPGIGPARKRALLLHFGTASKVRAAALEDLQRAPGVSNAVARKVYDFYHAGG

Sequences:

>Translated_696_residues
MSGTKAGSPNDPRGAERFNEERAAYTVASAKPDLEGGVKAIREVVRTLKPKPGVYRMLDARGDVLYVGKARSLKARVANY
TQVSNLSGRLQRMVSQTRGMEIVTTNSEAEALLLEAQLIKRYRPPFNVLLRDDKSFPFILLRADHDFPRIMKHRGARRAK
GNYYGPFASAGSVNTTINALQKLFLLRSCTDSFFSNRDRPCLLYQIKRCSAPCVGRIDEEGYAELVREAKDFLGGKSDAV
QRKIERQMARAAEDLDFETAAILRDRLRAATFIQGSQAINASGVGDADVFALAHKNGQIAVQAFFIRGGQNWGHRAFFPT
HTKDVEEPQVLSNVILQFYEEVPPPPTVLVDRELPESELIEAALSELAGKKVQLSIPQRGDRRKLMQQASRNATEALDRR
LAERGTQAKLNRELAEFLELDAPPERIEVYDNSHIQGAKAVGAMVVAGPEGFIKNQYRKFNIREAQSNDDFGMMREVMRR
RFRKLAEGEGPYEEDLSTRARTASSAAARDERDGAADTVRPEQRSSEAKRSRERGSRGKKDTHETIWPDLVLIDGGKGQM
SSVRDTLAEMGIEDVPLVAIAKGPDHGREGREVFHFPDGREKTLPVNSPLLFHLQRLRDEVHRYAIGAHRAKRSRAITAS
PLDEIPGIGPARKRALLLHFGTASKVRAAALEDLQRAPGVSNAVARKVYDFYHAGG
>Mature_695_residues
SGTKAGSPNDPRGAERFNEERAAYTVASAKPDLEGGVKAIREVVRTLKPKPGVYRMLDARGDVLYVGKARSLKARVANYT
QVSNLSGRLQRMVSQTRGMEIVTTNSEAEALLLEAQLIKRYRPPFNVLLRDDKSFPFILLRADHDFPRIMKHRGARRAKG
NYYGPFASAGSVNTTINALQKLFLLRSCTDSFFSNRDRPCLLYQIKRCSAPCVGRIDEEGYAELVREAKDFLGGKSDAVQ
RKIERQMARAAEDLDFETAAILRDRLRAATFIQGSQAINASGVGDADVFALAHKNGQIAVQAFFIRGGQNWGHRAFFPTH
TKDVEEPQVLSNVILQFYEEVPPPPTVLVDRELPESELIEAALSELAGKKVQLSIPQRGDRRKLMQQASRNATEALDRRL
AERGTQAKLNRELAEFLELDAPPERIEVYDNSHIQGAKAVGAMVVAGPEGFIKNQYRKFNIREAQSNDDFGMMREVMRRR
FRKLAEGEGPYEEDLSTRARTASSAAARDERDGAADTVRPEQRSSEAKRSRERGSRGKKDTHETIWPDLVLIDGGKGQMS
SVRDTLAEMGIEDVPLVAIAKGPDHGREGREVFHFPDGREKTLPVNSPLLFHLQRLRDEVHRYAIGAHRAKRSRAITASP
LDEIPGIGPARKRALLLHFGTASKVRAAALEDLQRAPGVSNAVARKVYDFYHAGG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=451, Percent_Identity=40.3547671840355, Blast_Score=331, Evalue=1e-91,
Organism=Escherichia coli, GI1788037, Length=198, Percent_Identity=29.2929292929293, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 77474; Mature: 77343

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTKAGSPNDPRGAERFNEERAAYTVASAKPDLEGGVKAIREVVRTLKPKPGVYRMLDA
CCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCC
RGDVLYVGKARSLKARVANYTQVSNLSGRLQRMVSQTRGMEIVTTNSEAEALLLEAQLIK
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
RYRPPFNVLLRDDKSFPFILLRADHDFPRIMKHRGARRAKGNYYGPFASAGSVNTTINAL
HHCCCCEEEEECCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
QKLFLLRSCTDSFFSNRDRPCLLYQIKRCSAPCVGRIDEEGYAELVREAKDFLGGKSDAV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
QRKIERQMARAAEDLDFETAAILRDRLRAATFIQGSQAINASGVGDADVFALAHKNGQIA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEE
VQAFFIRGGQNWGHRAFFPTHTKDVEEPQVLSNVILQFYEEVPPPPTVLVDRELPESELI
EEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHH
EAALSELAGKKVQLSIPQRGDRRKLMQQASRNATEALDRRLAERGTQAKLNRELAEFLEL
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHC
DAPPERIEVYDNSHIQGAKAVGAMVVAGPEGFIKNQYRKFNIREAQSNDDFGMMREVMRR
CCCHHHEEECCCCCCCCHHHHCEEEEECCCHHHHCCHHCCCCEECCCCCCHHHHHHHHHH
RFRKLAEGEGPYEEDLSTRARTASSAAARDERDGAADTVRPEQRSSEAKRSRERGSRGKK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
DTHETIWPDLVLIDGGKGQMSSVRDTLAEMGIEDVPLVAIAKGPDHGREGREVFHFPDGR
CCHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCCCC
EKTLPVNSPLLFHLQRLRDEVHRYAIGAHRAKRSRAITASPLDEIPGIGPARKRALLLHF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHCEEEEEE
GTASKVRAAALEDLQRAPGVSNAVARKVYDFYHAGG
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGTKAGSPNDPRGAERFNEERAAYTVASAKPDLEGGVKAIREVVRTLKPKPGVYRMLDA
CCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCC
RGDVLYVGKARSLKARVANYTQVSNLSGRLQRMVSQTRGMEIVTTNSEAEALLLEAQLIK
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
RYRPPFNVLLRDDKSFPFILLRADHDFPRIMKHRGARRAKGNYYGPFASAGSVNTTINAL
HHCCCCEEEEECCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
QKLFLLRSCTDSFFSNRDRPCLLYQIKRCSAPCVGRIDEEGYAELVREAKDFLGGKSDAV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
QRKIERQMARAAEDLDFETAAILRDRLRAATFIQGSQAINASGVGDADVFALAHKNGQIA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEE
VQAFFIRGGQNWGHRAFFPTHTKDVEEPQVLSNVILQFYEEVPPPPTVLVDRELPESELI
EEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHH
EAALSELAGKKVQLSIPQRGDRRKLMQQASRNATEALDRRLAERGTQAKLNRELAEFLEL
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHC
DAPPERIEVYDNSHIQGAKAVGAMVVAGPEGFIKNQYRKFNIREAQSNDDFGMMREVMRR
CCCHHHEEECCCCCCCCHHHHCEEEEECCCHHHHCCHHCCCCEECCCCCCHHHHHHHHHH
RFRKLAEGEGPYEEDLSTRARTASSAAARDERDGAADTVRPEQRSSEAKRSRERGSRGKK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
DTHETIWPDLVLIDGGKGQMSSVRDTLAEMGIEDVPLVAIAKGPDHGREGREVFHFPDGR
CCHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCCCC
EKTLPVNSPLLFHLQRLRDEVHRYAIGAHRAKRSRAITASPLDEIPGIGPARKRALLLHF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHCEEEEEE
GTASKVRAAALEDLQRAPGVSNAVARKVYDFYHAGG
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA