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The map label for this gene is glmS [H]

Identifier: 85373313

GI number: 85373313

Start: 522217

End: 524040

Strand: Direct

Name: glmS [H]

Synonym: ELI_02430

Alternate gene names: 85373313

Gene position: 522217-524040 (Clockwise)

Preceding gene: 85373312

Following gene: 85373314

Centisome position: 17.11

GC content: 64.31

Gene sequence:

>1824_bases
ATGTGCGGAATCATTGGCATTGTCGGCAAGGAAGAGGTGGCGGACCGCCTGGTCGACGGCCTGCGTCGCATGGAATATCG
CGGCTATGACAGCGCCGGTGTCTGCACGATTGCGGACGGCACACTGATCCGCCGCAGGGCCCAGGGCAAGCTGCAGAACC
TCGTCGCCGAATTGGCCAAGGCGCCGGCGCCGGGCGATATCGGCATCGCTCATACGCGCTGGGCCACCCACGGTGCGCCG
ACGGCCGAGAATGCCCATCCCCACGCCACCGATGAAGTGGCGCTGGTGCACAACGGGATCATCGAGAACTTCAAGCCGCT
GAAGGCCGAACTCACGGAGGGCGGCCGCTCGCTCACGAGCGATACGGACTCCGAGGTGGTCGCGCATCTCGTCTCGGCCG
AGGTGGAACGCGGCGCAAGCCCGGAAGAGGCAATAAAAACTGTCCTGCCGCGGCTGCGCGGTGCCTTCGCACTGGCGATC
GCGTTCCGCCAGCGTCCCGACATGCTGATCGGTGCCCGGCTCGGTTCGCCGCTGGTGGTGGGCTACGGTGAGGGCGAGAC
CTATCTCGGTTCTGACGCCCTTGCCCTCGCTCCGCTGACGCAAAAGATCGCCTATCTCGAGGAAGGCGACTGGGTCGTGA
TCACGCGCGACGGAGCGCAGATTTACGATGCCGAAAACACCCCGGTCGAGCGTGAGACCGTCACGTCCGGCGCCTCCGCC
GCTGCTGTCGAAAAGGGCAATTATCGCCATTTCATGCAAAAGGAGATTTTCGAGCAGCCGACCGTCGTCGCCCAGACTCT
CAATTCCTATGTCCGGCAGGCCGATGAAAGCGTAGCGCTGCCGCAGATCGACTTCGACCTGACGGCGATCAAGCGCATTA
CCATCGTCGCCTGCGGCACGTCGTTCTATGCTGGCATGGTCGCGAAATACTGGTTCGAAACCTTCGCCCGCGTGCCGGTG
GATATCGATGTCGCCAGCGAGTTCCGCTATCGCGAGCCGGTGCTCGAAGATGGCGGCCTCGCCATCTTCATCTCGCAGAG
CGGCGAGACGGCGGACACGCTTGCGGCGCTGCGCCATTGCAAGGAAAACGGCCAGACCATCGCGGCCGTCGTCAATGTCC
CAACCAGCACCATGGCGCGCGAAGCCGACCTGCTGCTGCCGACGCATGCCGGCCCGGAAATCGGGGTCGCTTCGACCAAG
GCCTTCACCTGCCAGCTGGCCGTATTGGCAGCGGTGGCAGCGCATATGGCGGTCAAGAAAGGCAAGATGTCGCGCGAGGA
AGAGCAGGAAGTAGTGCGGCATTTGCTCGAAGCGCCCGCGTGCCTCAATGCCGCGCTCGATCACGACGACGACATTGCGG
CCATGGCGCCGCTGATCGCGCCTGCGCGCGACGTGCTCTACCTCGGTCGCGGGCAGGATTACCCGCTGGCGATGGAGGGC
GCGCTCAAACTCAAGGAGATCAGCTATATCCATGCCGAAGGCTATGCCTCGGGCGAGATGAAGCACGGGCCGATCGCGCT
CATCGACGAAGCGGTGCCGGTGATCGTGCTCGCGCCATCGGGCCCGCTGTTCGAAAAGACCGTCTCCAACATGCAAGAAG
TCAGCGCCCGCGGCGGCAAGATCGTGCTGATCTCCGATGCCGAAGGGCTCGCCGAAGCGGGCGACGGGTGCCTCGCCACG
ATAGAGATGCCCAAGGTCCACCCGCTTATCGCGCCGCTGGTTTATGCGGTGCCGGTCCAGTTGCTCGCCTACCACGTGGC
CGTGGTCAAGGGCACGGATGTCGATCAGCCGCGCAATCTGGCCAAGTCGGTCACGGTCGAATAG

