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The map label for this gene is yqeC [H]

Identifier: 84625374

GI number: 84625374

Start: 4202164

End: 4203105

Strand: Reverse

Name: yqeC [H]

Synonym: XOO_3717

Alternate gene names: 84625374

Gene position: 4203105-4202164 (Counterclockwise)

Preceding gene: 84625375

Following gene: 84625372

Centisome position: 85.08

GC content: 64.12

Gene sequence:

>942_bases
ATGGAACTGGGTATGGTGGGACTGGGCCGCATGGGCGCCAATATGGCCGAGCGCCTGATCAACGGCGGGCATCGCGTGCA
TGGCTACGACCCGGGCGCGAACGCGCGCACCAGCGCGCAGGCCAAGGGCATTGTGACGGCCGATGCGCTGGCAGCGCTGG
TGTCCGCATTGCCGACCCCGCGCGTGGTGTGGTTGATGGTGCCGGCGGGCAAGATCGTCGATGACACCCTGGCGCAGCTG
CTCCCTTTGCTGCAGACCGGCGACATCGTCATTGATGGCGGTAATTCGTATTACAAGGATTCGCAGCGTCGTGCAGCGCT
GCTGCAGGCCAGCGGCATTGCCTTCGTCGACTGCGGCACCAGCGGCGGTGTTTGGGGTCTGCAGGAAGGCTACAGTTTGA
TGGTGGGTGGCGACGAAGCAGCGGTGACTGCGTTGCATCCGATCCTGGCAACGCTTGCGCCAGCGCCGGACAAGGGCTGG
GGACGGGTCGGCCCAAGCGGTGCCGGCCACTTCACCAAGATGGTCCATAACGGCATCGAATACGGAATGATGCAGGCCTA
TGCCGAAGGCTTCGCGCTGATGCAGCACAAGACCGATTTCGCGCTGGACCTGCACCAGGTCGCCGAGATCTGGCGCGACG
GCAGCGTGGTGCGTTCGTGGTTGCTGGATCTCACGGCCGATGCGTTGACGCATAACCCGACCATGGCCGGCATCGCGCCG
TTCGTGGCAGATTCGGGCGAAGGCCGCTGGACGGTGGCCGAGGCGATCGATCTGGAAGTCTCGGCACCGGTCATCACCTT
GTCGCTAATGGAGCGGTTGCGCTCGCGCGACAAGGATTCGTTTACCGACAAACTGCTGGCGGCGATGCGCAATCAGTTCG
GTGGCCACGCCGTGATGACCACGACCTCTGCAGTACCGACGATCGGCAGCAAGGACGCGTAA

Upstream 100 bases:

>100_bases
GCGGCGCCGCGACCGCAGCGGAACAATCCATTGAGAATTCCGCCACGCCAGCGTACGCCGGGCGTGGCACCCTGCACTGA
TCAACGCATGAGGAGCGATT

Downstream 100 bases:

>100_bases
GCGGTTGGATGCCAGGGCGGTGCGTGCCTTGAATGCGGCGCGCACTGTCGGTAGTGCAGAACGTTTGGCATTGCATCCGA
ATGCACGAGCGCGTTTGCAG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: CO2; Nicotinamide adenine dinucleotide phosphate - reduced; D-Ribulose 5-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MELGMVGLGRMGANMAERLINGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPTPRVVWLMVPAGKIVDDTLAQL
LPLLQTGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGTSGGVWGLQEGYSLMVGGDEAAVTALHPILATLAPAPDKGW
GRVGPSGAGHFTKMVHNGIEYGMMQAYAEGFALMQHKTDFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMTTTSAVPTIGSKDA

Sequences:

>Translated_313_residues
MELGMVGLGRMGANMAERLINGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPTPRVVWLMVPAGKIVDDTLAQL
LPLLQTGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGTSGGVWGLQEGYSLMVGGDEAAVTALHPILATLAPAPDKGW
GRVGPSGAGHFTKMVHNGIEYGMMQAYAEGFALMQHKTDFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMTTTSAVPTIGSKDA
>Mature_313_residues
MELGMVGLGRMGANMAERLINGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPTPRVVWLMVPAGKIVDDTLAQL
LPLLQTGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGTSGGVWGLQEGYSLMVGGDEAAVTALHPILATLAPAPDKGW
GRVGPSGAGHFTKMVHNGIEYGMMQAYAEGFALMQHKTDFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMTTTSAVPTIGSKDA

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=313, Percent_Identity=37.3801916932907, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1788341, Length=292, Percent_Identity=35.6164383561644, Blast_Score=160, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17542558, Length=301, Percent_Identity=36.2126245847176, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321695, Length=303, Percent_Identity=35.6435643564356, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6321977, Length=331, Percent_Identity=35.0453172205438, Blast_Score=153, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24639279, Length=300, Percent_Identity=36.6666666666667, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24655230, Length=244, Percent_Identity=29.9180327868852, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922568, Length=244, Percent_Identity=29.9180327868852, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44 [C]

Molecular weight: Translated: 33008; Mature: 33008

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGMVGLGRMGANMAERLINGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPTP
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCC
RVVWLMVPAGKIVDDTLAQLLPLLQTGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGT
CEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEECCC
SGGVWGLQEGYSLMVGGDEAAVTALHPILATLAPAPDKGWGRVGPSGAGHFTKMVHNGIE
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YGMMQAYAEGFALMQHKTDFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMT
HHCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEE
TTSAVPTIGSKDA
ECCCCCCCCCCCC
>Mature Secondary Structure
MELGMVGLGRMGANMAERLINGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPTP
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCC
RVVWLMVPAGKIVDDTLAQLLPLLQTGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGT
CEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEECCC
SGGVWGLQEGYSLMVGGDEAAVTALHPILATLAPAPDKGWGRVGPSGAGHFTKMVHNGIE
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YGMMQAYAEGFALMQHKTDFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMT
HHCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEE
TTSAVPTIGSKDA
ECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-Phospho-D-gluconate; Nicotinamide adenine dinucleotide phosphate [C]

Specific reaction: 6-Phospho-D-gluconate + Nicotinamide adenine dinucleotide phosphate --> CO2 + Nicotinamide adenine dinucleotide phosphate - reduced + D-Ribulose 5-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]