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The map label for this gene is mip [H]

Identifier: 85373099

GI number: 85373099

Start: 308148

End: 308741

Strand: Direct

Name: mip [H]

Synonym: ELI_01360

Alternate gene names: 85373099

Gene position: 308148-308741 (Clockwise)

Preceding gene: 85373098

Following gene: 85373100

Centisome position: 10.1

GC content: 66.84

Gene sequence:

>594_bases
ATGACCGAAGTTACCCGCGTTCCGCTCCAGCCGATTGCCAAGGGCTCGCTGACCAAGCTGTGGCTGGGCGTCATCGTCGC
CGTGCTGATCGGCGCAGGCGTCGCCTGGGCCGCGGTGCCCAAGGGTGTAAGCGTCGAAACCATCACCGCCGGTTCGGGCG
GTAGCCCGTCGATCGGCGATGTCGCCTTCGTGAAATACAAGGGCACGCTGGCCGACGGTACCGTGTTCGACGAAAGCGGC
CCGTCGCCGTTCCCCCCGGGCATCTTCCCCGAAGGCACGCCCTTCCTGCTCGAGGAAGGCCAGGTGGTCGATGGCTTCCT
GATCGGTCTCCAGCAGATGGAAAAGGGCGGCACCTATGAGCTCTATATCCCGTCCGAATTCGCCTATGGCGACGAGCCGC
GCCCCGGATCGCCGATCCCGCCGGGCGCCGACCTCACTTTCGAAGTCGAACTCGTCGATTTCATGAGCCGCGAAGATGCC
GAGCGCCGCGTGATGGCGATGCAGCAGGCGATGGAAGCGCAGCAGGGCGGCGAGGGCGGTGTCGCTCCTCCGCCCCCGCC
ACAGCAGGTCCCCGGCCCGCCGCCGCAGAACTAA

Upstream 100 bases:

>100_bases
TTGAAGTGGCGGCACGGTTACGCCAAAGGGCGCGGGAAGCAATTTCCGCGCCCTTCGCCTATCTGCAATCGCGGCGGGCG
CCGCAAATCCAGGATTGGTC

Downstream 100 bases:

>100_bases
TCTCCCTCACGACAGGAGGCCCCCGACGCCATGTCCGTCGACAAGGAAACCGTAGCCAAGATCGCTTCGCTCGCGCGGAT
CAAGATGACCGATGCCGAGC

Product: peptidyl-prolyl isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTEVTRVPLQPIAKGSLTKLWLGVIVAVLIGAGVAWAAVPKGVSVETITAGSGGSPSIGDVAFVKYKGTLADGTVFDESG
PSPFPPGIFPEGTPFLLEEGQVVDGFLIGLQQMEKGGTYELYIPSEFAYGDEPRPGSPIPPGADLTFEVELVDFMSREDA
ERRVMAMQQAMEAQQGGEGGVAPPPPPQQVPGPPPQN

Sequences:

>Translated_197_residues
MTEVTRVPLQPIAKGSLTKLWLGVIVAVLIGAGVAWAAVPKGVSVETITAGSGGSPSIGDVAFVKYKGTLADGTVFDESG
PSPFPPGIFPEGTPFLLEEGQVVDGFLIGLQQMEKGGTYELYIPSEFAYGDEPRPGSPIPPGADLTFEVELVDFMSREDA
ERRVMAMQQAMEAQQGGEGGVAPPPPPQQVPGPPPQN
>Mature_196_residues
TEVTRVPLQPIAKGSLTKLWLGVIVAVLIGAGVAWAAVPKGVSVETITAGSGGSPSIGDVAFVKYKGTLADGTVFDESGP
SPFPPGIFPEGTPFLLEEGQVVDGFLIGLQQMEKGGTYELYIPSEFAYGDEPRPGSPIPPGADLTFEVELVDFMSREDAE
RRVMAMQQAMEAQQGGEGGVAPPPPPQQVPGPPPQN

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=42.4242424242424, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI206725530, Length=101, Percent_Identity=43.5643564356436, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI17149844, Length=101, Percent_Identity=43.5643564356436, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI17149842, Length=101, Percent_Identity=43.5643564356436, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082390, Length=119, Percent_Identity=37.8151260504202, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789745, Length=112, Percent_Identity=39.2857142857143, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20576; Mature: 20444

Theoretical pI: Translated: 3.98; Mature: 3.98

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVTRVPLQPIAKGSLTKLWLGVIVAVLIGAGVAWAAVPKGVSVETITAGSGGSPSIGD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCCCCCCCC
VAFVKYKGTLADGTVFDESGPSPFPPGIFPEGTPFLLEEGQVVDGFLIGLQQMEKGGTYE
EEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCEE
LYIPSEFAYGDEPRPGSPIPPGADLTFEVELVDFMSREDAERRVMAMQQAMEAQQGGEGG
EEECCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
VAPPPPPQQVPGPPPQN
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEVTRVPLQPIAKGSLTKLWLGVIVAVLIGAGVAWAAVPKGVSVETITAGSGGSPSIGD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCCCCCCCC
VAFVKYKGTLADGTVFDESGPSPFPPGIFPEGTPFLLEEGQVVDGFLIGLQQMEKGGTYE
EEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCEE
LYIPSEFAYGDEPRPGSPIPPGADLTFEVELVDFMSREDAERRVMAMQQAMEAQQGGEGG
EEECCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
VAPPPPPQQVPGPPPQN
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA