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The map label for this gene is tdcB [H]

Identifier: 85373153

GI number: 85373153

Start: 367619

End: 368872

Strand: Direct

Name: tdcB [H]

Synonym: ELI_01630

Alternate gene names: 85373153

Gene position: 367619-368872 (Clockwise)

Preceding gene: 85373148

Following gene: 85373154

Centisome position: 12.04

GC content: 62.92

Gene sequence:

>1254_bases
ATGGACACGAGGGACCCTACGGAATCGGCACCCGGCATCGATGCGCTTACGCTCGACGATGTGCGTGCGGCGGCAAAGCG
GATCGAAGGCGCAGTCGTGCGCACGCCGACGATGCATTCTATCACGCTGTCGCAGATTACCGGGGCCGATATCTGGCTCA
AGTTCGAAAATCTGCAGTTCACCGCCGCCTATAAGGAACGCGGCGCGCTCAACGCGCTCCTGCAATTGAGCGAAAAGCAG
CGCGAGCGCGGCGTCATTGCGGCCTCGGCGGGCAACCACAGCCAGGGCCTCAGCTATCACGGCACCCGGCTCGGCGTGCC
GGTGACCATCGTCATGCCGCGCACCACGCCGTCGGTGAAAGTAATGCAGACCGAAAGCGTCGGCGGAGACGTGGTCCTGC
AAGGCGATACATTCGACGAAGCCTATGCCCATGCGCGCGAACTGGAGCGCGAACGCGGCCTTACTTTCGTACATCCCTTC
GACGATCCGCATGTGGCGGCCGGGGCCGGGACCACTGCGCTGGAGCTGTTCGAAGATGCCCCCGAACTGGACTGCATCGT
CACGCCTATCGGTGGCGGCGGATTGATGAGCGGCATGGCGACGGTCGCCAACGCGCTCTATCCCGACATGAAAGTGGTCG
GCGTACAGGCAGAACTGTTTCCGTCCATGTTCGCCAAGATCAACGGGGTGGAGAAGGATTGCGGCGGCGACACGCTGGCC
GAGGGCATCGCCGTCAAGGCGCCGGGCCAATTCACGTCGAAAGTGATTGCCGAGCGTGTCGACGAGATCCTGCTGGTTAG
CGAACCGAAGCTGGAAAACGCGGTTTCGCTGCTATTGCAGATCGAGAAGACCGTGGTCGAAGGGGCGGGCGCGGCGGGTC
TGGCCGCAGTCCTCGCGCATCCCGAGAAATTCAGGGGCCGCAAGATCGGCCTGGTGCTGTGCGGCGGCAATATCGATTCG
CGCCTACTTGCAAATGTGCTGCTGCGCGATCTCGCCCGGGCCGGGCGGCTCGCGCGTCTTCGCATCACGCTGCAGGATCG
CCCCGGTGCGCTCTACAACGTGATGCGCGAATTCGATGCGCACAACGTCAACATCATCGAAATCTATCACCAGCGCATCT
TCACCAACCTGCCCGCCAAGGGCCTGATTACCGATATCGAATGCGAGGCGCGCGATGCGCAGCAGCTTTCCGCACTGGTC
GCTGCGCTGCGCGGCAAGGGCTACATCGTGAGCCCGGTCGAACTCGACAAATAG

Upstream 100 bases:

>100_bases
TGATCTCGCTCATGCGGCCATGCGCGTAATGGCAATGTTTGCCGCTGCCAACATTCTTTCGAATTGCGCGAGGTGTGTAT
CGCCCCTAGGGCGCGCAGCC

Downstream 100 bases:

>100_bases
GCGCGGTTCCTGCGGCGTGCCGGCCCCGCCAGGTGTTGAAAGTCGTCGAATCTTAACCCTGTTACGTGGTTAAGGGCCTT
TTACCGACGGCCTCCGTCAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDTRDPTESAPGIDALTLDDVRAAAKRIEGAVVRTPTMHSITLSQITGADIWLKFENLQFTAAYKERGALNALLQLSEKQ
RERGVIAASAGNHSQGLSYHGTRLGVPVTIVMPRTTPSVKVMQTESVGGDVVLQGDTFDEAYAHARELERERGLTFVHPF
DDPHVAAGAGTTALELFEDAPELDCIVTPIGGGGLMSGMATVANALYPDMKVVGVQAELFPSMFAKINGVEKDCGGDTLA
EGIAVKAPGQFTSKVIAERVDEILLVSEPKLENAVSLLLQIEKTVVEGAGAAGLAAVLAHPEKFRGRKIGLVLCGGNIDS
RLLANVLLRDLARAGRLARLRITLQDRPGALYNVMREFDAHNVNIIEIYHQRIFTNLPAKGLITDIECEARDAQQLSALV
AALRGKGYIVSPVELDK

Sequences:

>Translated_417_residues
MDTRDPTESAPGIDALTLDDVRAAAKRIEGAVVRTPTMHSITLSQITGADIWLKFENLQFTAAYKERGALNALLQLSEKQ
RERGVIAASAGNHSQGLSYHGTRLGVPVTIVMPRTTPSVKVMQTESVGGDVVLQGDTFDEAYAHARELERERGLTFVHPF
DDPHVAAGAGTTALELFEDAPELDCIVTPIGGGGLMSGMATVANALYPDMKVVGVQAELFPSMFAKINGVEKDCGGDTLA
EGIAVKAPGQFTSKVIAERVDEILLVSEPKLENAVSLLLQIEKTVVEGAGAAGLAAVLAHPEKFRGRKIGLVLCGGNIDS
RLLANVLLRDLARAGRLARLRITLQDRPGALYNVMREFDAHNVNIIEIYHQRIFTNLPAKGLITDIECEARDAQQLSALV
AALRGKGYIVSPVELDK
>Mature_417_residues
MDTRDPTESAPGIDALTLDDVRAAAKRIEGAVVRTPTMHSITLSQITGADIWLKFENLQFTAAYKERGALNALLQLSEKQ
RERGVIAASAGNHSQGLSYHGTRLGVPVTIVMPRTTPSVKVMQTESVGGDVVLQGDTFDEAYAHARELERERGLTFVHPF
DDPHVAAGAGTTALELFEDAPELDCIVTPIGGGGLMSGMATVANALYPDMKVVGVQAELFPSMFAKINGVEKDCGGDTLA
EGIAVKAPGQFTSKVIAERVDEILLVSEPKLENAVSLLLQIEKTVVEGAGAAGLAAVLAHPEKFRGRKIGLVLCGGNIDS
RLLANVLLRDLARAGRLARLRITLQDRPGALYNVMREFDAHNVNIIEIYHQRIFTNLPAKGLITDIECEARDAQQLSALV
AALRGKGYIVSPVELDK

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=326, Percent_Identity=31.2883435582822, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI19923959, Length=144, Percent_Identity=35.4166666666667, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33469958, Length=324, Percent_Identity=26.5432098765432, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789505, Length=310, Percent_Identity=39.3548387096774, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1790207, Length=322, Percent_Identity=36.9565217391304, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71991565, Length=404, Percent_Identity=35.1485148514851, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17537387, Length=362, Percent_Identity=35.3591160220994, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=318, Percent_Identity=29.2452830188679, Blast_Score=131, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=37.3040752351097, Blast_Score=183, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320930, Length=355, Percent_Identity=32.9577464788732, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=169, Percent_Identity=27.810650887574, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355833, Length=373, Percent_Identity=38.0697050938338, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24645328, Length=266, Percent_Identity=34.5864661654135, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44719; Mature: 44719

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTRDPTESAPGIDALTLDDVRAAAKRIEGAVVRTPTMHSITLSQITGADIWLKFENLQF
CCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCEEECCCCCEEEHHHCCCCEEEEEEECEEE
TAAYKERGALNALLQLSEKQRERGVIAASAGNHSQGLSYHGTRLGVPVTIVMPRTTPSVK
EEHHHHCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEECCEEEEEEECCCCCEE
VMQTESVGGDVVLQGDTFDEAYAHARELERERGLTFVHPFDDPHVAAGAGTTALELFEDA
EEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCCCCHHHHHHHCC
PELDCIVTPIGGGGLMSGMATVANALYPDMKVVGVQAELFPSMFAKINGVEKDCGGDTLA
CCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCHHH
EGIAVKAPGQFTSKVIAERVDEILLVSEPKLENAVSLLLQIEKTVVEGAGAAGLAAVLAH
CCEEEECCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
PEKFRGRKIGLVLCGGNIDSRLLANVLLRDLARAGRLARLRITLQDRPGALYNVMREFDA
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHCC
HNVNIIEIYHQRIFTNLPAKGLITDIECEARDAQQLSALVAALRGKGYIVSPVELDK
CCCEEEEEEHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure
MDTRDPTESAPGIDALTLDDVRAAAKRIEGAVVRTPTMHSITLSQITGADIWLKFENLQF
CCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCEEECCCCCEEEHHHCCCCEEEEEEECEEE
TAAYKERGALNALLQLSEKQRERGVIAASAGNHSQGLSYHGTRLGVPVTIVMPRTTPSVK
EEHHHHCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEECCEEEEEEECCCCCEE
VMQTESVGGDVVLQGDTFDEAYAHARELERERGLTFVHPFDDPHVAAGAGTTALELFEDA
EEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCCCCHHHHHHHCC
PELDCIVTPIGGGGLMSGMATVANALYPDMKVVGVQAELFPSMFAKINGVEKDCGGDTLA
CCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCHHH
EGIAVKAPGQFTSKVIAERVDEILLVSEPKLENAVSLLLQIEKTVVEGAGAAGLAAVLAH
CCEEEECCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
PEKFRGRKIGLVLCGGNIDSRLLANVLLRDLARAGRLARLRITLQDRPGALYNVMREFDA
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHCC
HNVNIIEIYHQRIFTNLPAKGLITDIECEARDAQQLSALVAALRGKGYIVSPVELDK
CCCEEEEEEHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA