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The map label for this gene is 85373116

Identifier: 85373116

GI number: 85373116

Start: 330395

End: 332392

Strand: Direct

Name: 85373116

Synonym: ELI_01445

Alternate gene names: NA

Gene position: 330395-332392 (Clockwise)

Preceding gene: 85373115

Following gene: 85373118

Centisome position: 10.82

GC content: 61.56

Gene sequence:

>1998_bases
ATGAAGCTGCTGAAGACCGCCTGTTTTGCCGTTGCCGGGGCTGCGATGGCAGCTGGCCTGGCACCTGCCGCCATGGCCGC
CAAGGACAACCAGCCCTCGGTGCCGATCGAAGTCTGGGCGCTGCGCAATGTCGTGAACACCGTGCAGGTTTCGCCCGACG
GCAGGCACCTGCTGGTGCTGAAGACCGAGAGCCGCGAAGGCGAGCACATCCTCGAGATCTACAAGACCGACGACATGTCG
AAGCCGTTCCGCCGCCTGAACGCCGATCCGATGGAATTCATCAGCGCGAGCTGGGTCAGCAGCAACCACATTTTCGGCAC
CGCATGGCAGGTCAAGCGCAGCAAGGTGAACGGCCCCGAAGAGGACGTGCGCGAATATGCGACCTATTCCTACAATCTGG
AAAAGAACAAGTTCCAGCAGGTCGACGGCGAATTCAGCATCGTCAACATCCTGCCGGGCGAGCCGATGGAAGTGCTCGTC
GCCACCGGGCGCGACGATAGCGCGCTGACCGGCGTCGACCCGTTCTCAGCGTTCAAGCCGCGGTCCTATTACCGCTACAA
TCTCGAGACCGGCAAACGGAACCTCGTGATGCGCGGTACCGTGAAATACCCGCGCCCGACTTTCGATCTCGAAGGCAACC
CGCGCTATGTCGAATCCTACGATCCGGCGACCAAGACGCTCAAGACCTACTACCGTCTGCCAGGTGACGGGACCTGGACC
GAGTTCGGTCAGAGCTACGATCTCGACAGCCACGAGAATCTCTATCGCGTCCTCGGCGGCTTCATGGGGCTCGCCGGTTT
CAAGGAAGACGACCCGACGATCGGCTACATCATCGACAACCGTGGCGAGGACAAGGCCGCGCTGTGGGAGTTCGATTTCA
AGACCGGCCAGTTCGGCGAGAAGCTGTTTTCGACCCCCGATGCCGATGTGATGGGCATCGCGACGAGCTCGATGCCGGAT
TCGACCAAGCTGGTGGCCGCCGTCTACCCCGGTGCCAAGTTCGAGCGCGCCTGGTTCGACACCGAAGAACTCGCGTTGTA
CGAGCAGTTCTACAAGCTCATTCCCAACGCGCACCAGATCAGCGTTTCCAGCCGTTCGCTCGATGGCAATACCATGGTGG
TCCAGAACACGGGCCCAAAGGATCCCGGCTCGTTCTGGTTCGTCAAGGATGGCAAGATCACCAAGCTCGGCAGCCGCAAC
CCGCTGCTGCAGCCGGAACAGCTCGCCGATGTCGAGTTCATCAAATATCCGGCGCGCGACGGGCACATGATTCCGGCCTA
TTTGACCAAGCCCAAGGGCGAAGGTCCGTTCCCGCTGATCGTGCTGCCGCACGGCGGCCCGCACGTGACCGAAGTCGTCA
CCTATGACGAATGGGGCCAGCTGCTCGCCAATGCCGGCTACATGGTGTTGCAGCCGCAGTACCGCATGTCCGTCGGCTGG
GGGCAGAAGCACTTCGACGACGCTTACGGCCAGCACGGCCTGCTGATGCAGGACGACAAGGACGATGGCGCCAAGTACTT
GATCGAGCAGGGCCTGGTCGACCCCGACCGCGTCGCCATGTTCGGCTGGTCCTACGGCGGCTATGCGGCCTTGGTCGCGC
TGACGCGTGAAGACAATCTCTACCAGTGTGCGATTGCCGGCGCGGCCGTCGCGGATCCGGAGAAAGTGTACAAGAAGCGT
CGCAATCCCAACGATGCGAAGGCCCTGGACGACTGGAGCCAGCGTCGCGGCATGATCGGCATCAACCCGATCAAGGAGGT
GAACAAGCCCTCGATCCCGCTGCTGATGGTGCACGGCGACGTCGATGCGCGCGTGCTCTACTTCAACTTCACCGACTACA
AGAAGGCGATGGAGGACGCGGGCAAGACCAATGCGCAATACCTGACGCTCAAGGGTGCCGATCACTTCTCGCGCACGCTG
ATGTACGAGCACCAGGAAGCATTTTACACCAAGATGATCGACTATCTCGCCAACGATTGCGGGCCGGGCGGCCTGTGA

Upstream 100 bases:

>100_bases
CCAGGGAAGGGCGGCTCCGGGCAATTGCGCTTGGGCCGCCCTTTTCGTATCAATTCCAATCCGATATGTTCTCCATCCAC
CCAATTGTAAGAGTCGCATT

Downstream 100 bases:

>100_bases
TCCTGCGCTGACAGGCAATCAAACAGAAAAGGCGCGGCCCGCGGGTCGCGCCTTTTTCATGTCCAGCCCTGCGATTGCTG
AGGCTCAGTGCAAACGAGCC

Product: prolyl oligopeptidase family protein

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MKLLKTACFAVAGAAMAAGLAPAAMAAKDNQPSVPIEVWALRNVVNTVQVSPDGRHLLVLKTESREGEHILEIYKTDDMS
KPFRRLNADPMEFISASWVSSNHIFGTAWQVKRSKVNGPEEDVREYATYSYNLEKNKFQQVDGEFSIVNILPGEPMEVLV
ATGRDDSALTGVDPFSAFKPRSYYRYNLETGKRNLVMRGTVKYPRPTFDLEGNPRYVESYDPATKTLKTYYRLPGDGTWT
EFGQSYDLDSHENLYRVLGGFMGLAGFKEDDPTIGYIIDNRGEDKAALWEFDFKTGQFGEKLFSTPDADVMGIATSSMPD
STKLVAAVYPGAKFERAWFDTEELALYEQFYKLIPNAHQISVSSRSLDGNTMVVQNTGPKDPGSFWFVKDGKITKLGSRN
PLLQPEQLADVEFIKYPARDGHMIPAYLTKPKGEGPFPLIVLPHGGPHVTEVVTYDEWGQLLANAGYMVLQPQYRMSVGW
GQKHFDDAYGQHGLLMQDDKDDGAKYLIEQGLVDPDRVAMFGWSYGGYAALVALTREDNLYQCAIAGAAVADPEKVYKKR
RNPNDAKALDDWSQRRGMIGINPIKEVNKPSIPLLMVHGDVDARVLYFNFTDYKKAMEDAGKTNAQYLTLKGADHFSRTL
MYEHQEAFYTKMIDYLANDCGPGGL

Sequences:

>Translated_665_residues
MKLLKTACFAVAGAAMAAGLAPAAMAAKDNQPSVPIEVWALRNVVNTVQVSPDGRHLLVLKTESREGEHILEIYKTDDMS
KPFRRLNADPMEFISASWVSSNHIFGTAWQVKRSKVNGPEEDVREYATYSYNLEKNKFQQVDGEFSIVNILPGEPMEVLV
ATGRDDSALTGVDPFSAFKPRSYYRYNLETGKRNLVMRGTVKYPRPTFDLEGNPRYVESYDPATKTLKTYYRLPGDGTWT
EFGQSYDLDSHENLYRVLGGFMGLAGFKEDDPTIGYIIDNRGEDKAALWEFDFKTGQFGEKLFSTPDADVMGIATSSMPD
STKLVAAVYPGAKFERAWFDTEELALYEQFYKLIPNAHQISVSSRSLDGNTMVVQNTGPKDPGSFWFVKDGKITKLGSRN
PLLQPEQLADVEFIKYPARDGHMIPAYLTKPKGEGPFPLIVLPHGGPHVTEVVTYDEWGQLLANAGYMVLQPQYRMSVGW
GQKHFDDAYGQHGLLMQDDKDDGAKYLIEQGLVDPDRVAMFGWSYGGYAALVALTREDNLYQCAIAGAAVADPEKVYKKR
RNPNDAKALDDWSQRRGMIGINPIKEVNKPSIPLLMVHGDVDARVLYFNFTDYKKAMEDAGKTNAQYLTLKGADHFSRTL
MYEHQEAFYTKMIDYLANDCGPGGL
>Mature_665_residues
MKLLKTACFAVAGAAMAAGLAPAAMAAKDNQPSVPIEVWALRNVVNTVQVSPDGRHLLVLKTESREGEHILEIYKTDDMS
KPFRRLNADPMEFISASWVSSNHIFGTAWQVKRSKVNGPEEDVREYATYSYNLEKNKFQQVDGEFSIVNILPGEPMEVLV
ATGRDDSALTGVDPFSAFKPRSYYRYNLETGKRNLVMRGTVKYPRPTFDLEGNPRYVESYDPATKTLKTYYRLPGDGTWT
EFGQSYDLDSHENLYRVLGGFMGLAGFKEDDPTIGYIIDNRGEDKAALWEFDFKTGQFGEKLFSTPDADVMGIATSSMPD
STKLVAAVYPGAKFERAWFDTEELALYEQFYKLIPNAHQISVSSRSLDGNTMVVQNTGPKDPGSFWFVKDGKITKLGSRN
PLLQPEQLADVEFIKYPARDGHMIPAYLTKPKGEGPFPLIVLPHGGPHVTEVVTYDEWGQLLANAGYMVLQPQYRMSVGW
GQKHFDDAYGQHGLLMQDDKDDGAKYLIEQGLVDPDRVAMFGWSYGGYAALVALTREDNLYQCAIAGAAVADPEKVYKKR
RNPNDAKALDDWSQRRGMIGINPIKEVNKPSIPLLMVHGDVDARVLYFNFTDYKKAMEDAGKTNAQYLTLKGADHFSRTL
MYEHQEAFYTKMIDYLANDCGPGGL

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI16933540, Length=356, Percent_Identity=23.876404494382, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI23510451, Length=285, Percent_Identity=25.2631578947368, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI18450280, Length=224, Percent_Identity=29.0178571428571, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI37577089, Length=224, Percent_Identity=29.0178571428571, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25144537, Length=381, Percent_Identity=23.0971128608924, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25144540, Length=381, Percent_Identity=23.0971128608924, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI25144543, Length=295, Percent_Identity=25.7627118644068, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552908, Length=223, Percent_Identity=31.390134529148, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25149159, Length=237, Percent_Identity=25.3164556962025, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17550672, Length=333, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508019, Length=149, Percent_Identity=31.5436241610738, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508017, Length=149, Percent_Identity=31.5436241610738, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551969, Length=231, Percent_Identity=29.8701298701299, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45550825, Length=231, Percent_Identity=29.8701298701299, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45553511, Length=231, Percent_Identity=29.8701298701299, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 74436; Mature: 74436

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLKTACFAVAGAAMAAGLAPAAMAAKDNQPSVPIEVWALRNVVNTVQVSPDGRHLLVL
CCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEHHHHHHHHHEEEECCCCCEEEEE
KTESREGEHILEIYKTDDMSKPFRRLNADPMEFISASWVSSNHIFGTAWQVKRSKVNGPE
EECCCCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCH
EDVREYATYSYNLEKNKFQQVDGEFSIVNILPGEPMEVLVATGRDDSALTGVDPFSAFKP
HHHHHHHHEEECCCHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCHHCCCC
RSYYRYNLETGKRNLVMRGTVKYPRPTFDLEGNPRYVESYDPATKTLKTYYRLPGDGTWT
CCEEEEEECCCCCEEEEEEEECCCCCCEECCCCCCEEECCCHHHHHHHHHEECCCCCCHH
EFGQSYDLDSHENLYRVLGGFMGLAGFKEDDPTIGYIIDNRGEDKAALWEFDFKTGQFGE
HCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHH
KLFSTPDADVMGIATSSMPDSTKLVAAVYPGAKFERAWFDTEELALYEQFYKLIPNAHQI
HHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHCCCCEEE
SVSSRSLDGNTMVVQNTGPKDPGSFWFVKDGKITKLGSRNPLLQPEQLADVEFIKYPARD
EEECCCCCCCEEEEECCCCCCCCCEEEEECCEEEEECCCCCCCCHHHHCCEEEEECCCCC
GHMIPAYLTKPKGEGPFPLIVLPHGGPHVTEVVTYDEWGQLLANAGYMVLQPQYRMSVGW
CCEEEHEEECCCCCCCCEEEEECCCCCCEEEEEEHHHHHHHHHCCCEEEECCCEEEECCC
GQKHFDDAYGQHGLLMQDDKDDGAKYLIEQGLVDPDRVAMFGWSYGGYAALVALTREDNL
CCHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCHHHEEEEECCCCCEEEEEEEECCCCE
YQCAIAGAAVADPEKVYKKRRNPNDAKALDDWSQRRGMIGINPIKEVNKPSIPLLMVHGD
EEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEEEECC
VDARVLYFNFTDYKKAMEDAGKTNAQYLTLKGADHFSRTLMYEHQEAFYTKMIDYLANDC
CCEEEEEEECHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GPGGL
CCCCC
>Mature Secondary Structure
MKLLKTACFAVAGAAMAAGLAPAAMAAKDNQPSVPIEVWALRNVVNTVQVSPDGRHLLVL
CCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEHHHHHHHHHEEEECCCCCEEEEE
KTESREGEHILEIYKTDDMSKPFRRLNADPMEFISASWVSSNHIFGTAWQVKRSKVNGPE
EECCCCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCH
EDVREYATYSYNLEKNKFQQVDGEFSIVNILPGEPMEVLVATGRDDSALTGVDPFSAFKP
HHHHHHHHEEECCCHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCHHCCCC
RSYYRYNLETGKRNLVMRGTVKYPRPTFDLEGNPRYVESYDPATKTLKTYYRLPGDGTWT
CCEEEEEECCCCCEEEEEEEECCCCCCEECCCCCCEEECCCHHHHHHHHHEECCCCCCHH
EFGQSYDLDSHENLYRVLGGFMGLAGFKEDDPTIGYIIDNRGEDKAALWEFDFKTGQFGE
HCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHH
KLFSTPDADVMGIATSSMPDSTKLVAAVYPGAKFERAWFDTEELALYEQFYKLIPNAHQI
HHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHCCCCEEE
SVSSRSLDGNTMVVQNTGPKDPGSFWFVKDGKITKLGSRNPLLQPEQLADVEFIKYPARD
EEECCCCCCCEEEEECCCCCCCCCEEEEECCEEEEECCCCCCCCHHHHCCEEEEECCCCC
GHMIPAYLTKPKGEGPFPLIVLPHGGPHVTEVVTYDEWGQLLANAGYMVLQPQYRMSVGW
CCEEEHEEECCCCCCCCEEEEECCCCCCEEEEEEHHHHHHHHHCCCEEEECCCEEEECCC
GQKHFDDAYGQHGLLMQDDKDDGAKYLIEQGLVDPDRVAMFGWSYGGYAALVALTREDNL
CCHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCHHHEEEEECCCCCEEEEEEEECCCCE
YQCAIAGAAVADPEKVYKKRRNPNDAKALDDWSQRRGMIGINPIKEVNKPSIPLLMVHGD
EEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEEEECC
VDARVLYFNFTDYKKAMEDAGKTNAQYLTLKGADHFSRTLMYEHQEAFYTKMIDYLANDC
CCEEEEEEECHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GPGGL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]