Upstream 100 bases:

>100_bases
CAGCGGGGCGATCCTGATTACCCGAAACACAGAGGATTTCCCGGCCGCCATGCCGGGAATCCGCGTTCCCTACACGCTCT
AGCCCGAAGGATCTGAAAAC

Downstream 100 bases:

>100_bases
ATTGATTTAGCAAAATAATTTTCATCGTCGAACCCGTATTTTCGGCGATATCCTTTACCGCGAAATAACCTTTCGCACCT
AATTCTCGCGTCCGTGAGCG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIIGIVGKEEVADRLVDGLRRMEYRGYDSAGVCTIADGTLIRRRAQGKLQNLVAELAKAPAPGDIGIAHTRWATHGAP
TAENAHPHATDEVALVHNGIIENFKPLKAELTEGGRSLTSDTDSEVVAHLVSAEVERGASPEEAIKTVLPRLRGAFALAI
AFRQRPDMLIGARLGSPLVVGYGEGETYLGSDALALAPLTQKIAYLEEGDWVVITRDGAQIYDAENTPVERETVTSGASA
AAVEKGNYRHFMQKEIFEQPTVVAQTLNSYVRQADESVALPQIDFDLTAIKRITIVACGTSFYAGMVAKYWFETFARVPV
DIDVASEFRYREPVLEDGGLAIFISQSGETADTLAALRHCKENGQTIAAVVNVPTSTMAREADLLLPTHAGPEIGVASTK
AFTCQLAVLAAVAAHMAVKKGKMSREEEQEVVRHLLEAPACLNAALDHDDDIAAMAPLIAPARDVLYLGRGQDYPLAMEG
ALKLKEISYIHAEGYASGEMKHGPIALIDEAVPVIVLAPSGPLFEKTVSNMQEVSARGGKIVLISDAEGLAEAGDGCLAT
IEMPKVHPLIAPLVYAVPVQLLAYHVAVVKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIIGIVGKEEVADRLVDGLRRMEYRGYDSAGVCTIADGTLIRRRAQGKLQNLVAELAKAPAPGDIGIAHTRWATHGAP
TAENAHPHATDEVALVHNGIIENFKPLKAELTEGGRSLTSDTDSEVVAHLVSAEVERGASPEEAIKTVLPRLRGAFALAI
AFRQRPDMLIGARLGSPLVVGYGEGETYLGSDALALAPLTQKIAYLEEGDWVVITRDGAQIYDAENTPVERETVTSGASA
AAVEKGNYRHFMQKEIFEQPTVVAQTLNSYVRQADESVALPQIDFDLTAIKRITIVACGTSFYAGMVAKYWFETFARVPV
DIDVASEFRYREPVLEDGGLAIFISQSGETADTLAALRHCKENGQTIAAVVNVPTSTMAREADLLLPTHAGPEIGVASTK
AFTCQLAVLAAVAAHMAVKKGKMSREEEQEVVRHLLEAPACLNAALDHDDDIAAMAPLIAPARDVLYLGRGQDYPLAMEG
ALKLKEISYIHAEGYASGEMKHGPIALIDEAVPVIVLAPSGPLFEKTVSNMQEVSARGGKIVLISDAEGLAEAGDGCLAT
IEMPKVHPLIAPLVYAVPVQLLAYHVAVVKGTDVDQPRNLAKSVTVE
>Mature_607_residues
MCGIIGIVGKEEVADRLVDGLRRMEYRGYDSAGVCTIADGTLIRRRAQGKLQNLVAELAKAPAPGDIGIAHTRWATHGAP
TAENAHPHATDEVALVHNGIIENFKPLKAELTEGGRSLTSDTDSEVVAHLVSAEVERGASPEEAIKTVLPRLRGAFALAI
AFRQRPDMLIGARLGSPLVVGYGEGETYLGSDALALAPLTQKIAYLEEGDWVVITRDGAQIYDAENTPVERETVTSGASA
AAVEKGNYRHFMQKEIFEQPTVVAQTLNSYVRQADESVALPQIDFDLTAIKRITIVACGTSFYAGMVAKYWFETFARVPV
DIDVASEFRYREPVLEDGGLAIFISQSGETADTLAALRHCKENGQTIAAVVNVPTSTMAREADLLLPTHAGPEIGVASTK
AFTCQLAVLAAVAAHMAVKKGKMSREEEQEVVRHLLEAPACLNAALDHDDDIAAMAPLIAPARDVLYLGRGQDYPLAMEG
ALKLKEISYIHAEGYASGEMKHGPIALIDEAVPVIVLAPSGPLFEKTVSNMQEVSARGGKIVLISDAEGLAEAGDGCLAT
IEMPKVHPLIAPLVYAVPVQLLAYHVAVVKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=689, Percent_Identity=36.2844702467344, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=34.5985401459854, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI1790167, Length=611, Percent_Identity=50.5728314238953, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1788651, Length=246, Percent_Identity=29.2682926829268, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082251, Length=311, Percent_Identity=23.7942122186495, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532899, Length=720, Percent_Identity=33.0555555555556, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=36.6359447004608, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=36.3425925925926, Blast_Score=280, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=453, Percent_Identity=37.0860927152318, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=30.5045871559633, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=230, Percent_Identity=35.2173913043478, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323958, Length=167, Percent_Identity=29.940119760479, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=35.080058224163, Blast_Score=407, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 64874; Mature: 64874

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGIVGKEEVADRLVDGLRRMEYRGYDSAGVCTIADGTLIRRRAQGKLQNLVAELAK
CCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
APAPGDIGIAHTRWATHGAPTAENAHPHATDEVALVHNGIIENFKPLKAELTEGGRSLTS
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCC
DTDSEVVAHLVSAEVERGASPEEAIKTVLPRLRGAFALAIAFRQRPDMLIGARLGSPLVV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEE
GYGEGETYLGSDALALAPLTQKIAYLEEGDWVVITRDGAQIYDAENTPVERETVTSGASA
EECCCCCEECCCCEEHHHHHHHHHHEECCCEEEEECCCCEEEECCCCCCCHHHHCCCCCH
AAVEKGNYRHFMQKEIFEQPTVVAQTLNSYVRQADESVALPQIDFDLTAIKRITIVACGT
HHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEEEEEEECC
SFYAGMVAKYWFETFARVPVDIDVASEFRYREPVLEDGGLAIFISQSGETADTLAALRHC
HHHHHHHHHHHHHHHHCCCCEEEHHCCHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
KENGQTIAAVVNVPTSTMAREADLLLPTHAGPEIGVASTKAFTCQLAVLAAVAAHMAVKK
HHCCCEEEEEEECCCHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GKMSREEEQEVVRHLLEAPACLNAALDHDDDIAAMAPLIAPARDVLYLGRGQDYPLAMEG
CCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCCCEEHHC
ALKLKEISYIHAEGYASGEMKHGPIALIDEAVPVIVLAPSGPLFEKTVSNMQEVSARGGK
CEEEHHEEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHCCCCE
IVLISDAEGLAEAGDGCLATIEMPKVHPLIAPLVYAVPVQLLAYHVAVVKGTDVDQPRNL
EEEEECCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIIGIVGKEEVADRLVDGLRRMEYRGYDSAGVCTIADGTLIRRRAQGKLQNLVAELAK
CCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
APAPGDIGIAHTRWATHGAPTAENAHPHATDEVALVHNGIIENFKPLKAELTEGGRSLTS
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCC
DTDSEVVAHLVSAEVERGASPEEAIKTVLPRLRGAFALAIAFRQRPDMLIGARLGSPLVV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEE
GYGEGETYLGSDALALAPLTQKIAYLEEGDWVVITRDGAQIYDAENTPVERETVTSGASA
EECCCCCEECCCCEEHHHHHHHHHHEECCCEEEEECCCCEEEECCCCCCCHHHHCCCCCH
AAVEKGNYRHFMQKEIFEQPTVVAQTLNSYVRQADESVALPQIDFDLTAIKRITIVACGT
HHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEEEEEEECC
SFYAGMVAKYWFETFARVPVDIDVASEFRYREPVLEDGGLAIFISQSGETADTLAALRHC
HHHHHHHHHHHHHHHHCCCCEEEHHCCHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
KENGQTIAAVVNVPTSTMAREADLLLPTHAGPEIGVASTKAFTCQLAVLAAVAAHMAVKK
HHCCCEEEEEEECCCHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GKMSREEEQEVVRHLLEAPACLNAALDHDDDIAAMAPLIAPARDVLYLGRGQDYPLAMEG
CCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCCCEEHHC
ALKLKEISYIHAEGYASGEMKHGPIALIDEAVPVIVLAPSGPLFEKTVSNMQEVSARGGK
CEEEHHEEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHCCCCE
IVLISDAEGLAEAGDGCLATIEMPKVHPLIAPLVYAVPVQLLAYHVAVVKGTDVDQPRNL
EEEEECCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA