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The map label for this gene is pntAA [H]

Identifier: 85373294

GI number: 85373294

Start: 507165

End: 508277

Strand: Direct

Name: pntAA [H]

Synonym: ELI_02335

Alternate gene names: 85373294

Gene position: 507165-508277 (Clockwise)

Preceding gene: 85373293

Following gene: 85373295

Centisome position: 16.62

GC content: 66.58

Gene sequence:

>1113_bases
TTGCGGATCGTAGCCCTGAGGGAACGCGCGGCCGGGGAGACCCGCGTCGCGCTGACGCCGGAGACGGCGAAGAAATTCAT
CGCGCTGGGTGCAAAGGTCGCGGTCGAGGCAGGGGCGGGCGCCAGGGCTGCGATCCCCGATGCGGCTTACGAAGAGGCGG
GCGCGAGCGTCGGCACTGCCGAGGCGGTGCTGAAAGGCGCCGATATCGTGCTCGGGGTACAGGCTCCGGATGTCGATCTG
CTCGGAGGGGCGAAGCCGGGCGCGTGGGTCGCGGCGACTTTCGATCCGTTCCAGCAGCGCGATCGGGTCGAAGCCTATGC
CGCGGCGGGCCTTGAAGCGTTGAGCATGGAATTTATGCCGCGCATTACGCGTGCGCAGAGCATGGACGTGCTGTCCAGCC
AGGCCAATTTGGCTGGCTACAAAGCCGTGATCGCCGCAGCGGACCAGTACGGCCGCGCCTTCCCGATGATGATGACCGCC
GCCGGCACCGTGCAGGCGGCACGCTGCTTCGTGATGGGCGTGGGAGTCGCCGGCCTGCAGGCGATCGCGACCGCCCGGAG
GCTGGGCGCACAGGTCTCGGCGACCGACGTGCGCCCCGAGACTGCCGAGCAGATCAAGAGCCTGGGCGGCAAGCCAGTCT
TTGCCGAGGGTCTCGAAGCCTCGGGCGATGGCGGTTATGCGGCTGAACTATCAGACGAACAGAAGGCCGCGCAGGCCGAG
CTCGTCTCCGGCCATATCGCCAAACAGGATATCGTCATCACCACCGCTCTGATTCCGGGCCGCGCCGCACCGCGTCTGGT
CAGCGACGACCAGATCGCGACGATGAAGCCGGGCAGCGTGATATTCGATCTGGCCGTTGCGCAAGGCGGCAATGTCGAGG
GGTCGAAACCCGACGAGGTTGTCGAGCGCCACGGCGTTTCGATCATGGGCTTCTCCAATACCCCGGCAACATTGGGCCCC
GATGCCTCGGCCCTGTTCGCGCGCAACCTCTACAATTTCCTCTCCGCCTTCTGGGACGAGGACGCGGGCAGGCCGGTGCT
TGACGAAGAGATCGGCGACGCGGTGCGGCTGACGCATGGCGGCAAGGTCGTAAACGAGAGGCTTTTGCGCTAG

Upstream 100 bases:

>100_bases
AGAGACATATTCGGGATTCATCTCCGCTACCAAGGTCGCCATTCCGATCATCGCGGTGATTACGCTGATCGTCGTCATCC
TGATCGCCGACTGAGCGCCC

Downstream 100 bases:

>100_bases
TCGGGTCGGCTCACGCGACCAATGGTGCATCCGGAAACGGGTCCGCCGGGTAACTCCTGCATACGCAACAGGAGAACCAC
CATGCGCAATAAGCTCAAGA

Product: NAD(P) transhydrogenase, alpha subunit

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRIVALRERAAGETRVALTPETAKKFIALGAKVAVEAGAGARAAIPDAAYEEAGASVGTAEAVLKGADIVLGVQAPDVDL
LGGAKPGAWVAATFDPFQQRDRVEAYAAAGLEALSMEFMPRITRAQSMDVLSSQANLAGYKAVIAAADQYGRAFPMMMTA
AGTVQAARCFVMGVGVAGLQAIATARRLGAQVSATDVRPETAEQIKSLGGKPVFAEGLEASGDGGYAAELSDEQKAAQAE
LVSGHIAKQDIVITTALIPGRAAPRLVSDDQIATMKPGSVIFDLAVAQGGNVEGSKPDEVVERHGVSIMGFSNTPATLGP
DASALFARNLYNFLSAFWDEDAGRPVLDEEIGDAVRLTHGGKVVNERLLR

Sequences:

>Translated_370_residues
MRIVALRERAAGETRVALTPETAKKFIALGAKVAVEAGAGARAAIPDAAYEEAGASVGTAEAVLKGADIVLGVQAPDVDL
LGGAKPGAWVAATFDPFQQRDRVEAYAAAGLEALSMEFMPRITRAQSMDVLSSQANLAGYKAVIAAADQYGRAFPMMMTA
AGTVQAARCFVMGVGVAGLQAIATARRLGAQVSATDVRPETAEQIKSLGGKPVFAEGLEASGDGGYAAELSDEQKAAQAE
LVSGHIAKQDIVITTALIPGRAAPRLVSDDQIATMKPGSVIFDLAVAQGGNVEGSKPDEVVERHGVSIMGFSNTPATLGP
DASALFARNLYNFLSAFWDEDAGRPVLDEEIGDAVRLTHGGKVVNERLLR
>Mature_370_residues
MRIVALRERAAGETRVALTPETAKKFIALGAKVAVEAGAGARAAIPDAAYEEAGASVGTAEAVLKGADIVLGVQAPDVDL
LGGAKPGAWVAATFDPFQQRDRVEAYAAAGLEALSMEFMPRITRAQSMDVLSSQANLAGYKAVIAAADQYGRAFPMMMTA
AGTVQAARCFVMGVGVAGLQAIATARRLGAQVSATDVRPETAEQIKSLGGKPVFAEGLEASGDGGYAAELSDEQKAAQAE
LVSGHIAKQDIVITTALIPGRAAPRLVSDDQIATMKPGSVIFDLAVAQGGNVEGSKPDEVVERHGVSIMGFSNTPATLGP
DASALFARNLYNFLSAFWDEDAGRPVLDEEIGDAVRLTHGGKVVNERLLR

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=346, Percent_Identity=38.4393063583815, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI122939153, Length=346, Percent_Identity=38.4393063583815, Blast_Score=211, Evalue=6e-55,
Organism=Escherichia coli, GI1787887, Length=350, Percent_Identity=41.4285714285714, Blast_Score=253, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17550456, Length=335, Percent_Identity=38.8059701492537, Blast_Score=228, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38334; Mature: 38334

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVALRERAAGETRVALTPETAKKFIALGAKVAVEAGAGARAAIPDAAYEEAGASVGTA
CEEEEECHHCCCCCEEEECHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHCCCCCCHH
EAVLKGADIVLGVQAPDVDLLGGAKPGAWVAATFDPFQQRDRVEAYAAAGLEALSMEFMP
HHHHCCCCEEEEECCCCCCEECCCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHH
RITRAQSMDVLSSQANLAGYKAVIAAADQYGRAFPMMMTAAGTVQAARCFVMGVGVAGLQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHEECCHHHHH
AIATARRLGAQVSATDVRPETAEQIKSLGGKPVFAEGLEASGDGGYAAELSDEQKAAQAE
HHHHHHHHCCCCEECCCCCHHHHHHHHCCCCCEECCCCCCCCCCCEEECCCCHHHHHHHH
LVSGHIAKQDIVITTALIPGRAAPRLVSDDQIATMKPGSVIFDLAVAQGGNVEGSKPDEV
HHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCHHHH
VERHGVSIMGFSNTPATLGPDASALFARNLYNFLSAFWDEDAGRPVLDEEIGDAVRLTHG
HHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEECC
GKVVNERLLR
CHHHHHHHCC
>Mature Secondary Structure
MRIVALRERAAGETRVALTPETAKKFIALGAKVAVEAGAGARAAIPDAAYEEAGASVGTA
CEEEEECHHCCCCCEEEECHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHCCCCCCHH
EAVLKGADIVLGVQAPDVDLLGGAKPGAWVAATFDPFQQRDRVEAYAAAGLEALSMEFMP
HHHHCCCCEEEEECCCCCCEECCCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHH
RITRAQSMDVLSSQANLAGYKAVIAAADQYGRAFPMMMTAAGTVQAARCFVMGVGVAGLQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHEECCHHHHH
AIATARRLGAQVSATDVRPETAEQIKSLGGKPVFAEGLEASGDGGYAAELSDEQKAAQAE
HHHHHHHHCCCCEECCCCCHHHHHHHHCCCCCEECCCCCCCCCCCEEECCCCHHHHHHHH
LVSGHIAKQDIVITTALIPGRAAPRLVSDDQIATMKPGSVIFDLAVAQGGNVEGSKPDEV
HHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCHHHH
VERHGVSIMGFSNTPATLGPDASALFARNLYNFLSAFWDEDAGRPVLDEEIGDAVRLTHG
HHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEECC
GKVVNERLLR
CHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]